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All Journal The Journal of The Indonesian Medical Students´ Association Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Indonesian Andrology and Biomedical Journal

Citrawati Dyah Kencono Wungu

Department Of Biochemistry, Faculty Of Medicine, Universitas Airlangga, Indonesia

Author-ID : 3996058

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 9 Documents Claim Missing Document

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Articles

The Potency of Propolis on Honey Bees Nest on Inhibiting The Infection of P. Falciparus as Supporting Therapy on Malaria Tropicana Azizah, Nurul; Kencono Wungu, Citrawati Dyah; Viradella, Jofan
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

Show Abstract | Download Original | Original Source | Check in Google Scholar

The incidence of malaria in Indonesia increases every year, even reached seven times higher in 2000 thank that in 1997. This disease is caused bt Plasmodium parasite. Plasmodium falciparum and Plasmodium vivax are the most common species, but the deadliest one is Plasmodium falciparum. However, there are many P. falciparum cases resistant to antimalaria drugs. Hence, it is necessary to look for other antimalaria drugs as alternative therapy.There are many medicating effects of bees products. In this paper, we try to study propolis, a compound extracted from resin, mixed with bee wax, honey, and enzyme. Luteplin 7-O glucoside is a flavonoid compound in propolis, identified as antimalaria agent. Luteolin 7-O glucoside has specific target FabI, regulator and repressor exzyme for type 2 FAS. This compound inactivated FabI enzyme, blocked the biosynthesis of Plasmodium fatty acid, and hence disturbed the metabolism and growth of Plasmodium.Another flavonoid component of propolis, chalcone, has also important effect on blocking erythrocyte hemolysis in P. falciparum infection so symptoms can be reduced.ÃÂ Key words: P. falciparum, flavonoid, Luteolin 7-O glucoside, type21 FAS, chalcone

Socialization Program for Prevention and Early Detection of Congenital Hearing Loss in the Families of Deaf School children Gwenny Ichsan Prabowo; Citrawati Dyah Kencono Wungu; Retno Handajani; Nyilo Purnami; Fis Citra Ariyanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16878

Objective: socializing hearing loss examination and early detection to patients and their families in deaftype B schools. Methods: A community service program in the form of socialization was performed to thefamily of patients with hearing loss in deaf school type B, Surabaya, Indonesia. Pretest and posttest wereconducted to determine the initial understanding and post socialization knowledge of these people. We alsoasked the participants to fill on a questionnaire regarding the possible causes of the hearing loss (familyhistory, drug use, history of disease, and history of head trauma). Results: Based on the summary of pretestand posttest from the participants, an increase in participants’ knowledge of hearing lost was found. Thisactivity was attended by 90 family members of 37 patients with hearing loss. Pre and post test results. Theresults of the questionnaire showed that 94.59% of the patients came from Javanese ethnicity. As many as21.62% of patients had a family history of hearing loss, and even 2 patients had a father, mother, and siblingwith hearing loss. A total of 18.92% had a history of using ototoxic drugs, 16.22% had a history of maternalRubella infection during pregnancy, and 2.7% had a history of head trauma. Conclusion: Socializationprogram was effective to increase knowledge of congenital hearing loss for family of deaf schoolchildren.The result of the questionnaire showed that deaf schoolchildren had several risk factors for the occurrenceof hearing loss. Similar program can be performed in communities in other areas to increase prevention andearly detection of hearing loss in Indonesia.

