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CORRELATION BETWEEN GLOMERULUS FILTRATIONS AND PLASMA BICARBONATE CONDITIONS IN KIDNEY DISEASE CHRONIC STADIUM 5 WITH METABOLIC ACIDOSIS rendri bayu hansah; Dessy Abdullah
Jurnal Kesehatan Medika Saintika Vol 12, No 1 (2021): Juni 2021
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v12i1.774

ABSTRAKKadar bikarbonat plasma yang rendah berhubungan dengan tingginya mortalitas pada pasien PGK stadium lanjut, Beratnya derajat hipobikarbonatemia berkaitan dengan derajat laju filtrasi glomerulus (LFG) dimana semakin rendah LFG maka semakin rendah pula kadar bikarbonat plasma. maka berdasarkan adanya hubungan bahwa derajat hipobikarbonatemia berkaitan dengan derajat LFG, penelitian ini bertujuan ingin mengetahui lebih lanjut peran diagnostik nilai LFG dalam memperkirakan kadar bikarbonat plasma pada PGK stadium 5 dengan asidosis metabolik.Metode, penelitian ; Populasi penelitian adalah semua pasien yang menderita PGK stadium 5 dengan asidosis metabolik yang dirawat di Bagian Ilmu Penyakit Dalam, RS Dr. M. Djamil. Dari hasil penelitian diperoleh pria lebih banyak menderita PGK stadium 5 dengan asidosis metabolic,Kesimpulah; Laju Filtrasi Glomerulus (LFG) tidak dapat dijadikan alat diagnostik untuk memperkirakan kadar bikarbonat plasma kurang dari 12 mmol/l pada PGK stadium 5 dengan asidosis metabolik.Kadar bikarbonat plasma pasien PGK stadium 5 dengan asidosis metabolik memiliki kadar rerata 9,1 (SD 3,4) mmol/l dengan estimasi selang 8,2 - 10,0 mmol/l.Tidak terdapat hubungan bermakna antara nilai LFG dan kadar bikarbonat plasma.Terdapat korelasi positif antara kadar bikarbonat plasma dan nilai base excess pada PGK stadium 5 dengan asidosis metabolik.Kata kunci : laju filtrasi glomerulus; Kadar bikarbonat ;penyakit ginjal kronik stadium 5ABSTRACTLow plasma bicarbonate levels are associated with high mortality in patients with advanced CKD. The severity of the degree of hypobycarbonatemia is related to the degree of glomerular filtration rate (GFR) where the lower the GFR, the lower the plasma bicarbonate level. Therefore, based on the relationship that the degree of hypobycarbonatemia is related to the degree of GFR, this study aims to find out more about the diagnostic role of GFR in estimating plasma bicarbonate levels in stage 5 CKD with metabolic acidosis. Method, study; The study population was all patients suffering from CKD stage 5 with metabolic acidosis who were treated at the Internal Medicine Department, Dr. M. Djamil. The results showed that men suffered more from CKD stage 5 with metabolic acidosis. Kesimpulah; Glomerular Filtration Rate (GFR) cannot be used as a diagnostic tool to estimate plasma bicarbonate levels of less than 12 mmol / l in stage 5 CKD with metabolic acidosis. Plasma bicarbonate levels in CKD stage 5 patients with metabolic acidosis had a mean level of 9.1 (SD 3, 4) mmol / l with an estimated range of 8.2 - 10.0 mmol /l. There was no significant relationship between LFG values and plasma bicarbonate levels. There was a positive correlation between plasma bicarbonate levels and base excess values in stage 5 CKD with metabolic acidosis.Keywords : Bicarbonate levels ;glomerular filtration rate; stage 5 chronic kidney disease

SIMULATION DOCKING ACTIVE COMPOUNDS LAB AS ANGIOTENSIN CONVERTING HUMAN ENZYME CHAIN A (ACE2) dessy abdullah; Rendri Bayuhansah
Jurnal Kesehatan Medika Saintika Vol 12, No 1 (2021): Juni 2021
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v12i1.773

