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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Islam : Islamic Health Journal The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran Komunitas (Journal of Community Medicine) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rahma Triliana
Faculty Of Medicine, Islamic University Of Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Result Comparison of Fecal Occult Blood Test between FOBT Hb and FOBT Hb tambah Tranferrin in Detecting Upper Gastrointestinal Tract Bleeding Widijanti, Anik; Sulistiandari, Sri; Hariyanto, Tony; Triliana, Rahma
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 1, April 2010
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/11120102-6

Abstract

Background: Immunological fecal occult blood test (FOBT) using anti human hemoglobin (Hb) has a low sensitivity in detecting upper gastrointestinal (GI) bleeding, due to Hb degradation. Transferrin (Tf) is more stable in stool when compared to Hb, provides an alternatives on diagnosing upper GI bleeding. This study aim to determine the advantage of FOBT Hb + Tf in detecting upper GI bleeding compared with FOBT Hb alone. Method: This study was conducted by comparing the diagnostic value of Rapid Immunochromatographic FOBT that use anti-human Hb alone, with the one using combination of anti human Hb & Tf simultaneously in detecting upper GI bleeding. Stool sample from 48 patients with upper GI bleeding and 29 controls (without any upper GI bleeding) were collected then tested with both FOBT Methods. Endoscopy study was used as gold standard endoscopy to determine test’s diagnostic value. Result: In detecting upper GI bleeding, the sensitivity of FOBT Hb + Tf (85.42%) was higher than FOBT Hb (29.17%). The specifity of both Methods were accurate at 89.66% and 93.10% respectively. Positive predictive values (PPV) for both Methods were also good at 93.18% and 87.50% while negative predictive value (NPV) FOBT Hb + Tf (78.79%) were higher than FOBT Hb (44.26%). Conclusion: Between these two test Methods on detecting upper GI bleeding, FOBT Hb + Tf has higher sensitivity, PPV and NPV value compared to FOBT Hb. It is advisable to use FOBT Hb + Tf for upper GI bleeding screening. Keywords: FOBT, immunochromatography, hemoglobin, transferrin, upper GI bleeding
Peran Gender dan Interval Puasa pada Profil Lipid Tikus Wistar dengan Diet Atherogenik Triliana, Rahma; Airlangga, Hardadi
Jurnal Kesehatan Islam : Islamic Health Journal Vol 7, No 01 (2018): JURNAL KESEHATAN ISLAM
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

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Abstract

AbstractIntroduction: Atherogenic diet can induced.hyperlipidemia leading to abnormal lipid profile. Time restricted feeding is proposed as treatment for hyperlipidemia. However, the effect of gender and which type of time-restricted feeding is the best to alter lipid profile is unknown.Method: The study was conducted in female and male wistar rats which was devided into 5 groups, Negative Control (KN, n=8), Positive Control (KP, n=8), Daily restricted group (KRam, n=8), alternate restricted group (KDaud, n=8) and Monday-Thursday restricted group (KSeKa, n=8) respectively. Atherogenic diet were administrated for six weeks followed by 4 weeks of time-restricted feeding. At 15 weeks of age, all rats were humanely culled and serum samples were collected for analyses. Lipid profile were assesed using spectrophotometry and analysed using two way Anova followed by post hoc LSD and p < 0.05 is considered as statiscally significant.Results: Gender and time restricted feeding affects serum total cholesterol and non-HDL cholesterol levels while gender influenced HDL and time restricted feeding influenced LDL levels. Both gender and time restricted feeding did not altered trigliseride level. Interestingly, no significant differences were found in lipid profile of KN vs KP in male or female group. Time restricted feeding had no significant effect in male but significant effect on female with higher, undesireable lipid profile.Conclusion: Atherogenic diets did not lipid profile in male or female rats, but higher lipid profile were observed in female with atherogenic diet. Time restricted feeding has gender related effect cholesterol and non-HDL cholesterol level, but no gender effect on LDL. HDL is solely dependent on gender and not affected by atherogenic diet or time restricted feeding.Keywords: Atherogenic diet, Time-restricted feeding,HDL, LDL, Triglyceride, Cholesterol.
The Combination Effect of Ceftriaxone and Chloramphenicol on Staphylococcus aureus Isolate of Diabetic Gangrene: Efek Kombinasi Seftriakson dan Kloramfenikol pada Staphylococcus aureus Isolat dari Gangren Diabetik Yudi Purnomo; Pasha Chandra; Rahma Triliana
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 1 (2022): (March 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i1.15819

