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All Journal Global Medical and Health Communication Medical Laboratory Technology Journal JURNAL INFO KESEHATAN Meditory : The Journal of Medical Laboratory Jurnal Kesehatan Manarang The Indonesian Journal of Infectious Diseases Jurnal Ilmu dan Teknologi Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung Medica Hospitalia Health Information : Jurnal Penelitian Health Media Muhammadiyah Journal of Midwifery (MyJM) Ahmar Metastasis Health Journal (AMHJ) Journal of Community Engagement in Health

Rizana Fajrunni’mah

Poltekkes Kemenkes Jakarta III

Author-ID : 4189296

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Perbandingan Metode RT-PCR dan Tes Rapid Antibodi untuk Deteksi COVID-19 Agustina, Anita Suswanti; Fajrunni'mah, Rizana
Jurnal Kesehatan Manarang Vol 6 No Khusus (2020): Oktober 2020
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v6iKhusus.317

COVID-19 is caused by SARS-CoV-2, which can spread rapidly from human to human. There are several laboratory tests to detect COVID-19, including the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) method and a rapid test antibody test to detect antibody reactions to SARS-CoV-2. Both methods have advantages and disadvantages of each, while the literature study comparing the two methods is currently limited. The type of research used is library research. Research materials have been collected from various journals, books, and guidelines, in line with the research topic, to obtain 24 library sources. The results of the literature study indicate that the target genes that can be used to detect COVID-19 RT-PCR methods include the N, E, RdRp, and ORF1a/b genes. The sensitivity of rapid antibody tests is known to range from 68âˆ’89%, while the specificity of rapid antibody tests ranges from 91âˆ’100%. RT-PCR has the advantage of being able to detect low-concentration antigens, but RT-PCR has weaknesses such as requiring expensive equipment and inspection fees, specially trained laboratory personnel, long working time, and high risk of exposure. Rapid antibody testing has advantages, including ease of sampling, lower testing costs, reduced risk of exposure to officers, does not require special equipment and space, but has the potential for cross-reactivity with other coronaviruses. Both the RT-PCR method and the rapid antibody test have their advantages and disadvantages, but rapid antibody testing with RT-PCR can improve the diagnosis of COVID-19. The results of this literature study are expected to be continued as a basis for further research on RT-PCR examination and antibody rapid test for COVID-19 detection in Indonesia, accompanied by information on onset time and time-testing with a large sample of research.

Faktor Pendukung dan Penghambat Penderita Diabetes Melitus dalam Melakukan Pemeriksaan Glukosa Darah Rizana Fajrunni'mah; Diah Lestari; Angki Purwanti
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Universitas Islam Bandung

