Titik Sunarni
Faculty of Pharmacy Setia Budi University Jl. Letjen Sutoyo Mojosongo – Solo, 57127, Phone. 0271-852518, HP:08121520941

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Antioxidant-Free Radical Scavenging of Some Euphorbiaceae Herbs Sunarni, Titik; Leviana, Fransiska
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

In order to screen natural antioxidant, the research about antioxidant of some Euphobiaceae herbs,have been conducted.The air-dried herbs of Euphorbia heterophyllaL,Phyllanthus  acidus  (L.) Skeels, and Phyllanthus  buxifolius  Muell Arg were extracted with metanol.The obtained extract was concentratedand then suspended to producen-hexane, ethyl acetat and aqueous fractions. Free radical scavenger activity against DPPH (1,1diphenyl2pycrylhydrazyl) measured by spectrophotometric method and the IC50 value was determined.The compounds of active fraction had been identified by TLC method. All of theherbs showed activity as DPPH scavenger.Among these herbs,Euphorbia heterophylla L. and Phyllanthus buxifolius Muell, Arg. exhibited a strong free radical scavenging of ethyl acetatfraction with IC50 value 5,883g/ml and 4,643g/ml.The result ofTLC by mobile phase n-buthanol acetic acid water(4:1:5) andacetic acid 15% showed flavonoid compound.
Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC) Sunarni, Titik; Prastiwi, Rini; Kuncahyo, Ilham; Mardiyono, .; Rinanto, Yudi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

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Abstract

Formulation of chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda citrifolia L fruits and investigation of the activity towards liver damage induced by tuberculosis drugs has been performed. The rats were devide into six groups. The normal control without any treatment, negatif control were given INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol, and the treatment group were given INH-RIF with chewable tablets of papaya extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and 28th day. The study showed that the group that given chewable tablets of combination of papaya extract 120mg/200g and morinda extract 20mg/200g can prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%) and 19,90 (PVP1%), compared to the negative control of 41.78% as well as reducing the value of ALT, AST and bilirubin. The tablet formula that can be received on the best of taste and most effective as hepatoprotektor is the chewable tablet with PVP 3%.Keywords : Hepatoprotector, Carica papaya L., Morinda citrifolia L., Isoniazid, Rifampicin
Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC) Sunarni, Titik; Prastiwi, Rini; Kuncahyo, Ilham; Mardiyono, .; Rinanto, Yudi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.28 KB) | DOI: 10.35617/jfi.v6i4.144

Abstract

Formulation of chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda citrifolia L fruits and investigation of the activity towards liver damage induced by tuberculosis drugs has been performed. The rats were devide into six groups. The normal control without any treatment, negatif control were given INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol, and the treatment group were given INH-RIF with chewable tablets of papaya extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and 28th day. The study showed that the group that given chewable tablets of combination of papaya extract 120mg/200g and morinda extract 20mg/200g can prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%) and 19,90 (PVP1%), compared to the negative control of 41.78% as well as reducing the value of ALT, AST and bilirubin. The tablet formula that can be received on the best of taste and most effective as hepatoprotektor is the chewable tablet with PVP 3%.Keywords : Hepatoprotector, Carica papaya L., Morinda citrifolia L., Isoniazid, Rifampicin
OPTIMASI KOMBINASI CARBOMER DAN CMC Na DALAM SEDIAAN GEL PEWARNA RAMBUT EKSTRAK BUNGA TELANG (Clitoria ternatea L.) Mardiana, Lia; Sunarni, Titik; Murukmihadi, Mimiek
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 2, No 2 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.3 KB) | DOI: 10.35799/pmj.2.2.2019.26531

