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All Journal Medical Journal of Indonesia Majalah Kesehatan Pharmamedika Jurnal Penyakit Dalam Indonesia
Sarwono Waspadji
Department of Internal Medicine, Universitas Indonesia Faculty of Medicine, Jakarta.
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The outcome of pregnancy among Graves women treated with PTU Mukhsin, Ali I.; Waspadji, Sarwono; Subekti, Imam; Soegondo, Sidartawan; Ranakusuma, Asman B.; Suyono, Slamet
Medical Journal of Indonesia Vol 9, No 4 (2000): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.657 KB) | DOI: 10.13181/mji.v9i4.623

Abstract

[no abstract available]
Left ventricular diastolic dysfunction in type 2 diabetes mellitus patient without cardiovascular disease: the association with microalbuminuria Alwi, Idrus; Harun, S.; Soehardjono, Soehardjono; Nugroho, Nugroho; Waspadji, Sarwono; Rahman, A. M.; Ismail, Dasnan
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.005 KB) | DOI: 10.13181/mji.v14i3.192

Abstract

Twenty-eight cases of type 2 diabetes mellitus (DM) without any cardiovascular disease were recruited from the Department of Metabolic-Endocrine, Faculty of Medicine, University of Indonesia / Dr. Cipto Mangunkusumo General Hospital, Jakarta. Recruitment of the study began in October 2001 and was completed by December 2001. Participants were examined for echocardiography and microalbuminuria urinary examination. Diastolic dysfunction was found in 73.7% of type 2 diabetic patients without microalbuminuria and 66.7% in type 2 diabetic patients with microalbuminuria. Neither type 2 diabetic groups with nor without microalbuminuria indicated any significant association to the occurrence of diastolic dysfunction. (Med J Indones 2005; 14: 169-72)Keywords: microalbuminuria, diastolic dysfunction, type 2 diabetes mellitus
The correlation between hs C-reactive protein and left ventricular mass in obese women Alwi, Idrus; Harun, S.; Sukmoko, Satrio; Soewondo, Pradana; Waspadji, Sarwono; Soegondo, Sidartawan
Medical Journal of Indonesia Vol 15, No 2 (2006): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.996 KB) | DOI: 10.13181/mji.v15i2.223

Abstract

Plasma C-reactive protein (CRP) concentrations are increased in obese individuals. In this study, we examined the correlation between hsCRP and left ventricular mass (LV mass). Fourty five healthy obese women and fourty five healthy non obese women as the controls group were studied by echocardiography and hsCRP. There was no significant correlation between hsCRP and left ventricular mass in obese women (r = 0.29, p 0.06). There was a significant correlation between hs CRP and body mass index (r = 0.46, p 0,002), and also hsCRP and visceral fat (r= 0.33, p 0.03). (Med J Indones 2006; 15:100-4) Keywords: hs C-reactive protein, LV mass, obese women
The effect of non-surgical periodontal therapy on systemic immune response and blood glucose level of NIDDM patients Santoso, Oedijani; Waspadji, Sarwono
Medical Journal of Indonesia Vol 17, No 1 (2008): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.27 KB) | DOI: 10.13181/mji.v17i1.298

