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All Journal Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Anik Widijanti
Laboratorium Sentral RSU dr. Saiful Anwar Malang
Health Professions Medicine & Pharmacology Public Health

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Result Comparison of Fecal Occult Blood Test between FOBT Hb and FOBT Hb tambah Tranferrin in Detecting Upper Gastrointestinal Tract Bleeding Widijanti, Anik; Sulistiandari, Sri; Hariyanto, Tony; Triliana, Rahma
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 1, April 2010
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/11120102-6

Abstract

Background: Immunological fecal occult blood test (FOBT) using anti human hemoglobin (Hb) has a low sensitivity in detecting upper gastrointestinal (GI) bleeding, due to Hb degradation. Transferrin (Tf) is more stable in stool when compared to Hb, provides an alternatives on diagnosing upper GI bleeding. This study aim to determine the advantage of FOBT Hb + Tf in detecting upper GI bleeding compared with FOBT Hb alone. Method: This study was conducted by comparing the diagnostic value of Rapid Immunochromatographic FOBT that use anti-human Hb alone, with the one using combination of anti human Hb & Tf simultaneously in detecting upper GI bleeding. Stool sample from 48 patients with upper GI bleeding and 29 controls (without any upper GI bleeding) were collected then tested with both FOBT Methods. Endoscopy study was used as gold standard endoscopy to determine test’s diagnostic value. Result: In detecting upper GI bleeding, the sensitivity of FOBT Hb + Tf (85.42%) was higher than FOBT Hb (29.17%). The specifity of both Methods were accurate at 89.66% and 93.10% respectively. Positive predictive values (PPV) for both Methods were also good at 93.18% and 87.50% while negative predictive value (NPV) FOBT Hb + Tf (78.79%) were higher than FOBT Hb (44.26%). Conclusion: Between these two test Methods on detecting upper GI bleeding, FOBT Hb + Tf has higher sensitivity, PPV and NPV value compared to FOBT Hb. It is advisable to use FOBT Hb + Tf for upper GI bleeding screening. Keywords: FOBT, immunochromatography, hemoglobin, transferrin, upper GI bleeding
PERANAN LABORATORIUM DALAM MENUNJANG PENATALAKSANAAN PENDERITA Widijanti, Anik
Jurnal Kedokteran Brawijaya Vol 18, No 1 (2002)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2201.204 KB)

Abstract

Banyak faktor yang dapat menyebabkan ketidaksesuaian hasil pemeriksaan laboratorium dengan keadaan klinik penderita. Hal tersebut dapat diatasi dengan komunikasi antar petugas laboratorium dan klinisi, serta interpretasi yang tepat dari hasil pemeriksaan laboratorium. Dokter laboratorium bertugas untuk mengatasi masalh di bidang laboratorium dengan berbagai cara yaitu mengawasi mutu pemeriksaan sehingga sampelnya memenuhi syarat, persiapan penderita memadai, metodenya tepat, administrasi dan interpretasi hasil pemeriksaan secara benar. Perlu difahami mengenai ?cut off?, nilai rujukan dan nilai kritis, sensitifitas dan spesifitas tes, agar interpretasi hasil pemeriksaan laboratorium menjadi baik. Pada keadaan tertentu perlu diberikan komentar laboratorium pada jawaban interpretatif. Indikasi pemeriksaan dan interpretasi hasil pemeriksaan yang tepat akan sangat menunjang penatalaksaan penderita. Untuk itu dibutuhkan komunikasi klinisi dan laboratorium  yang dilakukan dengan membuat laporan interpretatif, konsultasi langsung pribadi maupun dalam ?team?. Hasil pemeriksaan petugas laboratorium yang tidak sesuai keadaan klinik penderita dikembalikan kepada dokter penanggung jawab laboratorium yang sama untuk diselesaikan permasalahannya.
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINETERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei Mulyastuti, Yuanita; Widijanti, Anik; Ali, Mulyohadi; Iskandar, Agustin; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 20, No 1 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.731 KB) | DOI: 10.21776/ub.jkb.2004.020.01.8

Abstract

Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area which is endemic to malaria, about 15 million new case ofmalaria occurred every year. In malaria immune response forms free radical which assist to eliminate the cause of disease but  also destroys endothelial cells at various organ. This oxidative damage plays an important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of Choroquine combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination of Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infected by Plasmodium berghei. Measurement of the degree ofparasitemia was done everyday and the amount of the platelet as one of the nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups, group of chloroquine(0,05 mg/gr), group of N-Acetylcysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combination group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consistedof infected mice without treatment as control group.
Laporan Kasus : WANITA USIA 20 TAHUN DENGAN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DAN HbA1c RENDAH PALSU Santoso, Jessica; Widijanti, Anik
Majalah Kesehatan FKUB Vol 6, No 4 (2019): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.112 KB) | DOI: 10.21776/ub.majalahkesehatan.2019.006.04.6

Abstract

Pengukuran HbA1c memberikan informasi mengenai kadar gula pasien selama tiga bulan. Kadar HbA1c rendah palsu dapat dipengaruhi oleh beberapa faktor seperti hemoglobinopati, anemia, turnover eritrosit abnormal (anemia hemolitik, perdarahan, transfusi darah, anemia defisiensi Fe). Kami melaporkan presentasi klinis pada pasien wanita yang memiliki kadar HbA1c sangat rendah (1,8%) yang diakibatkan oleh anemia hemolitik pada SLE. Seorang wanita usia 20 tahun datang dengan keluhan utama sesak napas, disertai adanya badan terasa lemas, nafsu makan menurun, dan kedua kaki bengkak. Pasien memiliki riwayat PDA (patent ductus arteriosus). Pemeriksaan fisik menunjukkan takikardia, takipnea, konjungtiva anemis, ruam malar, distensi JVP (jugular venous pressure), kardiomegali dengan murmur sistolik, ronki basal paru bilateral, dan edema tungkai bawah. Pemeriksaan laboratorium menunjukkan anemia normokrom makrositer, trombositopenia, peningkatan RDW (red cell distribution width), HbA1c 1,8%, hipoalbuminemia, alkalosis respiratorik, proteinuria dan hematuria. Tes Coombs’ positif 3, ANA dan anti-dsDNA positif. Ekokardiogram menunjukkan PDA sedang. Rendahnya kadar HbA1c diakibatkan menurunnya usia eritrosit. Namun, terlalu cepatnya turnover eritrosit seperti pada anemia hemolitik dapat menyebabkan hemoglobin tidak dapat terglikasi sehingga kadar HbA1c menjadi rendah palsu.  Disimpulkan hasil pemeriksaan HbA1c tidak akurat pada pasien dengan anemia hemolitik pada SLE. Maka, disarankan melakukan pemeriksaan gula darah puasa dan gula darah 2 jam post prandial.   
Co-Authors Agustin Iskandar Loeki Enggar Fitri Mulyohadi Ali Rahma Triliana Santoso, Jessica Sri Sulistiandari Tony Hariyanto Yuanita Mulyastuti