Associations between P53, Transforming Growth Factor Beta-1, and Interleukin-10 Serum Levels with Advanced Liver Disease and Hepatitis B Virus Infection Citrawatidyahkencono Wungu; Mochamad Amin; Ulfa Kholili; Gwennyichsan Prabowo; Poernomoboedi Setiawan; Soetjipto; Retno Handajan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15736

Distribution of Hepatitis B Virus Genotypes Among Patients at Internal Medicine Unit, Dr. Soetomo General Hospital, Surabaya Citrawati Dyah Kencono Wungu; Mochamad Amin; Ulfa Kholili; Gwenny Ichsan Prabowo; Poernomo Boedi Setiawan; Soetjipto Soetjipto; Retno Handajani
WMJ (Warmadewa Medical Journal) Vol 4 No 1 (2019): May 2019
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.4.1.1032.6-13

Background: Hepatitis B virus (HBV) infection is a major health problem worldwide, especially in developing countries. The study of HBV genotypes is important to find out the diversity of HBV genotypes related to the severity of the disease, response to therapy, and clinical symptoms. Objective: This study was aimed to detect HBV genotypes in patients at Hepatology Outpatient Clinic, Dr. Soetomo Hospital Surabaya. Methods: This study was conducted on new patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya in one month. Nested PCR was performed by targetting HBV surface genes. Samples with positive HBV DNA were sequenced and analysed further. Results: In this study, a total of 27 samples were obtained. The prevalence of HBV infection shown by positive HBsAg in patients with symptoms of liver disease was 55.55% (15/27 patients). Based on the results of electrophoresis from PCR products, positive HBV DNA was obtained in these 15 patients (100%). After sequencing samples with positive HBV DNA, genotype B of Indonesian strain was found to be predominant genotype (100%). Subgenotype analysis showed that 7/15 samples had B3 subgenotype (46.67%). Conclusion: In patients at Hepatology Outpatient Clinic of Dr. Soetomo General Hospital, Surabaya, the prevalence of HBV infection was high (55.55%) and genotype B was predominant. In Surabaya, HBV genotype infection still remained like the previous pattern, although in Indonesia there have been many inter-island and ethnic migration. Further similar studies are needed to obtain the diversity of other HBV genotypes.

The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Siti Khaerunnisa; Irmi Syafa'ah; Citrawati Dyah Kencono Wungu; Gwenny Ichsan Prabowo; Retno Handajani; Indri Safitri; Harianto Notopuro; Ema Qurnianingsih; Lina Lukitasari; Ira Humairah; Arief Bakhtiar; Suwandito Suwandito; Susi Wahyuning Asih; Zuhrotul Eka Yulis Anggraeni; Ginanjar Sasmito Adi; Ely Rahmatika Nugrahani; Ayesie Natasha Zulka; Soetjipto Soetjipto
Folia Medica Indonesiana Vol. 57 No. 2 (2021): June
Publisher : Universitas Airlangga

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.

DETECTION OF TUMOR NECROSIS FACTOR- (TNF- ) GENE PROMOTERS POLYMORPHISM AMONG LIVER CIRRHOSIS PATIENTS WITH CHRONIC HEPATITIS B VIRUS (HBV) INFECTION IN SURABAYA, INDONESIA Citrawati Dyah Kencono Wungu; Mochamad Amin; S. Eriaty N. Ruslan; Priyo Budi Purwono; Ulfa Kholili; Ummi Maimunah; Poernomo Boedi Setiawan; Maria Inge Lusida; Soetjipto Soetjipto; Retno Handajani
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 5 (2019)
Publisher : Institute of Topical Disease Universitas Airlangga

