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Anti Acne Vulgaris Topical Cream From Combination Extract of Gymnanthemum Amygdalinum Del. and Elaeis Guineensis Jacq. Leaves Wahyudi; Ayu Syahfitri; Berkat Waruwu , Syukur; Dian Ika Perbina
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.4048

Abstract

Acne is one problem in adolescents and adults who can reduce self-confidence. This study aimed to formulate the combination cream of African leaf extract and palm oil leaves to determine the antibacterial activity of African leaf extract against several acne-causing bacteria (Propionibacterium acne and Staphylococcus epidermidis). Test antibacterial activity of extracts and cream with disc diffusion method. The cream is made with concentration of 5, 10 and 20% w/w. The evaluation results of cream with concentration of 5, 10 and 20% were physically stable for 4 weeks of storage at temperature room, homogeneous, pH and it did not cause irritation. Based on the test results, a combination of African leaf extract with concentration of 5% effectively inhibited bacterial growth with an average inhibition zone diameter of 12.06 mm for Propionibacterium acne bacteria and 13.63 mm for Staphylococcus epidermidis bacteria. The result of this study suggest that combination of African leaf extract and palm leaves posses potent anti-bacterial activity against Propionibacterium acne and Staphylococcus epidermidis.
FORMULASI TABLET EKSTRAK DAUN AFRIKA (VERNONIA AMYGDALINA DEL.) SEBAGAI OBAT TUKAK LAMBUNG Wahyudi Wahyudi; Herviani Sari
Jurnal 'Aisyiyah Medika Vol 6, No 1: Februari 2021 Jurnal 'Aisyiyah Medika
Publisher : stikes 'aisyiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/jam.v6i1.558

Abstract

Latar Belakang: Tukak lambung adalah suatu penyakit yang ditandai dengan adanya tukak pada dinding mukosa lambung yang jika tidak ditangani dengan tepat akan dapat menyebabkan kematian. Daun afrika memiliki kandungan senyawa tanin yang dapat membentuk lapisan protektif pada tukak, saponin mengaktivasi faktor protektif membran mukosa, dan flavonoid yang dapat meningkatkan produksi prostaglandin dan menurunkan sekresi HCl lambung yang semuanya tersebut berperan dalam penyembuhan tukak lambung. Tujuan: Untuk memformulasikan tablet ekstrak daun afrika (TEDA) sebagai obat tukak lambung. Metode: Penelitian ini merupakan penelitian kuantitatif menggunakan metode eksperimental yang dilaksanakan pada Mei-Oktober 2020. Daun afrika segar diolah menjadi serbuk simplisia yang selanjutnya diekstraksi menggunakan pelarut etanol 96% dan kemudian diformulasikan menjadi bentuk sediaan tablet TEDA. Agar dapat diberikan kepada hewan uji maka TEDA selanjutnya dibuat dalam bentuk suspensi dalam Na CMC 0,5%. Uji efektivitas penyembuhan tukak lambung dilakukan dengan mengamati penurunan jumlah tukak dan kohesi sel mukosa lambung hewan uji tikus yang diinduksi menggunakan Aspirin dosis 400mg/kgbb. Kelompok uji dibagi dalam 3 variasi dosis yaitu suspensi TEDA 100mg/kgbb, 200 mg/kgbb dan 400mg/kgbb dengan kontrol positif menggunakan sirup sukralfat. Data jumlah tukak lambung dianalisa menggunakan metode ANOVA dan dilanjutkan dengan uji post hoc Tukey. Hasil: Hasil penelitian menunjukkan bahwa dosis suspensi TEDA 100, 200 dan 400mg/kgbb dapat menurunkan jumlah tukak yang terbentuk dan memperbaiki kohesi sel mukosa lambung yang rusak. Hasil analisa data statistik menunjukkan perbedaan secara signifikanjumlah tukak lambung antara kelompok TEDA dibandingkan kontrol negatif (p-value<0,05) yaitu sebesar 0,000. Kesimpulan: semua kelompok TEDA dapat menyembuhkan tukak dan yang paling efektif adalah TEDA dosis 400mg/kgbb karena dapat menyembuhkan tukak lambung pada hari ke-7 dan memiliki efek yang sama dengan kelompok kontrol positif. Kata Kunci: Tukak Lambung, Daun Afrika, Sukralfat, Kohesi Sel Mukosa Lambung
FORMULATION AND TEST THE EFFECTIVENESS OF ANTIHYPERLIPIDEMIC COMBINATION OF ETHANOL EXTRACT OF BITTER MELON (Momordica charantia L.) AND RED GINGER (Zingiber officinale rosc var.rubrum) AGAINST WHITE MALE RATS (Rattus norvegicus) Delisma Marsauli Simorangkir; Wahyudi Wahyudi
JBIO: jurnal biosains (the journal of biosciences) Vol 7, No 3 (2021): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v7i3.28524

