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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Silvikultur Tropika (JST) Hemera Zoa Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Majalah Obat Tradisional JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu dan Teknologi Kayu Tropis Britain International of Exact Sciences Journal (BIoEx Journal) Jurnal Kedokteran Hewan

IETJE WIENTARSIH

Institut Pertanian Bogor

Author-ID : 416884

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary

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PF-18 Photomicrograph of Nanogel Andrographolide-Beta Cyclodextrine Inclusion Complex As Anti-Burns Bayu Febram Prasetyo; Ietje Wientarsih; Dondin Sajuthi; Vetnizah Juniantito
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.194 KB)

Inclusion complex is a complex formed between drug molecules which act as guest or located inside the cavity of host molecule. Host molecules are commonly originated from the derivative group of cyclodextrin. Among cyclodextrin groups, beta cyclodextrin (BCD) is mostly used in formula development and drug delivery system [1].Andrographolide (AG) is a pure isolate chemically syntesized from sambiloto herbs (Andrographis paniculata Nees), in the form of needle cystal-like which is colorless and extremely bitter. AG has variety of medical properties, particularly as anti-inflamation to treat skin burns [2]. However AG has poor solubility in water. This will result in low abillity to solute, penetrate membrane, and distribute the drug when applied transdermally in burn skin. In burn skin, there is tendency to skin damage, especially in stratum corneum which acts as semipermeable barrier. The ability of drugs that applied transdermally tends to be high.Formation of inclusion complex using AG and BCD to increase the ability of AG in penetrating membrane should be done. Transmission Electron Microscope (TEM) is a fast technique to confirm the formation of drug or inclusion complex by comparing the shape and particle size [3]. Study on percutaneous penetration of AG-BCD inclusion complex is produced through solvent evaporation method at mole ration 1:2 in viscolam gel preparation.

Formation of Andrographlolide-BetaCyclodextrin Inclusion to Increase Solubility and Dissolution Rate Bayu Febram Prasetyo; Ietje Wientarsih; Dondhin Sajuthi; Vetnizah Juniantito
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Andrographolide (AG) is a pure isolate of the chemical synthesis of sambiloto (Andrographis paniculata Nees.) which has various pharmacological properties such as anti-inflammatory and antimicrobial. In order to improve the ability of AG to penetrate the membrane in transdermal use, an inclusion complex was formed using beta-cyclodextrin (BCD) by modifying the physical chemistry properties of AG, particularly the solubility in its base, partition, and distribution on the skin, as well as by changing the permeability of the stratum corneum. The inclusion complexes of AG with BCD were prepared by the solvent evaporation method in the mole ratios of 1:1, 1:2, and 2:1. The solid of the yield of AG inclusion complex in BCD has been tested with a solubility test until it reached equilibrium at 37 ± 5 °C for 24 hours and In vitro dissolution rate test using the II USP method (paddle type), then compared to a single AG compound, and a physical mixture of AG-BCD. Based on the solubility and dissolution rate tests, it showed that the formation of AG-BCD inclusion complex was obtained at the mole ratio of 1:2. Moreover, the AG solubility increased 38 timesand the dissolution rate in the 60th minute increased twice in the inclusion complex with BCD.Key words: andrographolide, inclusion complex, beta cyclodextrin, solubility, dissolution rate

Comparative lactic acid bacteria (LAB) profiles during dadih fermentation with spontaneous and back-slopping methods, as identified by terminal-restriction fragment length polymorphism (T-RFLP) Chandra Utami Wirawati; Mirnawati Bachrum Sudarwanto; Denny Widaya Lukman; Ietje Wientarsih; Eko Agus Srihanto
Indonesian Journal of Biotechnology Vol 26, No 3 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.61164

