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Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mudjiani Basuki1, Muhammad Hamdan1, Fidiana1, Fadil1, Deasy Putri Sukarno1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3132

Background: Diabetic Peripheral Neuropathy is a chronic microvascular complication of type 2 diabetes mellitus (T2DM) leads to increased risk of foot ulceration and morbidity.The increased serum uric acid (SUA) levels have been linked to macro vascular disease in T2DM. We found that the correlation between SUA levels and diabetic peripheral neuropathy has not been investigated. Objective: To determine the correlation between high serum uric acid levels and diabetic peripheral neuropathy. Method: The case-control design was used in this study and the sampling was done consecutively by following the inclusion and the exclusion criteria. The diabetic peripheral neuropathy was evaluated using EMNG and the serum were taken for uric acid levels examination. Chi square test was used for data analysis. Results: Thirty subjects were enrolled and divided into an experimental group of 15 subjects and a control group of 15 subjects as well. We found that the diabetic peripheral neuropathy did not show a significant correlation with high serum uric acid levels, p=0,136 and OR 3,143 (CI 95% 0,681-14,503). Conclusion: High serum uric acid levels did not have correlation with diabetic peripheral neuropathy.

The Association between Blood Glucose Control Measured with Serum Hna1c Level with Peroneal Motor Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus with Polyneuropathy Muhammad Hamdan1, Raini Wisnujono1 , Mudjiani Basuki1, Fidiana, Fadil1, Intan Sudarmadi1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3162

Background and Objective. The poor control of blood glucose levels in patients with diabetes mellitus is a major risk factor from various complications of diabetes mellitus, such as polyneuropathy. One of the nerves that are often affected in the case of diabetic neuropathy is the peroneal nerve. This study aimed to determine the association between blood glucose level control measured with serum hemoglobin A1c (HBA1c) levels with peroneal motor nerve conduction velocity in type 2 diabetes mellitus patients with polyneuropathy. Methods. The study was conducted on diabetic neuropathy patients who fulfilled inclusion and exclusion criteria in neurology unit and diabetes unit Dr. Soetomo General Hospital Surabaya on a consecutive basis from February to July 2013. The serum HbA1c level and nerve conduction velocity in peroneal motor nerve were examined; then, the results were grouped into two groups which were serum HbA1c <7% and ?7% and NCV in normal and low peroneal motor nerve Results. There were 26 subjects, consisting of 6 subjects with serum HbA1c <7% and 20 subjects with serum HbA1c ? 7%. There was an association between blood glucose level control measured by serum HbA1c levels and NCV in peroneal motor nerve with statistical significance of p = 0.0018 (Odd ratio 15; 95% IK 1.397 - 161.045). Conclusion. There was an association between blood glucose level control measured by serum HbA1c levels with NCV in peroneal motor nerve in type 2 diabetes mellitus patients with polyneuropathy

Association of Gamma-GT Serum and Nerve Conduction Velocity of Nervus Peroneus Motor Vehicles on Diabetic Polyneuropathy Patients Januar1 , Mudjiani Basuki2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13681

Background and Objectives: Diabetic Polyneuropathy is one of the common complications of diabetesmellitus (DM) and can lead to foot ulcers or amputation. The pathophysiology of Diabetic Polyneuropathyincludes several factors such as metabolic, vascular, autoimmune, oxidative stress and neurohormonalgrowth-factor deficiency. The recent studies have suggested the use of serum gammaglutamyl transferase(GGT) as an early marker of oxidative stress. Therefore, we investigated whether serum GGT may be usefulin predicting Diabetic Polyneuropathy.Methods: The study was conducted in patients with diabetic polyneuropathy who meet the criteria forinclusion and exclusion in neurological outpatient clinic and EMG room departments of NeurologyDr.Soetomo General Hospital Surabaya consecutively started in June 2014 to April 2015.Result: We obtained 20 study subjects (8 subjects with increased serum levels of gamma GT and 12 subjectswith normal serum levels of gamma GT). There was statistically no significant between serum levels ofgamma GT with motoric nerve conduction velocity (NCV) of peroneal nerve (p = 0.582 ; Odds ratio 0.600).Conclusion: There was no relationship between elevated levels of serum gamma GT with decreased motornerve conductivity velocity peroneal nerve in patients with diabetic polyneuropathy.

