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F. D. Suyatna
Department of Pharmacology, Medical Faculty, Universitas Indonesia, Jakarta.
Medicine & Pharmacology

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Oxidant and antioxidant status of police officer in the city and rural area Suyatna, F. D.; Priyanto, Priyanto; Istiantoro, J.; Sadikin, M.
Medical Journal of Indonesia Vol 13, No 2 (2004): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.133 KB) | DOI: 10.13181/mji.v13i2.132

Abstract

This study was designed to investigate the biochemical alteration in human caused by free radical accumulation due to air pollution. The policemen recruited were 60 country policemen consisting of 30 non smokers (group I) and 30 smokers (group II); 30 smoking policemen with administrative work in Jakarta (group III) and 30 smoking traffic policemen from Jakarta (group IV). Our results show that the plasma malondialdehyde (MDA) contents of groups I, II, III, IV, respectively were : 3.34 ± 0.81 umol/l; 4.28 ± 0.77 umol/l; 5.20 ± 0.66 umol/l and 5.12 ± 0.78 umol/l which were statistically different (p < 0.01) among each others, except between groups III and IV. The activity of superoxide dismutase (SOD) of the groups respectively, were: 16.75 ± 9.80 U/mg protein; 22.83 ± 6.82 U/mg protein; 26.10 ± 8.50 U/mg protein and 26.90 ± 9.34 U/mg protein, which were statistically different (p < 0.05) between group I vs the other groups. The catalase activity of the groups respectively were : 106.25 ± 47.47 U/mg protein; 118.84 ± 42.73 U/mg protein; 119.83 ± 35.35 U/mg protein and 145.57 ± 61.85 U/mg protein. The statistical difference (p < 0.05) was found between group I & IV. Administration of vitamins C (500 mg) and E (300 mg) daily for 30 days to the policemen with high oxidant stress caused a decreased in the activities of SOD from 27.34 ± 10.05 U/mg protein to 16.91 ± 6.51 U/mg protein (p < 0.05) and catalase from 134.29 ± 53.28 U/mg protein to 67.07 ± 25.26 U/mg protein (p < 0.05). This study shows us that the oxidant status of city policemen was higher than that of rural policemen and that a combination of vitamins C & E could reduce the oxidant stress to a certain extent. (Med J Indones 2004; 13: 77-80) Keywords: malondialdehyde, superoxide dismutase, catalase, population study.
Acute eye irritation study of a mixture of glyphosate isopropylamine salt and 2,4 D-isopropylamine Suyatna, F. D.; Darmayanti, S.
Medical Journal of Indonesia Vol 12, No 3 (2003): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.929 KB) | DOI: 10.13181/mji.v12i3.102

Abstract

This is an acute irritation study of the eye of a mixture of herbicides containing 240 g/l of glyphosate isopropylamine and 2,4 D-isopropylamine in the rabbits. This study was conducted according the methods as dercribed by the United States Environmental Protection Agency (EPA). Our results show that the combination of the herbicides causes mild conjunctivitis, mild chemosis, eye discharge and corneal injury. The ocular alteration, however, was reversible in nature. (Med J Indones 2003; 12: 135-41) Keywords: glyphosate isopropylamine, 2,4 D-isopropylamine, acute eye irritation study, the United States Environmental Protection Agency (EPA)
Lipid peroxides level in the Indonesian elderly Purwantyastuti, Purwantyastuti; Kamso, Sudijanto; Suyatna, F. D.
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.299 KB) | DOI: 10.13181/mji.v14i2.174

Abstract

A cross-sectional study was done to see the possible association of plasma lipid peroxides in the elderly with age and other factors. Plasma lipid peroxides is a product of free radical reactions which according to the latest theory of aging is the cause of aging process. Lipid peroxides were also found high in coronary heart disease. Four hundred forty relatively healthy elderly, age 55-85 years, were randomly chosen from free living elderly under guidance of health care centers (PUSKESMAS) in Jakarta. Anamnesis and physical examination were done in the morning in the health centers. Blood samples were taken in fasting conditions, plasma lipids and lipid peroxides were measured according to standard methods. There was an age difference of lipid peroxides level in the elderly, which increased with age up to 70 years old. Elderly 70 years old and over had low plasma lipid peroxides. The level was not related to high plasma lipids. Higher level was found when more chronic degenerative diseases were found. (Med J Indones 2005; 14: 71-7)Keywords: lipid peroxides, aging
Identification of C5+ extraband of butyrylcholinesterase and two protein bands cathodic to it Suyatna, F. D.; Setiabudy, R.; Tjandra, O.; Herwana, E.
Medical Journal of Indonesia Vol 10, No 3 (2001): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.947 KB) | DOI: 10.13181/mji.v10i3.23

Abstract

Electrophoresis of human plasma yields 4 butyrylcholinesterase (BChE) protein bands, i.e. C1, C2, C3, C4 and in some individuals also an extraband C5+. In addition to that other protein bands called "S" bands are also invariably detected. In order to know whether the C5+ and the "S" bands are related to the BChE protein, we have carried out immunological and peptide mapping studies on these proteins. The immunology approach was done by raising polyclonal antibodies against each protein bands (S1, S2, C4 and C5+) and reacted to the plasma protein bands transferred on nitrocellulose papers. Individual raised antibodies recognized all protein bands studied including the C4, an isozyme of BChE, indicating that the protein bands contain similar epitopes. Several protein bands cathodic to S1 also reacted with the antibodies, suggesting that they are probably fractions of the BChE protein, as well. When individual protein bands were digested with S. aureus V8 toxin and α-chymotrypsin, they revealed a striking similarity in peptide pattern among each other. These studies indicate that the S1, S2 and C5+ protein bands belong to the BChE protein. (Med J Indones 2001; 10: 144-9)Keywords: Butyrylcholinesterase, C5+ variant, immunodetection, peptide mapping
Determination of.TGFβ1 activity in placental extracts Suyatna, F. D.; Nafrialdi, Nafrialdi
Medical Journal of Indonesia Vol 7, No 3 (1998): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.885 KB) | DOI: 10.13181/mji.v7i3.764

Abstract

[no abstract available]
Co-Authors E. Herwana J. Istiantoro M. Sadikin Nafrialdi Nafrialdi O. Tjandra Priyanto Priyanto Purwantyastuti Purwantyastuti R. Setiabudy S. Darmayanti Sudijanto Kamso