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All Journal Indonesian Journal of Urology
Suwandi Sugandi
Department of Urology, Faculty of Medicine/Padjadjaran University, Hasan Sadikin Hospital. Jl. Pasteur No. 38 Bandung
Health Professions Medicine & Pharmacology Public Health

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ATHEROSCLEROTIC PLAQUE OF RENAL VASA RECTA ON PATIENT WITH CALCIUM STONE Pramod, Sawkar Vijay; Sugandi, Suwandi; Sihombing, Aaron T.; Makmuri, Makmuri
Indonesian Journal of Urology Vol 20 No 1 (2013)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v20i1.45

Abstract

Objective: We would like to identify whether atherosclerotic plaque inside renal vasa recta correlates with the formation of calcium stone. Material & Method: Samples are taken from kidney tissue removed by nephrectomy due to stone and non-stone disease. Histopathological examination with specific staining was performed by a single pathologist to find the atherosclerotic plaques inside the renal vasa recta. The result of each group was compared, and then analyzed using the Chi square test/Fischer exact test (SPSS ver.16.0; p < 0,05). Results: We found that the risk of calcium lithiasis is two-fold higher in the group with atherosclerotic plaques inside the renal vasa recta. (PR = 2,15; p < 0,05). Conclusion: Calcium stone are more likely to occur on patients with renal vasa recta atherosclerotic plaque, as possible sequelae of vascular injury.Keywords: Atherosclerotic plaque, vasa recta, calcium renal stone.
DISTRIBUTION OF GLEASON SCO¬RE IN PROSTATE ZONES AMONG PROSTATIC CANCER PATIENTS Jaya, Indra; Sugandi, Suwandi; Yantisetiasti, Anglita; Hernowo, Betthy S. S.
Indonesian Journal of Urology Vol 19 No 1 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i1.50

Abstract

Objective: To analyze the distribution features of Gleason score in the different prostate zones. Material & Method: Twenty paraffin block specimens of radical prostatectomy were analyzed looking for Gleason score distribution in each zone. Specimens were stained with Hematoxilin Eosin. Results: Among the 20 cancers, 16 (80%) specimens had more than one focus. Most foci were found in peripheral zone (95%), only one specimen contained foci solely found in transitional zone. More than half (55%) prostate specimens contain three different Gleason grades. Only one specimen contained a single grade. Conclusion: Our results confirm the heterogeneous, multifocal, and multizonal nature of prostate carcinomas. Most specimens had more than one tumor focus, with predominant location in the peripheral zone. Almost all transition zone foci were found concomitantly with peripheral zone foci. Keywords: Prostate cancer, prostate zones, Gleason score.
THE EFFECT OF TESTOSTERONE DEPRIVATION ON ATHEROPLAQUE FORMATION, TESTOSTERONE RECEPTORS, AND COLLAGENIZATION IN WISTAR PENILE TISSUE Azrul, Imam Dirgantara; Tigor, Aaron; Sugandi, Suwandi; Hernowo, Betthy S.
Indonesian Journal of Urology Vol 19 No 1 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i1.51

Abstract

Objective: To evaluate the association between testosterone deprivation and atheroplaque formation, testosterone receptors, and collagenization in Wistar penile tissues. Material & method: Two months after orchiectomized bilaterally, penile tissue of eight Wistar were harvested for semi-quantitative analysis of atheroplaque formation using hematoxyllin-eosin staining. Similar analysis were also conducted to look for collagenization by collagenase staining as well as the expression of testosterone receptors by immunohistochemistry staining. Control group were eight Wistar underwent Sham surgery. Statistical analysis for atheroplaque formation in Wistar compare to control group used was Chi-square, Fishers’ exact test was used for the expression of testosterone receptors, and independent t-tests for evaluating collagenization. Results: A significant decline in the testosterone receptors and increase collagenization were obtained in orchiectomized Wistar, while atheroplaque formation was not significantly different. Conclusion: Testosterone deprivation revealed a significant decline in the expression of testosterone receptors, and a significant increase in collagenization while atheroplaque formation was not significantly changed. Keywords: Erectile dysfunction, testosterone receptors, collagenization, atheroplaque formation, orchiectomy.
THE EFFECT OF PREDNISONE ON SERTOLI CELL OF CONTRALATERAL TESTICULAR TORSION Tanuwidjaja, Dandy; Sugandi, Suwandi; Sihombing, Aaron Tigor Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S.
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.58

