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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Folia Medica Indonesiana Global Medical and Health Communication Majalah Obat Tradisional Journal of Medicine and Health Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat jurnal teknik informatika dan sistem informasi
Teresa L. Wargasetia
Faculty Of Medicine, Maranatha Christian University, Bandung, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Free Radical Scavenging Activity of Ethanolic Leaves Extract and Its Different Solvent Fractions of Piper betle L. In Vitro Risdian, Chandra; Widowati, Wahyu; Mozef, Tjandrawati; Wargaseti, Teresa Liliana; Khiong, Khie
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Research Gateway

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Abstract

Various diseases including cancer and cardiovascular diseasesare induced by free radicals via lipid peroxidation, protein peroxidation, DNA damage, and cellular degeneration in thecells.Piper betle L.,commonly called betel,belongs to thePiperaceae family.It originated from South and South Eas tAsia,and has been used as a traditional medicine by people theredue to its medicinal properties.In the present study, free radicalscavenging activity of ethanolic leaves extract of Piper betle L.together with its different solvent fractions(hexane,ethylacetate,butanol,and water)were evaluated by DPPH freeradical scavenging assay.The ethanolic extract and the ethylacetate fraction had shown very significant DPPH (1,1)diphenyl)2)picryl)hydrazyl) radical scavenging activitycompared to the other fractions.In DPPH free radical scavengingassay,the IC50 value of the ethanolic extract and the ethyl acetate fraction were found to be 17.431g/mL and 11.53 1g/mL, respectively. The free radical scavenging activity was assumed due to the total phenolic content.The total phenoliccontent was found to be highest in the ethanol extract(277.68µgEGCG/mg)and the ethyl acetate fraction(559.38µgEGCG/mg).The results concluded that the ethanolic leaves extract of Piper  betle L. and its ethyl acetate fraction have a consider ably freeradical scavenging activity.
Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Permadi, Achmad R.; Ratnawati, Hana; Wargasetia, Teresa L.
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

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Abstract

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients characteristics, prevalence 
The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Wargasetia, Teresa L.
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

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Abstract

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy
Repair of Cerebrospinal Fluid Leak After Functional Endoscopy Sinus Surgery Sapta, Mohamad I; Wargasetia, Teresa L
Journal of Medicine and Health Vol 1, No 5 (2017)
Publisher : Maranatha Christian University

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Abstract

Cerebrospinal fluid (CSF) leak is one of Functional Endoscopic Sinus Surgery (FESS)complications. Since 2001, it was reported that there is one case of CSF leak as FESScomplication in ENT-HN Department, Faculty of Medicine, Maranatha Christian University -Immanuel Hospital in Bandung. The purpose of this case report is present clinical findings andmanagement of CSF leak as FESS complication. A-45 year old male with headache as chiefcomplain after undergone FESS five days before. There was a clear rhinorrhea running frompatient’s right nose. In nasoendoscopic examination, it was showed there was a defect in laminacribrosa. The result of paranasal sinus computed tomography scanning showed an air columnin brain ventricular system. The defect in lamina cribrosa was repaired by transnasalendoscopic using materials such as surgicel, cartilages, and fat tissues. The conclusion is weroll out one case about repair of CSF leak as a FESS complication and it was done with a goodresult.Keywords: cerebrospinal fluid leak, functional endoscopic sinus surgery
Lung Cancer Patient Description in Immanuel Hospital Bandung from January 2013 to December 2014 Bulan, Ida AKT; Ratnawati, Hana; Wargasetia, Teresa L
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

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Abstract

Lung cancer is a disease which has high incidence and mortality rate. It makes lung cancer become one of the biggest public health problems. The aim of this study is to find out the description of lung cancer patients in Immanuel Hospital Bandung from January 2013 to December 2014 based on the prevalence, gender, age, clinical features, metastasis, and mortality percentage. The method design was a descriptive retrospective method with data retrieval and collection of patient medical records that have been diagnosed with lung cancer in Immanuel Hospital Bandung from January 2013 to December 2014 period. This study showed that lung cancer prevalence was 51 patients, the majority of patients were males compared to females with the ratio of 2.7:1, the most common age group was 61–70 years old, the most common clinical features were dyspnea and cough, the most common site of metastasis was liver, and the mortality percentage was 33.33%.Keywords: Immanuel hospital Bandung, lung cancer, patient’s description
Suplementasi Vitamin D3 Dosis Tinggi Menurunkan Kalsifikasi Tulang Femur pada Janin Mencit Maranatha, Timothy Imanuel; Herdiman, Heddy; Wargasetia, Teresa Liliana
Jurnal Kedokteran Brawijaya Vol 29, No. 3 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.03.1

