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Characteristics of Renal Cell Carcinoma in Dr. Hasan Sadikin General Hospital Bandung, 2010â2014 Putra, Dicky Suryana; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.376 KB)

Background: Data characteristics for renal cell carcinoma are mostly derived from developed countries. However, data from developing countries, specifically in Indonesia have not been fully described. This study aimed at describing renal cell carcinoma (RCC) characteristics based on age, gender, and histopathology type in Dr. Hasan Sadikin General Hospital Bandung.Methods: This was a descriptive study conducted in AugustâOctober 2015. The data were collected from histopathology medical records of patients who had been diagnosed with RCC at Department of Pathology Anatomy Dr. Hasan Sadikin General Hospital Bandung, from 2010 to 2014. Total sampling was used as sampling method. Only RCC records that had complete variables; which were age, gender, and histopathological type; included in this study.Results: There were 25 cases of renal cell carcinoma discovered in this study, 17 cases discovered in men and 8 cases discovered in women. The histopathology type found in this study was clear cell renal cell carcinoma (12 cases), papillary renal cell carcinoma (8 cases), chromophobe renal cell carcinoma (3 cases), and carcinoma of the collecting ducts of bellini (2 cases). There were no cases found below the age range 2â29 years old and above the age range 70â79 years old.Conclusions: Men have higher incidence than women with the ratio of 2:1. Peak incidence is found on the age range 50â59 years old. The most common histopathology type is clear cell renal cel carcinoma.[AMJ.2016;3(4):644â8]Â DOI:Â 10.15850/amj.v3n4.953

Five Years Facts of Bladder Cancer at West Javaâs Top Referral Hospital, in Indonesia Perix, Vivien Kate; Suryanti, Sri; Sihombing, Aaron Tigor
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.293 KB)

Background: Bladder cancer is the second most common genitourinary cancer and its incidence is rising 15% annually in Indonesia. Smoking is the leading risk factor of bladder cancer and two thirds of men in Indonesia smokes. This study was conducted to describe the characteristics of bladder cancer based on sex, age and histopathology type inÂ West Javaâs Top Referral Hospital, Indonesia. Methods: This study was a descriptive study conducted during theperiod of September to November 2015 using 372 histopathological medical records of patients who had primary and secondary bladder cancer at the Pathology Department, Dr. Hasan Sadikin General Hospital Bandung from January 2010 to December 2014. Data were collected using total sampling method based on the characteristics of age, sex histopathology type, and staging of bladder cancer.Results: Out of the 372 cases, 298 cases were male and 38 cases were female with a male to female ratio of 7.8:1. The age group with the highest incidence was the 50â59 years old group. Infiltrating urothelial carcinoma was the most common histopathology type (71.1%) in primary cancers, 66.1% of cases was muscle invasive while 33.9% was non muscle invasive. Staging pT1 had the most number of cases. The most common site of origin for secondary neoplasm was cervix with adenocarcinoma as the most common histopathology type. Conclusions: Bladder cancer is more common in male than female and peaks at the sixth decade of life. Infiltrating urothelial carcinoma is the most common histopathology type. [AMJ.2017;4(1):94â9]Â DOI:Â 10.15850/amj.v4n1.1028

THE EFFECT OF PREDNISONE ON SERTOLI CELL OF CONTRALATERAL TESTICULAR TORSION Tanuwidjaja, Dandy; Sugandi, Suwandi; Sihombing, Aaron Tigor Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S.
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.58

Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wistar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral torsion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an hour after torsion, continued till one month later. Orchiectomy of contralateral testis was performed one month later. Those testes were examined by a pathologist. Results: In group A, no abnormality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p = 0,01). Ischemic time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In group B and C, prednisone administration inhibited Sertoli cell damage. Prednisone administration in 6 hours group gave better results than 24 hours group (3 rats vs 1 rat with good Sertoli cell quality). Conclusion: Sertoli cell in contralateral testis is significantly affected by unilateral testicular torsion. Prednisone inhibit Sertoli cells damage. Ischemic time affected Sertoli cell quality of contralateral testis and respond to prednisone.Keywords: Prednisone, unilateral testicular torsion, sertoli cell.

EFFECT OF TESTICULAR TORSION ON SPERMATOZOA IN CONTRALATERAL EPIDIDYMIS Pramod, Sawkar Vijay; Sugandi, Suwandi; Sihombing, Aaron Tigor; Tan, Marselina
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.62

Objective: To determine the abnormality of spermatozoa in the contralateral epididymis after unilateral testicular torsion. Material & method: Twenty wistar rats were divided into two groups i.e. Group B (sham procedure) Group A (torsio and orchiectomy 24 hours later), and contralateral epididymectomy was performed a month later. Spermatozoa in the contralateral epididymis are extracted and analyzed by an experienced biologist. Data were analyzed using Chi-square or Fischer exact test. Results: Sperm morphology changes in group B is higher than Group A (6,6% vs 0,5%, p = 0,009). Conclusion: Unilateral testicular torsion causes sperm abnormal morphology in the contralateral epididymis. Keywords: Unilateral testicular torsion, contralateral epididimal spermatozoa.

