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All Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology
Ilka Zerfaß
Institut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, Germany
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology

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New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina Robert A. Bara; Ilka Zerfaß; Daowan Lai; Weihan Lin; Abdessamad Debbab; Heike Brötz-Oesterelt; Peter Proksch
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 8, No 3 (2013): December 2013
Publisher : Research and Development Center for Marine and Fisheries Product Processing and Biotechnol

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.v8i3.86

Abstract

Chemical investigation of the endophytic fungus Botryosphaeria australis isolated from Avicennia marina originally from Hainan Province, P.R. China, yielded a new compound botryosphaenin (1), from the class of napthoquinone, together with 5 known compounds, botryosterpene (2) and 5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (3) and its derivatives, 6-ethyl-5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (4), O-methylaspmenone (5), O-methylasparvenone (6) and 5-(carboxymethyl)-7-hydroxy-1,4a-dimethyl-6-methylene decahydron aphthalene-1-carboxylic acid (7). Their structures were determined on the basis of spectroscopic methods including 1D (1H, 13C, and DEPT) and 2D (COSY, HMQC, HMBC, and ROESY) NMR experiments and by mass spectroscopic measurements The new compounds, 1 showed activity against the bacterial pathogens Staphylococcus aureus, several Streptococcus species and Bacillus subtilis, but also against the eukaryotic cell lines THP-1 (human leukemia monocyte) and BALB/3T3 (mouse embryonic fibroblast).
Co-Authors Abdessamad Debbab Daowan Lai Heike Brötz-Oesterelt Peter Proksch Robert A. Bara Weihan Lin