The diversity of lactic acid bacteria (LAB) present during the manufacture of traditional fermented buffalo milk from West Sumatra, known as dadih, was studied via a culture-independent approach using terminal-restriction fragment length polymorphism (T-RFLP) to compare the dynamic diversity in back-slopping and spontaneous fermentation methods. Total LAB and pH were measured in freshly prepared buffalo milk and in \textit{dadih} fermented for 24 and 48 hours. The results indicated significant differences between the fermentation methods, with higher total LAB, and greater phylotype richness and relative abundance being identified in the back-slopping method. Terminal fragment lengths (TRFs) of 68 and 310 bp were common to both techniques, similar to those of Lactobacillus fermentum, Fructobacillus pseudoficulneus, Leuconostoc citreum, Leuconostoc kimchii, and Leuconostoc sp. The changes in phylotype number (species number) and relative abundances of LAB communities identified are expected to produce data needed to formulate the best fermentation process for dadih manufacturing. A 24-hour back-slopping fermentation method is recommended, as fermentation time of longer than 24 hours reduced viable LAB significantly. Our results also indicated that the T-RFLP technique is not only clearly sensitive enough and adequate for segregating LAB diversity in both fermentation methods, but that it also provides good information regarding the structure of microbial communities and their composition change during the fermentation process.

Biomass and Carbon Mass Allometric Equation Models of Avicennia marina (Forsk.) Vierh. Case Study Pulau Dua Natural Reserve Banten PERSAMAAN ALOMETRIK BIOMASSA DAN MASSA KARBON Avicennia marina (Forsk.) Vierh. Studi Kasus Cagar Alam Pulau Dua Banten Tyas Ayu Lestari; Aswin Rahadian; M. Yanuar J. Purwanto; Ietje Wientarsih
Jurnal Silvikultur Tropika Vol. 7 No. 2 (2016): Jurnal Silvikultur Tropika
Publisher : Departemen Silvikultur, Fakultas Kehutanan dan Lingkungan, Institut Pertanian Bogor (IPB)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/j-siltrop.7.2.%p

Research measurements of carbon stocks Avicennia marina has been done by Dharmawan and Siregar (2008) with a DBH 5 cm. Calculation of carbon stocks Avicennia marina with DBH less than 5 cm hadn’t been done. Currently, approaches to measuring biomass and carbon mass mangrove species is being developed through allometric equation. Allometric equation to estimate carbon stocks are still limited, especially for mangrove with DBH less than 5 cm. Therefore, this research carried out calculations to obtain allometric equations for estimating biomass and carbon mass Avicennia marina with DBH less than 5 cm. The results of research can complement allometric equations that have been published previously. Allometric equations constructed using two equations, namely linear and logarithmic with two variables such as total height (x1) and diameter at breast height / DBH (x2). Allometric equation to estimated total biomass, root, stem, branch and leaves are Log YTotal = -7.92 + 2.02 Log (Tt), Log YRoot = -8.37 + 1.94 Log (Tt), Log YStem = -8.83 + 1.99 Log (Tt) + 0.419 Log (DBH), Log YBranch = -8.63 + 2.01 Log (Tt), dan Log YLeaves = -7.73 + 1.63 Log (Tt). Allometric equation to estimated total carbon root, stem, branch and leaves are Log YTotal = -8.82 + 2.21 Log (Tt), Log YRoot = -9.11 + 2.04 Log (Tt), Log YStem = -8.89 +2.06 Log (Tt) + 0.467 Log (DBH), Log YBranch = -9.41 + 2.13 Log (Tt), dan Log YLeaves = -8.46 + 1.64 Log (Tt).Key words: Seedling, stake, total height, diameter at breast height