Diabetes melitus (DM) adalah sekelompok gangguan metabolisme bersifat kronik yang ditandai peningkatan kadar glukosa darah serta gangguan metabolisme karbohidrat, lemak, dan protein. Setiap tahun lebih dari empat juta orang meninggal akibat DM, dan jutaan orang mengalami efek buruk atau kondisi yang mengancam jiwa seperti serangan jantung, strok, gagal ginjal, kebutaan, dan amputasi. Kemampuan individu mengelola kehidupan sehari-hari serta mengendalikan dan mengurangi dampak penyakit yang dideritanya dikenal dengan self-management, yaitu mengikuti pola makan sehat, meningkatkan kegiatan jasmani, menggunakan obat DM dan obat pada keadaan khusus secara aman dan teratur, melakukan pemantauan kadar gula darah, serta perawatan kaki secara berkala. Beberapa penelitian melaporkan bahwa masih sedikit penderita DM melakukan pemantauan gula darah dengan baik. Penelitian ini bertujuan memperoleh pemahaman mendalam tentang pengalaman penderita DM dalam pemeriksaan kadar glukosa darah dengan menggunakan metode penelitian kualitatif pendekatan fenomenologi. Penelitian dilaksanakan pada bulan Juli–September 2016 di wilayah kerja Puskesmas Jatiwarna, Bekasi. Hasil analisis data teridentifikasi faktor pendukung pemeriksaan glukosa darah adalah faktor psikologis, sosial, edukasi, ekonomi, dan akses. Faktor penghambatnya adalah faktor psikologis, sosial, edukasi, penggunaan obat, sikap terhadap penyakit, dan persepsi terhadap jaminan kesehatan. Hasil penelitian diharapkan dapat menjadi masukan dalam meningkatkan kualitas edukasi dan pendampingan tenaga kesehatan kepada pasien sehingga pasien terbantu meningkatkan adaptasi dan kemampuannya memantau glukosa darah secara mandiri.SUPPORTING AND INHIBITING FACTORS OF DIABETES MELLITUS PATIENTS IN PERFORMING BLOOD GLUCOSE EXAMINATIONDiabetes mellitus (DM) is a chronic metabolic disorder marked by an increase in blood glucose levels and impaired metabolism of carbohydrates, fats, and proteins. Every year more than four million people die because diabetes and millions of people experience the ill effects of diabetes or life-threatening conditions such as heart attack, stroke, kidney failure, blindness, and amputation. The individual's ability to manage life, control and reduce the impact of the disease known as self-management is to follow a healthy diet, increasing physical activity, using the drug safely and regularly, monitoring blood sugar levels as well as maintenance feet regularly. Several studies reported only small number of DM patients examined blood glucose levels routinely. This study aim to gain a thorough understanding of individual experience with DM in examining blood glucose levels. This study used qualitative research with a phenomenological approach from July to September 2016 at Jatiwarna, Bekasi. The results identified factors supporting blood glucose examination were: psychological factors, social, educational, economic, and access to health care. The inhibiting factors were psychological factors, social, educational, drug use, attitudes toward the disease, and perceptions of health insurance. The results expected to improve the quality of education and mentoring for health workers. It will help patients improving the adaptability and the ability to blood glucose self-monitoring.

Hubungan Antara Lama Penggunaan Kontrasepsi Suntik Depo Medroxy Progesteron Acetate (DMPA) dengan Kadar Kolesterol Total pada Akseptor KB Tri Prasetyorini; Yasyavia Hatifah Islami; Rizana Fajrunni’mah; Karningsih Karningsih
Muhammadiyah Journal of Midwifery Vol 1, No 2 (2020): Muhammadiyah Journal of Midwifery (MyJM)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Latar belakang: jumlah penduduk terbanyak di dunia posisi ke-4 adalah Indonesia. Upaya untuk menekan jumlah pertumbuhan penduduk yaitu dengan program Keluarga Berencana (KB). Secara nasional pengguna KB yang paling banyak adalah KB suntik Depo Medroxy Progesteron Acetate (DMPA) yaitu lebih dari 50% dari jumlah peserta KB aktif. DMPA yang mengandung hormon Progesteron dapat mempengaruhi metabolisme lemak, khususnya lipoprotein. Lama pemakaian kontrasepsi suntik lebih dari 1 tahun akan mengakibatkan ketidak seimbangan hormon estrogen dan progesteron yang berakibat penurunan HDL dan peningkatan LDL sehingga akan meningkatkan kadar kolesterol total. Tujuan: diketahuinya hubungan antara lama penggunaan kontrasepsi suntik DMPA dengan kadar kolesterol total pada akseptor KB DMPA. Metode: jenis penelitian yang digunakan observasional analitik cross sectional dengan jumlah sampel sebanyak 35 responden. Uji statistik yang digunakan adalah uji chi-square dengan tingkat kepercayaan 95%. Hasil: menunjukan bahwa nilai p sebesar 0,011 (p<0,05). Hal ini berarti bahwa terdapat hubungan antara lama penggunaan kontrasepsi suntik Depo Medroxy Progesteron Acetate (DMPA) dengan kadar kolesterol total pada akseptor KB. Sehingga semakin lama penggunaan kontrasepsi DMPA maka semakin meningkatkan kadar kolesterol. Kesimpulan: terdapat hubungan antara lama penggunaan kontrasepsi suntik DMPA dengan kadar kolesterol total.

