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Peranan Hormon Ghrelin dalam Fungsi Reproduksi Pakpahan, Cennikon; -, Agustinus
Cermin Dunia Kedokteran Vol 47, No 7 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Ghrelin lebih dikenal sebagai hormon lapar atau hormon yang mengatur siklus kenyang-lapar mahkluk hidup. Fungsi reproduksi ghrelin mencakup aksi hipotalamus-hipofisis-gonad (ovarium dan testis) dan juga hormon reproduksi lain. Selain itu ghrelin juga diketahui memiliki pengaruh pada proses patologis beberapa penyakit pada kehamilan dan infertilitas.Ghrelin is better known as a hunger hormone or a hormone that regulates the cycle of satiety- hunger. The reproductive function of ghrelin includes action to the hypothalamus-pituitary-gonad (ovary and testis) axis and other hormones. Ghrelin is also known to influence the processes of several diseases in pregnancy and infertility.

Peranan Antioksidan Koenzim Q10 dalam Tatalaksana Infertilitas Pria Pakpahan, Cennikon
Cermin Dunia Kedokteran Vol 46, No 12 (2019): Kardiovaskular
Publisher : PT. Kalbe Farma Tbk.

Infertilitas pada pria sering akibat masalah kuantitas atau kualitas sperma. Antioksidan, salah satunya koenzim Q10 dilaporkan memiliki peranan memperbaiki kuantitas dan kualitas sperma.Infertility in men is often caused by sperm quantity and quality. Coenzyme Q10 has been reported to improve quantity and quality of sperm.

Interpretation of Detection SARS Cov-2 in Semen Cennikon Pakpahan; Agustinus Agustinus; Aucky Hinting
Indonesian Andrology and Biomedical Journal Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus with a high virulence which cause SARS-CoV-2, a disease with potentially dangerous implications for human health and pandemic. The involvement of other organs in the spread of this virus is still being debated. Considering the presence of (Angiotensin Converting Enzyme-2 (ACE-2) and Transmembrane Serine Protease 2 (TMPRSS2) in the reproductive organs including male reproduction,the male reproductive system possiblity for spreading SARS-CoV-2 should be studied. Reviews: Five studies were reveal the presence of SARS-CoV2 in semen. The reported results are inconsistent. Some of these studies also used unclear methods and procedures, which led to bias in the final results. Ongoing studies are needed to confirm the definite findings before specific recommendations can be made for further management. Summary: There is no definite interpretation of whether SARS-CoV-2 spreads through semen, but protection is still needed when it comes into contact with the semen.

Computer Assisted Sperm Analysis: A Review Agustinus; Cennikon Pakpahan
Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 (2020): December
Publisher : Universitas Airlangga

Background: A semen analysis exam is a routine check that is done to evaluate fertility. The World Health Organization (WHO) recommended a manual method to obtain objective and standardized values. However, sometimes some errors can be found with this method such as motility. Computer-Assisted Sperm Analysis offers a way to reduce inaccuracies that often occur with manual methods. Reviews: CASA systems consist of a microscope which connected into a camera to detect microscopic sperm suspension images and a computer installed with special software to extract desired information and produce the desired output. In the morphological examination, CASA can reduce the coefficient of variation (CV) which is around 4.8% compared to the manual examination but the time required is longer than manual. CASA can visualize and evaluate sperm kinematics. Various parameters such as mean path velocity (VAP), curved velocity (VCL), straight-line velocity (VSL), lateral head displacement amplitude (ALH), or beat cross frequency can be obtained, and this allows a detailed view into the behavior of individual sperm. The limitations affecting CASA's ability to provide accurate results for sperm concentration and percentages of motile or progressively motile spermatozoa. Summary: CASA has several advantages through its ability to calculate more detailed parameters, but a qualified operator must operate it because there is some potential for misinterpretation. The combination of The Manual and CASA is highly recommended for better results.

