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All Journal Jurnal Sains dan Teknologi Farmasi AcTion: Aceh Nutrition Journal
Noni Zakiah
Pascasarjana Fakultas Farmasi Universitas Andalas
Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Toksisitas Perkembangan Siprofloksasin dan Studi Histologi Terhadap Mencit Putih Zakiah, Noni; Almahdy, Almahdy; Muchtar, M. Husni
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study was conducted to determine the “development toxicity” of ciprofloxacin and litters kidney. The aim of this study was to observe teratogenic effect of ciprofloxacin, and observing its effect on behaviour development and litters kidney. Twenty four pregnant mice were divided into 4 groups : control, and treatments with oral dose of ciprofloxacin of 14,3 mg, 28,5 mg, and 57,1 mg/kg body weight/day for 10 days, coincided with sixth day until fifteenth day of pregnancy for prenatal and posnatal test. Half of the animals were killed on day 18 of gestation and the others half were allowed to deliver. Fetuses were removed by caesarean section. For postnatal test, ciprofloxacin exposed at first day of lactation until weaning. Behaviour toxicity was conducted by Behavioral Test Battery, and observing its effect on litters kidney by paraffin method. Quantitative data were analyzed with Anova and Duncan’s Multiple Range Test. Results showed that teratogenic effects of ciprofloxacin were fetuses death, resorption and hemorrhage. For behaviour toxicity, delayed ability was noticed at 28,5 mg/kg BW obviously, histologically there were disturbances of kidney, which were the thickening of bowman’s capsule, constriction of glomerular capillaries and necrosis.
ARSENIC CONTAMINATION SURVEY IN WHITE RICE IN ACEH Hanum, Farida; Sudiarto, Dwi; Zakiah, Noni; Safwan, Safwan; Al Rahmad, Agus Hendra
AcTion: Aceh Nutrition Journal Vol 4, No 2 (2019): AcTion Vol 4 No 2 Tahun 2019
Publisher : Jurusan Gizi Politeknik Kesehatan Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (924.072 KB) | DOI: 10.30867/action.v4i2.177

Abstract

White rice as the major staple food for Indonesian people has the opportunity to be contaminated with chemical hazards. Research in USA shows that arsenic is contained in rice. The arsenic emissions of 75% are estimated to originate from the mining, fertilizers and pesticides. This study aims to determine qualitatively arsenic contamination of white rice consumed by Acehnese people and how to cook it. A total of 30 white rice samples were obtained with purposive technique from the Aceh Health Polytechnic employees who brought breakfast. The the consideration that they come from various regions in Aceh. Arsenic analysis contamination in samples was carried out using arsenic test kit. Data collected is in the form of interviews about white rice cooking techniques and the analysis of arsenic contamination. The results showed that white rice consumed by the employees was safe from arsenic and that the rice cooking technique on a household is feasible. Besides that the arsenic test was also carried out on white rice sold in stalls, the results were positive. This indicates that white rice is consumed by people in Aceh, there are those which are contaminated with arsenic. This study provides evidence that the contamination is still present in rice which has been processed into rice cooked.  Keywords:   ABSTRAKNasi putih sebagai salah satu sumber makanan pokok di Indonesia memiliki peluang tercemar bahan kimia yang sangat berbahaya. Penelitian di USA menunjukkan bahwa arsen terkandung di dalam beras, 75% emisi arsen diperkirakan berasal dari aktivitas penambangan, pemupukan dan pestisida. Penelitian ini bertujuan untuk mengetahui cemaran arsen secara kualitatif pada nasi putih di Aceh dan bagaimana teknik memasaknya. Penelitian ini merupakan survey deskriptif berbasis laboratorium. Populasi adalah seluruh pegawai Poltekkes Kemenkes Aceh. Sebanyak 30 sampel nasi putih dicuplik secara purposif dari 30 orang pegawai yang membawa bekal sarapannya. Pertimbangan bahwa mereka berasal dari berbagai daerah di Aceh. Analisis arsen menggunakan arsen test kit. Data primer dikumpulkan dari hasil wawancara tentang teknik memasak nasi putih dan hasil analisis arsen pada nasi putih. Hasil penelitian menunjukkan bahwa nasi putih yang dikonsumsi oleh pegawai Poltekkes Kemenkes Aceh aman dari cemaran arsen. Hasil ini menegaskan bahwa teknik memasak nasi pada skala rumah tangga dapat menghasilkan nasi putih yang bebas dari cemaran kimia arsen. Analisis arsen juga dilakukan pada nasi putih yang dijual di warung sebagai pembanding, hasilnya positif. Ini menunjukkan bahwa nasi putih yang dikonsumsi oleh masyarakat Aceh, ada yang tercemar arsen. Penelitian ini membuktikan bahwa cemaran arsen masih ada pada beras yang telah diolah menjadi nasi.
Co-Authors Agus Hendra Al Rahmad Almahdy A Farida Hanum Muchtar, M. Husni Safwan Safwan, Safwan Sudiarto, Dwi