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All Journal journal of internal medicine Jurnal Medika Hutama
Ketut Suardamana
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health Veterinary

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ASOSIASI CARA PEMBERIAN OBAT DENGAN ONSET DAN DERAJAT KLINIS REAKSI HIPERSENSITIFITAS AKUT/ANAFILAKSIS PADA PENDERITA YANG DIRAWAT DI RSUP SANGLAH DENPASAR BALI Eka Imbawan, I GN; Suryana, Ketut; Suardamana, Ketut
journal of internal medicine Vol. 11, No. 3 September 2010
Publisher : journal of internal medicine

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Abstract

Acute hypersensitivity reaction/anaphylaxis is a post exposure acute reaction involving dermatologic system/mucosal and subcutaneous tissue; while anaphylaxis is an acute systemic reaction involving two or more organ systems (the skin/mucosa and subcutaneous tissue, respiratory system, cardiovascular system, gastrointestinal system). Drugs as allergens can trigger these reactions orally, parenteral, or topically (contact). Different modes of drug administration are known to relate with onset and degree of the resulting clinical features. We conduct a cross sectional study to determine the association between modes of drugs administration with onset and clinical degree in patients hospitalized at Sanglah General Hospital Denpasar. This study involved 205 patients with acute hypersensitivity reactions/anaphylaxis (105 male and 100 female). Mean age was 33.12 (12 ! 80) years, 131 persons (63.9%) were triggered by drugs, while 57 patients (27.8%) were triggered by food, 13 patients (6.3%) by insect sting, and 3 patients (1.5% ) by other allergens. Of 131 patients with drugs as the trigger, 108 patients (82.4%) were given orally, 22 patients (16.8%) were given parenterally and 1 patient (0.8%) was triggered via contact. The mean onset of an acute hypersensitivity reaction/anaphylaxis triggered by oral and parenteral drugs were 4.2 hours and 0.6 hours respectively (p < 0.01). We conclude that modes of drug administration are associated with the onset of symptoms, but not with the degree of clinical manifestation of acute hypersensitivity reaction/anaphylaxi
A LITERATURE REVIEW ( Imunodefisiensi Primer): Imunodefisiensi Primer IDA BAGUS ADITYA NUGRAHA; I WAYAN WAWAN; KETUT SUARDAMANA
Jurnal Medika Hutama Vol. 3 No. 03 April (2022): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

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Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of adaptive immunity (i.e., T-cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). Although the clinical manifestations of PIDs are highly variable, most disorders involve at least an increased susceptibility to infection. Early diagnosis and treatment are imperative for preventing significant disease-associated morbidity and, therefore, consultation with a clinical immunologist is essential. PIDs should be suspected in patients with: recurrent sinus or ear infections or pneumonias within a 1 year period; failure to thrive; poor response to prolonged use of antibiotics; persistent thrush or skin abscesses; or a family history of PID. Patients with multiple autoimmune diseases should also be evaluated. Diagnostic testing often involves lymphocyte proliferation assays, flow cytometry, measurement of serum immunoglobulin (Ig) levels, assessment of serum specific antibody titers in response to vaccine antigens, neutrophil function assays, stimulation assays for cytokine responses, and complement studies. The treatment of PIDs is complex and generally requires both supportive and definitive strategies. Ig replacement therapy is the mainstay of therapy for B-cell disorders, and is also an important supportive treatment for many patients with combined immunodeficiency disorders. The heterogeneous group of disorders involving the T-cell arm of the adaptive system, such as severe combined immunodeficiency (SCID), require immune reconstitution as soon as possible. The treatment of innate immunodeficiency disorders varies depending on the type of defect, but may involve antifungal and antibiotic prophylaxis, cytokine replacement, vaccinations and bone marrow transplantation.
Co-Authors I GN Eka Imbawan I Wayan Wawan Ida Bagus Aditya Nugraha Ketut Suryana