Polymorphisms in TNF-α gene promoter region are known of its role in the production of TNF-α which may influences the pathogenesis of liver disease. SNPs in positions 238 and 308 of TNF-α gene promoters may affect the production of these cytokines. This study was aimed to detect Single Nucleotide Polymorphism (SNP) on -238 and -308 positions in the TNF-α gene promoter among liver cirrhosis patients with HBV infection in Surabaya, Indonesia. This was descriptive exploratory research with cross sectional study design using serum liver cirrhosis patients with HBV infection in Endoscopy Outpatient Clinic Dr. Soetomo General Hospital, Surabaya from April-May 2017. SNPs at -238 and -308 on TNF-α gene promoter (rs361525 and rs1800629 respectively) were detected using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) with primers specific for the TNF-α promoter region and restriction enzymes NcoI and MspI. The genotypes of TNF-α gene promoter were assessed according to the length of the fragments produced in RFLP. Serum TNF-α levels was measured by commercial ELISA. In this study, as much as 149 positive HBsAg patients was found in Endoscopy Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya. From those amount, as much as 30 liver cirrhosis patients with positive HBsAg were obtained. From 2/30 (6.7%) patients showed the GA heterozygote SNP either position -238 or -308. No patient had the AA genotype. Median blood TNF-α level in women (38 ng / L) was higher than in men (33 ng / L). TNF-α levels in patients with GA heterozygote genotype at -238 and -308 in this research was not different than wild-type (GG genotype). Among patients with liver cirrhosis due to chronic HBV infection in Surabaya, Indonesia, Surabaya, we found GA polymorphisms the TNF-α promoter gene at positions -238 and -308 in 6.7% patients, and did not find homozygous AA polymorphisms. Further studies including larger numbers of patients from various ethnic backgrounds in Indonesia are needed to provide robust data on TNF-α gene promoter polymorphisms and their role in the pathogenesis of liver cirrhosis with HBV infection in this country.

ANTI-HIV DAN SUBTIPE HIV PADA PASIEN HEMODIALISIS Retno Handajani; Mochammad Thaha; Mochamad Amin; Citrawati Dyah Kencono Wungu; Edhi Rianto; Pranawa Pranawa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1124

Anti-Human Immunodeficiency Virus (Anti-HIV) was performed from 100 plasma Chronic Kidney Disease (CKD) stage 5 patientswith continuous hemodialysis (HD) at the Hemodialysis Instalation Dr Soetomo hospital, Surabaya, Indonesia, using three (3) kind ofreagents: Tri-line HIV Rapid test Device from Acon for HIV 1/2/O as strips form, Foresight HIV 1/2/O Antibody EIA Test Kit from Aconand Anti-HIV 1+2/Subtype O ELISA from Axiom. HIV RNA and HIV subtype were detected by Reverse Transcription Polymerase ChainReaction (RT-PCR) based on HIV gag region and analysis of DNA result. Seventy three % patients were hemodialysed twice in a week andonly 14% with duration more than five (5) years. Most of the patients (43%) were hemodialysed between 100−300 times. From the 100plasma samples was obtained only one (1%) man patient plasma sample with positive anti-HIV. A weak positive of RT-PCR result wasnot succeed to be sequenced for determining the HIV subtype. This cause was suspected due to low levels of HIV RNA in blood. The resultsof this study was expected can be used as an additional management consideration of hemodialysis patients at the Hemodialysis Unit.

HIIT for Improving Maximal Aerobic Capacity in Adults Sedentary Lifestyle Fajar Syamsudin; Lilik Herawati; Ema Qurnianingsih; Citrawati Dyah Kencono Wungu
Halaman Olahraga Nusantara : Jurnal Ilmu Keolahragaan Vol 4, No 1 (2021): Halaman Olahraga Nusantara (Jurnal Ilmu Keolahragaan)
Publisher : Universitas PGRI Palembang

World Health Organization (2020) telah merekomendasikan setidaknya 150-300 menit aktifitas fisik intensitas sedang 40-60% HRM (Heart Rate Maximal) atau 75-150 menit aktivitas fisik intensitas tinggi/virgorous 60-85% HRM perminggu untuk mempertahankan dan meningkatkan kebugaran orang dewasa. Namun, hambatan yang sering dikutip untuk terlibat dalam aktifitas fisik adalah “kurangnya waktu”, motivasi rendah, dan ketidakpatuhan terhadap pedoman yang sudah diberikan. HIIT membutuhkan lebih sedikit waktu yang dihabiskan untuk berolahraga, sekaligus memberikan manfaat kesehatan yang serupa atau bahkan lebih besar dibandingkan dengan rekomendasi aktivitas fisik yang telah ditetapkan WHO. Penelitian ini bertujuan untuk mengetahui seberapa besar efek HIIT terhadap VO2max. Metode yang digunakan adalah literature review, mencari artikel dari DataBased Elektronik berupa PubMed, ScienceDirect dan ProQuest. Hasil penelitian menunjukkan bahwa HIIT dapat meningkatkan VO2max dengan signifikan dan efisien.

