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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Paediatrica Indonesiana The Avicenna Medical Journal
Sumadiono Sumadiono
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Severe atopic dermatitis with xerophthalmia in children: A case report Sumadiono, Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 04 (2001)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.586 KB)

Abstract

The management of the atopic dermatitis is not easy and in the severe cases it is a chalenge for the physician. It was reported a 6 year and 3 month old boy with severe atopic dermatitis with erythroderma, secondary infection, marasmic type of severe malnutrition with xerophthalmia, suspected iron defeciency anemia, acute gastroenteritis and miliary tuberculosis. The child had suffered from this disease since he was 3 months old, spreading and becoming worse. The clinical manifestations were redness and black appearance of the skin, excoriation and cast in the skin, some pats of the skin chaping and watery, there was a lacerated wound around his nose. There were many relatives with atopic history in his family tree. The patient had allergy to some medicines (ampicillin and sulfa), and also to many kinds of food. There was eosinophilia in the peripheral blood. The patient had been treated with topical skin medicine, systemic antihistamin/corticosteroid, anti tuberculosis, antibiotics, and local treatment for his eyes, but no improvement. According to the discussion between pediatricians and dermatologists the patient was suffered from severe atopic dermatitis, and was suspected had another disease (geno dermatitis). It is important to avoid drugs that had triggerred allergy before. The limitation of the diet had caused severe malnutrtion. Vitamin A had to be given early. Second generation antihistamine was actually needed to be given early and for several months. It was necessary to do many examinations to establish more exact diagnosis, but the patient died before the examinations were done.Keywords : Atopi dermatitis in children - eosinophil - marasmus xerophthalmia - treatment
The correlation between the absolute eosinophil count and the degree of asthma attack in children Sumadiono, Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.506 KB)

Abstract

Background: The presence of eosinophil in the blood count during an asthmatic attack has been the focus of study. More airway collapse occured in the eosinophil-positive patients, even the eosinophil-positive patients had a much higher incidence of respiratory failure and mechanical ventilation use than the eosinophil-negative group.Objectives: The purpose of this study was to know the correlation between the eosinophil count and the degree of the asthma attack in children.Methods: The subjects of the study were medical records of the asthmatic children who were hospitalized in Sardjito Hospital from 1995 to 2000. The asthma criteria was according to the international consensus. The asthma attack degree evaluation was according to GINA classification. Exclusion criterias: the patients with parasitic infection and no asthmatic respiratory disturbances patients.Results: There were 169 asthmatic patients hospitalized in Sardjito Hospital from 1995 to 2000. The incidence of the hospitalized asthmatic patients was tend to increase from year to year. The percentage of the asthmatic patients with mild and severe degree attack tend to increase. The mean of the absolute eosinophil count in some degree attack group were 143.4 in mild 221.9 and in severe degree attack group were 350.7.Conclusion: There was no significant difference of the absolute eosinophil count between some, mild and severe degree attack of the asthma patients.Keywords: asthma - children - eosinophil - degree of attack
The correlation between the absolute eosinophil count and the degree of asthma attack in children Sumadiono Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 03 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.506 KB)

Abstract

Background: The presence of eosinophil in the blood count during an asthmatic attack has been the focus of study. More airway collapse occured in the eosinophil-positive patients, even the eosinophil-positive patients had a much higher incidence of respiratory failure and mechanical ventilation use than the eosinophil-negative group.Objectives: The purpose of this study was to know the correlation between the eosinophil count and the degree of the asthma attack in children.Methods: The subjects of the study were medical records of the asthmatic children who were hospitalized in Sardjito Hospital from 1995 to 2000. The asthma criteria was according to the international consensus. The asthma attack degree evaluation was according to GINA classification. Exclusion criterias: the patients with parasitic infection and no asthmatic respiratory disturbances patients.Results: There were 169 asthmatic patients hospitalized in Sardjito Hospital from 1995 to 2000. The incidence of the hospitalized asthmatic patients was tend to increase from year to year. The percentage of the asthmatic patients with mild and severe degree attack tend to increase. The mean of the absolute eosinophil count in some degree attack group were 143.4 in mild 221.9 and in severe degree attack group were 350.7.Conclusion: There was no significant difference of the absolute eosinophil count between some, mild and severe degree attack of the asthma patients.Keywords: asthma - children - eosinophil - degree of attack
Severe atopic dermatitis with xerophthalmia in children: A case report Sumadiono Sumadiono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 04 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.586 KB)