Abstract

Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wistar rats were divided into three groups i.e. group A (sham procedure), group B (unilateral torsion + orchiectomy after 6 hours), and group C (unilateral torsion + orchiectomy after 24 hours). Group B and C were further divided into subgroup with and without Prednisone administration. Prednisone was given orally once a day an hour after torsion, continued till one month later. Orchiectomy of contralateral testis was performed one month later. Those testes were examined by a pathologist. Results: In group A, no abnormality on Sertoli cell quality was found. There is significant difference among groups in Sertoli cell quality (p = 0,01). Ischemic time is associated with Sertoli cell quality (2 rats with severe damage in group C and none in group B). In group B and C, prednisone administration inhibited Sertoli cell damage. Prednisone administration in 6 hours group gave better results than 24 hours group (3 rats vs 1 rat with good Sertoli cell quality). Conclusion: Sertoli cell in contralateral testis is significantly affected by unilateral testicular torsion. Prednisone inhibit Sertoli cells damage. Ischemic time affected Sertoli cell quality of contralateral testis and respond to prednisone.Keywords: Prednisone, unilateral testicular torsion, sertoli cell.
EFFECT OF TESTICULAR TORSION ON SPERMATOZOA IN CONTRALATERAL EPIDIDYMIS Pramod, Sawkar Vijay; Sugandi, Suwandi; Sihombing, Aaron Tigor; Tan, Marselina
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.62

Abstract

Objective: To determine the abnormality of spermatozoa in the contralateral epididymis after unilateral testicular torsion. Material & method: Twenty wistar rats were divided into two groups i.e. Group B (sham procedure) Group A (torsio and orchiectomy 24 hours later), and contralateral epididymectomy was performed a month later. Spermatozoa in the contralateral epididymis are extracted and analyzed by an experienced biologist. Data were analyzed using Chi-square or Fischer exact test. Results: Sperm morphology changes in group B is higher than Group A (6,6% vs 0,5%, p = 0,009). Conclusion: Unilateral testicular torsion causes sperm abnormal morphology in the contralateral epididymis. Keywords: Unilateral testicular torsion, contralateral epididimal spermatozoa.
COMPARISON BETWEEN GLYCOGEN LEVEL OF KIDNEY TUBULAR CELLS IN DIABETIC KIDNEY STONE PATIENTS AND NON DIABETIC KIDNEY STONE PATIENTS Ramadhan, Ken; Sugandi, Suwandi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati; Safriadi, Ferry; Siregar, Safendra; Adriansjah, Ricky; Adi, Kuncoro; Sihombing, Aaron Tigor; Yusuf, Makmuri
Indonesian Journal of Urology Vol 18 No 1 (2011)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v18i1.76

Abstract

Objective: To compare glycogen level of kidney tubular cells in diabetic kidney stone patients with nondiabetic kidney stone patients. Material & method: We reviewed kidney stone patients who underwent nephrectomy in Hasan Sadikin Hospital from February 2008 to January 2009. Age, gender, type of DM, and urine pH were recorded. Glycogen level of kidney tubular cells were evaluated histochemically using HE, PAS, and PAS diastase. The results were categorized into 3 grades, based on the staining appearance compared to liver cells as controls. The results of diabetic group were compared to non diabetic patients. Results: There were 30 patients eligible for this study, 15 in diabetic group and 15 non diabetic patients. In the diabetic group, there were 10 patients with urine pH < 6 and 5 patients with a pH of 6,5. In the non diabetic group all urine pH were > 6,5. Examination revealed that glycogen level of kidney tubular cells in diabetic group was higher than in non diabetic group. Conclusion: Glycogen level of kidney tubular cells in diabetic kidney stone patients was higher than in non diabetic kidney stone patients. Keywords: Tubular cell, kidney stone, diabetes mellitus.
EVALUATION OF PROSTATE BASAL CELL BY CYTOKERATIN 903 STAINING IN PROSTATIC ADENOCARCINOMA GLEASON SCORE 6 Nasution, Ramlan; Sugandi, Suwandi; Sihombing, Aaron Tigor; Yantisetiasti, Anglita; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 1 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i1.341