Abstract

Cholesterol, is one of the energy sources that provides the highest calories. In addition, cholesterol excess can cause disease.One of a plant that can reduce cholesterol levels is the combination of bitter melon and red ginger which contains flavonoids to lower cholesterol levels. This study aimed was to determine the effectiveness of the combination of red ginger rhizome extract with bitter melon in lowering cholesterol levels, and to determine the most effective dose of combination of red ginger rhizome extract with bitter melon in lowering cholesterol levels. Extraction was carried out by percolation using 96% ethanol solvent, then made into capsules, cholesterol testing was carried out using an experimental method using 35 male white rats induced with duck egg yolk and divided into 7 groups.Each group of 5 animals were given  1% CMC Na, simvastatin, ethanol extract of bitter melon fruit 100mg/Kgbb, ethanol extract of red ginger rhizome 100mg/Kgbb, ethanol extract of fruit bitter melon and red ginger each 50 mg/kg, 100 mg/kg, 150 mg/kg.The results of cholesterol testing in each the treatment group, the best reduction in cholesterol levels was combination doses of 150 mg/kgBW of bitter melon and 150 mg/kgBW of red ginger. Based the results of this study. The best reduction in cholesterol levels was the combination group with a dose of 150 mg/kgBW of bitter melon and 150 mg/kgBW of red ginger which was comparable to the simvastatin in reducing cholesterol levels.Kolesterolmerupakan salah satu sumber energi yang memberikan kalori paling tinggi. Jika dalam jumlah berlebih dapat menyebabkan penyakit. Tanaman yang dapat menurunkan kadar kolesterol adalah buah pare dan jahe merah yang memiliki kandungan flavonoid untuk menurunkan kadar kolesterol.Tujuan penelitian ini untuk mengetahui efektivitas serta dosis yang paling efektif kombinasi ekstrak rimpang jahe merah dengan buah pare dalam menurunkan  kadar kolesterol. Ekstraksi dilakukan secara perkolasi menggunakan pelarut etanol 96%, lalu dibuat dalam sediaan kapsul, uji kolesterol dilakukan menggunakan metode eksperimental menggunakan 35 ekor tikus putih jantan yang diinduksi dengan kuning telur bebek dan dibagi menjadi 7 kelompok. Tiap kelompok sebanyak 5 ekor diberikan CMC Na 1%, simvastatin, ekstrak etanol buah pare 100mg/Kgbb, ekstrak etanol rimpang jahe merah 100mg/Kgbb, ekstrak etanol buah pare dan jahe merah masing-masing 50mg/Kgbb, 100 mg/Kgbb, 150 mg/Kgbb. Dari hasil penelitian ini hasil evaluasi sediaan kapsul memenuhi syarat. Hasil pengujian kolesterol dari kelompok perlakuan, penurunan kadar kolesterol yang paling baik dosis 150 mg/kgBB buah pare dan 150 mg/kgBB jahe merah. Penurunan kadar kolestrol yang paling baik adalah kelompok kombinasi masing-masing dosis 150 mg/kgbb yang sebanding dengan simvastatin.
UJI EFEKTIVITAS ANTIKOLESTEROL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalina Del.) DENGAN EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS HIPERKOLESTEROL Herviani Sari; Nurmaulia Nurmaulia; Wahyudi Wahyudi; Firdaus Fahdi
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.206

Abstract

African leaves (Gymnanthemum amygdalina Del.) and palm leaves (Elaeis guineensis Jacq.) which is contain flavonoid, saponin, alkaloid, and tannin can be used to decrease cholesterol levels and reduced the risk of cardiovascular disease. This study aims to determine the effect of EEDA dan EEDKS combination on blood cholesterol levels in hypercholesterolemic mice. Sample in this study was African leaves and palm leaves which were taken purposively without comparing samples from other regions, then extracted by maceration using ethanol 96%. The results of data analysis from the three EEDA and EEDKS groups effected cholesterol reduction due to the sig value <0.05. Based on ANOVA one way analysis of the five most effective treatments is simvastatin then dose 400-600mg/kgBB, dose 200-300mg/kgBB, dose 100-150mg/kgBB and CMC Na 1%. The combination of EEDA and EEDKS has an antihypercholesterol effect, the combination of EEDA and EEDKS has an antihypercholesterol effect that is comparable to the positive control, and the finding from this study that the most effective dosage of EEDA and EEDKS as antihypercholesterol is at dosage 400-600 mg/kgBB.
FORMULASI DAN UJI AKTIVITAS KRIM TABIR SURYA EKSTRAK BIJI KAKAO (Theobroma cacao L.) DENGAN KOMBINASI AVOBENZONE DAN OCTYL METHOXYCINNAMATE Dian Ika Perbina Meliala; Wahyudi Wahyudi; Nelva Nelva
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.278