Abstract

ABSTRACTColor and perfume substance factors are essential in a hair dye preparation. Anthocyanin in Butterfly Pea flower (Clitoria ternatea L.) has the potency to act as a natural dye. The physical attributes of hair dye are determined from the combination of carbomer gel and CMC Na as the gelling agent. This research aimed to discover the effect of the combination of carbomer and CMC Na on the physical attributes of the hair dye and to know the optimal formula composition as well as its physical stability during storage and in irritation test. Dry powder of the Butterfly Pea flower was macerated in water that was acidified with tartaric acid using ultrasonic wave to obtain the filtering result’s filtrate with vacuum filtration. The extract was obtained through freeze dry process for 3 days. Eight Butterfly Pea flowers’ extracts with various carbomer and CMC Na compositions were tested for its physical attributes in order to obtain the optimal formula which included adhesiveness, dispersion, pH, and viscosity. To obtain the optimal formula, stability test was conducted on its physical qualities using freeze and thaw method in 3 cycles and another stability test conducted on its dying duration, washing, as well as the sunlight’s effect on it. The result showed that carbomer had dominant effect in improving viscosity, adhesiveness, and pH of the gel; meanwhile CMC Na had dominant effect in increasing the gel’s dispersion. The optimal formula for Butterfly Pea flower hair dye contained 1,66% carbomer and 6,00% CMC Na. There were no significant differences between the experiment’s response and prediction. Unstable viscosity, adhesiveness, dispersion (p<0,05) was analyzed through paired t-test in both before and after the stability test for 3 cycles. The optimal formula of the hair dye caused light irritation to the skin and the gel was the panelists’ favorite during the hedonic test (texture, color, fragrance, and ease of use).    Keywords : Butterfly Pea Flower, Carbomer, CMC Na, Factorial Design, Hair Dye. ABSTRAKFaktor zat warna dan pewangi sangat penting dalam sediaan kosmetik pewarna rambut. Antosianin pada Tanaman Bunga Telang (Clitoria ternatea L.) berpotensi sebagai zat pewarna alami. Sifat fisik pewarna rambut ditentukan dari kombinasi basis gel carbomer dan CMC Na sebagai gelling agent. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi carbomer dan CMC Na terhadap sifat fisik pewarna rambut, mengetahui komposisi formula optimum, stabilitas fisik selama penyimpanan dan pengujian iritasi. Serbuk kering bunga telang dimaserasi dengan air yang diasamkan dengan asam tartarat menggunakan gelombang ultrasonik hingga didapatkan filtrat hasil penyaringan dengan vacuum fitrat. Ekstrak diperoleh dengan metode pengeringan freeze dry selama 3 hari. Delapan formula pewarna ekstrak bunga telang dengan variasi basis gel carbomer dan CMC Na diuji sifat fisiknya untuk mendapatkan formula optimum meliputi daya lekat, daya sebar, pH dan viskositas. Formula optimum yang dibuat dilakukan uji stabilitas mutu fisik dengan metode freeze and thaw selama 3 siklus dan uji stabilitas warna terhadap lama pewarnaan pada rambut, pencucian serta pengaruh sinar matahari. Hasil menunjukkan bahwa carbomer dominan meningkatkan viskositas, daya lekat dan pH gel sedangkan CMC Na dominan meningkatkan daya sebar gel. Interaksi dari carbomer dan CMC Na meningkatkan viskositas, daya lekat, pH dan daya sebar. Formula optimum pewarna rambut bunga telang mengandung carbomer sebesar 1,66% dan CMC Na sebesar 6,00%. Tidak ada beda signifikan antara respon percobaan dengan prediksi. Viskositas, daya lekat, daya sebar, dan pH tidak stabil (p<0,05) dianalisa dengan paired t-test pada sebelum dan sesudah uji stabilitas selama 3 siklus. Formula optimum pewarna rambut menyebabkan iritasi ringan pada kulit dan merupakan gel yang disukai oleh panelis pada uji hedonik (Tekstur, warna, aroma dan kemudahan pengambilan sediaan). Kata kunci: Bunga Telang, Carbomer, CMC Na, Factorial Design, Pewarna Rambut.
Pelatihan Pembuatan Cairan Pencuci Piring Antibakteri dengan Zat Aktif Minyak Lemon untuk Meningkatkan Kesehatan dan Kesejahteraan Keluarga bagi kader PKK Kelurahan Kadipiro Banjarsari Surakarta Nopiyanti, Vivin; Sunarni, Titik; Harjanti, Reslely; Aisiyah, Siti; Suhartinah, Suhartinah
ADI WIDYA : JURNAL PENGABDIAN MASYARAKAT Vol 5, No 1 (2021): ADIWIDYA
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v5i1.3619

