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All Journal Jurnal Sains Materi Indonesia Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease MEDISAINS Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology I-Com : Indonesian Community Journal Jurnal Rekayasa Kimia & Lingkungan Prosiding Seminar Nasional Unimus

Prihartini Widiyanti

Biomedical Engineering Study Program, Department Of Physics, Faculty Of Science And Technology, Universitas Airlangga Institute Of Tropical Disease, Universitas Airlangga

Author-ID : 508655

Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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A Patient with Suspected Diphtheria Muhammad Vitanata Arfijanto; Siti Irma Mashitah; Prihartini Widiyanti; Bramantono Bramantono
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

It was reported that a mature woman, Mrs. S, 42 years old with several complaints and symptoms such as fever, swallowing painweak body, swollen tonsil with beslag, dirty uvula of mouth cavity and tongue, and bullneck. The final diagnosis indicated that thepatient was suspected diphtheria, candidiasis oris, sepsis, and pneumonia. The sudden death of the patient was probably caused bymyocarditis.

The Role of Hyperbaric Oxygen to Platelet Aggregation in Diabetic Patients Type II (NIDDM) Prihartini Widiyanti
Indonesian Journal of Tropical and Infectious Disease Vol. 1 No. 2 (2010)
Publisher : Institute of Topical Disease Universitas Airlangga

Prevalency of Diabetes Mellitus in Indonesia has tendency to be increased from year to year. Hyperbaric Oxygenation (HBO) has been used as treatment of Diabetes Mellitus's complication especially diabetic gangrene. But the effect of HBO to the rheology's disfunction especially platelet's aggregation in the patients of NIDDM was investigated. The randomized pretest-posttest design was used in this study. An experimental laboratory study was performed at Naval Health Institution in Surabaya. 32 patients of NIDDM,women, 40–75 years old, normal physic's diagnosa, normal thorak's photo, normal EKG, normal Ear Nose and Throat, Diabetes Mellitus's family's record, normal weight (BMI), blood glucose level didn't exceed 400 mg/dl (including controlled DM FBG < 120 mg/dl dan 2 H BG < 160 mg/dl), NIDDM, normal level of HbA1c (4–5,9), as long as this research they couldn’t take their Oral Hipoglikemic Agent, Oral Anti Trombotic, vitamin C and vitamin E. They are divided into 2 group: group of HBO 100% O 2,4 ATA for 3x30 minutes with interval 5 minutes to inhalate air once a day daily for 5 days subsequently and the extraction of data (PAT) had been held before oxygenation hyperbaric therapy at the first day and the end of fifth days, in control group only giving 20% O2 with the pressure 1 ATA for 90 minutes once a day daily for 5 days subsequently and the extraction of data (PAT) had been held before normoxia normobaric therapy at the first day and the end of fifth days. The results were significant decrease of the platelet’s aggregation level especially percent of aggregation after 5 days from 76,56 ± 8,06 become 69,13 ± 6,03. Latent Periode has also decrease from 28,75 ± 3,87 become 25,75 ± 2,82. Speed of Aggregation has also decrease from 66,25 ± 3,17 become 62,50 ± 3,44. Index of Aggregation has also decrease from 0,763 ± 0,071 become 0,581 ± 0,083. Using paired t-test, it could be seen the decrease of Latent Periode (p= 0,001) and index of aggregation (p= 0,000) significantly after exposure of oxygenation hyperbaric HBO 2,4 ATA 100% O 3×30 minutes with interval 5 minutes inhalate air once a day for 5 days,subsequently. Speed of aggregation (p = 0,022) and percent of aggregation (p= 0,013) are nonsignificantly. The conclusion of this research is that oxygenation hyperbaric 2,4 ATA 100% O2 3×30 minutes with interval 5 minutes inhalate air once a day for 5 days,subsequently could decrease latent periode, speed of aggregation, index of aggregation and percent of aggregation in NIDDM

CLINICAL MANIFESTATION APPROACH OF DENGUE VIRAL INFECTION Ganis Tjahjono; Prihartini Widiyanti; Nasronudin Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 2 (2016)
Publisher : Institute of Topical Disease Universitas Airlangga

Currently by an estimated 50-100 million dengue fever cases per year in worldwide, 500.000 were in the form of a disease is heavy Dengue Hemorraghic Fever (DHF) and Dengue Shock Syndrome (DSS). Survey serology in Indonesia show that DEN-1 and DEN-2 are the dominant serotipe virus until the end of the 1980s but the recent shift has occurred epizoötic where viruses DEN-3 dominant. (Dos Santos, 2004; Malavige, 2004; Stephenson, 2005). Dengue virus infection induces transient immune aberrant activation of CD4/CD8 ratio inversion and cytokine overproduction, and infection of endothelial cells and hepatocytes causes apoptosis and dysfunction of these cells. The aberrant immune responses not only impaire the immune response to clear the virus, but also result in overproduction of cytokines that affect monocytes, endothelial cells, and hepatocytes. Dengue-virus-induced vasculopathy and coagulopathy must be involved in the pathogenesis of hemorrhage, and the unbalace between coagulation and fibrinolysis activation, and prolonged duration of shock increase the likelihood of severe hemorrhage in DHF/DSS. Capillary leakage is triggered by the dengue virus itself or by antibodies to its antigen. To date, there are no effective strategies to prevent the progression of DHF/DSS. The control of dengue will be possible only after an efficient vaccine has been developed.

