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ISOLASI DAN ELUSIDASI STRUKTUR SENYAWA TRITERPENOID DARI KULIT BATANG AMBACANG (Mangifera foetida L.) SERTA UJI BRINE SHRIMP LETALITY TEST (BSLT) Santoni, Adlis; -, Sabariah; Efdi, Mai
Jurnal Riset Kimia Vol 9, No 1 (2015): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v9i1.252

Abstract

A brine shrimp toxic compound has been isolated from Mangifera foetida L. steam bark. Based on spectroscopic data (IR,1H- NMR, 13C-NMR 1D and 2D), the structure of this compound was identified as mangiferenes B, C30H47O2. In this study, the n-hexane, ethyl acetate, methanol extracts and isolated compound showed toxic effects (LC50 471.9543; 534.5209, 678.4421, and 22.1615 μg/mL, respectively). The toxicity degree among the three extracts and isolated compound is isolated compound > n-hexane extract > ethyl acetate extract > methanol extract.
KAJIAN BIOAKTIFITAS DAN ANALISA KANDUNGAN SENYAWA METABOLIT SEKUNDER DARI TUMBUHAN Hornstedtia scyphifera var. fusiformis DENGAN HPLC (High Performance Liquid Chrimatography) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Zarah Vol 5 No 2 (2017): Jurnal Zarah
Publisher : Program Studi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.33 KB)

Abstract

Hornstedtia scyphifera var. fusiformis merupakan tumbuhan endemik dari famili Zingiberaceae yang tersebar di Sumatera. Tumbuhan ini  mengandung beberapa metabolit sekunder seperti fenolik, flavonoid, saponin, triterpenoid, steroid dan alkaloid. Pengujian Bioaktifitas meliputi uji antioksidan dan antibakteri. Aktivitas antioksidan ditentukan dengan metoda DPPH. Sedangkan aktivitas antibakteri diuji dengan metode difusi cakram terhadap bakteri Staphylococcus aureus (bakteri gram positif) dan Escherichia coli (bakteri gram negatif). Hasil analisa aktitifitas antioksidan dari ketiga ekstrak, diperoleh bahwa ekstrak metanol menunjukkan aktifitas antioksidan yang paling aktif dengan IC50 = 51,8943 mg/L dibandingkan dua ekstrak lainnya. Ketiga esktrak Hornstedtia scyphifera var. fusiformis memberikan aktivitas antibakteri, selanjutnya esktrak n-heksan dan etil asetat pada konsentrasi 500 ppm memiliki zona hambat 10 mm terhadap bakteri Escherichia coli  dan Staphylococcus aureus memiliki zona hambat 10,3 mm. Untuk mengetahui jumlah senyawa metabolit sekunder  yang terkandung dalam  tumbuhan ini dilakukan analisa dengan HPLC.
INHIBISI KOROSI BAJA RINGAN MENGGUNAKAN BAHAN ALAMI DALAM MEDIUM ASAM KLORIDA: Review Stiadi, Yeni; Arief, Syukri; Aziz, Hermansyah; Efdi, Mai; Emriadi, E.
Jurnal Riset Kimia Vol 10, No 1 (2019): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.321

Abstract

The corrosion of steel and its alloys is an important problem in industry, especially in acidic environments. Mild steel is one of the important alloys of iron which has many industrial applications because of its excellent mechanical properties, but mild steel is susceptible to corrosion. Corrosion problems need to be a concern and must be handled properly. Hydrochloric acid is widely used for pickling, cleansing, decomposition and metal etching, on the other hand also contributes to corrosion of metal surfaces. Plant extracts investigated the properties, mechanisms of adsorption and efficiency of inhibition as environmentally friendly corrosion inhibitors for various steel materials in different acidic media. The efficiency of corrosion inhibition of steel from plant extracts analyzed ranged from 72-98% and generally as a mixed-type inhibitor. Most of the inhibitors are adsorbed on the steel surface through a physisorption mechanism.
ISOLASI SENYAWA TRITERPENOID DAN UJI ANTIBAKTERI EKSTRAK n-HEKSAN DAUN KAYU ARA (Ficus aurata (Miq.) Miq) Santoni, Adlis; Efdi, Mai; Bumali, Restu
Jurnal Riset Kimia Vol 10, No 1 (2019): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.268

