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All Journal e-Journal Pustaka Kesehatan Folia Medica Indonesiana Journal of Agromedicine and Medical Sciences KOMUNIKA Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) ALLURE JOURNAL
Sugiyanta Sugiyanta
Faculty Of Medicine, Jember State University, Jember
Religion Arts Humanities Dentistry Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Social Sciences Veterinary Other

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The Correlation between Service Quality of Maternal and Child Healthcare/Family Planning Clinic and Degree of Maternal and Child Health at Two Primary Health Care Centers in Jember Makayasa Putri, Kunthi Kencana; Wiji Astuti, Ida Srisurani; Sugiyanta, Sugiyanta
Journal of Agromedicine and Medical Sciences Vol 2, No 1 (2016)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

The high Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) is still a major health problem in Indonesia. As an one of indicator to assess the quality of maternal and child healthcare is MMR and IMR. Service quality consists of five dimensions i.e., tangible, responsiveness, reliability, assurance, and empathy. The aim of this research was to determine the correlation between service quality of maternal and child healthcare/family planning polyclinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. This research used cross-sectional design with 144 respondents. Service quality was measured using ServQual questionnaire and degree of maternal and children health were measured using MMR and IMR. The results of statistical test with Spearman correlation test showed that the significance (p) = 0.000 and correlation coefficients (r) = 0.690. Thus, it can be concluded that there were a strong correlation between service quality of maternal and child healthcare/family planning clinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. Keywords: Maternal Mortality Rate, Infant Mortality Rate, ServQual. 
Pengaruh Ekstrak Air Ubi Jalar Ungu (Ipomoea batatas L.,) terhadap Jumlah Endhotelial Progenitor Cell (EPC) pada Tikus Wistar Diabetes Melitus Cynthia Parasetiayu Ariesty; Sugiyanta Sugiyanta; Heni Fatmawati
Pustaka Kesehatan Vol 2 No 3 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes melitus adalah penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia menjadi faktor penentu dalam perkembangan disfungsi endotel dan penurunan kemampuan pembentukan pembuluh darah baru. Proses pembentukan pembuluh darah baru dihasilkan dari proliferasi endotel setempat dan peran dari Endhotelial Progenitor Cell (EPC) yang dapat dicegah dengan pemberian antioksidan. Salah satu tanaman yang mengandung antioksidan adalah ubi jalar ungu. Dalam penelitian ini, 25 ekor tikus dibagi menjadi 5 kelompok, yaitu 2 kelompok kontrol dan 3 kelompok perlakuan. Pemberian ekstrak dilakukan selama 14 hari melalui cara sonde dengan dosis 1,4 cc/ekor/hari, 3,5 cc/ekor/hari dan 5,6 cc/ekor/hari untuk P1, P2 dan P3. Penghitungan jumlah EPC tikus dilakukan dengan flowcytometry, selanjutnya data dianalisis dengan analisis Oneway ANOVA. Meskipun tidak berbeda secara signifikan, jumlah EPC pada tikus yang diinduksi ekstrak ubi jalar ungu lebih tinggi dibandingkan dengan kelompok tikus diabetik tanpa perlakuan). Dapat disimpulkan bahwa pemberian ekstrak air ubi jalar ungu dengan berbagai dosis tidak menunjukkan adanya perbedaan nyata terhadap kadar EPC tikus yang diinduksi diabetes mellitus.   Kata Kunci: Antioksidan, Diabetes melitus, EPC, Ubi Jalar Ungu
Uji Aktivitas Fraksi N-Heksana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of N-Hexane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complementary Thera Sarah Andriani; Bagus Hermansyah; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Malaria is one of endemic disease in Indonesia that caused many deaths. Immune system plays important rules in preventing malaria severity. Bangle has been proven as an immunostimulant and could reduce parasitaemia in malaria infection. This study aimed to determine the activity of n-hexane fraction of bangle methanolic extract as complementary therapy of malaria. This study used 28 mice, divided into one positive control group, one negative control group, and five treatment groups. Bangle stimulation before induction was given to five treatment groups with dose: 0,005625mg/grbw, 0,01125mg/grbw, 0,0225mg/grbw, 0,045mg/grbw, and 0,09mg/grbw for 14 days. Plasmodium berghei induction was given to all groups, and then treatment groups were given ACT and bangle fraction, and positive control group was given ACT without fraction for three days. Parasitaemia was observed everyday, then plasmodium growth inhibition percentation was counted. Bangle fraction stimulation gave lower parasitaemia at the begining and Pearson correlation test showed strong positive correlation between dose of bangle fraction and plasmodium growth inhibition percentation (p<0,01). We can conclude that n-hexane fraction of bangle methanolic extract was active as complementary therapy of malaria (IC50=0,013 mg/grbb). Keywords: malaria, bangle, n-hexane, complementary therapy
