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All Journal PHARMACON JURNAL LPPM BIDANG SAINS DAN TEKNOLOGI
Weny Wiyono
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Education Medicine & Pharmacology

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MAYANA (Coleus atropurpureus [L] Benth) TERHADAP Staphylococcus aureus, Escherichia coli DAN Pseudomonas aeruginosa SECARA IN-VITRO Mpila, Deby; Fatimawali, Fatimawali; Wiyono, Weny
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.440

Abstract

The aims of this research were to study antibacterial activity, effective concentration and effect ofincreasing concentrations of ethanolic extract from mayana leaf (Coleus atropurpureus [L] Benth) onbacteria growth inhibition of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.Extraction was done by maceration using ethanol 96%. Antibacterial activity test was done by usingpitting method, Kirby and Bauer agar difussion with modification. The result was analyzed by Oneway anova, followed by Duncan test. The result showed that extract concentrations (5, 10, 20, 40 and80%) possess bacterial inhibition activity. Extract concentrations (20, 40 and 80%) were effectivelyinhibit S. aureus growth and on effective concentration to inhibit E. coli were at 10, 20, 40 and 80%,while for P. aeruginosa were at 5, 10, 20, 40 and 80% extracts. The increase concentrations ofmayana extract shows high inhibition diameter of bacterial growth.Keywords : Antibacterial activity, Coleus atropurpureus [L] Benth, pathogen bacterial, agar difussionmethod
Uji Ekstrak Daun Binahong ( Anredera cordifolia Steen.) Terhadap kadar Gula Darah Pada Tikus Putih Jantan Galur Wistar ( Rattus norvegicus) yang Diinduksi Sukrosa Makalalag, Indri Wirasuasty; Wullur, Adeanne; wiyono, Weny
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.883

Abstract

ABSTRACT The objective of this research were tostudy the effect of Binahong leaf extract (Anredera cordifolia Steen.) on blood glucose content of white male Wistar rats (Rattus norvegicus) induced with sucrose.  This research using Randomized Controlled Group Design (RAL).The subjects in these research were 15 mices which divided into 3 groups, namely a negative control group (aquadest), a positive control group (Glucobay4,5 mg/KgBB) and treatments groupusing crude extract of Binahong leaf 1,8 g/KgBB.  Data were obtained after blood glucose examination at 15, 30, 60, and 120 minutes treatment. Data were analyzed using ANOVA and LSD to compare the effect of treatment. Statistical analysis shows that there are significant effect between a negative control group and treatment group, a negative control group and a positive control group, but did not show differences between treatment group and a positive control group.  The conclusion is Binahong leaf extract possess activity to decrease blood glucose content of white male wistar induced with sucrose.   Keywords: Anredera cordifolia Steen.,Extract, blood glucose content
Penentuan Nilai Sun Protective Factor (SPF) Secara In Vitro Krim Tabir Surya Ekstrak Etanol Kulit Alpukat Mokodompit, Ade Novia; Edy, Hosea Jaya; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2385

Abstract

ABSTRACTPeel of avocado (Persea americana Mill) contain efficacious compounds as an antioxydant.This studyhave purpose to determinethe value of Sun Protective Factor (SPF) of sunscreenfrom avocado's peel extract (Persea americana Mill) with aconcentration of5%, 7.5% and10%. In the determination of in vitro SPF valuesusing a spectrophotometer produce SPFvalues obtainedat a concentration of 5% is 3.99, 7.5% is 5.88,10% is 6.81. This study provesthat the use of this creamis notefficaciousas a sunscreen because the value result of SPF notexceed the minimal limit of good sunscreen SPF, that is 15.Key word : Peel of avocado (Persea americana Mill), cream, value of Sun Protective Factor(SPF)
STUDI PENGGUNAAN OBAT PADA PASIEN MALARIA DI INSTALASI RAWAT INAP RSUD KABUPATEN MIMIKA Gultom, Febryan Leonardo; Wiyono, Weny; Tjitrosantoso, Heedy
PHARMACON Vol 8, No 3 (2019)
Publisher : PHARMACON