COMPARISON BETWEEN GLYCOGEN LEVEL OF KIDNEY TUBULAR CELLS IN DIABETIC KIDNEY STONE PATIENTS AND NON DIABETIC KIDNEY STONE PATIENTS Ramadhan, Ken; Sugandi, Suwandi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati; Safriadi, Ferry; Siregar, Safendra; Adriansjah, Ricky; Adi, Kuncoro; Sihombing, Aaron Tigor; Yusuf, Makmuri
Indonesian Journal of Urology Vol 18 No 1 (2011)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v18i1.76

Objective: To compare glycogen level of kidney tubular cells in diabetic kidney stone patients with nondiabetic kidney stone patients. Material & method: We reviewed kidney stone patients who underwent nephrectomy in Hasan Sadikin Hospital from February 2008 to January 2009. Age, gender, type of DM, and urine pH were recorded. Glycogen level of kidney tubular cells were evaluated histochemically using HE, PAS, and PAS diastase. The results were categorized into 3 grades, based on the staining appearance compared to liver cells as controls. The results of diabetic group were compared to non diabetic patients. Results: There were 30 patients eligible for this study, 15 in diabetic group and 15 non diabetic patients. In the diabetic group, there were 10 patients with urine pH < 6 and 5 patients with a pH of 6,5. In the non diabetic group all urine pH were > 6,5. Examination revealed that glycogen level of kidney tubular cells in diabetic group was higher than in non diabetic group. Conclusion: Glycogen level of kidney tubular cells in diabetic kidney stone patients was higher than in non diabetic kidney stone patients. Keywords: Tubular cell, kidney stone, diabetes mellitus.

EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 Nasution, Ramlan; Sugandi, Suwandi; Sihombing, Aaron Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.341

Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer.

PREOPERATIVE INTRAVENOUS TRAMADOL FOR PERCUTANEOUS NEPHROSTOMY TO REDUCE INTRAOPERATIVE PAIN Oetama, Harris; Sihombing, Aaron Tigor
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.426

Objective: To evaluate the effect of additional preoperative intravenous tramadol for reducing intraoperative pain. Material & Methods: This study was a double blind randomized controlled study from April - June 2017 in Urology Department in Hasan Sadikin Hospital. Inclusion criteria were cervical cancer patients who were performed percutaneous nephrostomy. Exclusion criteria were patients with infection and pain before the procedure. Written informed consent was obtained from each patient and the study protocol was approved by the local human ethics committee. The subjects were randomly divided into 2 groups. Group A were given 100 ml dripped normal saline 1 hour before the procedure and intraoperative local anesthesia with lidocaine 2% and group B were given preoperative intravenous tramadol 100 mg dripped within 100 ml of normal saline 1 hour before the procedure and intraoperative lidocaine 2%. Visual Analogue Score (VAS) were used to evaluate the pain score. All calculation were done using SPSS version 20. Results: There were 60 cervical cancer patients who were performed percutaneous nephrostomy (29 patients in Group A and 31 patients in Group B). The mean age in group A was 48.86 ± 8.524 (years old) and the mean age in group B was 51.90 ± 6.76 (years old). The median VAS score in group A was 4, with the minimum score was 2.00, maximum score was 6.00. The median VAS score in group B was 2, with the minimum score was 0.00, maximum score was 4.00. In group A, 11 patients (18.3%) were mild pain, 16 patients (26.7%) were moderate pain, 2 patients (3.3%) were severe pain. In group B, 29 patients (48.3%) were mild pain, 2 patients (3.3%) were moderate pain, 0 patients (0.0%) were severe pain. Based on Mann-Whitney U test, there was a significant pain score reduction in group B compared to group A (p=0.0001). There were no significant differences in the prevalence or proportion of patients with nausea and vomiting in group A and B (10% and 12%, respectively). There were no other adverse events and other complications observed in both groups. Conclusion: Preoperative intravenous tramadol significantly reduced intraoperative pain in cervical patients who were performed percutaneous nephrostomy compare to those who were only given intraoperative local anesthesia.