Post-orgasmic Illness Syndrome: A Closer Look William; Cennikon Pakpahan; Raditya Ibrahim
Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 (2020): December
Publisher : Universitas Airlangga

Background: Post-orgasmic illness syndrome (POIS) is a rare condition in which someone experiences flu-like symptoms, such as feverish, myalgia, fatigue, irritabilty and/or allergic manifestation after having an orgasm. POIS can occur either after intercourse or masturbation, starting seconds to hours after having an orgasm, and can be lasted to 2 - 7 days. The prevalence and incidence of POIS itself are not certainly known. Reviews: Waldinger and colleagues were the first to report cases of POIS and later in establishing the diagnosis, they proposed 5 preliminary diagnostic criteria, also known as Waldinger's Preliminary Diagnostic Criteria (WPDC). Symptoms can vary from somatic to psychological complaints. The mechanism underlying this disease are not clear. Immune modulated mechanism is one of the hypothesis that is widely believed to be the cause of this syndrome apart from opioid withdrawal and disordered cytokine or neuroendocrine responses. POIS treatment is also not standardized. Treatments includeintra lymphatic hyposensitization of autologous semen, non-steroid anti-inflamation drugs (NSAIDs), steroids such as Prednisone, antihistamines, benzodiazepines, hormones (hCG and Testosterone), alpha-blockers, and other adjuvant medications. Summary: This syndrome still needs more research to understand its mechanisms to obtainclearer treatment. Besides that, the clinician's awareness is needed to recognize this syndrome so that it is not misdiagnosed.

Case Report : A Woman 27 Year Old with Mosaic Turner Syndrome Associate Hypogonadotropic Hypogonadism Cennikon Pakpahan; Bella Amanda; Berliana Hamidah; Rina Yudiwati
Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 (2020): December
Publisher : Universitas Airlangga

Background: Turner syndrome is a chromosomal abnormality found in phenotypically women who have one intact X chromosome and the absence of second sex chromosomes. Case: The patient is a 27-year-old Javanese girl. At the age of 14 years, she came to the gynecology clinic with chief complaints of amenorrhea and then given cycloprogynova by the physcian, the complaint improved but menstruation did not appear in the following month did not return to the gynecologist for evaluation. At the age of 26, she returned to the gynecologist and then was given medicine to stimulate menstruation and was referred to an internist-endocrinologist because of a suspected hypothyroid. Then a few months later the patient returned to the gynecologist and then examined hormones, ultrasound, and karyotyping for evaluation as well as establishing the diagnosis. FT4 hormone examination results 0.87 ng / dl, TSHs 0.708 Uiu / mL, T3 (Total) 0.49 ng / mL, FSH 2.38 Miu / mL, LH 1.3 Miu / mL, prolactin 14.7 ng / ml, progesterone <0.10 ng / ml, estradiol <5 ng / ml indicates hypogonadotropic hypogonadism with hypothyroidism. Ultrasound results showed hypoplasia with uterine axis measuring 2.27 x 2.09 cm. Karyotyping result with 45x / 46xx indicate mosaic turner syndrome. Patients were given progestin, esthero and also thyrax for hormone replacement therapy. Discussion: Turner syndrome with hypogonadotropic hypgonadism is a rare variation of the turner syndrome. The definite cause is still uncertain. Some cases are usually accompanied by other hormone disorders such as thyroid and growth hormone. Conclusion: A 27-year-old woman with hypgonadotrophic hypgonadism associated with mosaic turner syndrome. The diagnosis is done by history taking, hormone examination, imaging, and karyotyping. treatment given progestin, estrogen, and thyrax.