Abstract

Background: Diabetic gangrene is a complication of Diabetes mellitus caused by Staphylococcus aureus. The combination of Ceftriaxone and Chloramphenicol is often used to cure gangrene infection, even though, they produce antagonist interaction based on theory. Objectives: To evaluate the potency of Ceftriaxone, Chloramphenicol and its combination on Staphylococcus aureus isolate of Diabetic gangrene. Material and Methods: The research was done by using disc diffusion methods with Muller Hinton media. Ceftriaxone, Chloramphenicol and its combination dose of 7,5 µg/ml, 15 µg/ml and 30 µg/ml, respectively were tested on Staphylococcus aureus culture taken form the diabetic gangrene patients. Antibacterial effect was observed by measuring inhibition zone on bacteria culture. Type of interaction was analyzed by Ameri-Ziaei Double Antibiotic Synergism Test (AZDAST) method. The results of study were tested statistically with One Way ANOVA (p=0.05) followed by Least Significant Difference (LSD) test. Results: The combination of Ceftriaxone and Chloramphenicol showed an antibacterial effect lower than Ceftriaxone. ß-lactam antibiotic like Ceftriaxone require the cell be growing and dividing in order to have a bactericidal action. Meanwhile, Chloramphenicol causes a slow growth of Staphylococcus aureus and impairs bactericidal effect of Ceftriaxone if they are combined. Conclusions: Ceftriaxone and Chloramphenicol combination has lower antibacterial effect than the single antibiotic groups on Staphylococcus aureus isolate of Gangrene diabetic and the type of interaction is antagonistic.
PEMBERIAN PROTEIN ADHESIN 38-KILODALTON MYCOBACTERIUM TUBERCULOSIS PERORAL MENINGKATKAN JUMLAH MAKROFAG DAN LIMFOSIT USUS MENCIT BALB/c Rahma Triliana; Ade A Kartosen; Dianika P Puspitasari; Sri Murwani; Sanarto Santoso; Maimun Z Arthamin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1015

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is one of the world health problems. Oral vaccination of M.tb hasa potential to reduce the risk and complication of TB. The 38-kDa adhesin protein as one of oral TB vaccine candidates has not beenproven. This study is aimed to determine M.tb 38-kDa adhesin protein effect on macrophage and lymphocyte numbers in mice intestineafter an oral administration. BALB/c mice (n=20), age 6–8 weeks, and were divided into 4 groups: control (K), adjuvant (A), 38-kDa100μg adhesin protein (P), and combination of 100μg 38-kDa adhesin protein with adjuvant (PA). An oral administration was givenat the beginning with 2 boosters every 4 weeks. After 3 days of the second booster, the mice were killed and the intestine was taken andstained with haematoxylin eosin (HE) to measure its macrophages and lymphocytes number. The mean ±2SD were 18.4 (3.71) and6.09 (0.34), 23.0 (7.78) and 8.86 (1.19), 42.2 (13.63) and 23.49 (3.91), 95.4 (30.11), and 53.57 (13.79) respectively for K, A, Pand PA group. The statistical test showed a significant difference among each group revealing the role of M.tb 38-kDa adhesin proteinas immunogenic inducing cellular immunity in intestine. In this study, so far it was found that the oral administration of M. tb 38-kDaadhesin protein has an ability to increase macrophage and lymphocyte numbers in the mice intestinal BALB/c.
Peran Gender Dan Interval Puasa Pada Profil Lipid Tikus Wistar Dengan Diet Atherogenik Rahma triliana; Hardadi Airlangga
Jurnal Kesehatan Islam : Islamic Health Journal Vol 7, No 2 (2018): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v7i2.8925