Characteristics of Renal Cell Carcinoma in Dr. Hasan Sadikin General Hospital Bandung, 2010–2014 Dicky Suryana Putra; Sri Suryanti; Aaron Tigor Sihombing
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.376 KB)

Background: Data characteristics for renal cell carcinoma are mostly derived from developed countries. However, data from developing countries, specifically in Indonesia have not been fully described. This study aimed at describing renal cell carcinoma (RCC) characteristics based on age, gender, and histopathology type in Dr. Hasan Sadikin General Hospital Bandung.Methods: This was a descriptive study conducted in August–October 2015. The data were collected from histopathology medical records of patients who had been diagnosed with RCC at Department of Pathology Anatomy Dr. Hasan Sadikin General Hospital Bandung, from 2010 to 2014. Total sampling was used as sampling method. Only RCC records that had complete variables; which were age, gender, and histopathological type; included in this study.Results: There were 25 cases of renal cell carcinoma discovered in this study, 17 cases discovered in men and 8 cases discovered in women. The histopathology type found in this study was clear cell renal cell carcinoma (12 cases), papillary renal cell carcinoma (8 cases), chromophobe renal cell carcinoma (3 cases), and carcinoma of the collecting ducts of bellini (2 cases). There were no cases found below the age range 2–29 years old and above the age range 70–79 years old.Conclusions: Men have higher incidence than women with the ratio of 2:1. Peak incidence is found on the age range 50–59 years old. The most common histopathology type is clear cell renal cel carcinoma.[AMJ.2016;3(4):644–8] DOI: 10.15850/amj.v3n4.953

Five Years Facts of Bladder Cancer at West Java’s Top Referral Hospital, in Indonesia Vivien Kate Perix; Sri Suryanti; Aaron Tigor Sihombing
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (680.293 KB)

Background: Bladder cancer is the second most common genitourinary cancer and its incidence is rising 15% annually in Indonesia. Smoking is the leading risk factor of bladder cancer and two thirds of men in Indonesia smokes. This study was conducted to describe the characteristics of bladder cancer based on sex, age and histopathology type in West Java’s Top Referral Hospital, Indonesia. Methods: This study was a descriptive study conducted during theperiod of September to November 2015 using 372 histopathological medical records of patients who had primary and secondary bladder cancer at the Pathology Department, Dr. Hasan Sadikin General Hospital Bandung from January 2010 to December 2014. Data were collected using total sampling method based on the characteristics of age, sex histopathology type, and staging of bladder cancer.Results: Out of the 372 cases, 298 cases were male and 38 cases were female with a male to female ratio of 7.8:1. The age group with the highest incidence was the 50–59 years old group. Infiltrating urothelial carcinoma was the most common histopathology type (71.1%) in primary cancers, 66.1% of cases was muscle invasive while 33.9% was non muscle invasive. Staging pT1 had the most number of cases. The most common site of origin for secondary neoplasm was cervix with adenocarcinoma as the most common histopathology type. Conclusions: Bladder cancer is more common in male than female and peaks at the sixth decade of life. Infiltrating urothelial carcinoma is the most common histopathology type. [AMJ.2017;4(1):94–9] DOI: 10.15850/amj.v4n1.1028

Urinary Tract Stones Risk Factors in Patients with Benign Prostatic Hyperplasia in West Java, Indonesia Iman Surendroputro Tjahjodjati; Bambang Sasongko Noegroho; Aaron Tigor Sihombing
Althea Medical Journal Vol 8, No 2 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n2.2257

Background: Urinary tract stones are common in patients with benign prostatic hyperplasia (BPH); therefore, an imaging test is needed for patients who have risk factors for the formation of urinary tract stones. The purpose of this study was to explore the factors associated with the presence of urinary tract stones in patients with BPH as information to conduct imaging tests.Methods: A cross-sectional quantitative analytic study was conducted on medical records of patients with BPH, both with and without urinary tract stones, or patients with urinary tract stones registered at the Department of Urology, Dr. Hasan Sadikin General Hospital, Indonesia, from 2015 to 2018. Data on age, body mass index, hypertension, use of antihypertensive drugs, diabetes mellitus, and hyperuricemia were collected and analyzed using the Mann-Whitney, Chi-square, Fisher exact test, and multivariate logistic regression statistical test to compare variables between BPH with and without urinary tract stones.Results: In total, 235 BPH patients were registered, of whom 74 (31.5%) had urinary tract stones. The median age was 64 years old. There was a relationship between age (p=0.030), diabetes mellitus (p=0.043), and the occurrence of urinary tract stones in patients with BPH. The most dominant risk factor was diabetes mellitus (OR=3.000, 95%CI 1.03-8.69).Conclusions: Age and diabetes mellitus are the risk factors for urinary tract stones in patients with BPH. BPH patients with diabetes mellitus are at a 3-fold risk for urinary tract stones. Diabetes mellitus in BPH patients is an indication to conduct imaging tests.

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