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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention

Lisa Soegianto

Fakultas Farmasi Unika Widya Mandala Surabaya

Author-ID : 383643

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Published : 13 Documents Claim Missing Document

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Effect of Various Concentration of Vegetable Protein in Hair Mask on The Hair Texture Helen, Ivony; Hadinoto, Idajani; Hadisoewignyo, Lannie; Soegianto, Lisa
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

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Effect of various concentrations of vegetable protein in hair mask on the hair texture including hair smoothness, hair shining, hair strength, and morphology of hair had been studied. Concentrations of vegetable protein are made 5%, 7.5%, and 10%. The hair mask was evaluated such as organoleptic, pH, viscosity, and allergy test. Hair mask used in six subjects that have damage hair for 8 times every 2 days. Then, the hair mask was evaluated such as hair smooth and hair shine that used tree trained panel and analyzed using non parametric method Q Cochran. Hair strength was evaluated using autographÃÂ thenÃÂ theÃÂ resultsÃÂ wereÃÂ ÃÂ ÃÂ analyzesÃÂ usingÃÂ ANOVAÃÂ testÃÂ (p<0.05),ÃÂ whileÃÂ hair morphologyÃÂ wasÃÂ evaluatedÃÂ usingÃÂ scanningÃÂ microscopeÃÂ electronÃÂ (SEM).ÃÂ The experimentalÃÂ resultsÃÂ showedÃÂ thatÃÂ vegetableÃÂ proteinÃÂ inÃÂ hairÃÂ maskÃÂ increasedÃÂ hair smoothness, hair strength, and morphology of damaged hair but did not give effect for hair shining. Various concentrations of vegetable protein (5%, 7.5%, and 10%) on hair mask given the same effect in hair texture (hair smoothness, hair strength, and hair morphology).

Perbandingan Antibakteri dari Ekstrak Etanol dan Fraksi Ekstrak Etanol Tanaman Ceguk (Quisqualis indica L.) Terhadap Staphylococcus aureus dan Escherichia coli Valeri, Sepvan; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Tanaman Ceguk merupakan tanaman yang berasal dari Myanmar dan Malaysia. Tanaman ini memiliki beberapa efek farmakologi antara lain immunomodulator, antihiperlipidemia, antipiretik, antioksidan dan antibakteri. Aktivitas antibakteri sebelumnya telah diteliti pada bagian bunga. Pada penelitian ini ekstrak etanol dan fraksi (n-heksana, etil asetat dan air) dari daun tanaman ceguk diuji aktivitas antibakterinya terhadap Staphylococcus aureus dan Escherichia coli. Fraksi aktif terpilih ditentukan dengan bioautografi kontak. Pengujian aktivitas antibakteri meliputi KHM (Kadar Hambat Minimum) dan KBM (Kadar Bunuh Minimum) dilakukan dengan metode mikrodilusi dan trifenil tetrazolium klorida 1% sebagai indikator visual. Golongan senyawa fraksi aktif ditentukan dengan uji kualitatif KLT dengan menggunakan penampak noda. Ekstrak dan fraksi n-heksana tanaman ini menghambat pertumbuhan pada bakteri Gram positif yaitu Staphylococcus aureus dengan nilai KHM 500 ppm pada fraksi n-heksana dan 1000 ppm untuk ekstrak. Ekstrak dan fraksi n-heksana tanaman ini tidak mampu membunuh Staphylococcus aureus dan Escherichia coli. Berdasarkan uji KLT, golongan senyawa fraksi aktif pada fraksi n-heksana yang diduga memiliki potensi sebagai antibakteri adalah golongan triterpenoid dengan harga Rf 0,63. Kata kunci : antibakteri, ceguk, fraksi, kadar hambat minimum, kadar bunuh minimum.

