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All Journal INDONESIAN JOURNAL OF PHARMACY JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Fivy Kurniawati

Fakultas Farmasi, Universitas Gadjah Mada

Author-ID : 3853441

Health Professions Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document

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Articles

Evaluation of Pain Scale Decrease and Adverse Effects of Ketorolac Injections: An Observational Study in Patients with Postoperative Pain Mawardi Ihsan; Fivy Kurniawati; Husna Khoirunnisa; Belladonna Chairini
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The use of ketorolac injections in Indonesia is restricted with the provision of 2-3 ampoules per day with a maximum of two days even though the literature states that ketorolac could be used for no more than five days. This study aimed to determine the decrease in pain scale as well as gastrointestinal and renal adverse effects of ketorolac injections in two days of use. This study was an observational study with one-group pre-test post-test design conducted prospectively. The group was a group of patients with postoperative pain who received ketorolac injections and were treated during January till April 2018 in an academic hospital in Yogyakarta. The results showed that ketorolac injections did not provide a statistically significant decrease in pain scale in two days of use compared to before surgery (median [range] = 2.0[0.0-9.33] vs 1.33[0.0-8.33]; p=0.32). Ketorolac injections decreased the kidney function of subjects in two days of use compared to before surgery based on creatinine values (0.76mg/dL vs 0.80mg/dL; p=0.024) and GFR (96.13mL/min/m2 vs 87.52mL/min/m2; p=0.023), and as many as 31 subjects (43.06%) experienced complaints that were suspected to be the gastrointestinal adverse effects of ketorolac injections with the three most complaints were bloating (18.06%), nausea (16.67%), and heartburn (15.28%). Those three results support the use of ketorolac injections following what has been regulated in the Indonesian National Formulary.

Explorative Study on Hipertension Treatment among Pregnant Women Anis Ristyaningsih; Fivy Kurniawati; Nanang Munif Yasin
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 8, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Maternal mortality in Indonesia is relatively high, hypertension becomes one of the causes. Hypertension and complication give particular contribution on morbidity and mortality on neonatal and maternal. On the other hand, antihypertensive drug use in pregnancy has both benefit and risk. Therefore, appropriate hypertension management needs to be assesed in order to minimize the risk in mother and baby. The aim of the study is to determine the utilization pattern of antihypertensive drugs that will be assesed for suitability with the standard of medical service and American College of Obstetrics and Gynecologists (ACOG) guideline, as well as to determine clinical outcome of the therapy, which includes achieving target blood pressure, proteinuria, and edema. This study was a cross-sectional study with retrospective data collected from hospitalized patients’ medical record in RS PKU Muhammadiyah Yogyakarta from 2012 – 2015. The data of patients’ medical records according to inclusion and exclusion criteria was obtained using consecutive sampling method. Data obtained was analyzed descriptively and reviewed with the suitability of standard of medical service and ACOG guideline. Research shows that most widely used antihypertensive drugs are nifedipine by 51,8%, methyldopa by 2,6%, and amlodipine by 2,6%. Based on the evaluation of sensibility of treatment, 75,3% stated right indication, 100% right patient, and right medication and dosage. Clinical outcome includes blood pressure that had achieved the target as many as 77 patient, with negative value of proteinuria and edema. Blood pressure when patients were dismissed from the hospital was on average of 128,9±15,9/85±10,9 mmHg. In general, the utilization pattern of hypertension drugs in pregnant women has been well and according to the standards used.

Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital Ardhanarishwari Umi Salamah; Fita Rahmawati; Fivy Kurniawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.40930

Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials.

Medication Literacy for Pharmacists: A Review Niken Nur Widyakusuma; Chairun Wiedyaningsih; Fivy Kurniawati
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The term health literacy has been emerging since the last decades. Poor health literacy had been realized as a main factor for poor health outcomes, higher medical costs, greater risk of death, and poor health status. With the health care system becoming increasingly complicated and the abundance of unclear health information, the ability to understand health information is important for the patients. Health literacy in the context of medicine was also being studied using different terms. It is rather difficult to compile when interventions to improve health literacy is in need of review. At the moment, the term “medication literacy” has been defined internationally by experts. With this definition, medication literacy studies will have the same concept and will be easier in benchmarking between studies. It is very important for pharmacists to recognize and assist patients with limited medication literacy. Although there are several barriers to do improvement in medication literacy, pharmacists can help both individually and through the system. Some of the interventions that can be carried out by pharmacists are assistance with drug information using literacy-sensitive techniques such as repetition, open questions, devices, demonstration on how to use drugs, and using printed materials to ensure patients understand their condition and treatment plans. Unfortunately, practicing pharmacists are lack of knowledge and even interest in medication literacy.

Kajian Adverse Drug Reactions Terkait Interaksi Obat di Bangsal Rawat Inap Rumah Sakit Akademik UGM Fivy Kurniawati; Nanang Munif Yasin; Amila Dina; Sanses Atana; Sarah Nabila Hakim
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.60228

Adverse Drug Reactions (ADRs) is one of the causes of patient’s prolonged length of stay in the hospital and drug interactions can be included as one of the causes of the cause of ADRs. ADR related to drug interactions is a clinical problem that requires proper prevention. This study aimed to identify potential drug interactions also identify adverse drug reactions (ADRs) related to drug interactions in hospitalized patients at Universitas Gadjah Mada Teaching Hospital. This cross-sectional study used retrospective data collection through patient’s medical records from January to June 2018. Patients included in this study were all patients who received therapy more than two kind of drugs simultaneously treated in hospital wards of Universitas Gadjah Mada Teaching Hospital, Yogyakarta, Indonesia. The data collected were then analyzed descriptively. Drug interactions were analyzed using Drug Interaction Facts 2012 and Stockley. ADRs were analyzed by monitoring documented effects of patients with potential drug interaction. There were 115 of 362 patients (31.8%) with potential drug interactions. The total numbers of potential interactions that occur were 182 interactions. The most potential type of interaction was the interaction with moderate severity, with 115 interactions (63.2%). The majority of drug interactions occur through unknown mechanisms (54.4%). Actual ADR occurs in 3.3% patients who were 2 pediatric patients and 4 geriatric patients. This study can be a reference for drug interactions and ADRs as well as guide for pharmacist and healthcare in providing the right medication.

Co-Authors Amila Dina Anis Ristyaningsih Ardhanarishwari Umi Salamah Belladonna Chairini Chairun Wiedyaningsih Husna Khoirunnisa Mawardi Ihsan Nanang Munif Yasin Nanang Munif Yasin Niken Nur Widyakusuma Rahmawati, Fita Sanses Atana Sarah Nabila Hakim

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