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Abstract

ABSTRACT Malaria is an infectious disease caused by the Plasmodium parasite (class of Sporozoa) that attacks red blood cells. In indonesia, there are 4 (four) species of malaria parasites, namely Plasmodium falciparum as the cause of tropical malaria which often causes brain malaria with death, Plasmodium vivax as the cause of malaria tertiana, Plasmodium malariae as the cause of malaria quartana and Plasmodium ovale as the cause of ovale malaria. This study aims to determine the patient characteristics and treatment patterns in malaria patients at the inpatient installation of the Mimika District Hospital in period June ? December 2018. This study was a descriptive study with retrospective data collection against 68 medical records of malaria patients who were hospitalized inclusion criteria. There were  more men group than women, 41 patiensts (60,29%). Most of malaria patients are in the 0 ? 5 year age group with 30 patients (44,12%). The most common type of malaria is uncomplicated vivax malaria 21 patients (33,82%). The most drug use of patients was Primaquin as many as 57 (83,82%) of 68 patients. The exact percentage of drug use for patients is 100%, right drug 89.71%, right dose 92.65%, timely 97.06% and right route 100%. Keywords : Malaria, Drug Utilization Study, Hospitalization.  ABSTRAK Malaria merupakan penyakit menular disebabkan oleh parasit Plasmodium (kelas Sporozoa) yang menyerang sel darah merah. Di Indonesia dikenal 4 (empat) macam spesies parasit malaria yaitu Plasmodium falciparum sebagai penyebab malaria tropika yang sering menyebabkan malaria otak dengan kematian, Plasmodium vivax sebagai penyebab malaria tertiana, Plasmodium malariae sebagai penyebab malaria quartana dan Plasmodium ovale sebagai penyebab malaria ovale. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dan pola pengobatan penyakit malaria pada pasien malaria di instalasi rawat inap RSUD Kabupaten Mimika periode bulan Juni ? Desember 2018. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif terhadap 68 data rekam medik pasien malaria rawat inap yang memenuhi kriteria inklusi. Jumlah pasien laki-laki lebih banyak dibandingkan perempuan yaitu sebanyak 41 pasien (60,29%). Pasien Malaria kebanyakan berada pada kelompok usia 0-5 tahun sebanyak 30 pasien (44,12%). Jenis malaria yang paling sering terjadi adalah Malaria vivax tanpa komplikasi sebanyak 23 pasien (33,82%). Penggunaan obat pasien paling banyak yaitu Primakuin sebanyak 57 (83,82%) dari total 68 pasien. Persentase ketepatan penggunaan obat yang tepat pasien 100%, tepat obat 89,71%, tepat dosis  92.65%, tepat waktu 97,06% dan tepat rute 100%. Kata kunci : Malaria, Studi Penggunaan Obat, Rawat Inap.
FAKTOR PENYEBAB MEDICATION ERROR DI INSTALASI GAWAT DARURAT (IGD) RUMAH SAKIT BHAYANGKARA TK.III MANADO Angkow, Leydia; Citraningtyas, Gayatri; Wiyono, Weny
PHARMACON Vol 8, No 3 (2019)
Publisher : PHARMACON

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Abstract

ABSTRACTPatients who enter the ECU room need fast and appropriate help, but in reality there are reports of Medication Errors in the ECU. The purpose of this research is to find out the causes factors of Medication Error in the prescribing and dispensing phase. This research is a descriptive study with prospective data collection using questionnaires. The results showed that the factors causing Medication Error on prescribing phase error included the workloads that were unbalanced of workloads and human resources (HR), interruptions which were interrupted by ringing the telephone, communication such as the incomplete writing of drug names, environmental conditions such as the temperature working area was less supportive while working, and education, namely prescription writing that does not meet the prescription completeness requirements. Factors that causes Medication Error on dispensing phase include workloads of health workers are not able to solve on the every of their own job, interruptions that interrupting working by telephone ringing, environmental conditions on the work area temperature is less supportive when working, education such as preparation of drugs that are not in recipe request, and communication, namely the communication system regarding the stock of pharmaceutical supplies in the Pharmacy Installation did not run smoothly.Keywords: Causes, Medication Error, Emergency Room, Bhayangkara Hospital.ABSTRAKPasien yang masuk IGD perlu pertolongan yang cepat dan tepat, namun kenyataannya terdapat pelaporan kejadian Medication Error di IGD. Tujuan penelitian yaitu mengetahui faktor penyebab Medication Error pada fase prescribing dan dispensing. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara prospektif menggunakan kuisioner. Hasil penelitian menunjukkan bahwa faktor penyebab Medication Error fase prescribing meliputi beban kerja yaitu beban kerja dan SDM tidak seimbang, gangguan/interupsi bekerja yaitu terganggu dengan dering telepon, komunikasi yaitu penulisan nama obat tidak lengkap, kondisi lingkungan yaitu suhu area kerja kurang mendukung saat bekerja, dan edukasi yaitu penulisan resep yang tidak memenuhi syarat kelengkapan resep. Faktor penyebab Medication Error fase dispensing meliputi beban kerja yaitu tenaga kesehatan tidak mampu menyelesaikan sendiri setiap pekerjaan, gangguan/interupsi bekerja yaitu terganggu dengan dering telepon, kondisi lingkungan yaitu suhu area kerja kurang mendukung saat bekerja, edukasi yaitu penyiapan obat yang tidak sesuai permintaan resep dan komunikasi yaitu sistem komunikasi mengenai stok perbekalan farmasi di Instalasi Farmasi tidak berjalan lancar. Kata Kunci: Faktor penyebab, Medication Error, Instalasi Gawat Darurat, Rumah Sakit Bhayangkara
DAMPAK PENYULUHAN PADA PENGETAHUAN MASYARAKAT TERHADAP PEMILIHAN DAN PENGGUNAAN OBAT BATUK SWAMEDIKASI DI KECAMATAN MALALAYANG Meriati, Ni Wayan Eka; Goenawi, Lily Ranty; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2391

