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All Journal PROSIDING SEMINAR NASIONAL Jurnal Kedokteran Brawijaya Jurnal Gizi dan Pangan Soedirman (JGPS)
Viva Ratih Bening Ati
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EFFECT OF ETHANOL EXTRACT OF SNAKE FRUIT‟S PEEL EFFECT ON URIC ACID AND CRP Pribadi, Fajar Wahyu; -, Setiawati; Ati, Viva Ratih Bening; Widiartini, Catharina; Panuntun, Hilmi Puguh
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Proceeding International Seminar of Occupational Health and Medical Sciences (I-SOCMED) 2017 â
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.211 KB)

Abstract

Unhealthy diet that consisted of high purine, derived from protein, had caused an increasing hyperuricemia-related disease in community. Anti-oxidant activity of snake fruit‟s peel had antihyperuricemia effect due to the flavonoid content. This study aimed to investigate the effect of ethanol extract of snake fruit‟s peel in reducing uric acid serum & C-Reactive Protein (CRP) level and to find outthe most effective dosage of the activity. The rats were grouped into 6 groups (negative control, positive control, Allopurinol, dosage I (105 mg/kgbw extract), dosage II (210 mg/kgbw) and dosage III (420 mg/kgbw). All, except negative control groups were fed by standard diet pellet mixed with 20 mg/day goat brain for 15 days. Serum uric acid and CRP level of all groups was measured on day 0,9 and 16. The result showed that the uric acid serum level of extract groups was lower than control groups and therewas CRP reduction in extract groups. The most effective dosage for reducing serum uric acid level was 420 mg/kgbw. Keyword : snake fruit‟s peel, uric acid serum, C-Reactive Protein (CRP)
Evaluasi Potensi Antidiabetes Sari Buah Markisa Ungu (Passiflora edulis var edulis) pada Tikus Model Diabetes Melitus yang Diinduksi Aloksan Muntafiah, Alfi; Pratama, Tisna Sendy; Ati, Viva Ratih Bening
Jurnal Kedokteran Brawijaya Vol 30, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.953 KB) | DOI: 10.21776/ub.jkb.2019.030.03.5

Abstract

Markisa ungu mengandung komponen nutrisi dan fitokimia non nutrisi, dan potensinya pada beberapa kondisi medis telah dilaporkan. Penelitian ini bertujuan mengeksplorasi potensi antidiabetes sari markisa ungu. Penelitian true experimental ini menggunakan 30 ekor tikus putih (Rattus norvegicus) jantan galur Wistar, dibagi 5 kelompok: I) kontrol normal,  II) kontrol DM, dan III, IV, V perlakuan sari markisa ungu dosis 1,05; 2,1; dan 4,2mL/200gBB/hari melalui sonde, selama 21 hari. Induksi diabetes dengan aloksan intraperitoneal 120mg/kgBB dosis tunggal. Sampel darah diambil sebelum induksi, setelah induksi dan setelah perlakuan, melalui vena infra orbita. Kadar GDP diukur menggunakan spektrofotometer. Uji Wilcoxon terhadap kadar GDP pasca induksi dan perlakuan, didapatkan p=0,000, menunjukkan perbedaan signifikan kadar GDP antar kelompok normal dan DM. Uji Kruskal-Wallis terhadap kadar GDP pasca perlakuan juga demikian, didapatkan p<0,05. Uji post hoc Mann-Whitney: I vs II p=0,006; I vs III p=0,006; I vs IV p=0,045; I vs V p=0,025; II vs III p=0,361; II vs IV p=0,917; II vs V p=0,584; III vs IV p=0,715; III vs V p=1,000; IV vs V p= 0,584, yang berarti perbedaan hanya antara kelompok normal dengan kelompok diabet dengan atau tanpa perlakuan sari markisa ungu, namun tidak ada perbedaan antar kelompok DM tanpa atau dengan perlakuan sari markisa ungu. Kesimpulan penelitian adalah tidak terdapat perbedaan kadar GDP antara kelompok kontrol DM dengan kelompok yang diberi perlakuan sari markisa ungu berbagai dosis. 
EFEK LAMA WAKTU PEMBERIAN EKSTRAK ETANOL SELEDRI (Apium graveolens L.) TERHADAP PENCEGAHAN PENINGKATAN KADAR IL-1β PADA TIKUS MODEL ISCHEMIA-REPERFUSION INJURY Afifah Afifah; Khusnul Muflikhah; Viva Ratih Bening Ati
Jurnal Gizi dan Pangan Soedirman Vol 3 No 2 (2019): Jurnal Gizi dan Pangan Soedirman
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.532 KB) | DOI: 10.20884/1.jgps.2019.3.2.2311