ANALISIS KORELASI SKOR GEJALA TOTAL NYERI DAN KUALITAS HIDUP SETELAH PENGOBATAN VITAMIN B 1 B6 DAN B12 DOSIS TINGGI PADA NEUROPATI PERIFER Manfaluthy Hakim,* Nani Kurniani,** Rizaldy Pinzon,*** Dodik Tugasworo,**** Mudjiani Basuki,***** Ha
NEURONA Vol. 35 No. 2 Maret 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar

INTRODUCTION PERIPHERAL NEUROPATHY PN IS A CLINICAL CONDITION IN WHICH NERVES OF THE PERIPHERAL NERVOUS SYSTEM ARE DAMAGED AND IS ASSOCIATED WITH VARIOUS SYMPTOMS AFFECTING THE PATIENTS QUALITY OF LIFE QOL

COMORBIDITIES OF MYASTHENIC CRISIS PATIENTS ACCORDING TO AGE AND GENDER IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN 2017-2019 Andi Muh Rahul Alfaidin; Viskasari P Kalanjati; Mudjiani Basuki
Majalah Biomorfologi Vol. 32 No. 1 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i1.2022.1-5

Highlight:1. Patients with myasthenia gravis (MG) can have both autoimmune and non-autoimmune comorbidities.2. MG patients were predominantly aged >50 years, females and the commonest comorbidity are hypertension and diabetes mellitus.3. Age and comorbidities were found to have significant correlation among these patients, but not between gender and comorbidities.Abstract:Background: There are limited studies on the comorbidities of myasthenic crisis (MC) associated with age and gender, specifically from Indonesia. These data might be valuable for treatment to improve the outcome of these patients. Objective: To analyze the correlation between age and gender with the comorbidities amongst the MC patients admitted in the ICU of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2017-2019. Materials and methods: A retrospective cross-sectional analytic study was conducted on 25 medical records of MC patients who fulfilled the inclusion and exclusion study criteria. Descriptive statistics and Chi-square tests were done to determine the potential correlation between variables (significant level of p<0.05). Results: The age of MC patients was £50 years (80%) and >50 years (20%) while the gender predominantly found were females (68%) with 32% males. A significant correlation was found between age and comorbidities (p=0.002) whilst not between gender and comorbidities (p=0.115). The most common comorbidities observed were hypertension (30%) and diabetes mellitus (20%). Conclusion: There were 40% of patients found with comorbidities. There was a significant association between age and comorbidities found amongst myasthenic crisis patients, whilst no significant association was found between gender and comorbidities.

Obstructive sleep apnea and chronic pain as risk factors of cognitive impairment in elderly population: A study from Indonesia Tiara Tiara; Fidiana Fidiana
Narra J Vol. 1 No. 3 (2021): December 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v1i3.62

Obstructive sleep apnea (OSA), one of the most prevalent sleep-related breathing disorders in the elderly, seems to be underdiagnosed. Meanwhile, the resulting complication on cognitive function could impact on patient’s quality of life. Association between OSA and cognitive function in the elderly varies highly, depending on study type, setting, and possibly by demographic differences. Therefore, this study sought to determine the risk of OSA among elderly and to assess the association of OSA risk and other plausible factors with cognitive function. In this cross-sectional study, patients aged 60 years and above who visited the outpatient clinic at two main hospitals in Surabaya of Indonesia were examined. A total of 178 participants were interviewed to evaluate the OSA risk using STOP-Bang questionnaire, the cognitive dysfunction using Montreal Cognitive Assessment Indonesian version (MoCA-Ina), depressive symptoms using Geriatric Depression Scale-15 (GDS-15), and sleep disorder using Insomnia Screening Questionnaire (ISQ). The Mann-Whitney and Chi-square tests were used to assess factors associated with cognitive impairment. In addition, logistic regression analyses were performed to evaluate the role of high risk of OSA on cognitive impairment. A total of 120 patients were considered having high risk of OSA (STOP-Bang score ≥3), and 129 had mild cognitive impairment (MCI) (MoCA-Ina <26). Among the elderly who had high risk of OSA, 94 were diagnosed with MCI (78.3%). Multivariate logistic regression analysis showed that high risk of OSA (OR: 2.99; 95%CI: 1.39, 6.46, p=0.005), chronic pain (OR: 5.53; 95%CI: 1.19, 25.64, p=0.029), and low education level (OR: 4.57; 95%CI: 1.79, 11.63) were associated with MCI. In conclusion, our data suggests a high prevalence of MCI among high risk OSA elderly. Screening and comprehensive management might be beneficial to improve or to preserve cognitive function in elderly group.