Abstract

 Introduction: Atherogenic diet can induced.hyperlipidemia leading to abnormal lipid profile. Time restricted feeding is proposed as treatment for hyperlipidemia. However, the effect of gender and which type of time-restricted feeding is the best to alter lipid profile is unknown.Method: The study was conducted in female and male wistar rats which was devided into 5 groups, Negative Control (KN, n=8), Positive Control (KP, n=8), Daily restricted group (KRam, n=8), alternate restricted group (KDaud, n=8) and Monday-Thursday restricted group (KSeKa, n=8) respectively. Atherogenic diet were administrated for six weeks followed by 4 weeks of time-restricted feeding. At 15 weeks of age, all rats were humanely culled and serum samples were collected for analyses. Lipid profile were assesed using spectrophotometry and analysed using two way Anova followed by post hoc LSD and p < 0.05 is considered as statiscally significant.Results: Gender and time restricted feeding affects serum total cholesterol and non-HDL cholesterol levels while gender influenced HDL and time restricted feeding influenced LDL levels. Both gender and time restricted feeding did not altered trigliseride level. Interestingly, no significant differences were found in lipid profile of KN vs KP in male or female group. Time restricted feeding had no significant effect in male but significant effect on female with higher, undesireable lipid profile.Conclusion: Atherogenic diets did not lipid profile in male or female rats, but higher lipid profile were observed in female with atherogenic diet. Time restricted feeding has gender related effect cholesterol and non-HDL cholesterol level, but no gender effect on LDL. HDL is solely dependent on gender and not affected by atherogenic diet or time restricted feeding.
PENINGKATAN KADAR SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGOT) TANPA PERUBAHAN MASSA OTOT DENGAN PENGUKURAN BIOELECTRICAL IMPEDANCE ANALYSIS (BIA) PADA LANSIA SEHAT DI KOTA MALANG Faqihatul Azizah Devitasanti; Fitria Nugraha Aini; Rahma Triliana
Jurnal Kedokteran Komunitas Vol 10, No 2 (2022)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

ABSTRAK Pendahuluan: Penuaan merupakan proses alami individu yang ditandai dengan penurunan fungsi tubuh, salah satunya massa otot. Untuk mengetahui adanya penurunan massa otot menggunakan metode Bioelectrical Impedence Analysis (BIA) dan kadar SGOT. Penelitian dilakukan karena sebelumnya belum ada penelitian yang menggunakan kedua metode secara bersamaan dengan membandingkan usia antara dewasa muda dan lansia.Metode: Penelitian ini menggunakan metode Descriptive Analityc Cross Sectional dengan sampel wanita dewasa muda 19-23 tahun (n=40) dan lansia 59-66tahun (n=40). Penilaian massa otot menggunakan Bioelectrical Impadance Analysis (BIA) dan kadar SGOT diukur dengan metode kinetik enzimatik. Data dianalisa dengan uji Mann-Whitney dan dilanjutkan dengan uji korelasi Spearman dengan p<0.05 dianggap signifikan.Hasil dan Pembahasan: Nilai rata-rata massa otot wanita dewasa muda 34.302±3.6776 dan lansia 35.862±3.6741 (p=0.088). Nilai rata-rata kadar SGOT wanita dewasa muda adalah 18.78±8.113 dan lansia 20.65±4.583 (p=0.004). Hasil korelasi usia dengan massa otot tidak memiliki korelasi (r=-0.143, p=0204), sedangkan usia dengan SGOT memiliki korelasi lemah (r=0.260, p=0.020). Hal ini diduga terjadi karena pengaruh dari aktifitas fisik yang cukup baik sehingga massa otot tetap terjaga, akan tetapi adanya kemungkinan kerusakan sel pada organ lain yang mengalami penuaan dapat terdeteksi dengan adanya peningkatan kadar SGOT.Kesimpulan: Penuaan meningkatkan kadar SGOT namun tidak mempengaruhi massa otot wanita sehat di Kota MalangKata Kunci : Usia, penuaan, SGOT, massa otot, BIA
Pengaruh Kendali Glukosa terhadap Kadar Kalsium Serum pada Penderita DM Tipe 2 di Malang Raya Ananda Kumala Ansar; Dewi Martha Indria; Rahma Triliana
Jurnal Kedokteran Komunitas Vol 8, No 2 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