Abstract

Kelebihan asupan vitamin D pada mencit yang bunting dapat menyebabkan penurunan massa tulang janin. Penelitian dilakukan untuk mengetahui apakah pemberian suplementasi vitamin D3 dosis tinggi dapat mengganggu kalsifikasi tulang femur janin mencit. Metode eksperimental laboratorium dengan rancangan acak lengkap dilakukan menggunakan lima ekor mencit jantan dan lima ekor mencit (Mus musculus L.) betina galur Swiss Webster berumur 8-12 minggu. Subjek penelitian adalah lima janin mencit dari hasil perkawinan yang hidup. Mencit dibagi ke dalam lima macam perlakuan yaitu KN (kontrol negatif), perlakuan A (13 IU vitamin D3), perlakuan B (13 IU vitamin D3), perlakuan C (13 IU vitamin D3), dan perlakuan D (13 IU vitamin D3). Mencit dikawinkan, kemudian diberi suplementasi sejak usia kebuntingan 11 hari. Pada usia kebuntingan 20 hari, mencit dikorbankan kemudian dilakukan pewarnaan Alizarin Red S terhadap janin. Parameter yang diuji adalah panjang tulang femur janin mencit yang mengalami kalsifikasi setelah diberi perlakuan. Analisis data menggunakan uji Analysis of Varian (ANOVA) satu arah yang dilanjutkan dengan uji Least Significance Different (LSD) dengan α=0,05. Hasil menunjukkan bahwa janin mencit yang diberi vitamin D3 dosis tinggi (kelompok C dan D) memiliki panjang kalsifikasi tulang femur yang berbeda bermakna (p≤0,05) yaitu lebih pendek dibandingkan dengan kontrol negatif, kelompok A, dan kelompok B. Simpulan penelitian adalah pemberian vitamin D3 dosis tinggi menurunkan kalsifikasi tulang femur janin mencit.Kata Kunci: Janin, kalsifikasi tulang, vitamin D3
Apoptotic Potential of Secretome from Interleukin-Induced Natural Killer Cells toward Breast Cancer Cell Line by Transwell Assay Wahyu Widowati; Diana Krisanti Jasaputra; Teresa Liliana Wargasetia; The Fransiska Eltania; Alya Mardhotillah Azizah; Mawar Subangkit; I Nyoman Ehrich Lister; Chrismis Novalinda Ginting; Ermi Girsang; Ahmad Faried
HAYATI Journal of Biosciences Vol. 27 No. 3 (2020): July 2020
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.27.3.186

Abstract

Breast cancer (BC) is the number one cause of deaths from cancer in women. Metastasis in BC is caused by immunosurveillance deficiency, including impairment of Natural Killer (NK) cell maturation, low NK activity, and decreasing cytotoxicity. This study was performed to improve activating receptors and cytotoxicity of NK cells using interleukin 15 (IL15) against BC cells. Human recombinant IL15 was used to induce NK cells. To evaluate the potential of IL15 in inducing NK cells, we measured the activating and inhibiting receptors (NKG2D, NKG2A), apoptotic potency of NK cells on BC cells (MCF7) using transwell assay. The IL15 inducer on the NK cell were measured NKG2D, NKG2A gene expression with quantitative polymerase chain reaction (qPCR), (GzmB) secretion using ELISA, apoptotic gene expression of MCF7 using qPCR. IL15 increased NKG2D expression 4.01-9.13%, but IL15 could not affect toward NKG2A expression on NK cells. IL15-activated NK cells, inhibited BC cells proliferation, induced apoptotic BC cells 25.89-32.19%, induced apoptotic genes of BC cells bax, p53. IL15 increase NK activating receptor (NKG2D), inhibit BC cells proliferation, induce apoptotic percentage and induce apoptotic gene expression.
Pelatihan Pencegahan dan Penanggulangan Demam Berdarah Dengue Ratnadewi Ratnadewi; Maria Christine; Rosida Tiurma Manurung; Teresa Liliana Wargasetia; Dani Dani
Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 1 (2019): April
Publisher : Lembaga Layanan Pendidikan Tinggi Wilayah IX Sulawesi

