Jaminsen Sinaga
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Short-term intravenous zoledronic acid in severe osteogenesis imperfecta : A report of three siblings of children Lim, Hadyanto; Zein, Umar; Siregar, Yahwardiah; Marpaung, Blondina; Sinaga, Jaminsen
Medical Journal of Indonesia Vol 17, No 2 (2008): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.322 KB) | DOI: 10.13181/mji.v17i2.310

Abstract

This report documented the clinical and biochemical side effects on the first dose of intravenous zoledronic acid therapy in three siblings with severe osteogenesis imperfecta. Zoledronic acid was administered in 50 ml 0.9% saline solution over a period of 30 minutes. All patients had fever during the first 6 to 48 hours after the first infusion. There were no renal side effects, apart from asymptomatic hypocalcemia and hypophosphatemia at 48 and 72 hours after zoledronic acid infusion. The minimal clinical side effects were easily manageable. (Med J Indones 2008; 17: 127-30)Keywords: zoledronic acid, osteogenesis imperfecta, side effects