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All Journal Jurnal Natur Indonesia Jurnal Ilmu Lingkungan Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Riset Kimia Jurnal Penelitian Farmasi Indonesia JURNAL PHOTON
Adel Zamri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Environmental Science Mathematics Medicine & Pharmacology Nursing Physics

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Synthesis of 4-(5-(2,3-Dimenthoxyphenyl)-3-(4-Methoxyphenyl)-4,5-Dihydro-1H-Pyrazol-1-y1) Benzenesulfonamide as a Promosing Tyrosinase Inhibitor Candidate Rahayu, Rahayu; Herfindo, Noval; Oscifiani, Nelly; Frimayanti, Neni; zamri, Adel
Jurnal Riset Kimia Vol 13, No 1 (2022): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v13i1.486

Abstract

In this study, titled compound 5 has been successfully synthesized with 93% yield. The pyrazoline compound was obtained from the cyclocondensation reaction of 4-hydrazinylbenzenesulfonamide 3 with chalcone (E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 4 under basic conditions. The molecular structure was confirmed through analysis of FTIR, NMR and HRMS spectroscopic data. Furthermore, its tyrosinase enzyme inhibitory activity was determined through in vitro assay against tyrosinase of Agaricus bisporus. However, the pyrazoline compound 5 showed lower inhibitory activity than the positive control, kojic acid, whereas the IC50 value of the compound 5 is higher than that of kojic acid. The compound 5 IC50 value was 262.15 µM, while kojic acid IC50 value was 88.52 µM.
PENYERAPAN TIMBAL (Pb) PADA SISTIM ORGAN IKAN MAS (Cyprinus carpio L) Yusni Ikhwan Siregar; Adel Zamri; Helmi Putra
Jurnal Ilmu Lingkungan Vol 6, No 1 (2012): Jurnal Ilmu Lingkungan
Publisher : Program Pascasarjana Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jil.6.1.p.43-51

Abstract

A study on the uptake of Pb in the organ system of carp was carried out in the laboratoryscale. The research aims to identify the uptake rate of Pb in the gill, intestine and muscle ofthe fish. A completely randomized design was done in the experiment laboratory with threetreatments and three replications. The total of 120 fish were exposed to three concentrationsof Pb (1, 3 and 5 ppm of PbNO3) in nine aquarium for 168 hours. Pb concentration in the organsystem of fish were analyzed at 24, 96 and 168 hours, respectively. The concentration of Pbin the intestine were 0.29, 0.44 and 0.47 ppm, for 24, 96 and 168 hour exposure, respectively.Meanwhile, Pb content in the gill were 0.21, 0.39 and 0.45 ppm, respectively. It revealed thatPb concentration in all organs of fish increased significantly (P<0.05) following increased ofexposure time.
S SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA 3ꞌ-BROMO-4-METOKSI KALKON TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli Rahma Dona; Haiyul Fadhli; Adel Zamri; Winda Tria Safitri; Abdi Wira Septama
Jurnal Penelitian Farmasi Indonesia Vol. 11 No. 2 (2022): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v11i2.1547

Abstract

Chalcone is a flavonoid derivative that has a variety of interesting biological activities. One of the compounds suspected of being an antibacterial agent is chalcone. The properties of chalcone compounds depend on the substituents that depend on the two aromatic rings, such as Cl, Br, OH groups and so on. The purpose of this study was to synthesize chalcone analogue compounds and determine the potential of these analog compounds as antibiotics. In this research, a chalcone analogue compound has been successfully synthesized, namely 3ꞌ-Bromo-4-methoxy-chalcone through the stirring method using KOH catalyst, ethanol solvent. The results of the synthesis carried out by recrystallization and the yield obtained were 64 %. Identification of compounds that have been carried out by TLC test, melting point, and HPLC analysis. The structure of the compound was characterized by UV-Vis spectroscopy, FTIR and 1H NMR, indicating that the analogue chalcone compound has a structure as expected. Testing the activity of chalcone analogue compounds was carried out on Staphylococcus aureus and Escherichia coli at a concentration of 1%, 5%, 10% and 20% test solutions. The test results showed that the antibacterial activity of the compound 3ꞌ-Bromo-4-methoxy-chalcone was categorized as weak.
Co-Authors -, Lelani Abdi Wira Septama Darian Alfatos David Aprianto, David Destawira Hariani Elka Yuslinda Fitrah Hayati Gasella, Raja Mutya Haiyul Fadhli Helmi Putra Herfindo, Noval Hilwan Yuda Teruna Ibnu Rush Ikhtiarudin, Ihsan Jasril Jasril Kamal Rullah Karsana, Elsaria Kurniati, - Lusrianti, - Neni Frimayanti, Neni Nur Balatif Oktavia, Denaria Oscifiani, Nelly Putri Bela Utama Rahayu Rahayu Rahma Dona Rahma Dona, Rahma Rahmi Miftahul Jannah Rahmita, Rahmita Riki Setiawan Rokim, Muhamad Siti Aisyah Syamsul Rizal Syilfia Hasti Widya Rachmi Winda Tria Safitri Yuana Nurulita Yuharmen - Yuharmen, - Yum Eryanti Yusni Ikhwan Siregar