Abstract

ABSTRACTThe efforts of society to heal theirself is called self-medication or swamedikasi. Selfmediacationis usually used to overcome the complaints and minor illnesses such the cough.The cough medicine can not be samed with all kinds of cough. This research is aimed toidentify the impact of socialization on public knowledge toward the selection and the use ofself-medication (swamedikasi ) cough medicine in Malalayang subdistrict. This is anexperimental research with one group pretest-postest design. The collecting process ofsample was done by random sampling technique with 150 respondences. The instrument ofthis research is questioner about cough medicine knowledge comprises of 18 questions andleaflet as the media. Based on the acquired information, the averagely score of publicknowledge in pretest is 64,55 and in postest is 90,11 with probability value (p) = 0.000 < (α)0.05, so H0 is rejected. It shows that there is an influence of socialization toward the selectionand the use of self-medication ( swamedikasi ) cough medicine in Malalayang subdistrict.There is a real difference averagely about the public knowledge before and after socialization.Key words: Socialization, Cough medicine, Self-medication ( swamedikasi )
ISOLASI DAN IDENTIFIKASI SENYAWA FLAVONOID DALAM DAUN BELUNTAS (Pluchea indica L.) Koirewoa, Yohanes Adithya; Fatimawali, Fatimawali; Wiyono, Weny
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.445

Abstract

Isolation and identification flavonoid compounds in beluntas leaf (Pluchea indica L.) have beenconducted. Isolation was carried out by using 96% p.a ethanol solvent of maceration extraction for 7days and partition using n-heksana solvent to obtain concentrated beluntas leaf extract. The extractwas purified by thin layer chromatography using eluent n-butanol : asetic acid : water (BAA) (4:1:5).Isolate 3, result from thin layer chromatography contain flavonoid compound. Ultra Violet - Visiblespectra showed that the flavonoid compound was flavonol, with characteristic wavelengths from 250to 280 nm for band II and 350-385 nm for band I.Keywords: beluntas, flavonoid, Thin Layer Chromatography, UV-Vis Spectrophotometer
Uji Efek Antidepresan Ekstrak Metanol Jamur Tlethong (Psilocybe cubensis) Pada Tikus Putih Jantan (Rattus norvegicus): ditinjau dari Immobility Time Dengan Metode Forced Swim Test Kurama, Nofri P.; Bodhi, Widdhi; Wiyono, Weny
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2328

Abstract

ABSTRACTTlethong mushroom (Psilocybe cubensis) contains psilocybin that potential as antidepressant.The aim of this research was to examine the effect of Tlethong extract as antidepressant onwhite male wistar (Rattus norvegicus). Antidepressant test were evaluate on white malewistar which divided into 5 groups. The first group were administered with aquadest asnegative control, Second group were administered with amitriptilin as positive control, thirdgroup were administered with Tlethong extract with dose 500 mg/KgBB, 625 mg/KgBB and750 mg/KgBB then tail suspension test were conducted. Immobility time dengan metodeforced swim test. Obtained data were analyzed by one way ANOVA. The result shows thatTlethong extract possess antidepressant activity evaluated by its immobility time using forcedswim test method.Keywords: Antidepressant, immobility time, forced swim test, tail suspension test, Psilocybecubensis
IDENTIFIKASI TINGKAT KEPATUHAN PASIEN GERIATRI YANG MENDERITA HIPERTENSI DISERTAI PENYAKIT PENYERTA DI RSU PANCARAN KASIH MANADO PERIODE SEPTEMBER-OKTOBER 2018 Runtuwene, Widia; Wiyono, Weny; Yudistira, Adithya
PHARMACON Vol 8, No 2 (2019)
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Abstract