Abstract

Triterpenoid isolation from n-hexane extract of kayu ara leaves (Ficus aurata (Miq.) Miq) has been performed. The Isolation has been done by column chromatography method using silica gel as a stationary phase and n-hexane and ethyl acetate as mobile phase with isocratic method and it is continued by trituration method. Isolated compound has white amorphous shape, decomposed at 86-87ºC and gives single spot with reddish brown violet in LB reagent and in H2SO4 reagent on TLC test. UV spectra indicate the presence of double bonds in the isolated compound at 204 nm λmax and IR spectra showed -OH functional group at 3290 cm-1, -CH stretching at 2912,90 cm-1, C=C at 1676 cm-1, C-O stretching at 1054,93 cm-1, and at 1374 cm-1 is spectra of geminal dimethyl compound that are characteristic of triterpenoids which supports ultraviolet spectroscopic data. Antibacterial activity test showed that isolated compound is active in inhibiting the growth of gram-positive bacteria Staphyloccocus aureus and gram-negative bacteria Escherichia coli.
STUDI OPTIMASI EKSTRAKSI KANDUNGAN SENYAWA FENOLIK TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN DARI DAUN MANGGIS (Garcinia mangostana Linn.) Salim, Emil; Afritunando, Yogi; Febriana, Nindi Antika; Efdi, Mai
Jurnal Riset Kimia Vol 10, No 1 (2019): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.308

Abstract

This study aims to determine antioxidant activity and total phenolic content of mangosteen leaves in several different solvents. The antioxidant activity test of the extract was determined by the DPPH method and the total phenolic content was determined by the Folin-Ciocalteu method. The phytochemical test of mangosteen leaves showed the presence of phenolic compounds, saponins, triterpenoids and alkaloids. The extraction results increase with increasing water content in methanol, ethanol and acetone. The highest amount of extract was obtained using 50% acetone solvent (34.98 ± 0.17%). Extraction using 100% ethanol showed the highest total phenolic content (614.25 ± 5.58 mg GAE / g extract) and the lowest IC50 value (5.81 mg / L). The results of this study indicate that the use of 50% acetone solvent can optimize the amount of extract and 100% ethanol can optimize the content of total phenolic compounds and antioxidant activity of mangosteen leaves.
KAJIAN BIOAKTIFITAS DAN ANALISA KANDUNGAN SENYAWA METABOLIT SEKUNDER DARI TUMBUHAN Hornstedtia scyphifera var. fusiformis DENGAN HPLC (High Performance Liquid Chrimatography) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Zarah Vol 5 No 2 (2017): Jurnal Zarah
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.33 KB) | DOI: 10.31629/zarah.v5i2.205

Abstract

Hornstedtia scyphifera var. fusiformis merupakan tumbuhan endemik dari famili Zingiberaceae yang tersebar di Sumatera. Tumbuhan ini mengandung beberapa metabolit sekunder seperti fenolik, flavonoid, saponin, triterpenoid, steroid dan alkaloid. Pengujian Bioaktifitas meliputi uji antioksidan dan antibakteri. Aktivitas antioksidan ditentukan dengan metoda DPPH. Sedangkan aktivitas antibakteri diuji dengan metode difusi cakram terhadap bakteri Staphylococcus aureus (bakteri gram positif) dan Escherichia coli (bakteri gram negatif). Hasil analisa aktitifitas antioksidan dari ketiga ekstrak, diperoleh bahwa ekstrak metanol menunjukkan aktifitas antioksidan yang paling aktif dengan IC50 = 51,8943 mg/L dibandingkan dua ekstrak lainnya. Ketiga esktrak Hornstedtia scyphifera var. fusiformis memberikan aktivitas antibakteri, selanjutnya esktrak n-heksan dan etil asetat pada konsentrasi 500 ppm memiliki zona hambat 10 mm terhadap bakteri Escherichia coli dan Staphylococcus aureus memiliki zona hambat 10,3 mm. Untuk mengetahui jumlah senyawa metabolit sekunder yang terkandung dalam tumbuhan ini dilakukan analisa dengan HPLC.
EKSTRAKSI DAN IDENTIFIKASI SENYAWA ANTOSIANIN DARI JANTUNG PISANG RAJA (Musa x paradisica L.) SERTA UJI AKTIVITAS ANTIOKSIDANNYA Alvionita, Jessica; Darwis, Djaswir; Efdi, Mai
Jurnal Riset Kimia Vol 9, No 2 (2016): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v9i2.284