Kombinasi Imbuhan Herbal Kunyit dan Zink dalam Pakan sebagai Alternatif Pengobatan Kolibasilosis pada Ayam Pedaging (THE COMBINATION OF CURCUMIN WITH ZINC IN FEED AS ALTERNATIF THERAPY COLLIBACIILOSIS IN BROILER ) Ietje Wientarsih; Sus Derthi Widhyari; Tika Aryanti
Jurnal Veteriner Vol 14 No 3 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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The use of antibiotics is one way to reduce the number of deaths in poultry industry. However, use maybe reduced because the impact for consumers. This study aims to find out the effect of the combinationbetween herbal turmeric (Curcuma domestica Val.), Garlic (Allium sativum Linn.) with Zn in the feed tothe number of erythrocyte, hematocrit and hemoglobin in chickens that is infected with Escherichia colibactery. Two hundred head of DOC were divided into 5 treatments and 4 repetitions, each repetitionconsisted of 10 chickens. Ration treatment K0 (basal ration as a healthy chickens), K (negative control)(basal ration chickens infected with Escherichia coli), P1 (basal ration + 1.5% turmeric powder + 180 ppmof ZnO / chickens infected with Escherichia coli), P2 (basal ration + 2.5% garlic powder + 180 ppm of ZnO /chickens infected with Escherichia coli), and K (positive control) (a basal ration + antibiotic / chickensinfected with Escherichia coli). At the age of 3 weeks, all treatment groups were challenged with E. coliwhich treated orally at a dose of 108 CFU/mL. K(+) group was given antibiotics a day after the challenge. Antibiotics are given for 3 days with a dose of medication. Blood sampling performed at the age of 3 weeks(before the challenge), 1 and 2 weeks after the challenge. The blood test includes the number of erythrocytes,hematocrit values and level of hemoglobin . The results showed the number of erythrocytes, hematocritvalues, and level of hemoglobin at treatment P1 (ration basal + 1.5% turmeric powder + 180 ppm of ZnO+ infected with Escherichia coli) tend to be higher than other treatments and have equal outcomes withtreatment K(+) (ration basal + antibiotics + infected with Escherichia coli). From the results of this studyconcluded that the use of combinations of herbs turmeric and Zn in the feed can be used as an alternativeof colibacillosis treatment.

Daun Binahong (Andredera cordifolia Steenis) Sebagai Alternatif Insektisida Terhadap Miasis yang Disebabkan Lalat Chrysomya bezziana (ANREDERA CORDIFOLIA STEENIS (BINAHONG) LEAF AS AN ALTERNATIVE INSECTICIDE AGAINST CHRYSOMYA BEZZIANA CAUSED MYIASIS) Ietje Wientarsih; Aulia Andi Mustika; April Hari Wardhana; Dodi Darmakusumah; Lina Noviyanti Sutardi
Jurnal Veteriner Vol 18 No 1 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Larvae Chrysomya bezziana caused myiasis in most livestock in Indonesia. Drugs of choice for treating myasis are synthetic insecticides. Unfortunately the insecticides has negative effect on animal product, killed insect non target and insect resistenst. The research was conducted on the activity of ethanol extract of binahong leaves against various stages of C. bezziana larvae (L1, L2, and L3). Five treatments group tested were: group without any treatment (negative control), groups treated with ethanol extracts of binahong leaves 0.5%, 1%, and 2%, respectively, positive control were given coumaphos. The treatments were applied with five replications. Number of living larvae and pupae, pupae weight and number of imago were observed. The results demonstrated that 0.5% of the extract effective consentration which was able to kill the larvae (L1 and L2). Finally 2% of the extract was the most effective concentration which was able to kill larvae (L3) and decrease the pupae weight. Ethanol extract of binahong leaves was significantly able to reduce the growth of C. bezziana larvae due to contact and digestive effect of the active compounds contained in Anredera cordifolia leaf. ABSTRAK Miasis merupakan infestasi larva lalat yang terdapat pada jaringan hidup. Penyakit ini umum menyerang hewan maupun manusia. Obat yang digunakan sebagai pengendalian kasus miasis di lapangan sampai saat ini sangat terbatas dan menggunakan insektisida sintetik. Penelitian ini bertujuan melihat aktivitas ekstrak etanol daun binahong terhadap larva lalat Chrysomya bezziana pada stadium L1, L2, dan L3. Penelitian dibagi menjadi lima kelompok perlakuan dengan lima ulangan. Kelompok perlakuan terdiri dari kontrol negatif (tanpa pemberian obat), kelompok perlakuan yang diberikan ekstrak binahong dengan konsentrasi berturut-turut 0,5%, 1%, 2%, dan kelompok yang diberikan coumaphos (kontrol positif). Peubah yang diamati adalah jumlah larva yang hidup dan berkembang menjadi pupa, bobot pupa, dan daya tetas pupa menjadi imago. Hasil penelitian menunjukkan bahwa ekstrak etanol daun binahong pada konsentrasi 0,5% mempunyai efikasi sebagai larvasidal terhadap L1 dan L2 serta pada konsentrasi 2% merupakan konsentrasi terbaik sebagai larvasidal L3 larva C. bezziana. Ekstrak etanol daun binahong memiliki kemampuan menghambat larva lalat C. bezziana akibat dari efek cerna dan efek kontak bahan aktif yang terkandung di dalam daun binahong.