JUS NONI UNTUK MENURUNKAN JUMLAH LEUKOSIT DAN NEUTROFIL SEBAGAI INDIKATOR INFLAMASI PADA PAPARAN ASAP ROKOK Rizana Fajrunni’mah Fajrunni’mah
Jurnal Ilmu dan Teknologi Kesehatan Vol 3 No 2 (2016): Maret
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.966 KB)

Noni is a functional food can increase antioxidant and anti-inflammatory activities. Cigarette smoke contains oxidants and can cause systemic inflammation, characterized by an increase in the number of leukocyte and neutrophil counts. Leukocytes and neutrophils expressed as an independent marker of prognosis of ischemic cardiovascular disease. The aim of this research was to prove the effect of noni juice to decrease in number of leukocytes and neutrophils in Wistar rats by exposure to cigarette smoke. This research used Pre-posttest control group design with Wistar rats were divided into 2 groups: control (K) and treatment (P) given noni juice 6 ml/day and cigarette smoke exposure for 30 days. The results of this research showed that in number of leukocyte and neutrophil counts in the group giving noni juice is smaller than the control group, with p value 0.016 and p value 0.032. Delivery of noni juice effect on decreasing the number of total leukocyte and neutrophil counts in Wistar rats by exposure to cigarette smoke.

Carcinoembryonic Antigen (CEA) dan Neutrofil-to-Limfosit Ratio (NLR) sebagai Faktor Prediktif Kanker Kolorektal Retno Martini Widhyasih; Suci Dwi Rahmadhanti; Rizana Fajrunni'mah
Jurnal Ilmu dan Teknologi Kesehatan Vol 7 No 1 (2019): September 2019
Publisher : Poltekkes Kemenkes Jakarta III

Colorectal cancer is a cancer that attacks the colon to the rectum. This cancer is the fourth most cancer in the world, and the second most cancer in western countries, and the third most common cause of cancer that occurs in men and women in 2012 in Indonesia. 72.4% of colorectal cancer patients have increased preoperative CEA levels, and increased NLR has been reported as a valuable predictive indicator of various types of cancer, including colorectal cancer. This study aims to analyze the correlation between CEA examination and NLR in colorectal cancer using secondary data with cross-sectional design. The sample of this study was all colorectal cancer patients in Tarakan Hospital, Central Jakarta, who examined CEA and complete hematology in 2014 - 2018. Based on the results of the study, it could be concluded that there was a correlation between CEA with NLR in colorectal cancer with a value of p = 0.000 smaller than alpha = 0.05, and the value of r = 0.78, meaning a strong correlation between CEA and NLR in colorectal cancer, so if there is an increase in CEA, it is accompanied by an increase in NLR.

PEMERIKSAAN GLUKOSA DARAH PADA PENDERITA DIABETES MELITUS (STUDI FENOMENOLOGI) Rizana Fajrunni'mah; Angki Purwanti
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 13 No 2 (2021): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Diabetes Melitus (DM) merupakan sekelompok kelainan metabolik yang ditandai oleh kenaikan kadar glukosa dalam darah atau hiperglikemia yang diakibatkan dari kurangnya sekresi insulin, gangguan metabolisme insulin, atau keduanya. Hal yang mungkin menyebabkan Self Management Diabetes Melitus (SMDM) pada aspek pemantauan gula darah yaitu kurangnya kesadaran dari pasien DM sendiri. Tujuan penelitian ini adalah diperoleh suatu pemahaman yang mendalam dari pengalaman penderita DM selama melakukan pemeriksaan glukosa darah. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan menggunakan pendekatan fenomenologi. Partisipan dalam penelitian ini adalah penderita diabetes melitus yang melakukan kunjungan di Puskesmas Jatiwarna Bekasi sebanyak 6 orang yang berjenis kelamin laki-laki sebanyak tiga orang, dan perempuan sebanyak tiga orang. Hasil penelitian didapatkan sepuluh sub tema yang muncul yaitu: frekuensi, tempat, cara, waktu, jenis, prosedur, peralatan, hasil, interpretasi hasil, serta penjelasan hasil. Kategori tersebut hendaknya menjadi perhatian bagi tenaga kesehatan untuk pemantauan dan evaluasi self-management yang dilakukan oleh penderita DM.