Abstract

Periodontal inflammation is a periodontal disorder of high prevalence in the population. Chronic periodontitis is associated with the accumulation of plaque and calculus as local factors, and systemic factors such an diabetes mellitus (DM) and HIV infection. Cytokine, especially IL-1β as inflammatory mediator for periodontal disease, may directly stimulated iNOS (inducible nitric oxide synthase) expression and NO (nitric oxide) production by β-cells, resulting in NO-mediated β-cell damage. The leucotoxin and proteases produced by periodontal pathogens will induce chemotactic and phagocytotic defect; therefore causing decreased PMN phagocytotic function. Hyperglicemia which occurs in diabetic patients increases calcium influx to the cell, resulting in the increased cytosol’s calcium ([Ca 2+]i) level and; therefore, resulting in dysfunction of PMN and impaired PMN phagocytotic function. Advanced glycosilation endproduct in NIDDM binds to monocytes resulting in the increase of pro-inflammatory cytokines (IL-1, TNFα) and produces activation of macrophages and osteoclasts. Hyperglicemia activates diacyl glycerol (DAG)-protein kinase C (PKC), thus increasing PGE2 and cytokine expression that induce inflammation and periodontal tissue destruction processes. Studies on the effect of scaling to remove calculus disposition on blood glucose control and cellular immune response in DM patient has never been carried out. The aim of the study was to analyze the effect of scaling as non-surgical periodontal therapy on immune response (IL-1β level and PMN phagocytotic function) and blood glucose level of type 2 diabetic patients. Subjects were diabetic patients, 60 controlled-DM (CDM) and 60 uncontrolled-DM (UCDM), in Metabolic-Endocrinology Clinic of Ciptomangunkusumo Hospital, aged 40-60 years. The subjects were divided into treatment (scaling) and control group, and cellular immune response and diabetic status, before and 6 weeks after treatment were evaluated. Statistical analysis (t test) were done using Stata 7.0 software, to compare the parameters before and after scaling in CDM and UCMD subjects. The results showed that scaling decreased IL-1β level and increased phagocytotic function significantly (P<0.05). Scaling decreased fasting and 2 hours post-prandial blood glucose levels and HbA1c level, but the decrease were not significant statistically (P>0.05), except for the decrease in HbA1c level in uncontrolled DM (P=0.00). (Med J Indones 2008; 17: 20-4)Keywords : IL-1β level, phagocytotic function, HbA1C level
The Sensitivity and Specificity of a new Scoring System Using High Resolution Computed Tomography to Diagnose Lung Cancer Abdullah, Arman A.; Bujang, Nurlela; Badril, Cholid; Hamdani, Chairil; Junadi, Purnawan; Jusuf, Anwar; Waspadji, Sarwono
Medical Journal of Indonesia Vol 18, No 3 (2009): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (549.769 KB) | DOI: 10.13181/mji.v18i3.360

Abstract

Aim To find a non-invasive diagnostic method for lung cancer with the results almost as accurate as histopathological examinations using HRCT scoring system.Method This study was conducted from December 2006 until March 2008. A total of 55 persons, comprised of 40 male and 15 female patients suspected of having lung cancer, underwent high resolution computed tomography with and without contrast as well as CT-guided transthoracic needle aspiration to obtain cytology specimens.Results Histopathological examinations revealed the existence of lung cancer in 43 patients (78%) and benign lesions in 12 patients (22%). A scoring system was then made based on the similarities of findings from CT and histopathologic examinations. In the the age group of 49 years and above, tumor volume of more than 68 cm3, HU of more than 21, spicula positive, angiogram positive and lymph node positive had a value of respectively 20, 19, 10, 24, 18, and 17 (total score 108).Conclusion This new method to diagnose lung cancer is constantly as accurate as histological findings with a sensitivity of 97.7% and a specificity of 83,3% and a cut-off score of 35. According to this system, a score of less than 35 indicates that the lesions were benign while a score higher than 35 is suggestive malignant. (Med J Indones2009;18:179-86)Key word: High resolution CT; Lung cancer; Scoring
Prevention of endothelial dysfunction in streptozotocin-induced diabetic rats by Sargassum echinocarpum extract Firdaus, Muhamad; Astawan, Made; Muchtadi, Deddy; Wresdiyati, Tutik; Waspadji, Sarwono; Karyono, Setyawati S.
Medical Journal of Indonesia Vol 19, No 1 (2010): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.838 KB) | DOI: 10.13181/mji.v19i1.382