Aktivitas Salep Ekstrak Rimpang Kunyit dalam Proses Persembuhan Luka pada Mencit yang Diinduksi Diabetes (THE ACTIVITY OF TURMERIC EXTRACT OINTMENT IN THE WOUND HEALING PROCESS OF INDUCED DIABETIC MICE) Wiwin Winarsih; Ietje Wientarsih; Lina Noviyanti Sutardi
Jurnal Veteriner Vol 13 No 3 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.798 KB)

The aim of this study was to evaluate the effectiveness of ethanol turmeric extract ointment in woundhealing process of streptozotocin-induced diabetic mice. Ethyl acetate and hexane fractions of ethanolturmeric extract were studied for their wound-healing properties in the formulation of ointment. Sixty micewere divided into 4 groups : group I was control (normal control, without treatment); group II was diabeticgroup (diabetic, without treatment); group III was diabetic and treated with ethyl acetate fraction ointment,group IV was diabetic and treated with hexane fraction ointment. The diabetic groups were i.p injectedwith 40mg/kg of streptozotocin and all groups were received incision 2 cm on their back skin. The ointmentsof ethyl acetate and hexane fraction were given topically twice a day. Three mice from each groups werenecropsied at 2nd, 4th, 7th, 14th and 21st days post incision (pi) for gross pathological and histopathologicalevaluation of the injured skin. Gross examination revealed that the ethyl acetate and hexane fractionointment groups showed better result on wound-healing process compared to the diabetic group.Microscopically, the ethyl acetate and hexane fraction ointment groups showed faster neovascularizationand reepithelialization compared to the diabetic group. In comparison with the diabetic group, the ethylacetate and hexane fraction ointment groups showed fewer neutrophils infiltration which indicated antiinflammatory activities of ethyl acetate and hexane fractions. Based on the macroscopic and microscopicobservation, the ointments of ethyl acetate and hexane fraction have properties to promote wound healingin diabetic mice.

The Efficacy and Safety of Topical Gel Formulation of n-Hexane Fraction of Curcuma longa in Wound Healing of Hyperglycemic Mice Ietje Wientarsih; Wiwin Winarsih; Lina Noviyanti Sutardi
Jurnal Veteriner Vol 14 No 1 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.169 KB)

Curcuma longa (turmeric) is one of the tropical plant belong to Zingiberaceae family. It has beneficialeffects in healing of variety diseases. The aim of this study was to evaluate the efficacy and safety of atopical gel formulation of n-hexane fraction of Curcuma longa in the wound healing of hyperglycemic mice.A total of 30 hyperglycemic mice were divided into three groups. They were given topical application, NC asa negative control (gel base), PC as a positive control (Neomycine sulfate 5%), treated groups (HF = n-hexane gel). Histopathological examination of the skin was performed to evaluate the wound healing. Theresult showed that, there were no changes on tha appearance of the gel preparation, physically. Evethoughupon the pH determination of the gel at six month of storage at 40ºC there were significant difference. Theeffect of n-hexane gel, in terms of decreasing the surface area of wound and histopathological characteristicswere significantly (p <0.05) different between the PC group and HF group. Skin irritant test showedneither rashes, swelling, inflammation, redness, irritation, itching nor any other toxicity symptoms followingapplication of the gel. Significant effect of n hexane fraction of C. longa gel on wounds without any adversedermal toxic effects sounds very promising and it may be employed in the management of diabetic wound.

Aktivitas Penyembuhan Luka oleh Gel Fraksi Etil Asetat Rimpang Kunyit pada Mencit Hiperglikemik (WOUND HEALING ACTIVITY OF AETHYL ACETATE OF CURCUMA LONGA GEL IN HYPERGLYCEMIC MICE) Ietje Wientarsih; Wiwin Winarsih; Lina Noviyanti Sutardi
Jurnal Veteriner Vol 13 No 3 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.487 KB)

Traditional remedies generally use plant based therapies for treatments. The availability of plantfor treatments is relatively abundant in Indonesia, whether as treatments for diabetic wounds or antiinflammation. Curcuma longa Linn has been reported as an alternative treatment for several diseasesincluding wound healing. The aim of this study was to investigate the possible effect on wound healing ofethyl acetate of C.longa gel in skin hyperglycemic mice. The ethyl acetate of C.longa gel was evaluated toassess its healing efficiency on excision wound. Thirty mice were used in this study. The mice were dividedinto three groups i.e.: KN as a negative control (without treatment), KP as a positive control (Neomycinsulfate), and treated groups (GE= ethyl acetate gel). There was a significant effect on histopathologicalcharacteristics in wound healing of treated mice with ethyl acetate gel compared with KN mice. It seemthat C.longa gel is a potential for phyto-therapeutic agent in management of wound healing.