Uji Efek Sedasi dan Durasi Waktu Tidur Ekstrak Etanol Herba Putri Malu (Mimosa microphylla D.) pada Mencit (Mus musculus) Galur Swiss Webster Muliadi, Yeremia Kevin; Tamayanti, Wahyu Dewi; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Sejak dahulu tanaman Putri Malu banyak digunakan oleh masyarakat sebagai obat batu ginjal, radang saluran nafas, anti mikroba, peluruh dahak, antipiretik, antiinflamasi, diuretik. Namun, tanaman Putri Malu dengan jenis spesies Mimosa microphylla D. masih jarang dilakukan penelitian serta masih sedikit literatur yang ada, terutama aktivitasnya dalam menimbulkan efek sedasi bila dibandingkan dengan tanaman Putri Malu dari spesies Mimosa pudica L. Oleh sebab itu dilakukan penelitian untuk menguji efek sedasi ekstrak herba Putri Malu (Mimosa microphylla D.) terhadap mencit (Mus musculus) galur Swiss webster untuk mengetahui potensi sedatifnya. Herba Putri Malu Mimosa microphylla D. diekstraksi dengan cara maserasi dengan etanol 96% dan diberikan kepada mencit jantan galur Swiss webster sebanyak 25 ekor yang dibagi dalam 5 kelompok dengan dosis pemberian 600 mg/kgBB, 1200 mg/kgBB, dan 2400 mg/kgBB masing-masing 1 ml/20 gBB. Penelitian ini dilakukan dengan berbagai metode: holeboard, evasion box, platform, rotarod untuk melakukan uji efek sedasi, uji induksi mula tidur, dan uji durasi waktu tidur, serta sebagai pembanding digunakan fenobarbital 30 mg/kgBB. Dari hasil percobaan uji sedatif, diketahui bahwa dosis 600 mg/kgBB ekstrak etanol herba Putri Malu (Mimosa microphylla D.) memiliki aktivitas sedatif terbaik dan pemberian pada 1200 mg/kgBB mampu memperpanjang durasi tidur mencit, namun ekstrak etanol herba Putri Malu (Mimosa microphylla D.) tidak mampu memperpendek waktu mula tidur mencit. Ekstrak etanol herba Putri Malu (Mimosa microphylla D.) memiliki aktivitas dalam menimbulkan efek sedatif, memperpanjang durasi waktu tidur, namun tidak mampu memperpendek waktu mula tidur mencit. Kata kunci: Mimosa microphylla D., efek sedatif, durasi waktu tidur, waktu mula tidur.

Pengaruh Pemberian Infus Kelopak Kering Rosella (Hibiscus sabdariffa) Terhadap Kadar Kolesterol Total Serum Darah Tikus Hiperkolesterolemia Octavia, Stefani Kartika; Surdijati, Siti; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Rosella (Hibiscus sabdariffa) merupakan salah satu tanaman bermanfaat sebagai bahan makanan, minuman maupun bahan obat. Kelopak Rosella berkhasiat sebagai antihipertensi, antidiabetes, antikolesterol, terapi gangguan liver dan asam urat. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh yang signifikan dari pemberian infus kelopak kering Rosella dalam menurunkan kadar kolesterol total serum darah tikus hiperkolesterolemia. Penelitian ini menggunakan 25 tikus putih jantan galur Wistar yang diberi propiltiourasil 0,01% dan makanan tinggi kolesterol selama 2 minggu. Kemudian dibagi dalam lima kelompok, yaitu kontrol (PGA 3%), pembanding (Simvastatin 0,9 mg/kgBB) dan 3 kelompok uji yang diberi infus Rosella dosis 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB, secara oral selama 2 minggu. Data dianalisis dengan uji statistik Anova dilanjutkan uji Tukey HSD 5%. Perhitungan korelasi digunakan untuk mengetahui hubungan antara peningkatan dosis dengan penurunan kolesterol total. Tidak ada perbedaan bermakna pada setiap pasangan kelompok dengan signifikansi >0,05 untuk semua kelompok kecuali antara K1 dan K5 (signifikansi