HASIL PEMERIKSAAN IMUNOKROMATOGRAFI COACTAIL ANTIGEN M.TUBERCULOSIS DAN METODE MOLEKULER PADA SUSPEK HIV Rizana Fajrunni'mah
Meditory : The Journal of Medical Laboratory Vol 8, No 1 (2020): Meditory, vol. 8 no 1 Juni 2020
Publisher : Jurusan Analisis Kesehatan, Poltekkes Kemenkes Denpasar

Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) infection. Tuberculosis is one of the most common infections in people with HIV/ AIDS. Deaths due to TB in HIV patients occur due to delayed diagnosis. GeneXpert is a breakthrough discovery for TB diagnosis based on molecular examination using the semi quantitative Real Time Polymerase Chain Reaction Assay (RT-PCR) method. An examination has now been developed to detect MTB antigens using the method of rapid immunochromatography in the hope that it can be used as a means of supporting TB diagnosis better than detection of antibodies to MTB.Aim This study aims to compare the results of the TB GeneXpert RTPCR method with the rapid immunochromatography method in suspect HIV.Method This study uses a quantitative design with observational analytic design (cross sectional) with primary and secondary data collection.Result The results of this study found the value of sensitivity, specificity, accuracy, positive predictive value, negative predictive value of the ICT test in a row of 21%, 76%, 40%, 55.8%.Conclusion ICT TB has low sensitivity and sufficient specificity so that it is still not good if used for initial screening to detect pulmonary TB in suspect HIV.

Relationship Between CD4+ Cell with GenExpert Molecular Mycobacterium tuberculosis Test in HIV/AIDS patients Al’fira Gita Islami; Rizana Fajrunni'mah; Mega Mirawati
Health Media Vol 3 No 2 (2022)
Publisher : UrbanGreen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/hm.v3i2.67

CD4+ cells in HIV/AIDS patients is an examination that serves to monitor the regulation of the immune system. HIV/AIDS patients experience a decrease in the number of CD4+ cells which results in various opportunistic infections, one of which is caused by Mycobacterium tuberculosis. This study aims to determine the relationship between the results of CD4+ cell with GenExpert Molecular Mycobacterium tuberculosis Test. This study was based on an analytic observational cross-sectional design on 53 samples of HIV/AIDS patients at Budhi Asih Hospital. Data analyze using Fisher Exact statistical test with α = 0.05. The result showed percentage CD4+ cells <200 with positive TCM result 48 (86,4%). CD4+ cells >200 with GenExpert positif result 0 (0,0%). The results showed that there was no relationship between CD4+ cell examination and TCM GenExpert MTB examination in HIV/AIDS patients (p = 0.574). From the result we can conclude that maybe other infection has happened.

Correlation of CRP Levels with Severity of Disease in Hospitalized Patients with Confirmed COVID-19: Korelasi Kadar CRP dengan Derajat Keparahan Penyakit pada Pasien Rawat Inap Terkonfirmasi COVID-19 Anisah Wulansari; Rizana Fajrunni'mah; Warida Warida
Ahmar Metastasis Health Journal Vol. 2 No. 1 (2022): Ahmar Metastasis Health Journal
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amhj.v2i1.97