Uji Kelarutan Kristal Kalsium Oksalat Urin Tikus Sprague Dawley setelah Pemberian Eliksir Ekstrak Etanol Daun Pelawan (SOLUBILITY TEST OF CALCIUM OXALATE CRYSTAL IN SPRAGUE DAWLEY RAT URINE AFTER GIVING ETHANOL EXTRACT OF PELAWAN LEAVES) Rahmawati Januar; Ietje Wientarsih; Sus Derthi Widhyari
Jurnal Veteriner Vol 21 No 1 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.009 KB)

Traditional medicine is an herbal medicine used from generation to generation by people in Indonesian. Pelawan leaves is believed can dissolve crystals in the urine that can be the initial cause of kidney stone formation. This study aimed to evaluate the potential of elixir of the ethanol extract of pelawan leaves as antilithiasis in rat was given ethylene glycol and ammonium chloride as inducer. Thirty male rat Sprague dawley was divided in five different groups (n=6). The control group (K1), ethylene glycol (EG) and ammonium chloride (AC) as inducer (K2), inducer and Batugin 5,4 mg (K3); inducer and the elixir of the ethanol extract ofpelawan leaves (EEEDP) 100 mg/kg body weight (K4) and 200 mg/kg body weight (K5). The treatments were done in 28 days with urines observated at day 14 and day 28. The result showed that pelawan contain flavonoid, tannin, saponin and steroid. The result showed that treatment groups dissolved calcium oxalate crystals. Observated at day 14, K3 dissolved calcium oxalate crystals with lowest number, while at day 28, K4 dissolved calcium oxalate crystals with lowest number. A dose of 100 mg/kg body weight in the K4 group effectively dissolves the calcium oxalate crystals.

Co-Authors Ahmad Kurniawan Andriyanto . ANGGARA ALDOBRATA April Hari Wardhana April Hari Wardhana April Hari Wardhana Aswin Rahadian Aulia Andi Mustika Aulia Andi Mustika Aulia Andi Mustika Aulia Andi Mustika Bambang Pontjo Priosoeryanto Bayu Febram Bayu Febram Bayu Febram Prasetyo Bayu Febran Prasetyo Chandra Utami Wirawati D R Agungpriyono Deded Sarip Nawawi Denny Widaya Lukman Dian Firnanda Dodi Darmakusuma Dodi Darmakusumah Dondhin Sajuthi Dondin Sajuthi Eko Agus Srihanto Erni H Purwaningsih Erni H Purwaningsih Esti Dhamayanti Eva Harlina Farra Sasmita Fikri Hanifah Gunanati Soedjono Hr. Sjarif, Sulistyantie Huda Shalahudin Darusman I Nyoman Jaya Wistara I Putu Kompiang Ikrar Trisnaning Hardi Utami Indra Bachtiar Irma Maulani Hamzah Istifharany Wahyudina L N Sutardi Lina Elfita Lina Noviyanti Sutardi M. Yanuar J. Purwanto Maulani Hamzah, Irma Meilisa Lidya Margarita Min Rahminiwati Miranti Fardesiana Putri Mirnawati Bachrum Sudarwanto Mirnawati Sudarwanto Muhammad Bintang Nopen Meisaroh Nova P. Sulistyawati R. Harry Soehartono Rahmawati Januar Rastina Rastina RINI MADYASTUTI Rita Kartika Sari Rizal Arifin Akbari Ros Sumarny Sajuthi, Dondhin Setyo Widodo Setyo Widodo Subangkit, Mawar Sulistyantie Hr. Sjarif Sus Derthi Widhyari TATI NURHAYATI Tika Aryanti Tyas Ayu Lestari Upik Kesumawati Hadi Vetnizah Juniantito Wiwin Winarsih

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