Karakterisasi dan Uji Aktivitas Antibakteri dari Fungi Endofit Ranting Tanaman Manggis (Garcinia mangostana L.) terhadap Escherichia coli dan Staphylococcus aureus Widjaja, Kevin; Soegianto, Lisa; Ervina, Martha
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Resistance is commonly caused by improper usage of antibiotics, so the treatment of the infection always needs a new and more potent compounds. Endophytic microbes are microbes that all or part of its life stay in the tissues of plant, which established a mutually beneficial relationship between them. In this research, isolation of endophytic fungi was conducted by sticking the sterilized twigs of mangosteen to the media Malt Extract Agar obtained three pure endophytic fungi colonies. The antibacterial activity assay with direct inoculation method at media Plate Count Agar which was inoculated with bacteria and showed that the antibacterial activity against Escherichia coli ATCC 8739 was one isolate (ER2) with inhibition average ratio 1.42 and against Staphylococcus aureus ATCC 6538 was three isolates (ER1, ER2, and ER3) with inhibition average ratio 1.66; 1.37; and 1.89. The fungus were observed characteristics of the macroscopic, microscopic and biochemical assay. ER1 and ER3 isolates are suspected as a Penicillium genus with specific characteristics such as the conidiophore, fialid, metulae, and conidiospore. ER2 isolate was suspected as a Rhizoctonia genus because there are nearly right-angled hyphae and monilioid cells.

Uji Aktivitas Antimikroba Ekstrak Etanol Daun Cayratia trifolia terhadap Staphylococcus aureus dan Candida albicans Sari, Rizki Sari Endah; Soegianto, Lisa; Hermanu, Liliek S,
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Cayratia trifolia is a wild plant that is easily found in the lowlands, tropical and subtropical regions. Cayratia trifolia is known to be efficacious as an antibacterial, antifungal, antiprotozoa, hypoglycemia, anticancer and diuretic. This study aims to determine whether the ethanol extract of Cayratia trifolia leaves has antimicrobial activity against Candida albicans and Staphylococcus aureus using well diffusion method; to determine the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using microdilution method; and to determine the secondary metabolite groups which have antimicrobial activity against Staphylococcus aureus and Candida albicans. In this study bioautography method was carried out to determine the secondary metabolite group that can inhibit microbial growth. Ethanol extract of Cayratia trifolia (Galing-galing) leaves has no antimicrobial activity against Candida albicans. The MIC value of the ethanol extract of Cayratia trifolia (Galing-galing) leaves against Staphylococcus aureus is at a concentration of 125 ppm, while the MBCvalue is at a concentration of 250 ppm. The group of compounds that have antibacterial activity against Staphylococcus aureus is polyphenol, meanwhile flavonoid suspected has activity against Candida albicans.

Studi pendahuluan: Korelasi Aktivitas Antikolesterol dengan Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium polyanthum) Wijaya, Sumi; Yonas, Stefani Maureen Kasih; Hartanti, Lanny; Setiawan, Henry K.; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Bay leaf leaves (Syzygium polyanthum) are known to have anti-cholesterol activity, with the mechanism inhibited HMG-CoA Reductase enzyme. The purpose of this study was to determine the correlation between anticholesterol activity of bay leaf ethanol extract obtained by percolation method and its antioxidant activity. The parameter used to measure anticolesterol activity is the IC50 value. Antioxidant activity was evaluated by DPPH and Frap methods. The results showed that the ethanolic extract of bay leaves had an IC50 value of 49.50 Â± 0.70 ppm. Ethanol extract of bay leaf showed antioxidant activity with IC50 value of 888.0835 ppm and equality of values with 1 mM FeSO4 of 295 ppm. Based on the results of the analysis, the anticholesterol activity of Bay leaf ethanol extract in inhibiting the HMG-CoA Reductase enzyme did not have a linear correlation with its antioxidant activity.

Uji Potensi Antibakteri dan Antibiofilm Minyak Atsiri Umbi Teki (Cyperus rotundus L.) terhadap Staphylococcus aureus ATCC 6538 Uthari, Ni Made; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Infectious disease is a disease that is caused by an invasion of pathogenic microorganisms in the body. Biofilm is a group of microorganisms that are able to differentiate and proliferate in the complex way as well as being able to communicate between cells through a matrix of polysaccharides. In chronic infection, biofilm has an important role to maintain the bacteria which can cause resistance to antibiotics. Teki (Cyperus rotundus L.) is one of the plants that has many benefits for different treatment. The aim of this study was to determine the antibacterial activity and inhibition of biofilm activity of essential oil of Cyperus rotundus L. tubers against Staphylococcus aureus. Essential oil was extracted by distillation using Stahl with water as the solvent and the yield of essential oil obtained was 0.22%. Determination of antibacterial activity and antibiofilm activity were carried out by microdilution method using microplate 96 U-PVC bottom wells against Staphylococcus aureus which is equivalent to the solution standard of Â½ Mc Farland I. The results of antibacterial activity tests showed that MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) values were 0.05% (v/v) and 12.5% (v/v). Antibiofilm activity test showed that the essential oil of Cyperus rotundus L. tubers is able to inhibit 89.01% of the biofilm formation of Staphylococcus aureus on the concentration of 0.09% (v/v).

