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Correlation between level of serum estrogen, c-telopeptide, and interleukin-6 in determining bone density in perimenopausal women Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume. 34. No. 2, April 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To evaluate the role of estrogen as a menopausal biochemical marker to c-telopeptide (CTx) and IL-6 as a biochemical marker of mineral bone density in perimenopausal women. Method: This is an observational, cross-sectional study in perimenopausal women between 45 - 51 years old, who matched the inclusion and exclusion criteria such as no contraception was taken before, no specific disease that could affect the laboratory findings. Samples were taken from outpatients clinic of Prof Dr. R.D. Kandou hospital. The patients were gathered for blood samples collection. Blood samples were tested in laboratory. All data were collected and being processed statistically using Pearson correlation coefficient (SPSS version 16). Result: From 60 perimenopausal women (45 - 51 years old) sample, mean age was 47.98 Â± 2.26 SD. Estrogen (estradiol) level: < 10 pg/ml, maximum 358 pg/ml, and mean 77.11 Â± 86.2 SD. IL-6 level: minimum is 1.645 pg/ml, maximum 7.771 pg/ml, and mean 4.317 Â± 2.112 SD. We found significant correlation between age and estrogen level (correlation level < 0.05) and CTx level (in level < 0.01). From regression curve, age has no significant correlation with IL-6 concentration. However, we found significant correlation between estradiol and CTx and IL-6 with respective correlation coefficient value of < 0.01. Likewise the correlation between CTx and IL- 6 showed significant statistically with the value of the correlation coefficient < 0,01. Conclusion: There is a significant correlation between estrogen, Il-6 and CTx. These variables play an important role in the occurrence of the physiological changes in the perimenopausal women. This study also showed the occurrence of a bone reabsorption process that was marked by the increase of CTx level in accordance with the increase in the age and the increase in the level of CTx together with the decline in the level of oestrogen. Therefore, prevention therapy of osteoporosis should begin in earlier age, before the further bone reabsorption take place. [Indones J Obstet Gynecol 2010; 34-2: 84-8] Keywords: c-telopeptide, bone mineral density, estrogen, interleukin- 6, perimenopause women

Heat Shock Protein 70 (HSP 70) Level in Threatened Abortion Mamengko, Linda M; Utomo, Bram M; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To determine the level of Heat Shock Protein 70 (HSP 70) in threatened abortion compared with normal pregnancy. Method: This was a cross-sectional analytic study design conducted to examine the HSP 70 level on 25 subjects of pregnant women with

The Prevalence and Risk Factors of Stress Urinary Incontinence in Postpartum Pratiwi, Renny; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To know the incidence of stress urinary incontinence in postpartum and determine the relationship among age, parity, infant birth weight, mode of delivery, episiotomy and perineum rupture. Method: This study used cross sectional analytic design. Qualified subjects from inclusion criteria were interviewed by researchers using pre-defined MESA questioner. Subjects with stress urinary incontinence were found from the questionnaire result. The acquired data was measured and analyzed using SPSS v. 22.0 software and discussed using available literature. Result: From 162 subjects, 36 cases (22.22%) had stress urinary incontinence, 47.22% aging ? 35 years old, 72.22% had multiple pregnancies, 88.89% had per vaginal delivery. Using multivariate logistic regression test, we found there was a relationship between stress urinary incontinence with age and parity (p 35 years old and multiple parities. Keywords: multiple parities, post-partum, stress urinary incontinence

Endometrial Histology in Abnormal Uterine Bleeding with Risk Factors Hasan, Rudy; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the endometrial histology in abnormal uterine bleeding (AUB) patients with risk factors. Method: This study involved 30 patients with complaints of AUB, aged over 35 years with associated risk factors of parity, obesity and fasting blood glucose in the outpatient clinic at Prof. Dr. R. D. Kandou General Hospital Manado, from July 2013 until October 2013. Patients who agreed to be involved in this study, underwent dilatation and curettage (D&C) to assess the endometrial histology that was grouped as the hyperplasia and non-hyperplasia groups. Result: From the results of the study, 7 patients were in the 35-40 years age group (23.3%) and in the 41-50 years age group were 23 patients (76.7%). Based on parity, 11 patients (36.7%) were nulliparous and 19 patients (63.3%) were multiparous. Based on the BMI, 16 patients (53.5%) were obese and 14 patients (46.7%) were non-obese. And based on the results of fasting blood sugar, similar results was obtained in normal and abnormal fasting blood glucose with the results of 15 patients in each groups (50%). And from all of patients who underwent D&C, endometrial hyperplasia was shown in 21 patients (70%) and non-hyperplasia endometrium in 9 patients (30%). From the results of Fischer exact test, a significantly high association was obtained between BMI and fasting blood glucose with the occurrence of endometrial hyperplasia. Conclusion: There is a significant relationship between BMI and high fasting blood glucose with endometrial hyperplasia. [Indones J Obstet Gynecol 2015; 3: 146-150] Keywords: age, AUB, BMI, endometrial hyperplasia, fasting blood sugar, parity