Hubungan Antara Rasio H/M pada Stroke Akut dengan Derajad Spastisitas Pascastroke Achmad Firdaus Sani; Yudhi Adrianto; Fadil; Mudjiani Basuki; Fidiana
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Pendahuluan: Spastisitas adalah gangguan motorik yang sering dijumpai dan muncul setelah stroke. Spastisitas dapat menyebabkan nyeri dan disabililitas pada bagian tubuh yang mengalaminya. Tujuan: mencari hubungan antara rasio H/M yang diukur dengan elektromiografi dengan derajad spastisitas yang terjadi setelah fase akut stroke. Metode: Penelitian ini adalah studi analisis korelatif observasional, dengan 26 sampel. Pasien diukur rasio H/M pada saat stroke akut dan diukur derajad spastisitasnya dengan menggunakan Modified Ashworth Scale setelah 3 bulan. Hasil yang didapatkan dilakukan analisa statistik dengan menggunakan tes korelatif kategorik dari Spearman. Hasil: Pasien yang mengikuti penelitian ini sebanyak 26 orang. Terdapat perbedaaan antara nilai H/M rasio antara sisi parese dengan sisi sehat dan tidak didapatkan hubungan yang bermakna antara nilai rasio H/M yang diukur saat fase akut stroke dengan derajad spastisitas yang diukur dengan Modified Ashworth Scale (MAS) setelah 3 bulan (p = 0,06 ; r = 0, 37). Kesimpulan: Rasio H/M pada pasien stroke akut meningkat pada sisi parese dibanding pada sisi sehat, namun peningkatan ini tidak memiliki hubungan yang signifikan dengan derajad spastisitas pasca stroke yang diukur dengan MAS, sehingga rasio H/M tidak dapat digunakan sebagai prediktor munculnya spastisitas pasca stroke

Hubungan Antara Rasio H/M pada Stroke Akut dengan Derajad Spastisitas Pascastroke Achmad Firdaus Sani; Yudhi Adrianto; Fadil; Mudjiani Basuki; Fidiana
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Pendahuluan: Spastisitas adalah gangguan motorik yang sering dijumpai dan muncul setelah stroke. Spastisitas dapat menyebabkan nyeri dan disabililitas pada bagian tubuh yang mengalaminya. Tujuan: mencari hubungan antara rasio H/M yang diukur dengan elektromiografi dengan derajad spastisitas yang terjadi setelah fase akut stroke. Metode: Penelitian ini adalah studi analisis korelatif observasional, dengan 26 sampel. Pasien diukur rasio H/M pada saat stroke akut dan diukur derajad spastisitasnya dengan menggunakan Modified Ashworth Scale setelah 3 bulan. Hasil yang didapatkan dilakukan analisa statistik dengan menggunakan tes korelatif kategorik dari Spearman. Hasil: Pasien yang mengikuti penelitian ini sebanyak 26 orang. Terdapat perbedaaan antara nilai H/M rasio antara sisi parese dengan sisi sehat dan tidak didapatkan hubungan yang bermakna antara nilai rasio H/M yang diukur saat fase akut stroke dengan derajad spastisitas yang diukur dengan Modified Ashworth Scale (MAS) setelah 3 bulan (p = 0,06 ; r = 0, 37). Kesimpulan: Rasio H/M pada pasien stroke akut meningkat pada sisi parese dibanding pada sisi sehat, namun peningkatan ini tidak memiliki hubungan yang signifikan dengan derajad spastisitas pasca stroke yang diukur dengan MAS, sehingga rasio H/M tidak dapat digunakan sebagai prediktor munculnya spastisitas pasca stroke