Isolasi dan Karakterisasi Fungi Endofit dari Daun Tanaman Bintaro (Cerbera odollam) yang Berpotensi sebagai Antibakteri Wonowijaya, Suwandi; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

The need of antibiotics is increasing, spurred to find compounds that have antimicrobial activity from natural ingredients. One way to obtain antimicrobial compounds is through endophytic fungi. This study aimed to isolate and characterize endophytic fungi obtained from the leaves of the plant Bintaro (Cerbera odollam) that potential as an antibacterial against Staphylococcus aureus and Escherichia coli. Leaf surface was sterilized by soaking in 70% alcohol for 2 minutes, 5.3% sodium hypochlorite for 5 minutes, 70% alcohol for 1 minute, rinsed with sterile distilled water and dried using sterile wipes. Bintaro leaf that have been sterilized was puton Potato Dextrose Agar (PDA) and then incubated at room temperature for 7-14 days. The growing fungi was inoculated in Potato Dextrose Yeast (PDY) for 7-14 days at room temperature based on the macroscopic difference. Endophytic fungi that have been purein macroscopic way was tested antibacterial activity on Staphylococcus aureus and Escherichia coli and continued to macroscopic and microscopic observation. Obtained three types of endophytic fungi were isolated from bintaro leaves (Cerbera odollam) with the code EB 1, EB 2 and EB 3 that suspected from genus Fusarium, Geotrichum and Aspergillus. The antibacterial activity test show that results of three endophytic fungi obtained has no antibacterial activity against Staphylococcus aureus and Escherichia coli.

Potensi Antibakteri dan Antibiofilm Ekstrak Etanol Bunga Bintaro (Cerbera odollam) terhadap Staphylococcus aureus ATCC 6538 Lestari, Dwi Rahma Suci; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Cerbera odollam was one of the plants that can inhibit the growth of bacteria that cause infectious diseases. The misuse of antibiotic in the treatment of infection frequent caused bacterial resistance. One of the forms of antibiotic resistance was the capability of microorganism forming biofilm. This study was conducted to determine the antibacterial and anti-biofilm activity of ethanolic extract from Cerbera odollam flower against Staphylococcus aureus. The ethanolic extract obtained by maceration method using 96% ethanol as a solvent. The ethanol extract of Suicide tree (10, 20 and 30%) were tested for antibacterial activity against Staphylococcus aureus using well diffusion method and anti-biofilm activity using microdilution method. Based on the results, ethanol extract of flowers Cerbera odollam inhibit the growth of Staphylococcus aureus with inhibition zone of 21.66Â±0.73 mm (10%), 25.66Â±1.50 mm (20%) and 27.10Â±1.06 mm (30%). The ethanol extract of Suicide tree flower inhibit biofilm formation 98.29% at the concentration of 3.75%. The bio autography results showed that alkaloid and tannin responsible as bioactive compounds from the ethanol extract Suicide tree flower.

Co-Authors Ardani, Yonas Bianityo Dwi Rahma Suci Lestari, Dwi Rahma Suci Hermanu, Liliek S, Idajani Hadinoto Ivony Helen Lannie Hadisoewignyo Lanny Hartanti Liliek S. Hermanu, Liliek S. Martha Ervina, Martha Muliadi, Yeremia Kevin Nurak, Elisabeth Octavia, Stefani Kartika Prasety, Oda Shantina Sari, Rizki Sari Endah Setiawan, Henry K. Siti Surdijati, Siti Sumi WIjaya, Sumi Uthari, Ni Made Valeri, Sepvan Wahyu Dewi Tamayanti, Wahyu Dewi Widjaja, Kevin Wonowijaya, Suwandi Yonas, Stefani Maureen Kasih

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