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Mudasir Mudasir

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia

Author-ID : 3959871

Chemical Engineering, Chemistry & Bioengineering Chemistry

Published : 11 Documents Claim Missing Document

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Attenuated Total Reflectance-FTIR Spectra Combined with Multivariate Calibration and Discrimination Analysis for Analysis of Patchouli Oil Adulteration Zaki Fahmi; Mudasir Mudasir; Abdul Rohman
Indonesian Journal of Chemistry Vol 20, No 1 (2020)
Publisher : Universitas Gadjah Mada

The adulteration of high priced oils such as patchouli oil with lower price ones is motivated to gain the economical profits. The aim of this study was to use FTIR spectroscopy combined with chemometrics for the authentication of patchouli oil (PaO) in the mixtures with Castor Oil (CO) and Palm Oil (PO). The FTIR spectra of PaO and various vegetable oils were scanned at mid infrared region (4000–650 cm–1), and were subjected to principal component analysis (PCA). Quantitative analysis of PaO adulterated with CO and PO were carried out with multivariate calibration of Partial Least Square (PLS) regression. Based on PCA, PaO has the close similarity to CO and PO. From the optimization results, FTIR normal spectra in the combined wavenumbers of 1200–1000 and 3100–2900 cm–1 were chosen to quantify PaO in PO with coefficient of determination (R2) value of 0.9856 and root mean square error of calibration (RMSEC) of 4.57% in calibration model. In addition, R2 and root mean square error of prediction (RMSEP) values of 0.9984 and 1.79% were obtained during validation, respectively. The normal spectra in the wavenumbers region of 1200–1000 cm–1 were preferred to quantify PaO in CO with R2 value of 0.9816 and RMSEC of 6.89% in calibration, while in validation model, the R2 value of 0.9974 and RMSEP of 2.57% were obtained. Discriminant analysis was also successfully used for classification of PaO and PaO adulterated with PO and CO without misclassification observed. The combination of FTIR spectroscopy and chemometrics provided an appropriate model for authentication study of PaO adulterated with PO and CO.

Adsorption and Photodegradation of Cationic and Anionic Dyes by TiO2-Chitosan Nanocomposite Imelda Fajriati; Mudasir Mudasir; Endang Tri Wahyuni
Indonesian Journal of Chemistry Vol 19, No 2 (2019)
Publisher : Universitas Gadjah Mada

The adsorption and photodegradation of cationic and anionic dyes by TiO2-chitosan nanocomposites have been studied. This study investigated the specific surface area, pores volume, pores size of TiO2-Chitosan nanocomposite, and determination kinetics of the reaction on the adsorption and photodegradation process. The methods were carried out by mixing TiO2-nanocomposite into cationic and anionic dyes in various contact times and initial dye concentrations. The results showed that nanocomposite adsorption capacity increased with an increase in the amount of chitosan (TiO2/Chit 0.13) even though the specific surface area (SBET) was reduced. The results indicated that the adsorption on nanocomposite was influenced by the amount of -NH2 and -OH on the chitosan surface. The maximum adsorption capacity (qm) and the observed reaction constant (kObs) for MO were also known to be higher than MB, which means that the TiO2-chitosan nanocomposites could remove anionic dye more than cationic one.

Investigation on the Effect of Addition of Fe3+ Ion into the Colloidal AgNPs in PVA Solution and Understanding Its Reaction Mechanism Roto Roto; Marcelina Marcelina; Nurul Hidayat Aprilita; Mudasir Mudasir; Taufik Abdillah Natsir; Bella Mellisani
Indonesian Journal of Chemistry Vol 17, No 3 (2017)
Publisher : Universitas Gadjah Mada

Analysis of Fe3+ ion present in aqueous solutions is always of interests. Recently, this ion has been analyzed by colorimetric methods using colloid of silver nanoparticles (AgNPs) in capping agents of polymers. The reaction mechanism between AgNPs and Fe3+ is still subject to the further investigation. In this work, 1,10-phenanthroline was used to probe the reaction mechanism between AgNPs and Fe3+ ion in the solution. The colloids of AgNPs were prepared in the polyvinyl alcohol (PVA) solution and reacted with Fe3+. The colloid surface plasmon absorbance decreases linearly along with the increase in Fe3+ concentration. The addition of 1,10-phenanthroline to mixture changes the solution to red, indicating that the reaction produces Fe2+. This suggests that the reduction of the AgNPs absorbance is the result of oxidation of the Ag nanoparticles along with the reduction of Fe3+.