Abstract

Aim This study aimed to elicit the protective effect of Sargassum echinocarpum extract on endothelial dysfunction in thoracic aorta of streptozotocin-induced diabetic rats.Methods The animals were divided into 5 groups. The first was normal, the second was diabetic non treated animals. The third to fifth groups were the diabetic animals which given Sargassum echinocarpum extract (150; 300, and 450 mg kg-1 body weight, respectively) by oral gavage and extract treatment was given for 12 weeks. Diabetes was induced by single administration of streptozotocin (45 mg kg-1, i.p.), dissolved in freshly prepared 0.1 M citrate buffer, pH 4.5. Diabetes was confirmed ten days latter in streptozotocin induced animals showing blood glucose levels > 200 mg dL-1 (11.1 mmol L-1) as monitored in the blood from tail vein using glucometer. After the treatment period, the blood serum acquired was used for antioxidant enzymes assays and the thoracic aorta was used for vasorelaxation assay.Results There was a significant decrease in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) in diabetic rats (3.31 ± 0.12;67.17 ± 0.62;35.10 ± 0.83) comaped to control rats (9.97 ± 0.12;185.31 ± 0.23;116.38 ± 0.88). Administration of Sargassum extract increased the activity of SOD, CAT, and GSH-px. The diabetic rats exhibit endothelial dysfunction as shown by loss of vasodilatory response to acethylcholine (ACH). This was restored by administration of Sargassum extract.Conclusion Sargassum echinocarpum extract ameliorates oxidative stress and reverses the endothelial dysfunction associated with diabetes. This effect appears to be due to its antioxidant properties. (Med J Indones 2010; 19:32-5)Keywords: oxidative stress, sargassum echinocarpum, endothelium dependent relaxation, thoracic aorta
Effect of laser photocoagulation and bevacizumab intravitreal in proliferative diabetic retinopathy: review on biomarkers of oxidative stress Victor, Andi A.; Gondhowiardjo, Tjahjono D.; Waspadji, Sarwono; Wanandi, Septelia I.; Bachtiar, Adang; Suyatna, Franciscus D.; Muhiddin, Habibah
Medical Journal of Indonesia Vol 23, No 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (545.754 KB) | DOI: 10.13181/mji.v23i2.756

Abstract

Background: This study was aimed to compare the effect of laser photocoagulation (LF), intravitreal bevacizumab (IVB) and combined treatments on biomarkers of oxidative stress such as aldehhyde dehidrogenase (ALDH), malondialdehyde (MDA) level, superoxide dismutase (SOD) activities, and vitreal vascular endothelial growth factor (VEGF) on proliferative diabetic retinopathy (DR) patients.Methods: In this single blind randomized clinical trial, 72 eyes from 69 cases of proliferative DR in Cipto Mangunkusumo Hospital between February 2011 - June 2013 were randomized into 4 groups : 1) control (n = 18); 2) LF pre-vitrectomy (n = 18); 3) IVB pre-vitrectomy (n = 18); and 4) combined IVB and LF pre-vitrectomy (n = 18). One-way ANOVA was used to compare oxidative stress parameters in the four groups.Results: There were no statistically significant differences in the average plasma ALDH activity (0.034 ± 0.02; 0.027 ± 0.02; 0.025 ± 0.02; 0.031 ± 0.11 IU/mg protein; p = 0.66), vitreal MDA level (1.661 ± 1.21; 1.557 ± 1.32; 1.717 ± 1.54; 1.501 ± 1.09 nmol/mL; p = 0.96) and SOD activity) (0.403 ± 0.50; 0.210 ± 0.18; 0.399 ± 0.49; 0.273 ± 0.32 U/mL; p = 0.38) among these four groups, respectively. However, the VEGF vitreal level (pg/mL) showed a statistically significant difference (0.356 ± 0.60; 0.393 ± 0.45; 0.150 ± 0.24; 0.069 ± 0.13; p = 0.05). The VEGF level in combination group was five times lower than the control group (p = 0.05).Conclusion: Combined treatments of DR by IVB and LF were correlated with lower vitreal MDA and plasma VEGF level, but did not have any effect on plasma ALDH and vitreal SOD in proliferative DR. Combined treatments with IVB and LF are recommended for the management of proliferative DR patients.  
Effect of chromium supplementation on chromium status, insulin and glucose level in Non-insulin Dependent Diabetes Mellitus (NIDDM) subjects Dinarto, Murjiah; Suyardi, Arifin; Waspadji, Sarwono
Medical Journal of Indonesia Vol 7, No 1 (1998): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.592 KB) | DOI: 10.13181/mji.v7i1.795

Abstract

[no abstract available]
Risk of anti-hepatitis A virus in an urban population in Jakarta Akbar, Nurul; Basuki, Bastaman; Garabrant, David H.; Waspadji, Sarwono; Sjaifoellah Noer, H.M.
Medical Journal of Indonesia Vol 5, No 4 (1996): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.18 KB) | DOI: 10.13181/mji.v5i4.877

