Background: Basic health research shows that the prevalence of non-communicable diseases has inÂcreased, including cancer, stroke, chronic kidney disease, diabetes mellitus, and hypertension. The impact of these changes can cause one of them to decrease the quality of life of patients. Stroke in individuals can cause several changes including physical, social and psychological changes that will affect the quality of life. This study aimed to analyze the determinants of the quality of life of paÂtients post stroke.Subjects and Method: This study was a cross sectional study conducted at Surakarta City HosÂpital, from September to October 2019. The sample used was 200 patients post stroke. The samÂpling technique used purposive sampling. The dependent variable was the quality of life of patients post stroke. The independent variables were age, gender, employment status, patient income, faÂmiÂly income, attack status, post-stroke comorbidity, duration of illness, marital status, family supÂport, level of functional disorders, and depression status. The data were collected by questionnaire. The data were analyzed by path analysis with the Stata 13 program.Result: The quality of life of post-stroke patients increased directly in patients with married status (b=1.79; 95% CI=0.24 to 3.35; p=0.024), have a job (b=1.93; 95% CI=0.13 to 3.72; p=0.035), good faÂmily support (b=2.17; 95% CI=0.46 to 3.88; p=0.013), and mild functional disorders (b=1.68; 95% CI=0.11 to 3.25; p=0.036). Quality of life decreased directly in patients aged ≥60 years old (b=-1.99; 95% CI=-3.80 to -0.17; p=0.032), female gender (b=-1.74; 95% CI=-3.28 to -0.19; p= 0.027), stroÂÂkes more than 1 time (b=-1.87; 95% CI=-3.59 to -0.15; p=0.033), sick ≥6 months (b=-2.12 ; 95% CI=-3.87 to -0.36; p=0.018), have comorbidities (b=-1.96; 95% CI=-3.67 to -0.24; p= 0.025), and deÂpression (b=-1.40; 95% CI=-2.97 to 0.16; p=0.078). Quality of life was indirectly affected by age, illÂness, marital status, family support, family income, and employment status.Conclusions: The quality of life of post-stroke patients increased directly affected by marital staÂtus, employment status, family support, and functional disorders. Quality of life was directly affecÂted by age, gender, attack status, duration of illness, comorbidity and depression.Keywords: stroke, quality of life, path analysis.Correspondence:Maki Zamzam. Master Program of Public Health Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta, Central Java. Email: makizz477@gmail.com. Mobile: +6281251543935.Journal of Epidemiology and Public Health (2020), 5(1): 1-14https://doi.org/10.26911/jepublichealth.2020.05.01.01