Abstract

The management of the atopic dermatitis is not easy and in the severe cases it is a chalenge for the physician. It was reported a 6 year and 3 month old boy with severe atopic dermatitis with erythroderma, secondary infection, marasmic type of severe malnutrition with xerophthalmia, suspected iron defeciency anemia, acute gastroenteritis and miliary tuberculosis. The child had suffered from this disease since he was 3 months old, spreading and becoming worse. The clinical manifestations were redness and black appearance of the skin, excoriation and cast in the skin, some pats of the skin chaping and watery, there was a lacerated wound around his nose. There were many relatives with atopic history in his family tree. The patient had allergy to some medicines (ampicillin and sulfa), and also to many kinds of food. There was eosinophilia in the peripheral blood. The patient had been treated with topical skin medicine, systemic antihistamin/corticosteroid, anti tuberculosis, antibiotics, and local treatment for his eyes, but no improvement. According to the discussion between pediatricians and dermatologists the patient was suffered from severe atopic dermatitis, and was suspected had another disease (geno dermatitis). It is important to avoid drugs that had triggerred allergy before. The limitation of the diet had caused severe malnutrtion. Vitamin A had to be given early. Second generation antihistamine was actually needed to be given early and for several months. It was necessary to do many examinations to establish more exact diagnosis, but the patient died before the examinations were done.Keywords : Atopi dermatitis in children - eosinophil - marasmus xerophthalmia - treatment
Outcome predictors in patients with juvenile idiopathic arthritis receiving intraarticular corticosteroid therapy Anindya Diwasasri; Sumadiono Sumadiono; Sri Mulatsih
Paediatrica Indonesiana Vol 59 No 5 (2019): September 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.108 KB) | DOI: 10.14238/pi59.5.2019.237-43

Abstract

Background Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. It can continue into adulthood and cause severe joint damage, resulting in disability and decreased quality of life. Objective To determine the predictors of clinical outcomes in JIA patients receiving intra-articular corticosteroid injections (IACS). Methods We conducted a retrospective cohort study of children with JIA receiving IACS therapy in Dr. Sardjito General Hospital from 1 January 2012 to 31 December 2017 by reviewing data from medical records. The dependent variables were disabilities and early remission time. Independent variables included age at diagnosis, JIA subtype, duration of disease at first diagnosis, timing of IACS, exposure to oral systemic therapy, as well as anti-nuclear antibodies (ANA), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) test results. External variables were gender and nutritional status. Results Of 36 patients who received intraarticular corticosteroid injections, 28 (77.8%) experienced remission, and 16 (50%) experienced disabilities. Female subjects (OR 5.296; 95%CI 1.143 to 24.548; P=0.027) and subjects with ESR >26 mm/h (OR 2; 95%CI 1.259 to 3.170; P=0.043) were more likely to have disabilities. Use of oral corticosteroids for ≤3 months and IACS treatment ≤ 3 months after diagnosis were predictors of early remission time (OR 6.897; 95%CI 1.869 to 25 and OR 3.290; 95%CI 1.195 to 9.091, respectively). However, only oral corticosteroid had a significant correlation in multivariate analysis. Conclusion Female gender and ESR > 26 mm/h predict disabilities in JIA patients receiving IACS. Duration of oral corticosteroid ≤3 months and early IACS within 3 months of diagnosis correlate to earlier remission time. Shorter duration of oral corticosteroid is the only significant predictor for earlier remission time in JIA patients receiving IACS therapy.
Correlation Between Allergy History in Family and Allergy Manifestation in School Age Children Fitria Mahrunnisa; Sumadiono Sumadiono; Sri Mulatsih
The Avicenna Medical Journal Vol 2, No 1 (2021)
Publisher : Faculty of Medicine, UIN (State Islamic University) Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.859 KB) | DOI: 10.15408/avicenna.v2i1.19736

Abstract

Background: Asthma, eczema and allergic rhinitis are influenced by both genetic factor and environtment factors. Based on family history of allergy, allergic trace cards can identify the level of allergic risk in children. The relationship between family history of allergy and manifestation of allergic disease as a single allergy disease and allergic multimorbidity still need to be explored. The objective of this study was to identify the associations between family history of allergic disease and manifestation of allergic disease in school-age children.Methods: We conducted a cross sectional study on school age children with 6-13 years old at eight elementary schools in Yogyakarta. Family history of allergy was defined as reported asthma, eczema and allergic rhinitis in a parent or sibling and classified the level of allergic risk based on allergic trace cards. Subjects were questioned by standardized ISAAC questionnaire. The relationship between the two was analyzed by the Chi-squared analysis to assess the prevalence ratio (PR).Results: A total of 272 children with an average age of 8.4 years, allergic manifestations occurred more as multimorbidity (53%) with the highest incidence of RA+asthma (9%) compared with one allergic disease (47%) with the highest incidence of RA (11%). There was a significant relationship between family history of allergy and all manifestations of allergic disease with an increased risk of developing allergies by 3.3 (PR 3.3; 95% CI 2.3-4.8) and 2.8 times (PR 2.8; IK95% 1.8-4.3) in the moderate and high-risk score group. Asthma, RA and DA have a risk for coexistence with 2 other diseases of 2.5 (RP 2.5 IK95%; 1.9-3), 2.25 (PR 2.25 IK95%; 1.7 -3) and 1.9 times (PR 2.5 IK95%; 1.45-2.4).Conclusion: Family history of allergic disease is a risk factors for the development of allergic manifestation both a single allergic disease and multimobidity.
Co-Authors Anindya Diwasasri Fitria Mahrunnisa I Nyoman Sujana