Abstract

[no abstract available]
Ende Diabetes Study: diabetes and its characteristics in rural area of East Nusa Tenggara Waspadji, Sarwono; Soewondo, Pradana; Subekti, Imam; Soebardi, Suharko; Harbuwono, Dante S.; Pramono, Laurentius A.; Supali, Taniawati
Medical Journal of Indonesia Vol 22, No 1 (2013): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.721 KB) | DOI: 10.13181/mji.v22i1.517

Abstract

Background: There are only few studies about diabetes in rural area in Indonesia. Epidemiological study are needed to formulate health policy of disease management in specific area. The aim of this study was to find the prevalence of diabetes and knowledge of diabetes among the community in Nangapanda Village, Ende District, East Nusa Tenggara.Methods: A cross-sectional study “Ende Diabetes Study” was conducted in Nangapanda Village. This study use cluster random sampling method to a total number of 19756 residents in Nangapanda village. From the sampling frame of 1800 adult subjects who underwent screening with glucometer in 2008 and 2009, 125 subjects have been diagnosed as diabetes or impaired fasting glucose (IFG). All of the subjects who were diagnosed as diabetes or IFG from the previous screening and 218 subjects from control (normal subjects in the 2008 and 2009 screening) were included in the present study. Each subject underwent general anamnesis, nutritional interview, complete physical examinations, and laboratory test (blood and urine). The data were analyzed using SPSS 13.0.Ressult: There were 343 subjects in this study. The prevalence of diabetes in Nangapanda using blood glucose criteria (using fasting and post-glucose load values) was 2%; using post glucose load criteria, the prevalence of DM was 1.56%; while with HbA1c criteria, the prevalence was 2.83%. The prevalence of impaired glucose tolerance (IGT) was 2.2%, and IFG was 6.2%. A number of 71.1% Nangapanda residents have sufficient knowledge about diabetes.Conclusion: Prevalence of diabetes in Nangapanda (using fasting and post-glucose load criteria) was 2% and 1.56% (using post-glucose load values). As much as 71.1% of Nangapanda residents have sufficient knowledge about diabetes. (Med J Indones. 2013;22:30-8)Keywords: Diabetes mellitus, Ende Diabetes Study, prevalence, rural Indonesia
Co-Authors A. M. Rahman A.A. Ketut Agung Cahyawan W Adang Bachtiar Ali I. Mukhsin Andi A. Victor Anwar Jusuf Arifin Suyardi Arman A. Abdullah Asman B. Ranakusuma Bambang Sutrisna Bastaman Basuki Budhi Setianto Chairil Hamdani Cholid Badril Christopher S. Suwita Dante S. Harbuwono Dasnan Ismail David H. Garabrant DEDDY MUCHTADI Em Yunir, Em Felix F. Widjaja Franciscus D. Suyatna H.M. Sjaifoellah Noer Habibah Muhiddin Harmani Kalim Herdiman T Pohan Idrus Alwi Ina Susanti Timan, Ina Susanti Ivan R. Widjaja Jimmy Posangi Judo Prihartono Khomimah Khomimah, Khomimah Kumalawati, July Laurentius A. Pramono Lukman Hakim Makmun MADE ASTAWAN Minarma Siagian Muchlis Ramli Muhamad Firdaus Murdani Abdullah Murjiah Dinarto Nurlela Bujang Nurul Akbar Oedijani Santoso Pradana Soewondo Purnawan Junadi Rustadi Sosrosumihardjo S. Harun Satrio Sukmoko Septelia I. Wanandi Setiabudy, Rahajuningsih D Setyawati S. Karyono Shufrie Effendi, Shufrie Sidartawan Soegondo Sirowanto Inneke Slamet Suyono Soehardjono Soehardjono Starry H. Rampengan Suharko Soebardi Suhendro Suhendro Suhendro Suwarto, Suhendro Sukartini, Ninik Sumarjo, Kusmardi Suzanna Immanuel Taniawati Supali Telly Kamelia Tjahjono D. Gondhowiardjo Tonny Loho Tutik Wresdiyati - Venna, Venna Victor, Andi A Yuni Astria