Abstract

Ischemia-reperfusion injury (IRI) is the condition that disrupted the blood supply to the organ followed by the restoration of blood flow. IRI in the kidneys promotes the inflammatory cascade. Interleukin-1β (IL-1β) belongs to the most powerful pro-inflammatory cytokine that released in the early phase of IRI. Prevention of inflammation is one of the strategies for reducing kidney damage due to IRI. Celery (Apium graveolens L) is a natural resource that reported has anti-inflammatory and antioxidant effects. This study aimed to investigate the effect of duration of the administration ethanol extract of celery on IL-1β level in the IRI rat model. Twenty-five rats male Sprague Dawley, 2-3 months old were divided into 5 groups: Sham operations (SO, n=5), Ischemia-reperfusion (IR, n=5), celery 1000 mg/ kg BW for 7 days before IR (IR7) (IR7, n=5), 14 days before IR (IR14, n=5), 28 days before IR (IR28, n=5). The IL-1β level was assessed using the ELISA. Data were analyzed using One-way ANOVA (p<0.05). The results showed that the mean of IL-1β levels in the IR7 group (5.99±4.28 ng/L) and R14 (4.68±2.64 ng/L) were lower than IR group (8.19±5.36 ng/L), while the R28 group (9.05 ± 4.38 ng/L) was higher than the IR group (8.19±5.36 ng/L). In conclusion, the administration of celery ethanol extract 1000 mg/ kg BW for 7 days and 14 days can prevent the increase of IL-1β level in the IRI rat model. Ischemia-reperfusion injury (IRI) adalah suatu keadaan yang terjadi ketika suplai darah sebagian atau seluruh organ terganggu diikuti pemulihan aliran darah. IRI pada ginjal memicu terjadinya inflamasi. Interleukin-1β (IL-1β) termasuk sitokin pro-inflamasi paling kuat yang keluar selama fase awal IRI. Pencegahan terhadap inflamasi merupakan strategi untuk menurunkan kerusakan ginjal akibat IRI. Seledri merupakan salah satu bahan alam yang diketahui mempunyai efek antiiflamasi dan antioksidan. Penelitian ini bertujuan mengetahui efek lama waktu pemberian ekstrak etanol seledri terhadap pencegahan peningkatan kadar IL-1β pada tikus model IRI. Sebanyak 25 ekor tikus jantan Sprague Dawley, 2-3 bulan, dikelompokkan menjadi 5, yaitu Sham Operation (SO, n=5), Ischemia-reperfusion (IR, n=5), seledri 1000 mg/kgBB selama 7 hari sebelum IR(IR7, n=5), 14 hari sebelum IR(IR14, n=5), dan 28 hari sebelum IR(IR28, n=5). Kadar IL-1β diukur menggunakan metode ELISA. Data dianalisis dengan One Way ANOVA (p<0,05). Rerata kadar IL-1β pada kelompok IR7 (5,99±4,28 ng/L) dan IR14 (4,68±2,64 ng/L) lebih rendah dibandingkan dengan kelompok IR (8,19±5,36 ng/L), sedangkan kelompok IR28 (9,05±4,38 ng/L) lebih tinggi dibandingkan dengan kelompok IR (8,19±5,36 ng/L). Pemberian ekstrak etanol seledri 1000 mg/kgBB selama 7 hari dan 14 hari dapat mencegah peningkatan kadar IL-1β pada tikus model IRI.
EFEK LAMA WAKTU PEMBERIAN EKSTRAK ETANOL SELEDRI (Apium graveolens L.) TERHADAP PENCEGAHAN PENINGKATAN KADAR IL-1β PADA TIKUS MODEL ISCHEMIA-REPERFUSION INJURY Afifah Afifah; Khusnul Muflikhah; Viva Ratih Bening Ati
Jurnal Gizi dan Pangan Soedirman Vol 3 No 2 (2019): JURNAL GIZI DAN PANGAN SOEDIRMAN
Publisher : Program Studi Ilmu Gizi, Jurusan Kesmas Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.532 KB) | DOI: 10.20884/1.jgps.2019.3.2.2311