The Menopausal Symptoms of Paramedics at a Tertiary Care Center Kumaat, Toar A; Loho, Maria F T; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 4, October 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To assess paramedic menopausal symptoms on theinpatient unit and outpatient unit.Methods: This was a cross sectional study. Data collect by fill thequestioner, the questioner fill by menopausal paramedic on Prof. Dr.R. D. Kandou Manado Hospital from October 2016 to January 2017.Data were analyzed using SPSS 22.0 for Windows.Results: Of 60 paramedics, 30 were divided to inpatient unit andthe other 30 were divided to outpatient unit. By the menopauserating scale, somatic and urogenital complaint in statistical testhave no significant differences. Psychology complaint with a moderatecomplaints on inpatient unit have 19 paramedic (63%) and12 paramedic (40%) on outpatient paramedic, in statistical havea significant differences (x2=9.62, p=0.022). On the total scoremenopausal complaints, the moderate complaints 18 paramedic(60%) on the inpatient unit and the minor complaints 21 paramedic(70%) on the outpatient unit, in statistical have a significantdifferences (x2=6.97, p=0.031).Conclusion: There is no significant difference in somatic andurogenital complaints on paramedic inpatient unit and outpatientunit. There is a significant difference in psychological complaintsand total score menopausal complaints on paramedic inpatientunit and outpatient unit.[Indones J Obstet Gynecol 2017; 5-4: 208-212]Keywords: menopause, menopause rating scale, paramedic

Relationship of Retinol Binding Protein Four Serum Level on Endometrial Hyperplasia and Endometrial Carcinoma Limy, Ivan; Suparman, Eddy; Tendean, Hermie M. M.
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective : To determine the relationship of elevated serum retinol binding protein 4 with abnormal uterine bleeding Methods : This study was an observational quantitative with cross sectional methods, with all women who had abnormal uterine bleeding caused either by endometrial carcinoma or endometrial hyperplasia at RSUP Prof.DR.RD Kandou, and affiliation hospitals from November 2016 until April 2017. Data were analyzed With SPSS version 2.0 to see the significancy level. Results: Of 26 research subjects, 23 subjects with endomtrial hyperplasia and 3 subjects with endometrial carcinoma. From the total of 26 malignancy and hyperplasia diagnoses, 21 had IMT> 25 and 23 were diagnosed with Endometrial Hyperplasia and 3 Carcinoma Endometrium. 18 subjects had elevated serum RBP4 levels, with 15 people with endometrial hyperplasia and 3 with endometrial carcinoma. With the Fischer Exact test statistic, serum retinol binding protein 4 levels were found in both endometrial hyperplasia and endometrial carcinoma p = 1.00, meaning no significant difference for the occurrence of abnormal uterine bleeding. Conclusion: There was no significant association between serum retinol binding protein 4 between endomterium carcinoma and endometrial hyperplasia. Keywords: abnormal uterine bleeding, endometrial carcinoma, endometrial hyperplasia, serum retinol binding protein 4   Abstrak Tujuan : Mengetahui adanya hubungan peningkatan kadar serum retinol binding protein 4 pada hyperplasia endomterium dengan carcinoma endometrium Metode : Penelitian ini adalah jenis kuantitatif observasional secara potong lintang, dengan semua perempuan yang mengalami perdarahan uterus abnormal yang disebabkan oleh hiperplasia endometrium atau carcinoma endometrium di Bagian Kebidanan dan Kandungan Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai November 2016 sampai April 2017.Data dianalisa dengan SPSS versi 2.0 untuk melihat tingkat kemaknaannya. Hasil : Dari 26 subjek penelitian, 23 subjek dengan hyperplasia endomtrium dan 3 subjek dengan carcinoma endometrium. Didapatkan data penelitian dari total keganasan diagnosa  dan hiperplasia sejumlah 26 orang, sebanyak 21 orang memiliki IM T>25 dan sebanyak 23 orang didiagnosa dengan Hiperplasia Endometrium dan 3 orang karsinoma Endometrium. Didapatkan sebanyak 18 subyek penelitian mengalami peningkatan kadar serum RBP 4, dengan 15 orang yang mengalami hiperplasia endometrium dan 3 orang dengan karsinoma endometrium. Dengan uji statistik Fischer Exact test, didapatkan kadar serum retinol binding protein 4 baik pada hiperplasia endometrium dengan karsinoma endometrium p=1.00, mengartikan tidak mempunyai perbedaan bermakna untuk terjadinya perdarahan uterus abnormal. Kesimpulan : Tidak terdapat hubungan bermakna kadar serum retinol binding protein 4 antara karsinoma endomterium dengan hiperplasia endometrium. Kata kunci : hiperplasia endometrium , kadar serum retinol binding protein 4, karsinoma endometrium, perdarahan uterus abnormal