Modified Silica Adsorbent from Volcanic Ash for Cr(VI) Anionic Removal Endang Tri Wahyuni; Roto Roto; Firda Ainun Nissa; Mudasir Mudasir; Nurul Hidayat Aprilita
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

In the present research, cetyltrymethyl ammonium bromide (CTAB)-modified silica from Kelud’s volcanic ash has been prepared and examined as adsorbent for removal of the hazardous Cr(VI) anion. The research was initiated with purification of SiO2 from the volcanic ash that was carried out by reacting the volcanic ash with NaOH powder at 900 °C for 2 h, followed by dissolving the ash to water at 100 °C, and then was acidified with HCl 1 M to form hydrogel. By calcination of the hydrogel, silica (SiO2) gel was obtained. The next step was modification of the silica with CTAB, that was performed by interacting the CTAB solution with the gel, in which the concentration of the CTAB was varied. Then the CTAB-modified silica samples were characterized by using FTIR, XRD, and SEM machines. The activity of the adsorbent was examined for adsorption of CrO4= in the solution. The results of the research demonstrate that the amorphous silica gel and the amorphous CTAB-modified silica have been obtained. The CTAB-modified silica was found to possess much higher ability in the adsorption of CrO4= anion, that was 48.90 mg/g, compared to that of the unmodified silica gel, as much 5.68 mg/g. These findings strongly prove that the negative surface of the CTAB-modified silica adsorbent has been successfully formed. Furthermore, it is also observed that increasing concentration of CTAB in SiO2-CTA can promote more effective adsorption of the CrO4= from the solution, but the further enlargement of the CTAB concentration leads to the adsorption decreased, and the highest adsorption was shown by CTAB-modified silica prepared with 0.10 mole of CTAB/1 mole SiO2.

Heavy Metal Removal from Aqueous Solution Using Biosurfactants Produced by Pseudomonas aeruginosa with Corn Oil as Substrate Venty Suryanti; Sri Hastuti; Tutik Dwi Wahyuningsih; Mudasir Mudasir; Dian Kresnadipayana; Inge Wiratna
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

The batch removal of Cu(II), Cd(II) and Pb(II) from individual heavy metal ion aqueous synthetic solution using biosurfactants produced by Pseudomonas aeruginosa with corn oil as substrate was investigated. The metal ion removal process of crude preparation biosurfactants (CPB) was established to be dependent on the initial pH and contact time. The optimum metal removal was observed at pH 6.0 of the initial metal solution and 10 min of contact time. The affinity sequence for metal ion removal was Pb(II)>Cd(II)>Cu(II). The removal capacity value of biosurfactant for Cu(II), Cd(II) and Pb(II) from single metal ions solution were 0.169, 0.276 and 0.323 mg/g, respectively. The removal capacity value of biosurfactant for Cu(II), Cd(II) and Pb(II) from multi metal ions solution were 0.064, 0.215 and 0.275 mg/g, respectively. The removal capacity of individual metal ion was diminished by the presence of other metal ions in multi metal ions from synthetic aqueous solution. The removal capacity value of biosurfactant for Cu(II), Cd(II) and Pb(II) from silver industry wastewater were 0.027, 0.055 and 0.291 mg/g, respectively. The results indicated that biosurfactants have potential to be used in the remediation of heavy metals in industrial wastewater.

Docking of New Designed Compounds Derived from 1,6-Dihydro-1,3,5-triazine-2,4-diamine Toward Quadruple Mutant Plasmodium Dihydrofolate Reductase Imam Siswanto; Harno Dwi Pranowo; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Resistance to the traditional antifolates is now widespread in Plasmodium falciparum and Plasmodium vivax. To find the interaction model of some compounds derived from 1,6-dihydro-1,3,5-triazine-2,4-diamine, molecular docking technique was carried out using these compounds ligand and pDHFR as the receptor. Complex ligand and the receptor from Protein Data Bank (PDB ID 1J3K) were chosen as an interaction model between a ligand and its receptor. Each compound was optimized using ab initio methods with 6-311G basis set. Partial charges of ligand were added using AM1-BCC methods. Each ligand was docked to the receptor utilizing Dock6 software. Theoretical prediction based on the binding energy between these compounds as the ligand with pDHFR as receptor resulted in 1 compound, namely 6,6-dimethyl-1-[3-(2-chloro-4,5-dibromophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine possessing binding affinity better than that of WR99210 which was known to have good antimalarial activity.

Inhibitive Determination of Hg(II) in Aqueous Solution Using Urease Amperometric Biosensor Dhony Hermanto; Bambang Kuswandi; Dwi Siswanta; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

An amperometric biosensor for the indirect determination of Hg(II) has been developed based on inhibition of urease (EC 3.5.1.5) immobilized into alginate–chitosan polyelectrolyte complexes membrane. The biosensor response was monitored by following the reduction peak of hydrolyzed urea at around -0.15 V. The amperometric biosensor has a dynamic range 40–90 ppb Hg(II) with limit of detection of 66.45 ppb toward Hg(II) ions, repeatability (CV) value of 0.86% and only Ag(I) as the main potential interference. The sensor shows a stable and reproducible response for more than 2 weeks when it stored dry at 4 °C. The analytical results of Hg(II)-spiked water sample showed a good agreement with those obtained by atomic absorption spectrometry method, suggesting that the developed method may be applied in the determination of Hg(II) in the water samples.

