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All Journal JK Unila (Jurnal Kedokteran Universitas Lampung) Majority
Alif Fernanda Putra
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pengaruh Pemberian Ekstrak Buah Bakau Hitam (Rhizophora mucronata) Terhadap Gambaran Histopatologi Hepar Tikus Putih (Rattus norvegicus Rizki Hanriko; Alif Fernanda Putra; Nisa Karima
Jurnal Kedokteran Universitas Lampung Vol 3, No 2 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i2.2508

Abstract

Dewasa ini, produk pangan yang beredar di pasaran banyak yang menggunakan bahan tambahan pangan (BTP). Namun, penggunaan BTP sering terjadi penyalahgunaan seperti methanyl yellow. Methanyl yellow dapat merusak jaringan tubuh seperti ginjal, otak, dan hepar. Untuk menghadapi kerusakan yang ditimbulkan oleh methanyl yellow, diperlukan suatu senyawa antioksidan seperti buah bakau hitam (Rhizophora mucronata). Dari uraian di atas, peneliti ingin mengetahui pengaruh pemberian ekstrak buah bakau hitam (Rhizophora mucronata) terhadap gambaran histopatologi hepar tikus putih yang diinduksi methanyl yellow. Penelitian ini menggunakan desain eksperimental dengan 20 ekor tikus putih jantan (Rattus norvegicus) dibagi menjadi 5 kelompok dengan masing-masing kelompok berjumlah 4 ekor tikus. Kelompok penelitian antara lain: K1: hanya akuades; K2: methanyl yellow 3000 mg/kgBB; P1: ekstrak buah bakau hitam 3,75 mg/kgBB + methanyl yellow 3000 mg/kgBB; P2: ekstrak buah bakau hitam 7,5 mg/kgBB + methanyl yellow 3000 mg/kgBB; P3: ekstrak buah bakau hitam 15 mg/kgBB + methanyl yellow 3000 mg/kgBB. Uji analisis yang digunakan adalah methanyl yellow dengan Post-hoc LSD. Hasil yang didapatkan berupa terdapat pengaruh pemberian ekstrak buah bakau hitam (Rhizophora mucronata) terhadap gambaran histopatologi hepar tikus putih (Rattus norvegicus) yang diinduksi methanyl yellow berupa penurunan rerata kerusakan sel hepar dibandingkan kelompok kontrol positif dengan dosis 3,75-15 mg/kgBB selama 30 hariKata Kunci: ekstrak buah bakau hitam, histopatologi hepar, methanyl yellow
Pendekatan Diagnosis Anemia pada Pasien dengan Penyakit Ginjal Kronik Alif Fernanda Putra; Yusuf Aulia Rahman
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Abstract

Globally, anemia occurs in 1.62 billion individuals or around 24.8% of the population. In Indonesia, anemia occurs in about 15.4% of the population. Anemia is often a problem with misdiagnosis and inaccurate management. The male patient presents with weakness since the last month. The patient began to feel symptoms of hypertension (220/110 mmHg) at 3 months ago accompanied by tightness, itching in the body, weakness and pale days, swelling almost all over the body, and decreased urine. On physical examination, there was hypertension (160/90 mmHg), the conjunctival was anemic and on the palpebrae, superior and inferior limbs there was pitting edema. On supporting examination, it was obtained patient with normocytic and normochromic anemia Hb 5 g/dL, erythrocyte 1.8 million/μL, hematocrit 15%, LED 90 mm/hour, ureum 486 mg/dL, creatinine 39.28 mg/dL, calcium 4.7 mg/dL, chloride 92 U/L, sodium 124 mmol/L, and potassium 6.6 mmol/L. USG of the abdomen shows the results of bilateral chronic kidney disease. Management of anemia in patients needs to be holistic considered starting from the causes and the choice of therapy used in order to reduce morbidity and mortality and improve the patient's quality of life. This journal will explain the approach to anemia through illustrations on case of patient with anemia in chronic kidney disease.
Co-Authors Nisa Karima Rizki Hanriko Yusuf Aulia Rahman