Abstract

Anthocyanin coumpound have been successfully extracted from plantain bud (Musa x paradisiaca L) which can used as natural colorant and antioxidant. Coumpound anthocyanin exracted using maceration method with solvent ethanol that has been acidified with acetic acid and citric acid until pH 1,5. The extract anthocyanin is identified by UV-Vis spectrophotometer (260-800 nm) and retrieved two peaks that is 277 nm (UV) and 533 nm (Visible). Further treatment is carried out with KCKT-DAD at a wavelength 516 nm. Anthocyanin treatment given temperature and pH. Total anthocyanin monomeric obtained for ethanol + acetic acid was 30,22 mg/L; ethanol + citric acid was 18,20 mg/L. The warming influence of the anthocyanin compound lead to degradation of color is highest for ethanol + acetic citric on temperature 100oC with percentage degradation of 61,97 %. The antioxidant activity of the extract was measured by 1,1- difenil-2-pikrilhidrazil (DPPH) the result showed that the anthocyanin extracts from Plantain bud has antioxidant activity ethanol + acetic citric acid extract is very active as an antioxidant with IC50  values of 3,74 mg/L.
Identifikasi Senyawa Metabolit Sekunder, Uji Antimikroba dan Antioksidan Ekstrak Akar Gantung Hornstedtia Scyphifera Var. Fusiformis Holttum (Sijangkang) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Riset Kimia Vol 10, No 2 (2019): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v10i2.264

Abstract

Hornstedtia scyphifera var. fusiformis Holttum is endemic plant of Zingiberaceae family that distributed in Sumatera. Hornstedtia scyphifera var. fusiformis Holttum contained some secondary metabolite such as phenolic, saponin, triterpenoid and alkaloid. The biological activity of methanol, ethyl acetate, and n-hexane extracts from Hornstedtia scyphifera var. fusiformis Holttum suspended roots was tested for antibacterial and antioxydant activity. Antioxidant activity was analized by DPPH method. The antibacterial activity  was tested by used disk difussion method againts Staphylococcus aureus bacteria (gram-positive bacteria) and Escherichia coli (gram-negative bacteria). Almost all of Hornstedtia scyphifera var. fusiformis Holttum suspended roots extract were given antibacterial activity, nonetheless the biggest inhibition zone of Escherichia coli that was inhibited by n-hexane and ethyl acetate extracts which have inhibtion zone 10 mm at  concentration 500 mg/L and also againts Staphylococcus aureus, the biggest inhibition by ethyl acetate and n-hexane extracts which have inhibition zone 10.30 mm at concentration 500 mg/L. Among all extracts tested, methanol extract of the possessed moderate free radical scavenging activity with IC50 = 51.89 mg/L.
Validasi Metode MPM untuk Penentuan Kandungan Antioksidan dalam Sampel Herbal serta Perbandingannya dengan Metode PM, FRAP dan DPPH Yefrida, Yefrida; Suyani, Hamzar; Aziz, Hermansyah; Efdi, Mai
Jurnal Riset Kimia Vol 11, No 1 (2020): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v11i1.342

Abstract

The Modified Phenanthroline Method (MPM) has been validated for determination of antioxidant content in herb samples. Validation was done using Relative Standard Deviation (RSD) and percentage of recovery. The RSD and percentage of recovery for herb samples are 3.13% and 98.6%, respectively. Based on these values, MPM method is valid for determining antioxidant content in herb samples. T test shows no significant differences of antioxidant content using any of these methods, MPM, PM, FRAP or DPPH, at a 95% confidence level. MPM method shows a very strong correlation with PM and FRAP method.  While with DPPH and TPC shows is strong.
The potency of secondary metabolites from traditional medicine plants as anti cancer agent Mai Efdi
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 2 | Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.498 KB)

Abstract

The seconday metabolites from traditional medicine plants have played an important role incancer treatment. Exploration of natural active compounds from medicinal plants for cancertreatment has attracted substantial attention worldwide. Several secondary metabolites thatwere isolated fom the plants, such as vincristne, vinblastine, campthothecins, have been usedhave been used clinically for over 40 years. Numerous techniques have been developedto obtain compounds for drug discovery including isolation from plants, synthetic chemistry,screening bioassays. As part of efforts to discover phytochemicals as anticancer agent, ourgroup were isolated several compunds mainly from Annonaceae and Melliaceae family thatshowed active againts human leukemia HL-60 cells.