ACE adalah singkatan dari Angiotensin-converting enzyme. Angiotensin adalah enzim yang berperan dalam sistem renin-angiotensin tubuh yang mengatur volume ekstraseluler (misalnya plasma darah, limfa, dan cairan jaringan tubuh), ACE inhibitor berguna untuk menurunkan tekanan darah pada pasien hipertensi, meningkatkan kerja jantung, dan mengurangi beban kerja jantung pada pasien gagal jantung. ACE inhbitor merupakan analog nonpeptida dari AT I. ACE inhibitor terikat kuat pada sisi aktif ACE, dimana terjadi kompleks dengan ion Zn dan berinteraksi dengan gugus bermuatan positif dan kantong hidrofobik. Penelitian ini bertujuan untuk melihat zat bioaktif pada BAL yang dapat digunakan sebagai kandidat terapi dengan metode molecular docking menggunakan Autodock Vina pada program PyRx 9.5. Protein yang digunakan sebagai target adalah Human angiotensin Converting Enzyme Chain A (ACE2) (PDB ID 1O86), sementara control inhibitor yang digunakan adalah Lisinopril dan untuk melihat interaksi asam amino yang terjadi digunakan program LigPlot 2.1. Berdasarkan hasil molekular docking diperoleh 7 senyawa bioaktive BAL dan bioaktive yang paling potensial adalah asam folat untuk menghambat ACE II dengan nilai binding activitynya -8,4.semakin negatif nilainya, maka semakin kuat interaksi yang terjadi antara reseptor dan ligand. Kesimpulan dapat diambil yakni senyawa bioaktive pada BAL tersebut dapat memiliki aktivitas sebagai inhibitor ACE , mirip dengan kerja lisinopril.

HUBUNGAN ANTARA INDEKS MASSA TUBUH DENGAN TEKANAN DARAH MASYARAKAT NAGARI ALAHAN NAN TIGO, KECAMATAN ASAM JUJUHAN, KABUPATEN DHARMASRAYA CORRELATION OF BODY MASS INDEX AND BLOOD PRESSURE OF NAGARI ALAHAN NAN TIGO SOSIETY, KECAMATAN ASAM JUJUHAN,KABUPATEN DHARMASRAYA Yolla Adelina Utami; Rendri Bayu Hansah; Eko Perdana Putra
Jurnal Kesehatan Saintika Meditory Vol 3, No 1 (2020): November 2020
Publisher : Stikes Syedza Saintika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v3i1.845

ABSTRAKIndeks Massa Tubuh merupakan suatu faktor utama (bersifat fleksibel) yang memengaruhi tekanan darah. Framingham Studi telah menemukan bahwa peningkatan 15% berat badan dapat menyebabkan peningkatan tekanan darah sistolik sebesar 18%. Dibandingkan dengan yang mempunyai berat badan normal, orang yang overweight dengan kelebihan berat badan sebesar 20% mempunyai resiko delapan kali lipat lebih besar terhadap hipertensi. Penelitian ini bertujuan untuk mengetahui hubungan indeks massa tubuh dengan tekanan darah Penduduk di Nagari Alahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya. Penelitian ini mengggunakan desain survei analitik, dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah penduduk Nagari Aahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya yang berusia 26-35 tahun yang berjumlah 134 orang. Teknik sampling yang digunakan adalah accidental sampling. Alat ukur yang digunakan adalah timbangan digital, mikrotoise dan tensimeter digital. Pada penelitian didapatkan indeks massa tubuh sebagian besar dalam kategori obese 1 yaitu 53 responden (39,6%), tekanan darah sebagian besar dalam kategori normal yaitu 90 responden (67,2%). Hasil penelitian memperlihatkan nilai sig = 0.000 (<0.005). Jadi, terdapat hubungan yang bermakna antara indeks massa tubuh dengan tekanan darah Penduduk di Nagari Alahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya.Kata Kunci: Berat badan; Indeks Massa Tubuh; Tekanan Darah ABSTRACT Body mass index is the one of main factor to influence blood pressure. Framingham Study said 15% increase of body weight can cause 18% increase in systolic blood pressure. Compared to people with normal weight, overweight people, with 20% excess, are 8 times more at risk for hypertension. The purpose of this research is to know the association between body mass index and blood pressure of the society in Nagari Alahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya. This study used analytical survey design with cross-sectional approach. The sample of this study was the society in Nagari Alahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya aged 26-35 as many as 134 respondents. The sampling technique used was accidental sampling. The measurement tools were scale, microtoise, and tensimeter. The analytical technique used was Chi-Square. This research found 53 respondents (39,6%) had obese 1 body mass index and 90 respondents (67,2%) had normal blood pressure. The result showed that the value of sig = 0.000 (<0.05). The conclusion is there is correlation between body mass index and population blood pressure in Nagari Alahan Nan Tigo Kecamatan Asam Jujuhan Kabupaten Dharmasraya.Keywords: Body Mass Index; Blood Pressure ; Body weight