Abstract

Objective: To evaluate the role of prostate basal cell staining in diagnosing Gleason score 6 prostate cancer. Materials & Methods: During research period, we collected 20 medical records and paraffin block specimens of Gleason score 6 prostatic adenocarcinoma patients. Specimens were taken from prostate needle biopsy. Demographic data and PSA level were extracted from medical records. Basal cells were detected by immunohistochemical staining for antikeratin 34β-E12 on paraffin block specimens analyzed by an experienced pathologist. Positive results suggest a benign lesion. Results: Mean age is 70 ± 6,5 years. Mean prostate volume and PSA level was 52±17cc and 25±21 ng/ml. Three specimens (15%) showed presence of basal cells on antikeratin 34β-E12 staining, which indicated benign lesions. Leucocyturia was found in all patients of this group. There was a significant association between PSA level and antikeratin 34β-E12 staining (p=0,03). In multivariate analysis, there is no significant association between antikeratin 34β-E12 staining with age, prostate volume, and leucocyturia. Conclusions: 15 % cases of prostatic cancer Gleason score 6 still showed basal cell existence. Immunohistochemical staining of basal cell should be considered in suspicious cases of prostatic cancer. 
ANGIOTENSIN II TYPE-1 RECEPTOR (AT1R) DISTRIBUTION IN BPH, HIGH GRADE PIN AND ADENOCARCINOMA OF THE PROSTATE Septiadi, Isdianto; Sugandi, Suwandi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati; Safriadi, Ferry; Siregar, Safendra; Adriansjah, Ricky; Adi, Kuncoro; Sihombing, Aaron T; Pramod, Sawkar V; Nasution, Ramlan; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 2 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i2.348

Abstract

Objective: The aim of the study was to detect the differences in number and the distribution of angiotensin II type-1 receptor (AT1R) in BPH, high grade PIN, and adenocarcinoma of the prostate. Material & method: A prospective study was performed in RSHS, in collaboration with the Department of Anatomical Pathology. Prostate samples were taken by TUR of the prostate, and then divided into 5 groups. They were BPH, high grade PIN, adenocarcinoma of the prostate in 3 difference grades (well, moderate, and poorly differentiated). Kidney tissue for control. Immunohistochemical staining was done to determine the angiotensin II type-1 (AT1R) receptor distribution as primary antibody used was mouse monoclonal antibody AT1 (TONI-1): sc-57036, Santa Cruz Biotechnology Inc., CA. Results: Angiotensin II type-1 receptor was found in material of BPH, high grade PIN and adenocarcinoma of the prostate. The number and distribution of the receptors were not different. Conclusion: There are no significant differences in number and distribution of angiotensin II type-1 receptor on BPH, high grade PIN, and adenocarcinoma of the prostate.
ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM Surur, Abu; Sugandi, Suwandi; Haroen, Zulhardi; Noegroho, Bambang S; Tjahjodjati, Tjahdjojati; Safriadi, Ferry; Siregar, Safendra; Adriansjah, Ricky; Adi, Kuncoro; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 2 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i2.349

Abstract

Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A pair T-test was use for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in wistar’s vagina. The mean thickness of epithelial layer in vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared to control group (p>0,05), while the first group showed insignificant difference compared to the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect.
LITOTRIPSI LASER HOLMIUM YAG UNTUK TERAPI BATU URETER Adi, Kuncoro; Safriadi, Ferry; Sugandi, Suwandi; Haroen, Zulhardi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati
Indonesian Journal of Urology Vol 15 No 2 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i2.352

Abstract

Objective: To assess the efficacy of pulsed holmium:YAG laser lithotripsy for ureteral stone therapy. Material and method: Ninety-one patients (70 males and 21 females) with age range 20 – 76 years underwent 93 ureteroscopic procedures for 101 ureteral stones. A preoperative diagnosis was established by ultrasound scanning and intravenous urography. An 8 F rigid Karl-Storz ureteroscope was used for a holmium:YAG laser (OmniPulse MaxTM 80 watt Holmium Laser System Model 1210-VHP, Trimedyne,Inc. Irvine CA, USA) as energy source for laser lithotripsy. The stone localization was mostly at the lower third of the ureter. The mean stone size was 9,6 mm, mean duration of procedure was 48,1 minutes, and the mean hospital stay was 2,1 days. Results: The overall stone clearance rate was 95,6% with the best results for stones in the middle third of the ureter (100%). At follow up we noted two patients with residual stones and two patients with a perforation of the ureteral wall. Conclusion: The Holmium:YAG laser is effective for ureteral stone treatment with a high success rate. Special attention and care should be afforded in impacted ureteral stones. 
Co-Authors Aaron T Sihombing, Aaron T Aaron T. Sihombing Aaron Tigor Aaron Tigor Sihombing Abu Surur, Abu Anglita Yantisetiasti Bambang S Noegroho Betthy S Hernowo, Betthy S Betthy S. Hernowo Betthy S. S. Hernowo Dandy Tanuwidjaja Ferry Safriadi Galuh Richata, Galuh Imam Dirgantara Azrul Indra Jaya Isdianto Septiadi, Isdianto Ken Ramadhan Kuncoro Adi Makmuri Makmuri Makmuri Yusuf Marselina Tan Muhammad Rivai Mumuh M E, Mumuh M Ricky Adriansjah Safendra Siregar Sawkar V Pramod, Sawkar V Sawkar Vijay Pramod Tjahjodjati Zulhardi Haroen, Zulhardi