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Solitary Fibrous Tumor: A Retrospective Study on Histopathologic Features and Immunohistochemistry Staining at Cipto Mangunkusumo Hospital Nurjati Chairani Siregar; Aina Angelina; Immanuel Natanael Tarigan
eJournal Kedokteran Indonesia Vol 6, No 2 (2018): Vol 6, No. 2 (2018): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Solitary fibrous tumor (SFT), is a rare mesenchymal spindle cell tumor and its biological behavior is hard to predict. There is no characteristic clinical manifestation and morphologic features showed broad spectrum, so often diagnosed as other spindle cell mesenchymal tumor, benign or malignant. In most cases, immunohistochemistry staining (IHC) is needed to diagnose SFT. The aim of this retrospective study is to see demographic data, histopathological features and the importance of IHC staining diagnosis of SFT. Secondary data was obtained from Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia in 2010-2016. There were 35 samples included in this review; most are male (20 cases) aged <55 years old. Thirty one cases were in the extrapleural site and most of the tumor is less than 5 cm in diameter. There are 20 cases of cellular SFT while the other is fibrous SFT. Commonly, cellular SFT shows moderate cellularity and pleiomorphism. Fibrous SFT are well circumscribed and without necrosis. There are only 3 cases of malignant SFT which is located in intra-abdominal and orbit. Generally, SFT is benign, small, and well circumscribed. Most of the cases are cellular than fibrous; mild to moderate nuclear pleiomorphism, mitotic activity low, and without necrotic. Features of malignant SFT are hypercellularity, moderate to high nuclear pleiomorphism, mitotic >4/10 high power field (HPF) and necrosis. Most SFT are benign, some may recurrence and metastasize.
PROFIL KLINIKOPATOLOGI ADENOKARSINOMA PROSTAT DI RSUD DR. SAIFUL ANWAR MALANG PERIODE TAHUN 2015 - 2019: SEBUAH PENELITIAN RETROSPEKTIF Ulfaningtyas, Kiki; Norahmawati, Eviana; Anita, Kenty Wantri; Angelina, Aina; Seputra, Kurnia Penta
Majalah Kesehatan FKUB Vol 8, No 2 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.02.4

Abstract

Kanker prostat adalah penyebab keganasan ke-5 pada pria di Indonesia. Atas dasar ini, dilakukan penelitian yang bertujuan  untuk  mengetahui  profil klinikopatologi pasien yang terdiagnosis adenokarsinoma  prostat  di Laboratorium Patologi Anatomi RSUD Dr. Saiful Anwar (RSSA) Malang. Penelitian ini dilakukan secara deskriptif retrospektif dengan data diperoleh dari rekam medis pada Laboratorium Patologi Anatomi RSUD Dr. Saiful Anwar Malang tahun 2015-2019. Kriteria inklusi sampel penelitian adalah semua kasus yang terdiagnosis adenokarsinoma prostat secara histopatologis. Sedangkan spesimen dengan kecurigaan adenokarsinoma prostat yang masih harus dilakukan pemeriksaaan imunohistokimia dikeluarkan dari penelitian. Penelitian menunjukkan penderita adenokarsinoma prostat di Laboratorium Patologi Anatomi RSSA Malang periode tahun 2015-2019 sebanyak 84 (7,58%) kasus, memiliki rentang umur 52-88 tahun, dengan rata-rata usia 68 tahun.  Paling banyak terdiagnosis dari spesimen kerokan, sebanyak 48 (57,14%) kasus.  Sebagian besar diagnosis klinis sesuai dengan hasil pemeriksaan histopatologinya yakni 55 (65,48%) kasus. Derajat diferensiasi yang terbanyak adalah poorly differentiated sebanyak 46 (54,76%) kasus dan prognostic Gleason group grade terbanyak didapatkan grade 4 sebanyak 25 (29,76%) kasus. Dapat disimpulkan kasus adenokarsinoma prostat  rata-rata terjadi pada usia 68 tahun, paling banyak didiagnosis pada bahan kerokan. Sebagian besar kasus memiliki kesesuaian antara diagnosis klinis dan diagnosis histopatologi.  Kasus yang didiagnosis umumnya termasuk dalam kategori poorly differentiated dan prognostic Gleason group grade  4.
Adenoid Cystic Carcinoma Nasal Yohanes Sudarmanto; Soehartono; Aina Angelina; Hendy Yudhanto; Anggie Putri
Jurnal Klinik dan Riset Kesehatan Vol 1 No 2 (2022): Februari
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (858.04 KB) | DOI: 10.11594/jk-risk.01.2.8

