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Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Abstract

Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then two– third of fetuses were immersed in alizarin red solution and the remainingin Bouin’s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.
Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (840.123 KB) | DOI: 10.35617/jfi.v8i2.511

Abstract

Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then twoâ?? third of fetuses were immersed in alizarin red solution and the remainingin Bouinâ??s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.
Co-Authors Ade Fitriani, Ade Almahdy A Andanawari, Suci Andi Dian Angriani, Andi Dian Andi Halimah Andriani, Rezky Annika Maizeli Ardita, Nur Akni Arifin Muslim Cahyono, Randi Wujud Darisman, Eka Kurnia Darisman, Eka Kurnia Daryatmo, Daryatmo, J Daryono Daryono, Daryono Dwi Listyorini Endang Budiasih Feri Kurniawan Fitriani Nur, Fitriani Hartati, Puji Hendrati, Etty Nuri Hendri Marhadi I Wayan Dasna Lathif, Yudrik Lathif, Yudrik Lestari, Ayu Rahmania Luqmanul Hakim Mu'minin, Ali Amirul Nadya Fulzi Nasarani, Rahmawanti Anggun Savira Prabewi, Nur Putra, Kurniawan Setia Putra, Kurniawan Setia Rahma Rahma Rahmi Yosmar Renny Risdawati Riri Wiyanti Retnaningtyas Rohani, Rohani, S. Satria, Aulia Siti Nur Aisyah Sovia, Sovia Sri Sulasteri, Sri Sriyanto Sriyanto Surjani Wonorahardjo Suyadi Suyadi Syahrilfuddin Syahrilfuddin, Syahrilfuddin Tahir, M. Yusuf Ulfiani Rahman