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All Journal Biomedika JPSCR : Journal of Pharmaceutical Science and Clinical Research
Ika Trisharyanti, Ika
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Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health

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ANTIOKSIDAN EKSTRAK ETANOL 70% DAUN SYZYGIUM POLYANTHUM (WIGHT) (SALAM) SECARA INVITRO Sutrisna, EM; Trisharyanti, Ika; Munawaroh, Rima; ., Suprapto
Biomedika Vol 7, No 1 (2015): Biomedika Februari 2015
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Radikal bebas merupakan satu faktor kontributor terjadinya penyakit degenerative. Antioksidan merupakan senyawa yang menghambat efek radikal bebas tersebut. Pada penelitian sebelumnya, ekstrak methanol daun Daun salam mempunyai efek antioksidan. Penelitian ini bertujuan menguji efek antioksidan ekstrak ethanol 70% daun salam (Syzygium polyanthum (Wight)). Metode yang digunakan adalah uji invitro dengan metode DPPH (Diphenyl picrylhydrazyl). Ekstrak dilarutkan dalam ethanol, kemudian dibuat dalam seri konsentrasi 10, 30, 50 dan 70 ug/mL. Masing-masing seri sebanyak 10 ml. Dalam masing-masing larutan tersebut ditambahkan 1 ml larutan DPPH 1 mM. larutan kemudian diinkubasi pada suhu 37°C selama 30 menit. Panjang gelombang yang digunakan adalah 515 nm. Metanol dan DPPH 1mM digunakan sebagai blanko.Untuk pembanding digunakan butylated hydroxytoluene (BHT) konsentrasi 2, 4, 6, 8 ug/mL. Hasil penelitian menunjukkan bahwa ekstrak ethanol 70% daun salam mempunyai efek antioksidan dengan IC 50 27,80 ug/mL.Kata kunci: daun salam (Syzygium polyanthum (Wight) , antioksidan, IC 50
Skrining Aktivitas Antibakteri Ekstrak Etanol Daun Terhadap Salmonella Typhi Resisten Kloramfenikol Trisharyanti, Ika
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 2, No 2 (2017)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.262 KB) | DOI: 10.20961/jpscr.v2i2.14386

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi, antibiotic chloramphenicol can be use to treatment, but S. typhi resistant with antibiotic choramphenicol so need to alternative treatment. The purpose of this study was to determine the antibacterial activity of ethanol extract of ten leaves against Salmonella typhi, and knowing the compounds contained in extracts of leaves that have the best antibacterial activity. The leaves was extracted with  ethanol 96% by maceration method. Screening antibacterial activity used disk diffusion method with 10% extract concentration. The best antibacterial activity was determined Minimum Inhibitory Concentration and Minimum Bactericidal Concentration used liquid dilution method, identification test of compounds with thin-layer chromatograpy (TLC), and bioautografi test. There were six extracts had antibacterial activity against S. Typhi, Phaleria macrocarpa leaves, Acalypha siamensis leaves, cherry leaves, clove leaves, tea leaves, and Eugenia polyantha leaves. Minimum Bactericidal Concentration from clove leaf extract was 2,5%. The results of identification by TLC compounds were alkaloids, phenolics, flavonoids, terpenoids, triterpenoids, and saponins. Based on bioautografi test,  phenolic can inhibit the growth of Salmonella typhi.
Co-Authors Em Sutrisna Rima Munawaroh Suprapto .