Abstract

Background: Sinonasal neoplasms are uncommon. Adenoid cystic carcinoma (ACC) is the 2nd commonest sinonasal malignancy, characterized by an indolent and slow growth but relatively high local recurrence and distant metastasis rate. Surgical management followed by adjuvant radiation therapy is the mainstay of treatment for sinonasal ACC. Surgical approach is modified according to the tumor size and location.In general, prognosis of sinonasal neoplasms is poor. Factors that contribute the overall prognosis such as type of histopathological findings, absent of perineural or perivascular invasion and distant metastases, site of tumour, age of patient and treatment modality. Aim: To report a case of nasal ACC with regional metastases treated with surgical management followed radiation therapy. Case Report: A 70-years-old man came to the ENT clinic at RSUD dr. Saiful Anwar Malang with right nasal obstruction and history of right epistaxis for 12 months. The patient underwent surgical using lateral rhinotomy approach with Moure’s incision, histopatological specimen revealed a cribiform type ACC. Conclusion: Surgical management and adjuvant radiation therapy is the gold standard for sinonasal ACC Longterm evaluation is a mandatory according to the high incidence of local recurrence and distant metastases of sinonasal ACC.
Profil Klinikopatologi Karsinoma Payudara di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang Rita Ervina; Eviana Norahmawati; Aina Angelina
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Oktober
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1871.232 KB) | DOI: 10.11594/jk-risk.01.1.3

Abstract

Kanker payudara pada wanita menempati urutan pertama kanker primer tersering, dengan tingkat kematian tinggi. Penelitian ini bertujuan memberikan data gambaran dasar profil klinikopatologi dan imunohistokimia karsinoma payudara invasif karena belum ada data profil klinikopatologi kanker payudara di RSUD Dr. Saiful Anwar Malang. Penelitian ini observasional deskriptif, teknik total sampling, desain penelitian Cross Sectional. Menggunakan data dari rekam medis di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang periode Januari 2018 - Maret 2020. Variabel yang diukur usia, lokasi payudara, jenis spesimen, histopatologi, derajat keganasan histopatolgis (grading), dan profil immunohstokimia. Hasil menunjukkan kejadian karsinoma payudara invasif terbanyak pada tahun 2019 sebanyak 270 kasus (50%), rentang usia tertinggi antara 46 - 55 tahun sebanyak 142 orang (28%). Teknik pengambilan sampel dengan cara mastektomi sebesar 316 (58%) dibandingkan biopsi sebanyak 226 (42%), lokasi tersering terjadinya karsinoma tidak didapatkan perbedaan bermakna antara payudara kanan atau kiri. Jenis histopatologi terbanyak Invasif Carcinoma of No Special Type (NST) sebesar 475 kasus (88%) dari 542 kasus karsinoma payudara invasif, derajat keganasan histopatologi terbanyak adalah grade III sejumlah 240 kasus (47%). Berdasarkan profil imunohistokimia, Luminal A merupakan kategori tebanyak sebesar 44 kasus (31%), dibandingkan Luminal B, Ekspresi HER2 ataupun kanker payudara tripel negatif. Kesimpulannya adalah usia terbanyak penderita karsinoma invasif payudara terjadi pada usia 46-55 tahun, tidak terdapat perbedaan distribusi karsinoma payudara pada payudara kanan atau kiri, jenis spesimen terbanyak diambil dari Teknik mastektomi, jenis histopatologi terbanyak yaitu invasive carcinoma of NST, derajat keganasan histopatologi terbanyak pada grade III, luminal A terbanyak pada pemeriksaan imunohistokimia karsinoma payudara invasif.
Plasma cell myeloma: Pendekatan diagnosis dari aspek kliniko-morfologik dan imunofenotipe Aina Angelina; Diah Retnani
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.5

Abstract

Plasma cell myeloma (PCM)/Mutiple myeloma (MM) is hematologic malignancy characterized by the proliferation of neoplastic plasma cells of bone marrow. The manifestation of disease include multifocal lytic bone lesions, increased serum or urine M protein, target organ damage, and can present as an extramedullary mass. Extramedullary tumor mass biopsy can show morphology that overlaps with other plasma cell neoplasms or malignant lymphoma, this become a diagnostic challenge especially if the clinical and radiological information is incomplete. End-organ damage attributable to abnormal plasma cell proliferation is known as CRAB consist of hypercalcemia, renal insufficiency, anemia and bone lesions. The clinical spectrum often varies so the diagnosis of PCM requires the integration of clinical, laboratory, imaging, morphology, and immunophenotype data. Histopathological examination of bone marrow biopsy and tumor mass biopsy needs to be confirmed by immunohistochemical examination and clonality tests to establish an accurate diagnosis. This review intends to explain the clinical, morphological and immunophenotypic aspects as well as construct an approach to the diagnosis of PCM.