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Abstract

Pelatihan pencegahan dan penanggulangan Demam Berdarah Dengue telah dilakukan oleh tim pengabdi Universitas Kristen Maranatha di Kelurahan Sukagalih Bandung pada tanggal 4 Desember 2018. Tujuan pengabdian kepada masyarakat berupa pelatihan tersebut adalah agar masyarakat dapat mempunyai perilaku yang baik untuk mencegah peningkatan jumlah nyamuk penyebab Demam Berdarah Dengue. Hal ini disebabkan Indonesia termasuk negara beriklim tropis yang hampir pada setiap tahun dan di beberapa kota ditemukan banyak penderita yang terinfeksi penyakit Demam Berdarah Dengue akibat cucukan nyamuk Aedes aegypti betina. Para peneliti merumuskan bahwa iklim dapat mempengaruhi perkembangan nyamuk Aedes aegypti, sementara peneliti lain menyimpulkan bahwa iklim tidak mempengaruhi hal tersebut. Terlepas dari polemik tersebut, pada kenyataannya yang terpenting untuk mengurangi bertambahnya jumlah nyamuk adalah perilaku masyarakat sehingga diperlukan pelatihan kepada masyarakat untuk pencegahan dan penganggulangan penyakit Demam Berdarah Dengue. Metode yang digunakan adalah ceramah, diskusi, dan peran aktif masyarakat. Hasil yang diperoleh sampai makalah ini dibuat adalah meningkatnya pengetahuan masyarakat terhadap pencegahan dan penanggulangan penyakit Demam Berdarah Dengue yang diperoleh dari kuesioner yang disebarkan. Simpulan yang diperoleh adalah pemahaman masyarakat tentang hal-hal mengenai penyakit Demam Berdarah Dengue telah meningkat dengan rata-rata pemahaman sebesar 85,6%.
Antioxidant Activity of TEMON (Clitoria ternatea and Citrus sp.) as an Infused Herbal Tea Wahyu Widowati; Teresa Liliana Wargasetia; Teddy Markus Zakaria; Meganita Marthania; Ria Aprilia Tri Puteri Permata Akbar; Michael Sebastian Gunadi; Nathanael Halim; Sherly Santiadi
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.71628

Abstract

Many people around the world believed that herbal tea had a lot of antioxidants contained in it, thus it was widely drunk all over the world. However, the antioxidant capacities of herbal tea may be various because it is affected by the usage of different plants as its primary ingredient. As a result, this study examines the antioxidant activity of herbal tea made from dried Citrus sp. and Clitoria ternatea flower petals. The antioxidant potential was assessed by performing a DPPH and H2O2 scavenging activity assay on 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) scavenging activity assay, total phenolic, and flavonoid content assay, ABTS reduction, and FRAP assay. This study showed that pure telang (Clitoria ternatea) herbal tea has antioxidant properties. Dried Telang (Clitoria ternatea) tea had the highest activity of antioxidants as we refer to the results of it had the highest activity value in DPPH, ABTS, and FRAP assay and also had the lowest IC-50 value. Followed by TEMON infusion which showed the second-highest antioxidant activity after pure telang infusion. The decrease in antioxidant activity in the mixture of telang and lemon was due to the mixture of lemons which tended to have the lowest antioxidant activity among the three types of infusions tested. The addition of dried lemon has the aim of enhancing the flavor of the tea infusion.
Free Radical Scavenging Activity of Ethanolic Leaves Extract and Its Different Solvent Fractions of Piper betle L. In Vitro Chandra Risdian; Wahyu Widowati; Tjandrawati Mozef; Teresa Liliana Wargasetia; Khie Khiong
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss1pp141-145

Abstract

Various diseases including cancer and cardiovascular diseases are induced by free radicals via lipid peroxidation, protein peroxidation, DNA damage, and cellular degeneration in the cells. Piper betle L., commonly called betel, belongs to the Piperaceae family. It originated from South and South East Asia, and has been used as a traditional medicine by people there due to its medicinal properties. In the present study, free radical scavenging activity of ethanolic leaves extract of Piper betle L. together with its different solvent fractions (hexane, ethyl acetate, butanol, and water) were evaluated by DPPH free radical scavenging assay. The ethanolic extract and the ethyl acetate fraction had shown very significant DPPH (1,1-diphenyl-2-picryl-hydrazyl) radical scavenging activity compared to the other fractions. In DPPH free radical scavenging assay, the IC50 value of the ethanolic extract and the ethyl acetate fraction were found to be 17.43µg/mL and 11.53 µg/mL, respectively. The free radical scavenging activity was assumed due to the total phenolic content. The total phenolic content was found to be highest in the ethanol extract (277.68 μg EGCG/mg) and the ethyl acetate fraction (559.38μg EGCG/mg). The results concluded that the ethanolic leaves extract of Piper betle L. and its ethyl acetate fraction have a considerably free radical scavenging activity.Keywords: Piper betle L., Piperaceae, free radical scavenging, DPPH
Co-Authors Abdullah Rasyad Ziyad Achmad R. Permadi, Achmad R. Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Chandra Risdian Chandra Risdian Chrismis Novalinda Ginting Dani Dani Diana Krisanti Jasaputra Elizabeth Elizabeth Ermi Girsang HANA RATNAWATI Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan, Ida AKT Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta, Mohamad I Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sherly Santiadi Sherly Santiadi Sherly Santiadi Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Wahyu Widowati Wahyu Widowati Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati