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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) GIZI INDONESIA
Suwijiyo Pramono
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Medicine & Pharmacology Public Health

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 1 
Antiinflammatory Effect of Several Umbelliferae Species SUWIJIYO PRAMONO
HAYATI Journal of Biosciences Vol. 12 No. 1 (2005): March 2005
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (29.482 KB) | DOI: 10.4308/hjb.12.1.7

Abstract

A screening for antiinflammatory effects was performed on several Indonesian Umbelliferae plants based on the contents of saponins and flavonoids. They were compared with Bupleurum falcatum L. as an introduced antiinflammatory plant. Roots and grains of each plant were collected, dried, and extracted with ethanol. The ethanolic extracts were then analyzed for their saponin and flavonoid contents by gravimetric and UV-vis spectrophotometric method. Antiinflammatory activity test was conducted on carragenin induced rat paw oedema. The results showed that the highest contents of saponin and flavonoid were found in the grains of Apium graveolens L. and showed antiinflammatory effect that was equivalent to that of the root of B. falcatum.
EFEK FRAKSI LARUT AIR EKSTRAK ETANOL 50% KEMUNING (Murraya paniculata (L.) Jack) TERHADAP BERAT BADAN TIKUS BETINA DIET LEMAK TINGGI Suwijiyo Pramono; Agung Endro Nugroho; Crisna Wardhani
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTObesity is considered as a health problem that can promote the risks of getting disease, beingnot active and death. In some developing countries, many traditional therapies are applied for somediseases, including obesity. Kemuning (Murraya paniculata (L.) Jack) has been commonly knownas slimming potion. In present, kemuning leaf is used as ingredient of traditional medicine formula,indicated as slimming potion. Former researcher mentioned that 30% ethanol-bemusing extract hadbeen able to reduce trigliserid content in the blood reduce cholesterol content in blood serum ofmale Wistar furrow white rat (Rattus norvegicus). This research is proposed to examine the effect ofwater soluble fraction of 50% ethanol-kemuning extract to female Wistar furrow white rat bodyweight which given high fat diet and to compare the effect with anorextica (mazindol). Testedanimal are divided into 6 groups, each group contain 5 rats. Group I as negative control is given0,5% CMC Na solution. Group II as positive control is given 0,27 mg/kgBody Weight mazindolsuspension. Group III is given 50% ethanol-kemuning extract suspension with 475 mg/kg BWdosage. Group IV is given watersoluble fraction suspension of kemuning extract dosage I that is145 mg/kgBW. Group V is given watersoluble fraction suspension of kemuning extract dosage IIthat is 295 mg/kgBW. Group VI is given dose III that is 585 mg/kgBW. The suspension is givenorally with repeated dosage. Data collected are the increase of body weight, woof consumption anddrinking consumption. Body weight and woof consumption increases are analyzed by one-wayAnava with 90% significancy level. Research result shows that water soluble fraction of 50%ethanol-kemuning extract with 585 mg/kgBW dosage and positive control (mazindol) are able toobstruct rat body weight increase significancy (p < 0,10) compared to negative control group.Keys word : Murraya paniculata (L.) Jack, obesity, antiobesity
PENGEMBANGAN FORMULA SIRUP ZINK DARI EKSTRAK IKAN BILIH (Mystacoleucus- padangensis) SEBAGAI ALTERNATIF SUPLEMENTASI ZINK ORGANIK PADA ANAK PENDEK (STUNTED) USIA 12-36 BULAN Eva Yuniritha; Mohammad Juffrie; Djauhar Ismail; Suwijiyo Pramono
GIZI INDONESIA Vol 38, No 1 (2015): Maret 2015
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v38i1.167

