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Ika Yustisia
Hasanuddin University
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Energy Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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IIn Silico Testing On The Activity Of Flavonol In Sterculia foetida Leaf As Natural Anti Hyperlipidemia Compounds Nindrahayu Syam; Andi Ariyandy; Ika Yustisia; Sulfahri; Yusfina
International Journal of Applied Biology Vol. 6 No. 1 (2022): International Journal of Applied Biology
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ijab.v6i1.19918

Abstract

This study aims to measure the biological activity of flavonols in the leaves of Sterculia foetida as an antihyperlipidemic drug. The chemical structure of flavonols contained in the leaves of Sterculia foetida was taken from the literature. The target protein used was 3-hydroxy 3-methylglutaryl coenzyme A reductase and the control was simvastatin. Water molecules have been removed with PyMol v2.5.2 Software. Docking between the target protein and flavonols was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds have greater potential for antihyperlipidemia compared to control compounds. The equivalent affinity of 3-hydroxy 3-methylglutaryl coenzyme A reductase for flavonols is -8.3, and the affinity of 3-hydroxy-3-methylglutaryl coenzyme A reductase for simvastatin is -7.9. Flavonol toxicity studies have shown that flavonols are not potentially carcinogenic and did not cause mutations. The absorption of flavonols in water was higher than that of the control compound.
High Urinary Cotinine Levels and Low Academic Performance of Elementary School Students in Families with Careless Smoking Habits Ika Yustisia; Nurdiana Sari; Suryani Tawali; Mutmainah Arif; Sitti Ramliah
eJournal Kedokteran Indonesia Vol 10, No. 3 - Desember 2022
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.10.199.197-203

Abstract

Children are the most vulnerable age group to become passive smokers due to cigarette smoke exposure, especially from family members. In addition, children who smoke passively are at high risk of experiencing declined cognitive performance. This study investigated the effect of cigarette smoke exposure on urinary cotinine levels and its relationship with elementary school students’ academic performance. The observational study with a cross-sectional design was located in Pannampu Village, Tallo District, Kota Makassar. Interviews, collecting academic performance data, and measuring urinary cotinine levels using colorimetric techniques were carried out on elementary school students (n=77). This study found that 88.5% of students stated that they had family members who smoked at home with inappropriate habits of exposing children to cigarette smoke. Urinary cotinine levels showed an average of 121.64 ng/mL. All students with urinary cotinine levels above 200 ng/mL (16.4%) had smoker family members. The urinary cotinine levels in boys were higher (p=0.014) with lower report card average marks than in girls. The smoking habits of family members were still a concern and had not protected children from cigarette smoke exposure, as evidenced by the high average urinary cotinine levels, especially in boys, which might affect their academic performance
Co-Authors Andi Ariyandy Mutmainah Arif Nindrahayu Syam Nurdiana Sari Sitti Ramliah Sulfahri Sulfahri Suryani Tawali Yusfina