Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

0.61

P-Index

This Author published in this journals

All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Archives Pharmacia

Naniek Widyaningrum

Prog. Studi Farmasi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Fakultas Farmasi Universitas Wahid Hasyim (UNWAHAS) Semarang

Author-ID : 416460

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 4 Documents Claim Missing Document

Claim Missing Document

Articles

EVALUASI SKALA NYERI PASCA OPERASI ORTOPEDI SETELAH PENGGUNAAN INJEKSI KETOROLAC DI RUMAH SAKIT ISLAM SULTAN AGUNG Timur, Willi Wahyu; Widyaningrum, Naniek
Archives Pharmacia Vol 3, No 1 (2021): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Evaluasi skala nyeri pada pasien pasca operasi penting dilakukan guna mengetahui keberhasilan dalam pengurangi tingkat rasa nyeri yang dialami pasien. Proses evaluasi tersebut dilihat dengan menilai tingkat skala nyeri yang dirasakan pada pasien sebelum menjalani operasi dan dilanjut dengan melihat tingkat skala nyeri pada pasien pasca operasi setelah diberikan injeksi ketorolac. Jenis penelitian yang digunakan adalah penelitian analitik observasional dengan rancangan penelitian secara retrospektif. Sampel yang diambil adalah pasien yang menjalani operasi ortopedi setelah diberikan injeksi ketorolac. Pengambilan data dilaksanakan pada bulan Agustus 2020, dengan jumlah sampel yang diambil sebanyak 98 pasien. Analisis dilakukan dengan melihat normalitas dan homogenitas, dan dilanjutkan dengan menganalisis menggunakan Wilcoxon. Hasil analisis Wilcoxon adalah p-value sebesar 0,000 < 0,05. Nilai p-value tersebut menunjukkan bahwa terdapat perbedaan yang bermakna antara nyeri sebelum operasi dengan nyeri pasca operasi setelah diberkan injeksi ketorolac. Kesimpulan yang diperoleh dari hasil analisis yang didapat menunjukan bahwa terdapat pengaruh yang ditimbulkan pada pasien sebelum menjalani operasi dengan pasien pasca operasi setelah diberikan injeksi ketorolac. Dengan rata-rata nilai skala nyeri sebelum operasi sebesar 4 dan setelah pemberian injeksi ketorolac pasca operasi sebesar 3.

Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer Widyaningrum, Naniek; Hussaana, Atina; Puspitasari, Nesya Ayu
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): January - June 2020
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity.OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells.METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values.RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 μg/mL, 679,593 μg/mL, 1562,356 μg/mL, 746,923μg/mL, 563,626 μg/mL and 13,707 μg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively.CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.

Pengaruh Konsentrasi Ekstrak Etanolik Daun Teh Hijau (Camellia sinesis L.) dalam Sediaan Krim terhadap Sifat Fisik dan Aktivitas Antibakteri Widyaningrum, Naniek; Murrukmihadi, Mimiek; Ekawati, Syarifatun Karunia
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Green tea, is one of the herbs that have been proven to be effective as an anti-acne, among others.Green tea leaves contain 30-40% polyphenols known as catechins most of which are antimicrobial. For ease of use, the ethanolic leaf extract of green tea is made in cream. This study aimed to determine the effect of variations in the concentration of ethanolic extract of green tea leaves in cream on the physical properties and antibacterial activity of acne bacteria in particular.Design and Method: In this study, green tea leaf extract condensed obtained by maceration using 50% ethanol solution. Cream formula that is made in five concentration ethanolic extract of green tea leaves 1%, 3%, 5%, 7%, and 9% use a modified formula antiacne cream. Cream tested physical properties include homogenity, percent separation, dispersive power and adhesion. During the antibacterial activity was also tested. The data obtained were analyzed statistically using the non-parametric Kruskal-Wallis test followed by Mann Whitney test with a level of 95%.Results: The preparation cream ethanolic leaf green tea extract at various concentrations have good homogenity and not separate, the greater concentration of cream ethanolic extract of green tea leaves get smaller power and energy dispersive adhesion, whereas the inhibitory against Staphylococcus aureus bacteria is getting biger. Conclusion: Cream ethanolic extract of green tea leaves that are comparable with the positive control (Ristra acne creaming) the physical properties and the antibacterial activity at a concentration of 7% (Sains Medika, 4(2):147-156).

Development of Anti Acne Cream (w/o/w Multiple Emulsion) Containing Green Tea Leaf Waste Widyaningrum, Naniek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): July-December 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: To date, green tea leaf waste is not well utilized, the waste is remain considered as a waste. Previous studies found that green tea leaf waste still have a fairly high EGCG content. EGCG has benefits as an antibacterial. Utilization of green tea leaf waste started from formulation until the diversification of multiple emulsion w/o/w products has not been reported.Objective: To develop anti acne cream (W/O/W) multiple emulsion containing green tea leaf waste and evaluate its antibacterial activity against acne-inducing bacteria of Propionibacterium acnes (P.acnes).Methods: Phase one of this research was green tea leaves was extracted by infundation and fractionation method using ethyl acetate and prepared in different concentration (1% to 6%). The second stage was ethyl acetate fraction of green tea leaf extract was tested for its antibacterial activity against P.acnes. Third stage was tested physical properties of formulation with w/o/w multiple emulsion.Results: The optimal antibacterial activity of ethyl acetate fraction of green tea leaf extract against P.acne was at the concentration of 6%, with inhibition zone of 32.6 mm ±0.57. The formula of w/o/w multiple emulsion loaded with green tea leaves waste of 6% active substance demonstrated a good physical properties which can spread 90.4 cm2 ± 0.03, pH 5.00 ± 0.02 and microscopic analysis showed multiple emulsion w/o/w.Conclusion: The concentration of 6% green tea leaf waste formulated in multiple emulsion had a good physical and antibacterial activity for a referred standard. It is necessary to test the stability of multiple emulsion formula.

Co-Authors Adi, Reza Saeful Atina Hussaana Djoko Wahyono Hussana, Atina Mimiek Murrukmihadi Puspitasari, Nesya Ayu Sampurno Sampurno Syarifatun Karunia Ekawati Tiastuti, Memi Utami, Karina Misti Willi Wahyu Timur

Title

Found 4 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 4 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 4 Documents
Search