ABSTRACT Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. C-Reactive Protein (CRP) has been found to be an important marker that is significantly altered in severe COVID-19 patients. This study aims to determine the correlation of CRP levels with the agglutination method with the severity of the disease in hospitalized patients who are confirmed positive for COVID-19. This research is an analytic observational with a cross sectional design. The sample is in the form of medical record data of 80 inpatients who are confirmed positive for COVID-19 at Pasar Rebo Hospital for the period August 2020 to January 2021. The data collection process uses a purposive sampling technique. CRP levels (mg/L) were divided into 5 groups, namely <6, 6, 12, 24 and 48. Meanwhile, the severity of the disease was divided into 2 groups, namely mild-moderate and severe-critical. Chi Square statistical test was used to assess the correlation of CRP levels with the severity of the disease. Subjects consisted of 80 confirmed COVID-19 patients with 52.5% male gender more than female (47.5%). Age group 60 years 38.8%, the most compared to other age groups. The severe-critical group 60% more than the mild-moderate (40%). CRP levels <6 mg/L in 17.5% patients, CRP levels 6 mg/L in 3.8% patients, CRP levels 12 mg/L in 27.5% patients, CRP 24 mg/L in 31.3% patients and CRP levels 48 mg/L in 20% patients. The results of the Chi Square test showed a significant correlation between CRP levels and the severity of disease in inpatients confirmed positive for COVID-19 at Pasar Rebo Hospital with a p value of 0.000 at a 95% confidence level. CRP examination can be used as a marker to see the severity of disease in hospitalized patients who are confirmed positive for COVID-19. ABSTRAK Pendahuluan: Coronavirus Disease 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh SARS-CoV-2. C-Reactive Protein (CRP) telah ditemukan sebagai penanda penting yang berubah secara signifikan pada pasien COVID-19 yang parah. Penelitian ini bertujuan untuk mengetahui korelasi kadar CRP metode aglutinasi dengan derajat keparahan penyakit pada pasien rawat inap terkonfirmasi positif COVID-19. Penelitian ini adalah observasional analitik dengan desain cross sectional. Sampel berupa data rekam medis 80 pasien rawat inap terkonfirmasi positif COVID-19 di RSUD Pasar Rebo periode Agustus 2020 hingga Januari 2021. Proses pengambilan data dengan teknik purposive sampling. Kadar CRP (mg/L) dibagi dalam 5 kelompok yaitu <6, 6, 12, 24 dan 48. Sementara derajat keparahan penyakit dibagi dalam 2 kelompok yaitu ringan-sedang dan berat-kritis. Uji statistik Chi Square digunakan untuk menilai korelasi kadar CRP dengan derajat keparahan penyakit. Subjek terdiri dari 80 pasien terkonfirmasi COVID-19 dengan jenis kelamin laki-laki 52,5% lebih banyak dibandingkan perempuan 47,5%. Kelompok usia ≥ 60 tahun 38,8% paling banyak dibandingkan kelompok usia yang lain. Kelompok berat-kritis 60%, lebih banyak dibandingkan ringan-sedang 40%. Kadar CRP <6 mg/L sebanyak 17,5% pasien, kadar CRP 6 mg/L sebanyak 3,8% pasien, kadar CRP 12 mg/L sebanyak 27,5% pasien, kadar CRP 24 mg/L sebanyak 31,3% pasien dan kadar CRP 48 mg/L sebanyak 20% pasien. Hasil uji Chi Square didapatkan korelasi yang signifikan antara kadar CRP dengan derajat keparahan penyakit pada pasien rawat inap terkonfirmasi positif COVID-19 di RSUD Pasar Rebo dengan nilai p 0,000 pada tingkat kepercayaan 95%. Pemeriksaan CRP dapat digunakan sebagai salah satu penanda untuk melihat derajat keparahan penyakit pada pasien rawat inap terkonfirmasi positif COVID-19.

