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All Journal Program Kreativitas Mahasiswa - Penelitian MNJ (Malang Neurology Journal)
Ni Putu Jeny Mardiati
Program Studi Ilmu Keperawatan, Fakultas Kedokteran, Universitas Brawijaya
Neuroscience

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EKSTRAK CACING TANAH SEBAGAI INOVASI PENYEMBUHAN ULKUS DIABETIK BERBASIS INDUKSI DENSITAS AKSON Mardiati, Ni Putu Jeny; Yunitasari, Arinda Nur; Sari, Dwi Astika; Saraswasta, I Wayan Gede; Putra, Fetreo Negeo; Kristianto, Heri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (435.784 KB)

Abstract

Reduction of nerve growth factor expression in diabetic ulcer affects overall wound healing. Earthworm (Pheretima aspergillum) can stimulate schwann cell proliferation and migration to support axonal elongation. The objective of this study is to compare wound healing functions in diabetic ulcer of rats using earthworm extract, hydrogel, and conventional dressing. This study applied a true-experimental posttest only controlled group design. 21 days after treatment, the group receiving earthworm extract had a significantly higher percentage of wound contraction and axonal density compared to the control group (p<0.05). These results show that earthworm extract can promote wound healing in diabetic ulcer. Keywords: Diabetic Ulcer, Earthworm (Pheretima aspergillum), Wound Contraction, Peripheral Nerve Regeneration.
THE EFFECTS OF EARTHWORMS’ (PHERETIMA ASPERGILLUM) ETHANOL EXTRACT TOWARD THE IMPROVEMENT OF NERVE FIBERS DENSITY IN DIABETIC ULCERS CARE DEGREE II OF RATS WISTAR Kristianto, Heri; Mardiati, Ni Putu Jeny
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.533 KB) | DOI: 10.21776/ub.mnj.2017.003.02.3

Abstract

Background. Diabetic ulcer is a chronic complication of diabetes mellitus which lead to infection and lower extremity amputation. Earthworm (Pheretima aspergillum) has bioactive substance of IGF-1 (insulin like growth factor 1) to promote Schwann cell proliferation, survival, and migration into the distal end in the injured nerve area to support axonal re-growth.Objective. To investigate the effect of earthworm extract (Pheretima aspergillum) on the enhancement of nervous fibers density in rats induced diabetic ulcer stage II.Methods. This study applied a true-experimental posttest only controlled group design. Samples were divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. The patterns of nervous fibers connecting to hair follicles were identified using silver impregnation stain.Results. The result shows the groups receiving earthworm extract have significantly higher nervous fibers density compared to the control groups (p=0.000). The administered of earthworm extract via topical has an optimal effect on improving nervous fibers density.Conclusion. Earthworm extract promote regeneration of peripheral nerve in rats model of diabetic.
Co-Authors Arinda Nur Yunitasari Dwi Astika Sari Fetreo Negeo Putra Heri Kristianto I Wayan Gede Saraswasta