GAMBARAN KADAR KOLESTEROL TOTAL PADA LANSIA DI PUSKESMAS ANDALAS DESCRIPTION OF TOTAL BLOOD CHOLESTEROL IN ELDERLY AT PUSKESMAS ANDALAS Diah Permata Sari; Rendri Bayu Hansah; Suharni .,
Jurnal Kesehatan Saintika Meditory Vol 3, No 1 (2020): November 2020
Publisher : Stikes Syedza Saintika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v3i1.849

ABSTRAK Keberhasilan pembangunan di berbagai bidang terutama bidang kesehatan menyebabkan terjadinya peningkatan usia harapan hidup (UHH) penduduk yang diikuti dengan masalah-masalah kesehatan yang mengirinya. Salah satunya peningkatan angka kejadian penyakit jantung koroner yang disebabkan oleh peningkatan kadar kolesterol total di dalam darah. Penelitian ini bertujuan untuk mengetahui gambaran kadar kolesterol total pada lansia di Puskesmas Andalas. Penelitian ini merupakan penelitian deskriptif. Sampel pada penelitian ini ialah lansia yang terdaftar di Puskesmas Andalas 2016 dan dipilih menggunakan teknik purposive sampling. Penelitian dilakukan melalui pengambilan langsung sampel darah kapiler pada responden yang diukur menggunakan metode rapid test cholesterol Electrode Based Biosensor dengan alat Easy Touch, sebanyak 50 responden. Data diolah menggunakan program SPSS 16.0 untuk menghasilkan distribusi frekuensi dan persentase. Hasil dari analisis data didapatkan kejadian hiperkolesterolemia lebih banyak ditemukan pada golongan usia 75-90 tahun dengan nilai rata-rata 229 mg/dl, jenis kelamin perempuan dengan nilai rata-rata 235 mg/dl, pensiun dengan nilai rata-rata 241,5 mg/dl, dan pendidikan tinggi dengan nilai rata-rata 236 mg/dl. Kesimpulan dari penelitian ini yaitu lebih dari separuh lansia di Puskesmas Andalas memiliki kadar kolesterol darah tinggi (≥200 mg/dl) dengan nilai rata-rata 228,56 mg/dl. Kata Kunci : Hiperkolesterolemia, Jenis Kelamin, Kolesterol Total, Lansia, Pendidikan, Pekerjaan, ABSTRACT The successfully on various sectors, especially on Health sector was caused by increasing a life age expectancy population. Therefore, it also in creases any health problem, one of health problems is Coronary Heart Disease which is being caused by increasing total cholesterol levels in the blood. PURPOSES: The purpose of this research to find out total blood cholesterol in Elderly on Puskesmas Andalas. This research was descriptive research.While, sample of this research was elderly which was registered at Puskesmas Andalas in 2016 and was choosen by using purposive sampling technique.This research will be held by taking direct capillary blood samples on respondents measured by using Rapid Test Cholesterol Electrode Based Biosensor of 50 respondents. Tabulation data used program SPSS 16.0 for showing us about frequency distribution and percentages. Based on tabulation data, Hypercholesterolemia more often to be found on elderly in range ages 75-90 years old have mean rate 229mg/dl, female gender has mean rate 235mg/dl, retired has mean rate 241,5mg/dl, and highly educated people have mean rate 236mg/dl. There are more than half elderly at Puskesmas Andalas has high blood cholesterol (≥200mg/dl) with mean rate 228,56mg/dl. Keywords: Hypercholesterolemia, gender, total blood cholesterol, elderly, education, occupation