Introduction : Diabetes mellitus (DM) is a glucose metabolism disorder that is able to cause organ damage if the patient has inadequate glycemic control. Organ damage in patient with DM leads to micronutrient metabolism disorder includes calcium. Decreased serum calcium level in DM patient could reduce the insulin sensitivity. The effect of glycemic control in type 2 DM on calcium serum level in Indonesia has never been studied. Therefore, further research is needed, especially in Malang City.Method : : A cross sectional study with control group post-test-only design was conducted using purposive non-random sampling. Total subject was 40 patients consist of 15 patients with good glycemic control and 25 with poor glycemic control. Each group examined for serum calcium level using Atomic Absorption Spectrophotometry (AAS). Data were analyzed by using Independent T-Test followed by Pearson correlation test with a significance level of p <0.05Results : Calcium level in type 2 DM patients with good glycemic control (4,25±1,54 mg/dL) were higher than poor glycemic control (3,32±1,43 mg/dL) with signifikasi p=0,404. Glycemic control is moderately correlated on serum calcium with correlation level r=-0,358 and signification level p=0,03.Conclusion : Glycemic control in type 2 diabetes mellitus moderate correlated with serum calcium level.Keywords: Glycemic control in type 2 DM is moderately correlated with serum calcium level.
Peran Kendali Glukosa terhadap Indeks Massa Tubuh dan Lingkar Lengan Atas pada Pasien Diabetes Mellitus Tipe 2 di Malang Raya Sukosari Devantari; Silvy Amalia Falyani; Rahma Triliana
Jurnal Kedokteran Komunitas Vol 8, No 2 (2020)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

Background: Diabetes Mellitus (DM) is a degenerative disease caused by impaired insulin function, marked by hyperglycemia. Chronic hyperglycemia may decrease the nutritional status of DM patients by measuring Body Mass ndex (BMI) and Upper Arm Circumference (UAC). This study aimed to look at the role of glucose control in BMI and UAC in Type 2 DM patients.Methods: This reserach was cross sectional studies. The respondents are male and female of diabetic patients without complications over the age of 40 years. The subjects were divided into the controlled group and uncontrolled group. Each group performed weight measurements with weight scale, body height with microtoise and UAC with a measuring tape. Independent T-Test was used to analyze the data , followed by a Pearson correlation test with a significance level of p<0.05.Results: There was no significant difference between glucose control, BMI (p=0.921), right UAC (p=0.611) and left UAC (p=0.406) in controlled group and uncontrolled group. Glucose control had no correlation to BMI (r=-0.061). There was also no correlation between glucose control, right UAC (r=0.161) and left UAC (r=0.197).Conclusion: Glucose control had no role in body mass index and upper arm circumference towards patients with diabetes mellitus type 2 in Malang.Keywords: Glucose control, body mass index, upper arm circumference, type 2 diabetes mellitus
PENGARUH DIABETES MELITUS TIPE 2 PADA MASSA TULANG DAN KADAR KALSIUM URIN DENGAN USIA DAN GENDER YANG SAMA DI MALANG RAYA Fachrudin Arrozaq; Dhanti Erma Widiasi; Rahma Triliana
Jurnal Kedokteran Komunitas Vol 9, No 2 (2021)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

Pendahuluan: Diabetes Melitus (DM) dapat memicu stress oksidatif dan hiperglikemi yang memicu kerusakan kolagen tulang sehingga terjadi osteoporosis. Namun penelitian perbedaan massa tulang dan kadar kalsium urin pasien DM tipe 2 dan non DM tipe 2 belum pernah dilakukan sehingga perlu untuk diteliti.Metode: Penelitian studi Cross-sectional dengan responden penelitian yang dibagi menjadi 2 kelompok, yaitu DMT2 dan non-DMT2 berdasarkan HbA1c. Masing-masing kelompok akan dilakukan pemeriksaan massa tulang menggunakan BIA dan kadar kalsium urin menggunakan AAS. Selanjutnya data dianalisa menggunakan SPSS.Hasil dan Pembahasan: Pada kelompok Non-DM dan DM didapatkan perbedaan yang signifikan HbA1c kedua kelompok (5,78±0,37 dan 10,22±2,49) (p=0,000). Tidak ada perbedaan yang signifikan antara masa tulang kedua kelompok (2,03±0,35 dan 2,05±0,35) (p=0,875) namun ada perbedaan yang signifikan pada kadar kalsium urin (10,81±6,66 dan 3,25±4,21) (p=0,000). Pada penelitian ini massa tulang kedua kelompok sama dan kadar kalsium urin Non-DM lebih tinggi dibanding kelompok DM. Hal tersebut diduga kuat akibat faktor bias usia, hormonal dan gangguan ginjal yang tidak terdeteksi sebelumnya.Kesimpulan: Tidak terdapat perbedaan yang signifikan massa tulang antara individu Non-DM tipe 2 dan DM tipe 2. Terdapat perbedaan signifikan kadar kalsium urin antara individu Non-DM tipe 2 dan DM tipe 2.Kata Kunci: Diabetes Melitus, Kalsium Urin, Massa Tulang, Bio-electrical Impedance Analysis (BIA)
PENURUNAN KADAR HEMOGLOBIN TANPA PERUBAHAN KADAR ZAT BESI SERUM PADA WANITA LANSIA SEHAT DI KOTA MALANG Nurbella Sannyngtyas; Yeni Amalia; Rahma Triliana
Jurnal Kedokteran Komunitas Vol 10, No 2 (2022)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

