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Bagian Patologi Anatomi FK.Unand.

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Hubungan Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Derajat Diferensiasi dan Invasi Limfovaskular pada Karsinoma Urotelial Infiltratif Kandung Kemih Dini Andri Utami; Salmiah Agus; Yenita; Husna Yetti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.86 KB) | DOI: 10.55816/mpi.v31i2.499

Abstract

Background Urothelial carcinoma is the most common malignancy in the bladder with an incidence up to 95% and 70-85% of them are bladder infiltrating urothelial carcinoma. To improve the management of bladder urothelial carcinoma, prognostic factors are required. One such factor is angiogenesis, which affects growth, development and metastasis. Vascular endothelial growth factor (VEGF) is the main pro-angiogenic factor to control angiogenesis. Expression of VEGF is correlated with progression of bladder infiltrating urothelial carcinoma, such as grade and lymphovascular invasion. The aim of this study was to determine the correlation of VEGF expression with grade of differentiation and lymphovascular invasion in bladder infiltrating urothelial carcinoma. Methods This research was a retrospective observational cross sectional study with 48 cases of bladder infiltrating urothelial carcinoma in four Anatomical Pathology Laboratory in West Sumatera 2018 and 2019. Samples were reevaluated of HE slide for grade of differentiation and lymphovascular invasion. VEGF expressions in tumor cell s were analyzed using immunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant. Results Bladder infiltrating urothelial carcinoma high grade had more positive VEGF expression (91.7%), while low grade had more negative VEGF expression (58.3%). Lymphovascular invasion positive was mostly found with positive VEGF expression (75%). Statistical analysis showed significant correlation between VEGF expression with grade of differentiation (p=0.001) and lymphovascular invasion (p=0.004). Conclusion The conclusion was VEGF expression had significant correlation with grade of differentiation and lymphovascular invasion of bladder infiltrating urothelial carcinoma.
Hubungan antara Ekspresi Epidermal Growth Factor Receptor (EGFR) dengan Derajat Histopatologik dan Invasi Perineural pada Adenokarsinoma Prostat Ria Oktavia; R. Zuryati Nizar; Yenita; Tofrizal
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.458

Abstract

ABSTRAKLatar belakangEpidermal Growth Factor Receptor (EGFR) berperan penting pada karsinogenesis beberapa karsinoma termasuk karsinoma prostat.Overekspresi EGFR pada adenokarsinoma menyebabkan sel tumor menjadi resisten terhadap terapi hormonal. Tujuan penelitian iniuntuk mengetahui hubungan antara ekspresi EGFR dengan derajat histopatologik dan invasi perineural pada adenokarsinomaprostat.MetodePenelitian ini merupakan penelitian observasional dengan desain cross sectional dengan sampel penelitian sebanyak 60 kasusadenokarsinoma prostat yang telah didiagnosis di 5 Laboratorium Patologi Anatomik di Sumatera Barat periode Januari 2015 sampaiDesember 2017. Sampel diperoleh dari blok parafin yang berasal dari jaringan hasil operasi transuretral resection of prostat (TURP)dan prostatektomi kemudian dilakukan reevaluasi terhadap derajat histopatologik dan invasi perineural. Ekspresi EGFR pada seltumor dilihat dengan pewarnaan imunohistokimia. Analisis statistik menggunakan uji Chi-Square.HasilEkspresi EGFR positif ditemukan pada 38 kasus (63,33%) dan kasus terbanyak dengan EGFR positif adalah poorly differentiated(57,9%). Kasus adenokarsinoma prostat dengan invasi perineural paling banyak ditemukan dengan ekspresi EGFR positif (42,1%).Analisis statistik menunjukkan terdapat hubungan bermakna antara ekspresi EGFR dengan derajat histopatologik (p=0,003) dan tidakterdapat hubungan yang bermakna antara ekspresi EGFR dengan invasi perineural (p=0,129).KesimpulanTerdapat hubungan yang bermakna antara ekspresi EGFR dengan derajat histopatologik pada adenokarsinoma prostat dan tidakterdapat hubungan antara ekspresi EGFR dengan invasi perineural.