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All Journal The Indonesian Journal of Community and Occupational Medicine
Irwan Suhadi
Post Graduate of Occupational Medicine Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Health Professions Medicine & Pharmacology

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Relationship Between Shift Work and the Risk of Prostate Cancer: An Evidence Base Case Report Irwan Suhadi; Indah Widyahening; Muhammad Ilyas
The Indonesian Journal of Community and Occupational Medicine Vol. 1 No. 1 (2021): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.24 KB) | DOI: 10.53773/ijcom.v1i1.4.23-31

Abstract

Prostate cancer has been associated with jobs that involve some degree of work at night. In 2007, the International Agency for Research on Cancer (IARC) concluded that shift work involving circadian disruption was probably carcinogenic in humans. Exposure to artificial LAN (Light at Night) suppresses pineal melatonin secretion and subsequently leads to an increase of sex hormones, which in turn could increase the susceptibility to hormone-dependent cancers. Disruption of the circadian rhythm regulated by several clock genes controlling apoptosis and cell proliferation, repeated phase shifting leading to internal desynchronisation and defects in the regulation of the circadian cell cycle, and also sleep deprivation alters immune function. In this case, the authors assessed the relationship between workers in a manufacture company who had worked shift work for 30 years and an increased risk of prostate cancer. This case takes evidence base from several journals that support this hypothesis while doing a critical appraisal to determine its validity and applicability.
Co-Authors Indah Widyahening Muhammad Ilyas