Effect of Kembang Bulan Leaf (Tithonia diversifolia) Ethanolic Extract to SGOT and SGPT Levels in Diabetic Rats (Rattus norvegicus) Achmad Firdaus Pamudya Wardhana; Arifa Mustika; Citrawati Dyah Kenconowungu
Indonesian Andrology and Biomedical Journal Vol. 2 No. 1 (2021): June
Publisher : Universitas Airlangga

Introduction: Kembang Bulan (Tithonia diversifolia) is one of Indonesian traditional medicine that contains saponins, flavonoids, and, tannins and is predicted has a lowering effect on blood-glucose. Diabetes mellitus (DM) is a disease caused by insufficient insulin secretory by the pancreas or ineffective usage of insulin that produced by the body thus cause a hyperglycemia condition. Hyperglycemia can cause an increase in Reactive Oxygen Species which can cause free radicals. Free radicals can cause damage to liver cells. Method: This was an experiment with posttest control group design. Samples were 40 rats, divided into five different groups (P1, P2, P3, P4 and P5). Each group were induced by multiple low doses STZ. P1 (give the extract of Tithonia diversifolia at a dose 50 mg/100 gr BB), P2 (give the extract of Tithonia diversifolia at a dose 150 mg/100 gr BB), and P3 (give the extract of Tithonia diversifolia at a dose 450 mg/100 gr BB), P4 was treated with metformin, P5 was not treated. After STZ induction and give the extract to diabetic rat model, the resulting liver cell damage will be measured using the SGOT and SGPT measurement methods. Result: On the average results of SGOT levels in the five treatments, using the ANOVA test p value was 0.877 (p> 0.05) which means there were no significant differences. Furthermore, on the average results of SGPT levels in all five treatments, using the ANOVA test p value was 0.822 (p> 0.05) which means there were no significant differences. But from all results obtained P4 (given metformin) with the results closest to normal levels (SGOT: 197.5 ± 37.25; SGPT: 90.33 ± 29.36). From the treatment given Tithonia diversifolia extract obtained P1 (with a dose of 50 mg / 200gr BB) with the results closest to normal levels compared to P2 and P3. Conclusion: The Extract of kembang Bulan Leaf (Tithonia diversifolia) obtained less significant results compared to the untreated group. However, there is no significant difference. And giving ethanol extract of the leaves of kembang Bulan (Tithonia diversifolia) at a dose of 50 mg / 100gr BB is the most effective way to reduce levels of SGOT and SGPT.

Co-Authors Achmad Firdaus Pamudya Wardhana Arifa Mustika Ayesie Natasha Zulka Bakhtiar, Arief Edhi Rianto Eka Sri Handayani Ely Rahmatika Nugrahani Ema Qurnianingsih Fajar Syamsudin Fis Citra Ariyanto Ginanjar Sasmito Adi Harianto Notopuro HERAWATI, LILIK Indri Safitri Ira Humairah Irmi Syafa'ah Jofan Viradella Lina Lukitasari, M.Si Maria Inge Lusida Mochamad Amin Mochamad Amin Mochammad Thaha NURUL AZIZAH Nyilo Purnami Poernomo Boedi Setiawan Poernomo Boedi Setiawan Poernomoboedi Setiawan Prabowo, Gwenny Ichsan Pranawa Pranawa PRIYO BUDI PURWONO Retno Asih Setyoningrum Retno Handajan Retno Handajani S. Eriaty N. Ruslan Siti Khaerunnisa SOETJIPTO Soetjipto Soetjipto Soetjipto Soetjipto Soetjipto Soetjipto Susi Wahyuning Asih Suwandito Suwandito Ulfa Kholili Ummi Maimunah Zuhrotul Eka Yulis Anggraeni

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