Identifikasi Boraks Pada Roti Murah Di Warung Kelurahan Jatirahayu Pondok Melati Bekasi: Identifikasi Boraks Pada Roti Murah Di Warung Kelurahan Jatirahayu Pondok Melati Bekasi Angki Purwanti; Bagya Mujianto; Rizana Fajrunni'mah
Ahmar Metastasis Health Journal Vol. 2 No. 1 (2022): Ahmar Metastasis Health Journal
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amhj.v2i1.98

ABSTRACT Introduction: Several cheap breads were found circulating in Jatirahayu Pondok Melati sub-district which did not grow mold after being stored for more than 16 days. It is feared that the cheap bread contains borax, a chemical that can inhibit the growth of mold. In PERMENKES no. 033 of 2012 borax is an ingredient that is prohibited for food preservation because of its carcinogenic properties. The research objectives were to observe the organoleptic of bread, observe the packaging of bread and identify the possibility of borax in bread through laboratory tests. The research population is bread with a price of not more than Rp. 20000.00 circulating in the Jatirahayu sub-district stalls, as a sample were 21 types of bread taken from the research area. Identification of borax using flame test and curcumin paper test. Two samples (9.52%) of bread containing borax were identified. The two breads have characteristics when they are crushed, do not have a distribution permit in the form of a P-IRT number, have no expiration date on the packaging and do not get moldy for more than 16 days. Borax can prevent mold growth by inhibiting the hydrolysis of flour into sugars needed by fungi for growth. For further research, it is recommended to identify fungi and mycotoxins that grow on the surface of these cheap breads. ABSTRAK Pendahuluan: Ditemukan beberapa roti murah beredar di kelurahan Jatirahayu Pondok Melati yang tidak ditumbuhi jamur setelah penyimpanan lebih dari 16 hari. Dikhawatirkan roti - roti murah tersebut mengandung senyawa boraks yaitu bahan kimia yang dapat menghambat pertumbuhan jamur. Dalam PERMENKES no. 033 Tahun 2012 boraks merupakan bahan yang dilarang untuk pengawetan makanan karena sifat karsinogeniknya. Tujuan penelitian adalah untuk mengobservasi organoleptik roti, mengobservasi kemasan roti dan mengidentifikasi kemungkinan adanya boraks dalam roti melalui uji laboratorium. Populasi penelitian adalah roti dengan harga tidak lebih dari Rp. 2000,00 yang beredar di warung kelurahan Jatirahayu, sebagai sampel adalah 21 jenis roti yang diambil dari wilayah penelitian. Identifikasi boraks menggunakan uji nyala dan uji kertas kurkumin. Teridentifikasi 2 sampel (9,52%) roti yang mengandung boraks. Kedua roti tersebut mempunyai ciri ketika dipilin hancur, tidak mempunyai izin edar berupa nomor P-IRT, tidak terdapat tanggal kadaluarsa pada kemasannya dan tidak berjamur sampai lebih dari 16 hari. Boraks dapat mencegah pertumbuhan jamur dengan cara menghambat hidrolisis tepung menjadi gula yang diperlukan jamur untuk pertumbuhannya. Untuk penelitian selanjutnya disarankan untuk melakukan identifikasi jamur dan mikotoksin yang tumbuh di permukaan roti-roti murah tersebut.

Co-Authors Agustina, Anita Suswanti Al’fira Gita Islami Angki Purwanti Angki Purwanti Aninda Dinar Widiantari Anisah Wulansari Anita Suswanti Agustina Bagya Mujianto Budi Setiawan Churiyyah Eka Choirunisa Dewi Astuti Dewi Astuti Diah Lestari Eva Ayu Maharani Farida Murtiani Farida Murtiani Fransiska Rada Furaida Khasanah Husjain Djajaningrat Isnawati Apriliani Karningsih Karningsih Kunti Wijiarti Lyana Setiawan Mega Mirawati Mita Puspita Sari Retno Martini Widhyasih Retno Martini Widhyasih Retno Martini Widhyasih Rika Erviani Sriyanto Sriyato Suci Dwi Rahmadhanti Syifa Amelia Nadayang Tri Prasetyorini Warida Warida Yasyavia Hatifah Islami

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