Hubungan Indeks Kepuasan Pasien tentang Mutu Pelayanan Dimensi Jaminan dengan Minat Berobat Kembali di Poli Interna RSD Kalisat Jember (The Relationship between Patient’s Satisfaction Index on Assurance of Service Quality and Utility at Internal Medicine Zuliyatul Masnunah; Dwita Aryadina Rachmawati; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The increasing number of hospitals causes competition among hospitals to get patients so that each hospital must provide quality services to reach patient’s satisfaction. Patient’s satisfaction determines patients behavior in the future, include their interest in utility. The purpose of this study was to find out the relationship between patient satisfaction index on assurance of service quality and utility. This study used cross-sectional design with 50 respondents. Patient’s satisfaction index and utility were measured using ServQual questionnaire. The results of statistic test with Spearman's Rho correlation test showed that the significance (p) = 0,030 with correlation coefficients (r) = 0.308. So, it can be concluded that there was a weak relationship between patient’s satisfaction index about assurance of service quality and utility at Interna Medicine Polyclinic Kalisat Hospital Jember. Keywords: Patient’s satisfaction, service quality, assurance, utility.
Terapi Nutritif Modifikasi Modisco Menggunakan Ekstrak Nanas Meningkatkan Hemoglobin pada Tikus Wistar KEP Berat Alfi Kamalia; Erma Sulistyaningsih; Sugiyanta Sugiyanta
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The data from the Health Research Association of Indonesian Ministry of Health in 2010 showed approximately 35.6% infants having PEM. The diet therapy for severe PEM is modisco. However, due to protein deficiency such as a protease enzyme resulting in nutrients malabsorption, modisco has not been able to compensate the lack of protein in PEM. It requires an active substance to increase protein absorption by adding a proteolytic enzyme. One of the source of proteolytic enzyme is pineapple. The study aimed to prove that addition of pineapple extract on modisco can increase levels of albumin and hemoglobin in severe PEM rats. This was a true experimental study with pre-post test control group design. The sample were 25 male Wistar rats aged 2 months. The data analysis using the Pairwise T test, one way ANOVA followed by LSD showed a significantly difference between pre and post test for both albumin and haemoglobin. The pineapple extract at a dose of 9 and 11 mg/day increased albumin level. And the dose of 7, 9 and 11 mg/day pineapple extract increase haemoglobin level. In conclusion, a modisco modification using pineapple extract for nutritive therapy increased both albumin and hemoglobin levels on severe MEP rats.   Keywords: Severe PEM, Modisco, Pineapple extract
Pengaruh Terapi Kombinasi Ekstrak Etanol Mentimun (Cucumis sativus) dan Vildagliptin terhadap Penurunan Kadar Glukosa Darah Tikus Wistar yang Diinduksi Aloksan (The Effect of Combination Treatment of Cucumber (Cucumis sativus) Ethanolic Extract and Vilda Chita Setya Widyani; Sugiyanta Sugiyanta; Kristianningrum Dian Sofiana
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Effective management is needed. Cucumber is one of traditional medicine contains saponins with antihyperglycemic effects. This study aimed to determine the differences between combination therapy of cucumber ethanolic extract and vildagliptin and monotherapy of cucumber ethanolic extract or vildagliptin to decrease the blood glucose. The rats were injected with alloxan 125 mg/kgBW. There were 5 groups: K1 was normal group, K2 was a group of diabetic rats without treatment, K3 was a group of diabetic rats with cucumber ethanolic extract (200 mg/kgBW), K4 was a group of diabetic rats with vildagliptin treatment (1,8 mg/200 gBW), K5 was a group of diabetic rats with combination treatment of cucumber ethanolic extract (200 mg/kgBW) and vildagliptin (1,8mg/200 gBW). After 14 days, fasting blood glucose (FBG) was measured. The result showed that the mean FBG after treatment (FBG 2) of K1, K2, K3, K4, and K5 were (82,4; 277,2; 188,2; 199,2; 180,6) mg/dL, respectively. In conclusion, the potential of cucumber ethanolic extract and vildagliptin in combination treatment was more effective to decrease the blood glucose levels than both monotherapy of cucumber ethanolic extract or vildagliptin in Wistar rats.   Keywords: Diabetes Mellitus, Cucumber, Vildagliptin, Blood Glucose Levels, Alloxan
Pengaruh Pemberian Cuka Apel 'A' terhadap Kadar MDA Hepar Tikus Wistar Jantan yang Diinduksi Parasetamol Dosis Toksik Niki Niki Rahmawati; Sugiyanta Sugiyanta; Elly Nurus Sakinah
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7667