ABSTRACTHypertension is one of chronic disease with commonly treatment for lifetime. The adherence of geriatric patients in following treatment very important that doesn?t happen can lead to death. This type of research is a descriptive study. The population of this study amounted to 465 patients. The number of samples taken was 40 patients. The sampling technique is consecutive sampling. The level of adherence was measured using the Modified MoriskyAdherence Scale-8 (MMAS-8)questionnaire. From the results of this study it can be concluded that geriatric patients who do treatment at the manado pancaran kasih hospital have a high level of adherence of 10%, have a moderate level of adherence of 40%, and have a low level of adherence of 50%. The results of this study found a problem related to the adherence of geriatric patients aged 60-69 years who took medication at the manado pancaran kasih hospital, namely because of forgetfulness and lack of information obtained from health workers regarding the patients condition and the importance of drugs to drink continue.Keywords : Hypertension, Geriatric, Adherence. ABSTRAKHipertensi merupakan salah satu penyakit kronis dengan pengobatan yang umumnya seumur hidup.Kepatuhan pasien geriatri dalam menjalani pengobatan sangat penting agar tidak terjadi komplikasi berbagai penyakit yang dapat berujung pada kematian. Jenis penelitian ini adalah penelitian deskriptif.Populasi dari penelitian ini berjumlah 465 pasien.Jumlah sampel yang di ambil sebanyak 40 pasien.Teknik pengambilan sampel secara consecutive sampling.Tingkat kepatuhan di ukur dengan menggunakan Kuesioner MMAS-8 (Modified MoriskyAdherence Scale). Hasil penelitian ini dapat disimpulkan pasien geriatri yang melakukan pengobatan di RSU Pancaran Kasih Manado memiliki tingkat kepatuhan tinggi sebanyak 10%, memiliki tingkat kepatuhan sedang sebanyak 40%, dan memiliki tingkat kepatuhan rendah sebanyak 50%. Hasil penelitian ini mendapatkan masalah terkait kepatuhan pasien geriatri yang berusia 60-69 yang melakukan pengobatan di RSU Pancaran Kasih Manado yaitu karena lupa dan kurangya informasi yang didapatkan pasien dari tenaga kesehatan terkait kondisi pasien dan pentingnya pengobatan secara kontinu.Kata Kunci : Hipertensi, Geriatri, Kepatuhan.
PENGARUH BASIS SALEP TERHADAP FORMULASI SEDIAAN SALEP EKSTRAK DAUN KEMANGI ( Ocimum sanctum L.) PADA KULIT PUNGGUNG KELINCI YANG DIBUAT INFEKSI Staphylococcus aureus Naibaho,, Olivia H; Yamlean, Paulina V. Y.; Wiyono, Weny
PHARMACON Vol 2, No 2 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.1553

Abstract

The basil plant (Ocimum sanctum L.) contains alkaloids, triterpenoids, flavonoids are able toprovide an antibacterial effect.The aims of this research were to study ointment base effectagainst physical properties and antibacterial effect of basil leaf extract ointment on Rabbits(Oryctolagus cuniculus) back skin infected with staphylococcus aureus.Extraction was doneby soxhlet extraction using ethanol 95% as solvent.Observation of healing time was done byobserving infectionhealingtime on rabbits back skin after anointment treatment, which basedonthe disappearance oferythema and pus. The result shows differences ointment base effectedon the physical properties of an ointment which include shape, color, pH, and dispersivepower, but had no effect on the smell and homogeneity of the preparation. Basil leavesextract ointment with base type hydrocarbons provide healing infections more quickly,followed by the type of water-soluble base, absorption, and washable base.Keywords: Base ointment, basil (Ocimum sanctum L.), Staphylococcus aureus, rabbit
Co-Authors Ade Novia Mokodompit Adeanne Wullur Adithya Yudistira Angkow, Leydia Antyka Bellah Esti Kawa Baluntu, Dwi Christian Aseng DEBY AFRIANI MPILA Deby Mpila Ekaningtyas, Angelia Fatimawali . Gayatri Citraningtyas Given Awulle Mamusung Gultom, Febryan Leonardo Hathasary, Rochmat Hidayat Heedy Tjitrosantoso Hosea Jaya Edy Hutauruk, Hamido Indri Wirasuasty Makalalag Julianri Lebang Lily Ranty Goenawi Marina Mamarimbing Meilani Jayanti Merry Senewe Ni Made Novi Trisnayanti Ni Wayan Eka Meriati Nofri P. Kurama Olivia H Naibaho, Paulina V. Y. Yamlean Paulina V.Y Yamlean Paulina yamlean Pratasik, Meyla Puasa, Novanda S. Runtuwene, Widia Solang, Natasia G Subadio, Nathanael Yngwie Christian Tasya Arta Mevia Putri Santoso Vethreeany Simamora Welong Surya Wewengkang, Defny Widdhi Bodhi Yohanes Adithya Koirewoa