Edukasi Dampak Penggunaan Cotton Buds untuk Membersihkan Telinga pada Siswa SMP YARI School Padang Nadia Purnama Dewi; Ade Teti Vani; Irwan Triansyah; Dessy Abdullah; Rendri Bayu Hansah
Jurnal Abdimas ADPI Sains dan Teknologi Vol. 3 No. 2 (2022): Jurnal Abdimas ADPI Sains dan Teknologi
Publisher : Asosiasi Dosen Pengabdian kepada Masyarakat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47841/saintek.v3i2.186

Ears are one of the most frequently cleaned parts of the body. There are many ways to clean the ears, for example by using cotton buds, using candles and so on. The act of cleaning the ear with cotton buds is not recommended, because it can cause earwax (cerumen prop) to be pushed into the ear so that over time it will cause hearing loss (deafness). Sometimes the use of cotton buds is too deep, causing damage to the eardrum. Education in the form of counseling given to junior high school students aims to reduce the risk of ear damage from an early age due to the use of cotton buds and how to clean the ears properly. Education is held at SMP Yari School Padang. The extension method uses power points and leaflets which are distributed to school students. At the time the counseling was carried out, pretest and posttest were given to see students' knowledge of the material presented. The results of the pretest and posttest showed an increase in students knowledge about the material that had been given with p value=0,000.

PROFIL DEMAM BERDARAH DENGUE DI RSUP DR M. DJAMIL PADANG TAHUN 2020-2022 Yuliza Birman; Pricillia Setiawan; Rendri Bayu Hansah
Nusantara Hasana Journal Vol. 2 No. 8 (2023): Nusantara Hasana Journal, January 2023
Publisher : Nusantara Hasana Berdikari

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DHF and Covid-19 may have similar clinical symptoms in the early stages and similar laboratory features. During the Covid-19 pandemic, the possibility of dual infection between Covid-19 and dengue infection should be considered in patients with fever in dengue endemic areas. During the Covid-19 pandemic, dengue cases also increased by more than 71,663 cases with 459 deaths. This study aims to determine the profile of Dengue Hemorrhagic Fever at Dr M. Djamil Hospital, Padang in 2020-2022. This type of research is descriptive using secondary data, namely patient medical records. The study was conducted from June 2021 to April 2022. The affordable population in the study were DHF patients who underwent an examination on the fifth day of fever at RSUP DR. M. Djamil Padang. Sampling by purposive sampling based on inclusion and exclusion criteria in order to obtain a sample of 97 samples. data processing using SPSS version 24.0. Data analysis was carried out univariately and presented in the form of a frequency distribution table. The highest age was adults as many as 53 people (54.6 %), the most gender was male, namely 52 people (53.6%), the highest body temperature was normal, namely 65 people (67%), the highest number of platelets was <100,000 i.e. 88 people (90.7 %), the highest number of leukocytes was 4,000- 10,000, namely 58 people (59.8%), the highest hematocrit value was < 40%, namely 55 people (56.7%), and the highest levels of hemolgobin is normal that is 56 people (57.7%).

Dukungan keluarga dan kepatuhan minum obat penderita tuberkulosis paru Rika Amran; Dessy Abdullah; Rendri Bayu Hansah; Naima Lessie; Eko Perdana Putra
Holistik Jurnal Kesehatan Vol 16, No 8 (2023)
Publisher : Program Studi Ilmu Keperawata Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v16i8.9042