Abstract

Cairan pencuci piring merupakan cairan kental bening berwarna yang berfungsi untuk membersihkan peralatan makan seperti piring, gelas, sendok/garpu. Kecenderungan pemakaian produk pencuci cair dari waktu ke waktu semakin meningkat. Hal ini menunjukkan jika pola pencucian peralatan rumah tangga mulai bergeser dari cara yang lama/tradisional dengan abu gosok dan sabun colek menuju cara baru yang lebih praktis. Adanya bentuk beruipa cairan menjadikan praktis dan mudah digunakan serta aroma produk yang khas menjsdikan cairan pencuci piring mempunyai nilai lebih dibandingkan produk pencuci piring yang lain. Bahan tanaman kaya akan senyawa yang mempunyai aktivitas antibakteri di antaranya minyak lemon. Selain digunakan sebagai zat aktif antibakteri, minyak lemon juga dapat dimanfaatkan untuk memberikan bau aromatic pada sediaan cairan pencuci piring.Bahan-bahan baku pembuatan cairan pencuci piring ini mudah diperoleh dengan bahan-bahan golongan sabun, garam, emulgator, pewangi dan pewarna. Cara pembuatannya juga sederhana dengan menggunakan prinsip melarutkan antar bahan yang digunakan. Oleh karena itu, berdasarkan dari uaraian di atas cairan pencuci piring mempunyai potensi dapatdikembangkan sebagai produk usaha mandiri yang dipasrkan secara komersial.Tujuan dari program kegiatan pengabdian masyarakat ini adalah memberikan pelatihan pembautan cairan pencuci piring kepada kader PKK lingkungan Suko Mulyo kelurahan Kadipiro Banjarsari Surakarta. Selain itu juga diadakan pelatihan terkait peluang untuk dikembangkan sebagai usaha mandiri warga. Kegiatan pengabdian dibagi menjadi beberapa tahapan dimulai dari survei dan observasi, dilanjutkan dengan pelatihan berupa tutorial kemuadian dilakukan pendampingan dari tim pengabdi dan diakhiri dengan evaluasi kegiatan.
Analisa Pengendalian Persediaan Dengan Metode EOQ, JIT dan MMSL DiInstalasi Farmasi Rumah Sakit XXX Kota Mojokerto Doso, Tri; Sunarni, Titik; Herdwiani, Wiwin
Jurnal Farmasi Sains dan Terapan Vol 7, No 2 (2020): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2793

Abstract

Pengendalian persediaan (managemen inventory) obat sangat penting karena persediaan obat merupakan permasalahan yang sangat krusial dalam manajemen operasional rumah sakit. Hal ini dikarenakan pengendalian persediaan obat yang tepat dapat berdampak yang kuat terhadap perolehan kembali atas investasi agar dapat melayani pasien dengan baik. Maka persediaan perlu dikelola dengan metode diantaranya Economic Order Quantity (EOQ), Just In Time ( JIT), dan Minimum Maximum Stock Level (MMSL). Tujuan penelitian ini adalah mengetahui pengendalian persediaan obat di Instalasi Farmasi Rumah Sakit XXX Kota Mojokerto serta pengaruh metode EOQ, JIT, dan MMSL terhadap nilai persediaan dan Inventory Turn Over Ratio (ITOR).Rancangan penelitian ini dilakukan secara deskriptif non eksperimental dengan pengambilan data secara retrospektif di Instalasi Farmasi Rumah Sakit XXX tahun 2016-2018. Analisa hasil dengan melakukan pengelompokan persediaan berdasarkan kategori ABC yang selanjutnya diterapkan metode EOQ, JIT, dan MMSL kemudian dibandingan nilai persediaan dan ITOR antara nilai riil dengan nilai perhitungan.Berdasarkan hasil penelitian diperoleh rata-rata nilai persediaan pada tahun 2016-2018 diperoleh nilai persediaan paling efisien dengan selisih paling besar bila dibandingkan dengan nilai persediaan riil yaitu pada metode EOQ dengan nilai persediaan Rp 15.262.175.782,00. Sedangkan pada perhitungan ITOR diperoleh nilai 28,26 kali. Hal ini berarti bahwa pengendalian persediaan pada Instalasi Farmasi Rumah Sakit XXX sudah efisien. Kesimpulan dari penelitian ini adalah pengendalian persediaan obat dan alat kesehatan di Instalasi Farmasi Rumah Sakit XXX Kota Mojokerto sudah efisien bila dibandingkan dengan menggunakan metode EOQ.
EVALUASI KINERJA MENGGUNAKAN METODE BALANCED SCORECARD PADA APOTEK XX YOGYAKARTA TAHUN 2019 Muslim, Ahmad Suriyadi; Sunarni, Titik; Andayani, Tri Murti
MEDIA ILMU KESEHATAN Vol 9 No 2 (2020): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v9i2.349

Abstract

Background: The growth rate of pharmacy in the city of Yogyakarta is very rapid so that it can cause competition between pharmacy. Objective: Pharmacy service performance is very important to be reviewed because it can be used as a parameter to determine management strategies. One method that is recommended in assessing pharmacy performance is the balanced scorecard method. Methods: This research is non-experimental explorative descriptive design with the aim to find out the performance of the apotek XX Yogyakarta based on four perspectives of the balanced scorecard method, financial side, customer, internal business processes, learning and growth of pharmacy and provide recommendations for improvement based on the results of the performance evaluation. Data collection was conducted retrospectively and prospectively in the form of qualitative and quantitative data. Results: The results of the performance apotek XX Yogyakarta using the balanced scorecard method research from a financial perspective shows the value of ITOR has decreased every year, Internal business process perspective is still found the existence of DRP and pharmacies have not met 100% of drug needs and in the perspective of learning and employee productivity growth is valued less. Conclusion: However, over all the results are good because it meets the standard values.