Abstract

Sirup zink ekstrak ikan bilih dibuat dari formulasi sirup dengan bahan dasar ikan bilih (mystacoleucus padangensis) yang mempunyai kandungan zink 27,8 mg/100 gram, lebih tinggi dibandingkan bahan pangan lain. Pemanfaatan ekstrak ikan bilih sebagai alternatif suplementasi zink organik untuk mengatasi defisiensi zink perlu diteliti dalam upaya percepatan penanggulangan masalah anak pendek (stunted) pada anak umur 12-36 bulan. Tujuan penelitian ini adalah mengembangkan formula sirup zink dari ekstrak ikan bilih (mystacoleuseus padangensis) sebagai alternatif suplementasi zink organik pada anak pendek (stunted). Penelitian eksperimental laboratorium ini dimulai dari ekstraksi ikan bilih dengan metode yang standar dilakukan di laboratorium Biologi dan Sediaan Cair Fakultas Farmasi Universitas Gadjah Mada Yogyakarta. Ekstrak ikan bilih mengandung kadar zink yang sangat tinggi (161,97 mg/100 gram), di formulasi menjadi formula sirup suspensi, dengan sediaan utama estrak Zink Citrat, Vitamin A dan protein, ditambah sirup simplek (64%), CMC-Na, Asam Citrat, perasa buah dan pewarna. Formula sirup suplementasi zink ini memenuhi syarat International Zinc Nutrition Consultative Group (IZiNCG), dengan 3 formulasi terbaik berdasarkan uji organoleptik, yaitu formula F 4.1, F 2.2 dan F 2.3. Formula sirup zink dari ektrak ikan bilih dapat dijadikan sebagai alternatif suplementasi zink organik untuk menanggulangi defisiensi zink pada anak pendek (stunted).ABSTRACT THE DEVELOPMENT OF ZINC SYRUP FORMULA FROM BILIH FISH EXTRACT (Mystacoleucus-padangensis) AS AN ALTERNATIVE FOR ZINC ORGANIC SUPPLEMENTATION IN STUNTED CHILDREN AGED 12-36 MONTH The extract of bilih fish (mystaleuseuspadangensis) zinc syrup is made from basic ingredient of bilih fish which contains 27,8 mg zinc/100 gram syrup. It is much higher than other food zinc source. The use of the extract of bilih fish as an alternative of organic zinc supplementation can be used for those who have zinc deficiency. Therefore, it is essential to be studied as an alternative intervention program for stunting in children aged 12-36 months. This objective of this study is to develop zinc formula syrup from the extract of bilih fish (mystaleuseuspadangensis) as an organic zinc supplementation for stunted children. This laboratory experimental research is begun by extracting the fish bilih using a standard method. The extract of bilih fish is formulated in the form of suspension syrup, at the laboratory of Biology and Liquid Preparation in the Faculty of Pharmacy, Gajah Mada University in Yogyakarta. The extract of bilih fish is very high in zinc content (161, 97 mg/100 gram), with main preparation of Zinc Citrate, Vitamin A and protein, added with simplex syrup (64%), CMC-Na, Citric Acid, fruit flavor and food color subtances. This supplement syrup formula is based on International Zinc Nutrition Consultative Group (IZiNCG), with 3 best formulas based on organoleptic test, formula F 4.1, F 2.2 and F 2.3. The zinc syrup formula from extract of bilih fish could be an alternative of organic zinc supplementation to address zinc deficiency in stunted children.Keywords: extract bilih, zinc supplementation, stunting
KARAKTERISASI SIMPLISIA DAN EKSTRAK ETANOL DAUN BERTONI (Stevia rebaudiana) DARI TIGA TEMPAT TUMBUH Dian Kartikasari; Nurkhasanah Nurkhasanah; Suwijiyo Pramono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.356 KB) | DOI: 10.31942/jiffk.v0i0.1216

Abstract

ABSTRAK Khasiat obat tradisional didasarkan pada senyawa kimia yang terkandung dalam suatu bahan obat. Bahan baku obat dari hasil pertanian atau kumpulan tumbuhan liar tidak dapat dijamin kandungan kimianya selalu konstan, karena adanya variasi bibit, tempat tubuh, iklim, maupun kondisi bahan bakunya (umur dan cara panen). Kandungan senyawa kimia yang bertanggung jawab terhadap respon biologis harus mempunyai spesifikasi kimia, yaitu informasi tentang komposisinya baik jenis maupun kadarnya. Oleh karena itu penetapan karakterisasi suatu simplisia dan ekstrak perlu dilakukan guna menjamin mutu suatu produk obat tradisional. Karakterisasi dilakukan terhadap simplisia dan ekstrak etanol 50% daun Stevia rebaudiana (Bertoni). Karakterisasi simplisia meliputi organoleptis, susut pengeringan, kadar sari larut air, serta kadar sari larut etanol. Cara penetapannya dilakukan sesuai prosedur yang telah ditetapkan Farmakope Herbal Indonesia (2008). Karakterisasi ekstrak etanol meliputi karakteristik non spesifik yakni kadar air, kadar abu total, dan kadar abu tidak larut asam. Hasil karakterisasi diperoleh nilai rentang dari tiap jenis parameter simplisia maupun ekstrak etanol daun Stevia rebaudiana yang diperoleh dari daerah Bogor, Malang, dan Tawangmangu. Kata kunci: Daun Stevia Rebaudiana (Bertoni), Karakterisasi simplisia, Karakterisasi ekstrak etanol 50%
PENETAPAN KADAR STEVIOSIDA PADA SIMPLISIA DAN EKSTRAK DAUN Stevia rebaudiana DARI TIGA DAERAH BERBEDA Dian Kartikasari; Nurkhasanah Nurkhasanah; Suwijiyo Pramono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.792 KB) | DOI: 10.31942/jiffk.v15i2.2574

Abstract

ABSTRACTPharmaceutical raw materials from agriculture or collection of wild plant chemical content can not be guaranteed always constant due to variable seed, the body, the climate, the conditions (age and how to harvest). The content of the chemical compounds responsible for the biological response must have chemical specifications, namely the composition information (type and concentration). The efficacy of traditional medicine based on the chemical compound. Therefore, the assay of the active substance a crude drugs and extracts needs to be done to ensure that a traditional medicinal products can be assured of quality and usefulness. The assay performed on botanicals and 50% ethanol extract of leaves of Stevia rebaudiana. The assay of the crude drugs and extracts from the stevia leaf area of Malang, Tawangmangu, and Bogor using High Performance Liquid Chromatograph method. Results of the assay stevioside on simplicia and stevia leaf extract obtained stevioside levels in simplicia stevia leaves from Malang, Bogor, Tawangmangu consecutive namely 5.65%; 3.89%; 1.59%. Stevioside levels in the stevia leaf extract of Malang, Bogor, Tawangmangu respectively, are 14.14%; 22.40%; 66.65%.Key word: Stevia rebaudiana leaf, stevioside content, High Performance Liquid Chromatograph
Co-Authors Agung Endro Nugroho Crisna Wardhani dian kartikasari Djauhar Ismail Mohammad Juffrie Nurkhasanah Nurkhasanah Yundari, Yundari