Background: The patient's adherence to taking medications is an important factor in the success of the treatment of pulmonary tuberculosis. The high number of dropouts resulted in high cases of drug resistance, namely multi-drug resistance.Purpose: To analyze the relationship between family support to adherence to taking medications for people with pulmonary tuberculosis.Method: Quantitative with analytic cross-sectional design. The population in this study was all pulmonary tuberculosis patients. The total sample in this study was 168 respondents consisting of 84 case groups and 84 control groups. The sampling technique used is consecutive sampling. The instrument used is a questionnaire. The statistical test used is chi-square.Results: Finding that there was a significant relationship between family support and adherence to taking medications for people with pulmonary tuberculosis (p = 0.003 and OR 2.956).Conclusion: People who lack support from family are 2.9 times more likely to be disobedient to taking medication than people who get support from family.Suggestion: It is expected to provide health education to the family and closest people of Pulmonary TB sufferers so that they can participate in reminding and motivating sufferers.Keywords: Pulmonary tuberculosis; Anti-Tuberculosis Drugs (ATD); Adherence; Family support.Pendahuluan: Kepatuhan pasien dalam minum obat merupakan faktor penting dalam keberhasilan suatu pengobatan tuberkulosis paru. Tingginya angka putus berobat mengakibatkan tingginya kasus resisten obat yaitu multi drug resistance.Tujuan: Untuk menganalisa hubungan dukungan keluarga dengan kepatuhan minum obat penderita tuberkulosis paru.Metode: Penelitian ini menggunakan desain kasus kontrol. Populasi dalam penelitian ini ialah seluruh pasien tuberkulosis paru. Jumlah sampel pada penelitian ini sebanyak 168 responden yang terdiri dari 84 kelompok kasus dan 84 kelompok kontrol. Teknik sampling yang digunakan adalah consecutive sampling. Instumen yang digunakan adalah kuesioner. Uji statistik yang digunakan adalah chi square.Hasil: Didapatkan ada hubungan yang signifikan antara dukungan keluarga dengan kepatuhan minum obat penderita tuberkulosis paru (p=0,003 dan OR 2,956).Simpulan: Orang yang kurang mendapatkan dukungan dari kelurga berpeluang 2,9 kali lebih besar tidak patuh minum obat dibandingkan dengan orang yang mendapatkan dukungan dari keluarga.Saran: Diharapkan memberikan pendidikan kesehatan kepada kepada keluarga dan orang terdekat penderita TB Paru agar dapat ikut serta mengingatkan dan memberikan motivasi pada penderita.

GAMBARAN PERSEPSI ORANG TUA TENTANG VAKSINASI COVID-19 DI SDIT ADZKIA 2 KOTA PADANG Adella Aprilia; Rendri Bayu Hansah; Nurwiyeni
Nusantara Hasana Journal Vol. 2 No. 9 (2023): Nusantara Hasana Journal, February 2023
Publisher : Yayasan Nusantara Hasana Berdikari

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Background: Children of all ages runs the risks of being exposed to an infectious agent sars-cov-2 and the manifestation of illness.Vaccination covid-19 to children aged 6 11 years has begun since december 2021 as one of the main prevent transmission of covid-19.The number of people who had dissented old their children in order to vaccinated with reason the absence of government accountability when vaccination had an impact on the health of children, worry the purpose of vaccination is not for health and fear that the vaccine is not yet tested.Aims: This study aims to find out the Picture of Parents' Perception About COVID-19 Vaccination at SDIT Adzkia 2 Padang City. Methods: This type of research is descriptive categorical with a cross-sectional approach that uses primary data derived from questionnaires given to respondents according to the criteria for describing parents' perceptions of COVID-19 vaccination at SDIT Adzkia 2 Padang city. The sampling technique of this study uses consecutive sampling techniques. The sample obtained was 100 people. Results: The research results show sexes respondents most were women made up 70 %, the age of respondents most were 40-49 of these families are 51 %, the level of education last respondents most were scholar namely 94 %, most were the kind of work the 2009 an army / police / bumn / bumd namely 42 %.And, perceptions on urgency vaccination covid-19 on child most were perception enough that is 50 percent, perception about the side effects of vaccination covid-19 on child most were perception enough namely 58 % and perceptions about the safety of the vaccination covid-19 on child most were enough that is 54 % perception. Conclusion : The most of parent’s perceptions regarding the urgency, side effects and safety of COVID-19 vaccination in children are in the sufficient category in SDIT Adkia 2 Padang city.

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