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All Journal Civil Engineering Dimension Jurnal Ilmiah Cendekia Eksakta
muhammad Nur Ikhsan
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Mechanical Engineering Medicine & Pharmacology

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Performance of a Cold Formed Steel Pedestrian Bridge under Static and Dynamic Loads Ali Awaludin; Maria Yasinta Menge Making; muhammad Nur Ikhsan; Yohan Adiyuano
Civil Engineering Dimension Vol. 23 No. 2 (2021): SEPTEMBER 2021
Publisher : Institute of Research and Community Outreach - Petra Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.705 KB) | DOI: 10.9744/ced.23.2.108-114

Abstract

This paper summarizes new application of CFS in bridge constructions where a seven meters long pedestrian bridge was constructed. The bridge has 1.2m width, 0.8m depth, and is composed of CFS Warren truss and bondek floor systems. Natural frequency of the bridge considering only dead load application was found as 8.54 Hz and decreased to 7.08 Hz when the live load was included. Under static load test, the application of dead load only and both dead and live loads yielded a maximum deflection of 3.53 and 8.1 mm, respectively. Normal walking and running pedestrian loads were carried out created a maximum acceleration equaled to 0.11g. Lastly, sinusoidal waves application facilitated through a three-phase induction motor having self-weight of 24.86 kgf at frequency equal to 8.5 Hz was performed for one hour resulting no decrease of the natural frequency, thus the bridge can be assumed to experience no noticeable stiffness degradation.
STUDI SISTEM DISPERSI PADAT CELECOXIB DENGAN POLIMER HPMC-PEG 6000 DALAM PENINGKATAN KELARUTAN OBAT Danang Novianto Wibowo; Muhammad Nur Ikhsan; Eva Kartalina
CENDEKIA EKSAKTA Vol 5, No 1 (2020)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v5i1.3318

Abstract

Celecoxib merupakan obat antiinflamasi non steroid (OAINS) yang bekerja sebagai obat rheumatoid arthritis dan osteoarthritis. Celecoxib adalah senyawa yang masuk ke dalam BCS kelas II yang kelarutan buruk. Teknologi sistem dispersi merupakan metode yang dapat digunakan untuk meningkatkan kecepatan melarut zat-zat yang sukar larut, sehingga meningkatkan laju disolusinya. Penelitian ini bertujuan untuk mengetahui peningkatan disolusi tablet celecoxib dispersi padat HPMC-PEG 6000. Sistem dispersi padat dibuat dengan metode pelarutan menggunakan polimer HPMC yang dikombinasikan PEG 6000 (1:1, 1:2 dan 2:1). Serbuk dispersi padat, campuran fisik, dan celecoxib murni diuji kelarutanya. Hasil kadar celecoxib terlarut pada masing –masing sampel dianalisis secara deskriptif. Hasil uji kelarutan menunjukkan bahwa dispersi padat celecoxib memiliki kelarutan yang lebih tinggi dibanding dengan campuran fisik dan celecoxib murni. Perbandingan kadar celecoxib terlarut dalam dispersi padat pada perbandingan 1:1, 1:2, dan 2:1 berturut-turut 55,5445g/mL; 14,1292g/mL; 19,8889g/mL. Berdasarkan hasil tersebut, dispersi padat celecoxib dengan polimer HPMC dan PEG 6000 perbandingan 1:1 menunjukkan hasil yang paling tinggi. Peningkatan kelarutan disebabkan dengan adanya penambahan PEG 6000 dan HPMC sebagai zat pembasah, cosolvent dan menghambat pembentukan kristal selama proses pembuatan dispersi padat. Kata kunci : Celecoxib, Dispersi padat, PEG 6000, HPMC
Co-Authors Ali Awaludin Eva Kartalina Maria Yasinta Menge Making Wibowo, Danang Novianto Yohan Adiyuano