Abstract

High dose of paracetamol is metabolized by cytochrome P-450 become free radical N-acetyl-p-benzoquinoneimine (NAPQI) but liver Glutathione (GSH) is not adequate to change it become nonreactive metabolite so that NAPQI bind to unsaturated fatty acid of cell membrane, causing lipid peroxidation and increase liver Malondialdehyde (MDA). 'A' apple vinegar contains anthocyanin with an antioxidant effect by electron donor to NAPQI and acetic acid to improve liver GSH level. The aim of research was to investigate the effect of 'A' apple vinegar on the rat liver MDA induced by toxic dose of paracetamol. Research groups consist of normal control (CMC Na 1% 1 ml for 14 days), negative control (CMC Na 1% 1ml for 14 days + paracetamol 291.6 mg/200gBW on the day 12nd,13rd,14th), and treatment group ('A' apple vinegar 0.4 ml/150gBW for 14 days + paracetamol 291.6 mg/200gBW on the day 12nd,13rd,14th). Liver MDA was measured on the day 15th with competitive ELISA. The average of normal control group was 21.58 ng/ml, negative control group was 70,71 ng/ml, treatment group was 37,67 ng/ml. One way ANOVA and Post hoc LSD test showed significantly differences between all groups (p<0,05). It can be concluded that 'A' apple vinegar had an effect on the liver MDA induced by toxic dose of paracetamol. Keywords: Paracetamol, NAPQI, MDA, 'A' apple vinegar, antioxidant
Influence of Administering Watermelon Rind Water Extract (Citrullus vulgaris Schard) on Glucose Level of Male White Rats (Rattus norvegicus) Induced with Streptozotosin Hasyim Asari; Sugiyanta Sugiyanta
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.488 KB) | DOI: 10.20473/fmi.v56i3.24528

Abstract

Watermelon rind water extract contain of citrulline. Citrulline is a precursor of generating Nitric Oxide (NO). NO possibly reduced the level of blood glucose in streptozotosin-induced diabetic rats. This study was a laboratory experimental study completely randomized design. A number of 30 male albino Wistar rats weighting 100 – 200 gr were devided into six groups (N=5), with group 1 served as normal control group. The other groups were given streptozotosin to induced diabetes mellitus. The rats in control diabetic group were given CMC 0,5%, the others were given watermelon rind extracs for 8 days with different doses for each group. The results showed that serum glucose levels in posttest control group was significantly different, from that group of the watermelon rind extract 250 mg/kg bw/day (p = 0,000), groups of watermelon rind extract 500 mg/kgbw/day (p = 0,000) and groups of watermelon rind extract 1000 mg/kgbw/day (p = 0,000). The level of triglyceride in postest control was significantly different from that group of the watermelon rind extract 250 mg/kg bw/day (p = 0,000), groups of watermelon rind extract 500 mg/kgbw/day (p = 0,000) and groups of watermelon rind extract 1000 mg/kgbw/day (p = 0,000).The conclusion, the watermelon rind water extrac can be used to reduced glucose serum level (250, 500, 1000mg/kg bw) with the optimal dose was 500 mg /kgbw/day with the optimal dose was 1000 mg /kgbw/day. 
The Effect Of Folic On Different Dosage Level Against Retina Destruction Level Of Mice With Peroral Methanol 50% I Gusti Ngurah Agung Darma Putra; Al Munawir; Sugiyanta sugiyanta
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5066

