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All Journal Indonesian Journal of Urology Technologic
Ahmad Kholis
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Automotive Engineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Electrical & Electronics Engineering Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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THE EFFECTIVENESS OF TNF-Α INHIBITOR THERAPY IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS Kholis, Ahmad; Soetojo; Djatisoesanto, Wahjoe
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.744

Abstract

Objective: To evaluate the effectiveness of TNF-α inhibitor therapy in Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) patients compared to placebo, assessed using Global Response Assessment (GRA). Material & Methods: A systematic review and meta-analysis. Subjects were patients with moderate to severe diagnosis of BPS/IC who were given TNF-α inhibitor versus placebo, with the Global Response Assessment (GRA) (patient-reported self-reported BPS/IC treatment response scale). A systematic literature search was carried out on the English databases PubMed/MEDLINE and Science Direct, published until September 2020. Data were extracted independently and assessed the bias and quality of each selected article. Results: Initially there were 124 studies. After further selection, 2 RCT studies were included in the criteria for this study. The number of samples obtained was 85 patients. There is 1 study that used 400 mg of certolizumab pegol subcutaneously and 1 study used adalimumab 80 mg subcutaneously and followed by 40 mg subcutaneously for 2 weeks. Both studies had statistically low heterogeneity with I2 = 0% (P = 0.34), so fixed effect statistical model was used to determine the result. Furthermore, there was no significant difference (P = 0.32) between the number of GRA responders from the TNF-α inhibitor and placebo therapy groups, with odds ratio of 1.61 (CI = 0.65-4.00). Conclusion: TNF-α inhibitor therapy did not increase GRA responders when compared to placebo.
TRAINING AND SHARING MANAGEMENT INFORMATION SYSTEM PT AKEBONO BRAKE ASTRA INDONESIA Suhendra Suhendra; Ahmad Kholis; Devi Lupita Putri
Technologic Vol 3, No 2 (2012): Technologic
Publisher : Politeknik Manufaktur Astra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52453/t.v3i2.44

Abstract

Training and Sharing Management Information System merupakan sistem pengelolaan proses training dan sharing yang terkomputerisasi dan dikembangkan di PT Akebono Brake Astra Indonesia. Saat ini, penjadwalan, pelaksanaan, dan evaluasi training dan sharing masih dilakukan secara manual. Training and Sharing Management Information System memberikan kemudahan dalam mengelola penjadwalan, pelaksanaan, serta evaluasi training dan sharing. Training and Sharing Management Information System dibuat dengan tahapan requirements, analysis, design, specification, implementation dan testing. Tahapan tersebut dilakukan secara berulang (iterative). Training and Sharing Management Information System dibangun menggunakan bahasa pemrograman PHP, database management system MySQL 5.1.41, web server Apache 2.2.14, SMS Gateway, dan memiliki arsitektur client-server.
Co-Authors Devi Lupita Putri Soetojo Soetojo Suhendra Suhendra wahjoe djatisoesanto