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All Journal ad-Dawaa : Journal of Pharmaceutical Sciences Journal Microbiology Science
Rachmat Kosman
Universitas Muslim Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Efek Hipoglikemik Ekstrak Etanol Daun Kelor (Moringa oleifera L.) pada Tikus Putih (Rattus norvegicus) Jantan Rizqi Nur Azizah; Rachmat Kosman; Syarifah Khaerunnisa
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 1 No 2 (2018)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.091 KB) | DOI: 10.24252/djps.v1i2.11335

Abstract

Daun Kelor (Moringa oleifera L.) secara empiris digunakan oleh masyarakat sebagai antidiabetes. Penelitian ini  bertujuan untuk menentukan pengaruh pemberian ekstrak etanol daun kelor terhadap penurunan kadar glukosa darah tikus putih. Penelitian ini menggunakan 15 ekor tikus jantan yang dibagi menjadi 5 kelompok. Kelompok I merupakan kontrol negatif yang diberikan larutan Na.CMC 1%. Kelompok II, III dan IV adalah kelompok perlakuan yang diberikan ekstrak etanol daun kelor, berurutan, 50, 100, dan 150 mg/Kg BB. Kelompok V merupakan kontrol positif diberikan suspensi glibenklamid®. Sebelum perlakuan tikus dipuasakan selama 18 jam kemudian diinduksi dengan aloksan 150 mg/KgBB. Pengukuran kadar glukosa dilakukan pada hari ke 1, ke 3, ke 5, ke 7 dan ke 9. Hasil penelitian yang dilakukan menunjukkan ekstrak etanol daun kelor dapat menurunkan kadar glukosa darah. Dosis 100 mg/Kg BB memberikan efek penurunan kadar glukosa yang optimal dibandingkan dengan dosis ekstrak lainnya.
Antibacterial Activity of Extra Ethanol Kopasanda Leaves (Chromolaena Odorate L.) Against Pathogenic Bacteria of Urinary Tract Infection by TLC-Bioautography and Agar Diffusion Alif Yusra Wirawan; Rachmat Kosman; Herwin Herwin
Journal Microbiology Science Vol 3, No 2 (2023)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v3i2.979

Abstract

Kopasanda  (Chromolaena odorata L.) leaves are one of the plants (herbs) containing various types of secondary metabolites, including saponins, tannins, alkaloids, and flavonoids, which function as antibacterial agents used as wound medicine for the community. This study aims to determine the antibacterial activity of the ethanol extract of Kopasanda (Chromolaena odorate L.) leaves using the TLC-bioautography and diffusion methods. The results of the antibacterial activity screening test obtained the active extract at a concentration of 0.1% against Escherichia coli and Staphylococcus aureus. The results of the antibacterial activity test using the TLC-Bioautography method with the eluent N-Hexane:Ethyl Acetate (4:1) showed results from Staphylococcus aureus bacteria with Rf values = 0.90, 0.78, 0.67, 0.52, 0.38, 0.27, 0.14, 0.05, and Escherichia coli bacteria with Rf values = 0.90, 0.52, 0.38, 0.27, 0.14, 0.05. Based on the results of testing the antibacterial activity with the agar diffusion method, the largest diameter of the inhibition zone at a concentration of 10% was obtained for Escherichia coli bacteria with an inhibition zone diameter of 13.59 mm, and Staphylococcus aureus with an inhibition zone diameter of 15.52 mm.
Co-Authors Alif Yusra Wirawan Herwin Herwin Rizqi Nur Azizah Syarifah Khaerunnisa