Non-Obstructive Azoospermia with Hypergonadotropic Hypogonadism without a Significant Abnormalities in the Physical Examination Raditya Ibrahim; Cennikon Pakpahan; Pety Narulita
Indonesian Andrology and Biomedical Journal Vol. 3 No. 1 (2022): June
Publisher : Universitas Airlangga

Background: Around 10 % of infertile men and 1 percent of all males have azoospermia. There are two types of azoospermia, which are obstructive and non-obstructive azoospermia. Non-obstructive azoospermia's main mechanism is because the testes fail to produce the sex hormone and induce spermatogenesis (primary testicular failure). Case: A patient is 28 years old and has a job as a car paint worker. He came with the chief complaint of infertility since two and a half years ago. He and his wife were having intercourse 3-4 times a week. Past medical history is unremarkable. His wife’s medical history is also unremarkable. Physical examination and ultrasound of the testes are normal. The semen analysis in this patient was azoospermia for 2 different times in the span of 2 weeks with no abnormalities in the accessory gland. Hormonal profiles results are testosterone level 2,32 ng/mL and FSH 15,03 mIU/mL, which indicatehypergonadotropic hypogonadism. The patient was suggested to evaluate further (complete hormonal profile, karyotyping analysis, and Y-Chromosome microdeletion) and educate about the possibility to conceive with assisted reproductive technology (ART). Discussion: Hypergonadotropic hypogonadism is a challenging case that needs a complete assessment such as complete hormonal profile, karyotyping analysis, Y-chromosome microdeletion analysis, and also, in this case, the paint thinner exposure in the workplace is needed to be considered. The chance of normal conception is very small, and the assisted reproductive procedure is necessary. Conclusion: Some abnormalities are usually present in the physical examination of azoospermia patients. This case convinces us of the importance of thorough history taking and other investigations. Managing this patient will be challenging, with the goal of the therapy is to achieve spermatogenesis to be able to use the spermatozoa available for ICSI.

Peranan Hormon Ghrelin dalam Fungsi Reproduksi Cennikon Pakpahan; Agustinus -
Cermin Dunia Kedokteran Vol 47, No 7 (2020): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i7.602

Ghrelin lebih dikenal sebagai hormon lapar atau hormon yang mengatur siklus kenyang-lapar mahkluk hidup. Fungsi reproduksi ghrelin mencakup aksi hipotalamus-hipofisis-gonad (ovarium dan testis) dan juga hormon reproduksi lain. Selain itu ghrelin juga diketahui memiliki pengaruh pada proses patologis beberapa penyakit pada kehamilan dan infertilitas.Ghrelin is better known as a hunger hormone or a hormone that regulates the cycle of satiety- hunger. The reproductive function of ghrelin includes action to the hypothalamus-pituitary-gonad (ovary and testis) axis and other hormones. Ghrelin is also known to influence the processes of several diseases in pregnancy and infertility.

Peranan Antioksidan Koenzim Q10 dalam Tatalaksana Infertilitas Pria Cennikon Pakpahan
Cermin Dunia Kedokteran Vol 46, No 12 (2019): Kardiovaskular
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i12.400

Infertilitas pada pria sering akibat masalah kuantitas atau kualitas sperma. Antioksidan, salah satunya koenzim Q10 dilaporkan memiliki peranan memperbaiki kuantitas dan kualitas sperma.Infertility in men is often caused by sperm quantity and quality. Coenzyme Q10 has been reported to improve quantity and quality of sperm.

Peranan Hormon Ghrelin dalam Fungsi Reproduksi Cennikon Pakpahan; Agustinus
Cermin Dunia Kedokteran Vol. 47 No. 5 (2020): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i5.383

Ghrelin lebih dikenal sebagai hormon lapar atau hormon yang mengatur siklus kenyang-lapar mahkluk hidup. Fungsi reproduksi ghrelin mencakup aksi hipotalamus-hipofisis-gonad (ovarium dan testis) dan hormon reproduksi lain. Selain itu, ghrelin juga diketahui memiliki pengaruh pada proses patologis beberapa penyakit pada kehamilan dan infertilitas. Ghrelin is better known as a hunger hormone or a hormone that regulates the cycle of satiety- hunger. The reproductive function of ghrelin includes action to the hypothalamus-pituitary-gonad (ovary and testis) axis and other hormones. Ghrelin is also known to influence the processes of several diseases in pregnancy and infertility.

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