Abstract

Sunscreen is a cosmetic ingredient that can physically resist UV A and UV B rays. UV A radiation can cause brown color on the skin and UV B rays can cause skin burn. Although the skin has protection against sunlight, it is still necessary to use sunscreen on the skin. Substances Antioxidants are substances that at small concentrations can significantly inhibit oxidation on the substrate caused by free radicals. One plant that contains natural antioxidants is cocoa beans.To determine the value of Sun Protection Factor (SPF) from cocoa bean extract formulated in cream form and in combination with Avobenxone and Octyl Methoxycinnamate (OMC). Making cocoa bean extract was extracted by maceration using 80% ethanol solvent, making sunscreen extract of cocoa bean extract made in three formulations with concentrations of 10%, 15% and 20%, evaluating cream preparations and determining SPF values (Sun Protection Factor). using UV-Vis spectrophotometry.The results of the study showed differences in SPF values between cocoa bean extract creams. The concentration that has the highest SPF value is 20% with an SPF value of 15.22. The SPF value obtained from each formula is in the maximum category, the recommended value is 15.00. The best SPF value is found at a concentration of 20%, which is 15.22.
BUAH MENGKUDU (Morinda citrifolia), KANDUNGAN DAN EFEKTIVITASNYA SEBAGAI ANTIHIPERTENSI: LITERATURE REVIEW Wahyudi Wahyudi
Jurnal Penelitian Farmasi & Herbal Vol 4 No 2 (2022): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v4i2.871

Abstract

Background: Hypertension is one of a disease high prevalence in the world today, often called the silent killer because it generally does not cause symptoms in sufferers. This disease is characterized by increased contraction of blood vessels which increases blood pressure against the walls of blood vessels. Mengkudu (Morinda citrifolia) is one of the most widely grown plants in Indonesia which has effective antihypertensive properties. Previous studies have shown that mengkudu can lower blood pressure significantly compared to negative controls. The purpose of writing this article is to make a literature review that comprehensively discusses the effectiveness of mengkudu as an antihypertensive from previous studies that have been carried out. Methods: The writing of this article uses the literature review method on research articles found in the Google Scholar and Science Direct database using the keywords mengkudu, Morinda Citrifolia, hypertension and blood pressure. The criteria for the selected articles are articles published between 2000-2022 in both national and international journals. Literature review was conducted by comparing research methods, processing methods and the results obtained from each article. Results: The results of previous studies showed that mengkudu had a significant effect on reducing blood pressure. The decrease in blood pressure is related to the content of prexeronin (endothelial vasoactive), scopoletin (causing vasodilation) and xeronine (diuretic effect) contained in mengkudu which can lower blood pressure by different mechanisms. Conlusion: The content of mengkudu has the potential as an antihypertensive because it can significantly lower blood pressure.
SEDIAAN SALEP EKSTRAK DAUN KELOR (MORINGA OLEIFERA LAM) SEBAGAI PENYEMBUHAN LUKA BAKAR TOPIKAL PADA KELINCI (ORYCTOLAGUS CUNICULUS) Wahyudi Wahyudi; Hanna Agustina
Jurnal FARMASIMED (JFM) Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.03 KB) | DOI: 10.35451/jfm.v1i1.91

Abstract

Burns is a form of tissue damage caused by contact with a heat source such as fire, hot water, chemicals, electricity and radiation. Burns occur on the skin, mucous membranes, respiratory tract and gastrointestinal tract. Actions that can be performed on burns is to provide local treatment with the aim to get relief as quickly as possible. One of the traditional medicines used empirically society as burn treatment is by softening Moringa leaves Moringa leaves and placed on the affected part of the wound. This tudy aim to determine the effect of healing of burns using Moringa leaf extract ointment and to determine the concentration of Moringa leaf extract in the ointment preparation is most effective in the healing of burns. Experimental method. Result of this study show phytochemical screening results indicate the presence of alkaloids, flavonoids, saponins, tannins. observations of Moringa leaf extract ointment preparation during storage of 7 days showed that the formula has a good appearance, homogeneous, smell and color. Diameter burns decline, a group of rabbits treated with the ointment extract of the leaves of Moringa 6% that is 0.9 cm, a group of rabbits given ointment extract of the leaves of Moringa 8% ie 0.91 cm, a group of rabbits given ointment extract of Moringa leaves 10% that is 0.95 cm, Bioplacenton® namely the group given 0.89 cm, while the group of rabbits given distilled water of 0.77 cm. Conclusion of this study show that extracts leaves of Moringa had an effect in the healing of burns. Ointments Moringa leaf extract 10% of the most effective in the healing of burns and has a greater potential than the Bioplacenton®. Burn healing effect on the concentration of 8% and 6% more effective than the negative comparison.
Efektifitas Lumatan Daun Jambu Biji (Psidium guajava linn) Terhadap Penyembuhan Luka Bakar (Vulnus combustion) Pada Kelinci Wahyudi Wahyudi Wahyudi; Dian Ika Perbina
Jurnal FARMASIMED (JFM) Vol 1 No 2 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.727 KB) | DOI: 10.35451/jfm.v1i2.148