The Effect of Simvastatin on Acute Phase Functional Outcome of Ischemic Stroke Fidiana Fidiana; Paulus Sugianto
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Introduction: Stroke is one of the leading causes of death and disability worldwide, and especially in Indonesia. Several studies showed the pleiotropic and neuroprotective effect of simvastatin in addition to lowering blood cholesterol levels. Objective: This trial was conducted to investigate if the administration of simvastatin in acute ischemic stroke management can improve functional outcomes. Methods: This randomized, double-blind, placebo-controlled trial of simvastatin was conducted in patients with acute ischemic stroke with an NIHSS score of 4-14. Participants were randomly assigned to receive 40 mg of simvastatin or placebo for seven days. The NIHSS scale was compared on admission day, 4th and 8th day after administration of simvastatin between the two groups. Results: 52 individuals were randomized: 28 to simvastatin and 24 to placebo. There was no significant improvement of functional outcome between the two groups (p > 0.05). Conclusion: Administration of simvastatin had no significant effect on outcome (measured by NIHSS) in patients with acute ischemic stroke.

Hubungan antara Kadar HBA1C dengan Hasil Sural Radial Amplitude Ratio (SRAR) pada Pasien DM Tipe 1 dengan Neuropati Diabetik Perifer Anny Hanifah; Mudjiani Basuki; Muhammad Faizi
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Pendahuluan: Neuropati diabetik perifer merupakan salah satu komplikasi mikroangiopati pada penderita diabetes mellitus. Manifestasi neuropati diabetik perifer paling banyak adalah polineuropati simetris distal, yang menunjukkan gangguan sensorik, motorik, serta penurunan refleks tendon dengan pola length-dependent. Diabetes Mellitus tipe 1 terbanyak diderita pada penderita usia muda, dimana saraf tepi memiliki amplitudo yang relatif masih tinggi, sehingga penurunan amplitudo yang relatif kecil, masih dianggap normal. Perbandingan amplitudo saraf sural dan radial dapat mendeteksi adanya neuropati subklinis. Penderita diabetes mellitus tipe 1 dengan kadar glukosa darah yang tidak teregulasi dengan baik mempunyai risiko 25.6% terkena neuropati diabetik perifer. Tujuan: untuk mengetahui hubungan antara kadar HbA1C dengan kejadian neuropati diabetik perifer pada penderita Diabetes Mellitus tipe 1. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan cross sectional dengan teknik pengambilan subjek penelitian menggunakan consecutive sampling admission yang memenuhi kriteria inklusi dan eksklusi. Subjek penelitian dilakukan pengukuran terhadap kadar HbA1C, amplitudo saraf sural dan radial dan dihitung perbandingan diantara keduanya. Hasil: Pada 38 subjek penelitian didapatkan 31 subjek penelitian dengan Sural Radial Amplitude Ratio (SRAR) rendah dan 7 subjek penelitian dengan nilai SRAR normal. Hasil analisis penelitian didapatkan bahwa pada subjek dengan nilai SRAR rendah lebih besar pada kelompok HbA1C tinggi yaitu 26 subjek (83.87%) dibandingkan dengan kelompok HbA1C normal yaitu 5 subjek (16.13%). Perbedaan tersebut bermakna secara statistik dengan p= 0.021, rasio odd 6.933 (IK 95% 1.173-40.981). Kesimpulan: Terdapat hubungan negatif antara kadar HbA1C dengan kejadian neuropati diabetik perifer pada penderita Diabetes Mellitus Tipe 1.

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