Synthesis, Characterization, and Stability Evaluation of β-Carotene Encapsulated in Starch-Chitosan/Tripolyphosphate Matrices Agnes Dyah Novitasari Lestari; Dwi Siswanta; Ronny Martien; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 20, No 4 (2020)
Publisher : Universitas Gadjah Mada

This study aims to investigate the synthesis and characterization of β-carotene encapsulated in the blending matrices of starch (native and hydrolyzed starch)-chitosan/TPP (tripolyphosphate) by examining the effects of starch-to-chitosan weight ratio, β-carotene addition level, and TPP addition level on the encapsulation efficiency (EE) and loading capacity (LC); and to evaluate their storage stability. The encapsulation was done by the dropwise addition of ethanolic β-carotene dispersion into the blending matrices. The results of XRD analysis show that the encapsulation process significantly decreases the crystallinity of the starches, chitosan, and β-carotene. Scanning electron microscope (SEM) images reveal that the encapsulation products form irregular lumps. The EE and LC tend to increase with the increase in polymer fraction of matrices and β-carotene addition level, and with the decrease in TPP addition level. The addition of chitosan and the replacement of native starch by hydrolyzed starch tend to increase storage stability of β-carotene encapsulated in the starch matrix because chitosan can act as a good film-forming and antioxidant, while hydrolyzed starch contains amylose amylopectin with a short chain which is better in film-forming ability. These results promote the use of the hydrolyzed starch-chitosan/TPP as a matrix to enhance the stability β-carotene via encapsulations.

Preparation, Characterization, and In Vitro Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane Khabibi Khabibi; Dwi Siswanta; Mudasir Mudasir
Indonesian Journal of Chemistry Vol 21, No 5 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.61704

This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in various monomers ratios, and the membranes formed were characterized by FTIR, SEM, and TGA. Furthermore, the hydrophilicity, swelling, porosity, mechanical strength, and dialysis performance of the membranes against urea and creatinine were systematically examined, and their in-vitro hemocompatibility tests were also conducted. The results showed that the CS/CMC-GA membranes have higher hydrophilicity, swelling, porosity, mechanical strength, and better dialysis performance against urea and creatinine than chitosan without modification. In addition, the hemocompatibility test indicated that the CS/CMC-GA membranes have lower values of protein adsorption, thrombocyte attachment, hemolysis ratio, and partial thromboplastin time (PTT) than that of pristine chitosan. Based on these results, the CC/CMC-GA membranes have better hemocompatibility and the potential to be used as hemodialysis membranes.

Superparamagnetic Composite of Magnetite-CTAB as an Efficient Adsorbent for Methyl Orange Nor Harisah; Dwi Siswanta; Mudasir Mudasir; Suyanta Suyanta
Indonesian Journal of Chemistry Vol 22, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.69499

In this study, a superparamagnetic composite of magnetite-cetyltrimethylammonium bromide (CTAB) has been prepared by the coprecipitation method and then applied as a charge-selective adsorbent of anionic methyl orange (MO). The VSM (Vibrating Sample Magnetometer) measurement suggests the superparamagnetic property of MNPs (Magnetite Nano Particles) with a magnetic saturation of 49.2 emu g–1. The SEM image exhibits the significant difference in particle size from nanometers in uncoated magnetite to micrometers in magnetite-CTAB. Calculations with ImageJ software indicate that the diameter of the composite is in the range of 2–13 µm, with an average diameter of 6.56 µm, possibly consisting of hundreds to thousands of magnetite-CTAB micelles. The adsorption kinetics of MO over magnetite-CTAB follows the pseudo-second-order adsorption model of Ho and McKay with a rate constant (k2) of 3.54 × 103 g mol–1 min. The adsorption isotherm is well described by the Langmuir model with a Langmuir constant (KL) of 7.46 × 104 L mol and a maximum capacity (qm) of 27.9 mg g–1. The developed material is intriguing because it can be easily and quickly recovered using an external magnet after adsorption and selectively adsorbs anionic dyes.

Co-Authors Abdul Rohman Agnes Dyah Novitasari Lestari Ahmad Akhib Ainul Yaqin Bambang Kuswandi Bella Mellisani Dhony Hermanto Dian Kresnadipayana Dwi Siswanta Endang Tri Wahyuni Firda Ainun Nissa Harno Dwi Pranowo Imam Siswanto Imelda Fajriati Inge Wiratna khabibi Khabibi Marcelina Marcelina Nor Harisah Nurul Hidayat Aprilita Ronny Martien Roto Roto Sri Hastuti Suherman, Suherman Suyanta Suyanta Taufik Abdillah Natsir Tutik Dwi Wahyuningsih Venty Suryanti Zaki Fahmi

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