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Abstract

ABSTRAK Pendahuluan: Anemia Defisiensi Besi (ADB) adalah penurunan kadar Hb karena kurangnya zat besi serum yang sering terjadi di Indonesia. Lansia memiliki resiko anemia lebih besar dibanding usia muda terutama wanita. Penelitian ini mengambil responden usia tua dan muda dengan gap kurang lebih 40 tahun untuk mengetahui perbedaan kadar zat besi serum dan Hb pada dua kondisi usia.Metode: Penelitian ini merupakan studi deskriptif jenis Cross-sectional dengan responden wanita sehat yang dibagi dalam 2 kelompok, yaitu kelompok dewasa muda (n=40) dan lansia(n=40). Kadar zat besi serum diukur dengan metode Spektrofotometri Serapan Atom (SSA) dan kadar Hb dengan menggunakan metode flow cytometry. Data zat besi serum dianalisis dengan uji Independent T-Test, sedangkan data Hb dianalisis dengan uji Mann-Whitney. Uji korelasi Spearman digunakan untuk menilai hubungan antar variabel yang ada dengan p<0.05 dianggap signifikan.Hasil dan Pembahasan: Kadar zat besi serum dewasa muda dan lansia didapatkan 72.400±26.467 vs 82.700±21.670 (p=0.061). Kadar hemoglobin dewasa muda dan lansia didapatkan 13.905±1.671 vs 13.105±0.991 (p=0.008). Uji korelasi usia dengan kadar zat besi serum didapatkan r=0.246 (p=0.028), sedangkan hasil uji korelasi usia dengan kadar Hb didapatkan r=-0.137 (p=0.226). Hal ini menunjukkan penurunan kadar Hb lansia yang terjadi karena lansia mengalami penurunan fungsi ginjal, sehingga berdampak pada penurunan produksi hormon eritropoietin hingga membuat jumlah eritrosit dan kadar Hb ikut menurun.Kesimpulan: Penuaan berperan dalam penurunan kadar hemoglobin (Hb), namun tidak mempengaruhi kadar serum zat besi.Kata Kunci : Usia, Penuaan, Serum Zat Besi, Hemoglobin (Hb).
Co-Authors Ade A Kartosen Alif Lailatul Mufidah Ananda Kumala Ansar Anik Widijanti Anik Widijanti Dewi Martha Indria Dhanti Erma Widiasi Dianika P Puspitasari Eryta Deka Wulan Agustin Fachrudin Arrozaq fancy Brahma Adiputra Faqihatul Azizah Devitasanti FitriaNugraha Aini Hanny Hafiar Hardadi Airlangga Hardadi Airlangga Kusumawati, Shinta Luthfiyyah Dewi Heriyanto Maimun Z Arthamin Muhammad Dwiki Kevin Pribadi Nurbella Sannyngtyas Pasha Chandra Qonitiya Nuriyah Qurrotu Ainayya Reza Hakim Riki Nur Taufiq Rosa Falih Wiliyarizki Sanarto Santoso Sasi Purwanti Silvy Amalia Falyani Sri Murwani Sri Sulistiandari Sukosari Devantari Tony Hariyanto Verry Setiawan Primadhiputra Winanda Putri Utami Yeni Amalia Yudi Purnomo