Abstract

In recent years, there are many methanol poisoned cases. Methanol poisoned cause of blindness, CNS problem, and metabolic acidosis. Folic acid is the one of many medicinal treatment for methanol poisoned. Folic acid has important role on methanol metabolism in our body. The aim of the study was to known the effect of addition folic acid on retina damage level of methanol poisoned. The method is experimental laboratories (true experiment design) with post test only control group design. The study included 5 separate test. The subject were mice which in 2 - 3 months age and had weight about 25 - 35 gr. There were 5 groups subject in the study. There were control group which given usual meals for mice and aquadest, negative control group which given methanol 7gr/ kgBW, treatment group 1,2, and 3 were given methanol 7gr/kgBW and folic acid 1 mg/kg BW, 3mg/kgBW, and 5 mg/kgBW. The treatment was given about 24 hours, then the eyes of the mice were taken to made blood smear. Damage of eyes were evaluated based score determined before. It can be concluded that addition folic acid can reduce retina damage level of metanol poisoned.
Comparative Effectiveness of Corn Oil (Zea mays) with Pure Coconut Oil (Cocos nucifera L.) to Reduced Glucose Blood Levels of Alloxane Injected Wistar Rats Khadijah Nur Al Firdausi; Sugiyanta Sugiyanta; Pipiet Wulandari
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6193

Abstract

Epidemiological studies show an increased incidence of diabetes mellitus. The initial therapy of diabetes mellitus is a diet treatment. The recommended intake of fat is a Saturated Fatty Acids (SFA) <7% and a Polyunsatturated Fatty Acid (PUFA) <10% of calories. The corn oil contains PUFA and the virgin coconut oil contains SFA as the main component. Aims of this study was to compare the effectivity of corn oil (Zea mays) and virgin coconut oil (Cocos nucifera L.) in decreasing blood glucose level in alloxane-ijnected wistar rats. This was a laboratory experiment research, used the posttest-only control design. The negative control group was wistar rats injected by aquabidest and standard feed diet (K-); the positive control group was alloxane-injected rats with standard feed diet (K+); alloxane-injected rats with standard food diet and 0.54 mL of corn oil/day for 28 days were P1 group; alloxane-injected rats with standard diet food and 0.54 mL of virgin coconut oil/day for 28 days were P2 group. Statistical analysis using the one way ANOVA test showed that the corn oil and virgin coconut oil decrease blood glucose level, but there was no significantly difference in decresing of blood glucose level between P1 and P2. This study concluded that the corn oil and the virgin coconut oil have the same effectiveness in decreasing blood glucose level in wistar rats injected with alloxane.Keywords: Corn oil, virgin coconut oil, blood glucose level, alloxane
Co-Authors Al Munawir Alfi Kamalia Amri Jahi Bagus Hermansyah Bangun Suharti Chita Setya Widyani Cynthia Parasetiayu Ariesty Djoko Susanto Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Erfan Efendi Erma Sulistyaningsih Farikhatul Islakhah Hairrudin Hairrudin Hasyim Asari Heni Fatmawati I Gede Setiawan Adi Putra I Gusti Ngurah Agung Darma Putra I Gusti Putu Purnaba Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Khadijah Nur Al Firdausi Kristianningrum Dian Sofiana Kunthi Kencana Makayasa Putri Kunthi Kencana Makayasa Putri, Kunthi Kencana Muhammad Isra Rafidin Rayyan Niki Niki Rahmawati Pang S. Asngari Pipiet Wulandari Ratna Septyawati Sarah Andriani Sukma Nur Ardini Tina Kartika Yudriani Nurfahimi Zahrah Febianti Zuliyatul Masnunah