I Wayan Gede Saraswasta
Program Studi Ilmu Keperawatan, Fakultas Kedokteran, Universitas Brawijaya

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EKSTRAK CACING TANAH SEBAGAI INOVASI PENYEMBUHAN ULKUS DIABETIK BERBASIS INDUKSI DENSITAS AKSON Mardiati, Ni Putu Jeny; Yunitasari, Arinda Nur; Sari, Dwi Astika; Saraswasta, I Wayan Gede; Putra, Fetreo Negeo; Kristianto, Heri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Reduction of nerve growth factor expression in diabetic ulcer affects overall wound healing. Earthworm (Pheretima aspergillum) can stimulate schwann cell proliferation and migration to support axonal elongation. The objective of this study is to compare wound healing functions in diabetic ulcer of rats using earthworm extract, hydrogel, and conventional dressing. This study applied a true-experimental posttest only controlled group design. 21 days after treatment, the group receiving earthworm extract had a significantly higher percentage of wound contraction and axonal density compared to the control group (p<0.05). These results show that earthworm extract can promote wound healing in diabetic ulcer. Keywords: Diabetic Ulcer, Earthworm (Pheretima aspergillum), Wound Contraction, Peripheral Nerve Regeneration.