Abstract

Ischemia-reperfusion injury (IRI) is the condition that disrupted the blood supply to the organ followed by the restoration of blood flow. IRI in the kidneys promotes the inflammatory cascade. Interleukin-1β (IL-1β) belongs to the most powerful pro-inflammatory cytokine that released in the early phase of IRI. Prevention of inflammation is one of the strategies for reducing kidney damage due to IRI. Celery (Apium graveolens L) is a natural resource that reported has anti-inflammatory and antioxidant effects. This study aimed to investigate the effect of duration of the administration ethanol extract of celery on IL-1β level in the IRI rat model. Twenty-five rats male Sprague Dawley, 2-3 months old were divided into 5 groups: Sham operations (SO, n=5), Ischemia-reperfusion (IR, n=5), celery 1000 mg/ kg BW for 7 days before IR (IR7) (IR7, n=5), 14 days before IR (IR14, n=5), 28 days before IR (IR28, n=5). The IL-1β level was assessed using the ELISA. Data were analyzed using One-way ANOVA (p<0.05). The results showed that the mean of IL-1β levels in the IR7 group (5.99±4.28 ng/L) and R14 (4.68±2.64 ng/L) were lower than IR group (8.19±5.36 ng/L), while the R28 group (9.05 ± 4.38 ng/L) was higher than the IR group (8.19±5.36 ng/L). In conclusion, the administration of celery ethanol extract 1000 mg/ kg BW for 7 days and 14 days can prevent the increase of IL-1β level in the IRI rat model. Ischemia-reperfusion injury (IRI) adalah suatu keadaan yang terjadi ketika suplai darah sebagian atau seluruh organ terganggu diikuti pemulihan aliran darah. IRI pada ginjal memicu terjadinya inflamasi. Interleukin-1β (IL-1β) termasuk sitokin pro-inflamasi paling kuat yang keluar selama fase awal IRI. Pencegahan terhadap inflamasi merupakan strategi untuk menurunkan kerusakan ginjal akibat IRI. Seledri merupakan salah satu bahan alam yang diketahui mempunyai efek antiiflamasi dan antioksidan. Penelitian ini bertujuan mengetahui efek lama waktu pemberian ekstrak etanol seledri terhadap pencegahan peningkatan kadar IL-1β pada tikus model IRI. Sebanyak 25 ekor tikus jantan Sprague Dawley, 2-3 bulan, dikelompokkan menjadi 5, yaitu Sham Operation (SO, n=5), Ischemia-reperfusion (IR, n=5), seledri 1000 mg/kgBB selama 7 hari sebelum IR(IR7, n=5), 14 hari sebelum IR(IR14, n=5), dan 28 hari sebelum IR(IR28, n=5). Kadar IL-1β diukur menggunakan metode ELISA. Data dianalisis dengan One Way ANOVA (p<0,05). Rerata kadar IL-1β pada kelompok IR7 (5,99±4,28 ng/L) dan IR14 (4,68±2,64 ng/L) lebih rendah dibandingkan dengan kelompok IR (8,19±5,36 ng/L), sedangkan kelompok IR28 (9,05±4,38 ng/L) lebih tinggi dibandingkan dengan kelompok IR (8,19±5,36 ng/L). Pemberian ekstrak etanol seledri 1000 mg/kgBB selama 7 hari dan 14 hari dapat mencegah peningkatan kadar IL-1β pada tikus model IRI.
Co-Authors Afifah Afifah Alfi Muntafiah Fajar Wahyu Pribadi, Fajar Wahyu Khusnul Muflikhah Panuntun, Hilmi Puguh Pratama, Tisna Sendy Setiawati - Widiartini, Catharina