Abstract

Guava (Guava guajava linn) or guava contains high pectin so it can lower cholesterol, contain tannins that serves to improve the digestive system. Chemical compounds contained in the fruit guava echoes its shape is quersetin i.e. the type of flavonoid compounds a flavonol, flavones, and flavol, which helps them were to treat the fragility of capillaries in the human. The purpose of this research is to know the effectiveness of guava leaf lumatan (Guava guajava linn) in burn healing in rabbits. The methods used in this study was an experimental method using a control group, the Group and the comparison group test (perlakuaan). The results showed that of the negative control group provides the longest healing impact i.e. on the 13th, the positive control healing burns on day 8, and control using lumatan guava leaf healing burns on day 9 control group comparison, bioplacenton indicates days of healing Burns most rapidly healed.
Literature Study: Efficacious Indonesian Herbs for Lowering Cholesterol Levels Wahyudi Wahyudi
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2464

Abstract

High cholesterol is generally suffered by obese people, but it is possible that thin people can also experience it, especially by consuming foods that are low in fiber but high in fat. Cholesterol can settle on artery walls, so blood flow to the heart, brain, and other body parts can be blocked. There are several herbal ways that can reduce cholesterol levels in the blood, namely by administering avocado leaf extract and avocado fruit, soursop leaf extract, red dragon fruit, rambutan leaf extract and chayote stew as alternative therapy so as not to depend on synthetic drugs. The method used in writing this journal uses a literature review approach. The process of collecting journals is done by searching for literature sources based on specified criteria. The inclusion criteria taken include: journals published in the last 10 years. And the research sample used was obtained from Google Scholar. The results of previous studies explained that cholesterol can not only be treated by using synthetic drugs that come from a doctor's prescription but can also use herbal medicines such as avocado, red dragon fruit, and soursop leaf water extract.
GAMBARAN PENGETAHUAN DAN UPAYA SWAMEDIKASI MAHASISWA FAKULTAS KESEHATAN MASYARAKAT UIN SUMATERA UTARA MEDAN Wahyudi Wahyudi
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.1057

Abstract

Swamedikasi merupakan upaya diri untuk menggunakan atau memperoleh obat tanpa diagnosis, resep, pengawasan ataupun konsultasi dengan dokter untuk mengobati suatu penyakit ringan tertentu. Penelitian ini bertujuan Untuk mendeskripsikan pengetahuan dan upaya mahasiswa Fakultas Kesehatan Masyarakat UIN Sumatera Utara Medan. Penelitian ini merupakan penelitian kuantitatif deskriptif menggunakan menggunakan metode survey. Pengumpulan data dilakukan dengan kuesioner via google form yang selanjutnya dianalisis untuk dapat mendeskripsikan hasil penelitian. Hasil penelitian menunjukkan bahwa tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik dimana 52,7% mahasiswa belum familiar dengan istilah swamedikasi dan hanya 25,9% yang mengetahui bahwa antibiotik harus dibeli dengan resep dokter. Upaya swamedikasi mahasiswa termasuk kategori baik karena 62,5% mahasiswa melakukan upaya swamedikasi jika mengalami sakit ringan, 43,8% mengetahui aturan pakai obat dari apoteker/asisten apoteker dan 52,7% mengetahuinya dari kemasan obat. Penelitian ini juga menunjukkan bahwa mahasiswa telah melakukan persiapan swamedikasi dengan cara menyimpan obat yang akan digunakan saat mereka sakit. Kesimpulan dari penelitian ini adalah tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik (36,6%) dan upaya swamedikasi termasuk kategori baik (80,36%). Obat yang paling banyak disimpan sebagai persiapan swamedikasi adalah obat penurun demam (82,1%).