Cystatin C Serum Level and the Severity of Preeclampsia Winarto, Abraham; Suparman, Eddy; Wantania, John
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Determining the cystatin C serum level among normotensive, mild preeclamptic, severe preeclamptic pregnant women and their relationship with the severity of preeclampsia. Method: The study was held using cross sectional design in Prof. Dr. RD Kandou Hospital in Manado and its network hospitals. We did on 51 samples at term pregnant women, consisting of 17 samples for each group in normotensive, mild preeclampsia, and severe preeclampsia. The data were analyzed using SPSS version 22.0 software through ANOVA and Kruskal Wallis statistical test. Result: The mean cystatin C serum concentration in normotensive pregnant women, mild preeclampsia, and severe preeclampsia were 0.82 mg/l, 1.03 mg/l, and 1.32 mg/l; respectively. The ANOVA statistical test showed the significant association between cystatin C level and severity of preeclampsia (p

Malondialdehyde Levels in Preeclampsia before and after Delivery Rumopa, Harold; Wagey, Freddy W.; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

  Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.   Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).   Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

Relationship between Vaginal Sialidase Levels with Threatened of Preterm Labour Sulistyo, Bambang; Warouw, Najoan N; Suparman, Eddy
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To investigate the association between vaginalsialidase levels and threatened of preterm labor.Methods: A cross sectional study design was used. Subjects weredivided into two groups; the first group were pregnant women withthreatened of preterm labour, whereas the second were pretermpregnant women in Prof. Dr. R.D. Kandou Manado hospitals andnetwork hospitals, during the period between August 2016 andOctober 2016. Data were analyzed with SPSS version 20 to see thesignificancy levels.Results: From the 16 pregnant women with threatened ofpreterm labor and 16 pregnant women with preterm pregnant,the statistical t test showed that there were significant differencesaverage level of sialidase vagina between the threatened ofpreterm labor and preterm pregnant group (p = 0.000).Conclusion: There is a relationship between the incidencethreatened of preterm labor with vaginal sialidase levels.Keywords: bacteria, threat of preterm labour, vaginal sialidase

Endometrial Histology in Abnormal Uterine Bleeding with Risk Factors Hasan, Rudy; Suparman, Eddy; Lengkong, Rudy A
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To determine the endometrial histology in abnormal uterine bleeding (AUB) patients with risk factors. Method: This study involved 30 patients with complaints of AUB, aged over 35 years with associated risk factors of parity, obesity and fasting blood glucose in the outpatient clinic at Prof. Dr. R. D. Kandou General Hospital Manado, from July 2013 until October 2013. Patients who agreed to be involved in this study, underwent dilatation and curettage (D&C) to assess the endometrial histology that was grouped as the hyperplasia and non-hyperplasia groups. Result: From the results of the study, 7 patients were in the 35-40 years age group (23.3%) and in the 41-50 years age group were 23 patients (76.7%). Based on parity, 11 patients (36.7%) were nulliparous and 19 patients (63.3%) were multiparous. Based on the BMI, 16 patients (53.5%) were obese and 14 patients (46.7%) were non-obese. And based on the results of fasting blood sugar, similar results was obtained in normal and abnormal fasting blood glucose with the results of 15 patients in each groups (50%). And from all of patients who underwent D&C, endometrial hyperplasia was shown in 21 patients (70%) and non-hyperplasia endometrium in 9 patients (30%). From the results of Fischer exact test, a significantly high association was obtained between BMI and fasting blood glucose with the occurrence of endometrial hyperplasia. Conclusion: There is a significant relationship between BMI and high fasting blood glucose with endometrial hyperplasia. [Indones J Obstet Gynecol 2015; 3: 146-150] Keywords: age, AUB, BMI, endometrial hyperplasia, fasting blood sugar, parity

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