Determination Reference of Concentration (RfC) Xylen Exposure Based on Xylen NOAEL in White Rats and Workers’ Body Weight and Height in Surabaya Car Painting Area, Indonesia Abdul Rohim Tualeka1 , Juliana Jalaludin2 , Prihartini Widiyanti 3, Syamsiar S Russeng4 , Pudji Rahm
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10662

This study aims to calculate the value of RfC from xylen exposure around the car painting area of Surabaya, Indonesia. This is an observational cross-sectional study with quantitative data analysis methods conducted manually. The population in this study was groups of car painting workers and groups of car repairer on Jalan Pengenal Kota Surabaya. The sampling technique was proportionate stratified random sampling to take 51 people. The measurement of xylen concentration around the car painting area was 635.98 mg/m3 (146.47 ppm). This value is above the threshold value according to Minister of Manpower and Transmigration Regulation Number 13 of 2011 and Minister of Manpower Regulation Number. 5 of 2018 is 434 mg/m3 (100 ppm). RfC of car painting workers with NOAEL 50 mg/kg was 7.76 mg/kg.

PENGEMBANGAN EKOWISATA DI KAWASAN WISATA PERKEBUNAN KOPI DI DESA KARE KECAMATAN KARE KABUPATEN MADIUN Julieta Kartikasari; Kirana Anugerah Putri; Radicha Arnanda Putri Indrawati; Veren Audia Nurmansya; Wulandari Prima Devi; Bella Wahyu Sukma Wati; Sherina Pradita Eka Wahyudi; Fa’ilal Chusna; Nabila Safira Khairina; Tria Refi Indriani; Cindy Narita Kusuma Astuti; Prihartini Widiyanti
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 5 No. 1 (2021): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v5i1.2021.177-184

IPE 63 Community Service Activities (KKN) Group 179 Airlangga University in Kare Coffee Tourism, Kare Village, Kare District, Madiun City, with the theme of ecotourism which was held on19 January 2021 to 13 February 2021 aimed at developing curry coffee tourism areas, increasing public awareness of health and providing health facilities in accordance with health protocols, attracting tourists through promotions on various social media, adding insight into how to utilize coffee processing waste so that it can be of economic value. as well as coffee cultivation techniques and ways to increase coffee production for coffee entrepreneurs and producers in Kare village. As for the design of activities carried out in the form of procurement of complete tourist facilities and procurement of complete protocol facilities that are not yet available in Kare Coffee tours and their availability is needed, by purchasing goods online and sending items that have been purchased directly to Kare Village. Promotion of curry coffee tourism, by utilizing existing social media such as Instagram and YouTube by uploading a coffee tour profile video so that it can be known to the wider community and can attract both local and international tourists. The use of coffee waste, by providing education and training to the community in Kare Village, is carried out online as well as uploading the video of the seminar results to YouTube regarding the utilization of coffee waste carried out online and uploading the seminar results video to YouTube. And webinars on ecotourism, CHSE protocols, coffee cultivation techniques, and increased coffee production were conducted online on the same day then uploaded the webinar results to Youtube. AbstrakKegiatan Kuliah Kerja Nyata (KKN) IPE 63 Kelompok 179 Universitas Airlangga di Wisata Kopi Kare, Desa Kare, Kecamatan Kare, Kota Madiun, dengan tema ekowisata yang dilaksanakan pada tanggal 19 Januari 2021 hingga 13 Februari 2021 bertujuan untuk mengembangkan kawasan wisata kopi kare, meningkatkan kesadaran masyarakat akan kesehatan dan memberikan fasilitas kesehatan yang sesuai dengan protokol kesehatan, menarik minat wisatawan melalui promosi di berbagai media sosial, menambah wawasan tentang cara memanfaatkan limbah pengolahan kopi agar dapat bernilai ekonomis. serta teknik budidaya kopi dan cara meningkatkan produksi kopi kepada pengusaha dan produsen kopi di desa Kare. Adapun rancangan kegiatan yang dilakukan berupa pengadaan kelengkapan fasilitas wisata dan pengadaan kelengkapan fasilitas protokol yang sekiranya belum tersedia di wisata Kopi Kare dan dibutuhkan ketersediaannya, dengan cara melakukan pembelian barang- barang secara online dan mengirimkan barang yang sudah dibeli langsung ke Desa Kare. Promosi wisata kopi kare, dengan memanfaatkan media sosial yang ada seperti Instagram dan youtube dengan mengunggah video profil wisata Kopi Kare agar dapat dikenal masyarakat luas serta dapat menarik wisatawan baik lokal maupun internasional. Pemanfaatan limbah kopi, dengan memberikan edukasi serta pelatihan kepada masyarakat di Desa Kare dilakukan secara daring serta mengupload video hasil seminar ke youtube terkait pemanfaatan limbah kopi dilakukan secara daring serta mengupload video hasil seminar ke youtube. Dan webinar mengenai ekowisata, protokol CHSE, teknik budidaya kopi, dan peningkatan produksi kopi yang dilakukan secara daring pada hari yang sama kemudian mengunggah hasil webinar ke Youtube.

The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing Herry Wibowo; Prihartini Widiyanti
Folia Medica Indonesiana Vol. 58 No. 2 (2022): June
Publisher : Universitas Airlangga

Highlights: Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. Sodium diclofenac with a some dose of body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac sodium, are standard treatments to relieve pain associated with bone fractures. The bone healing process consists of four stages: inflammation, soft callus formation, complex callus formation, and bone remodeling. Previous studies mentioned that intake of NSAIDs (sodium diclofenac) could inhibit the bone healing process. This study examined the effect of diclofenac sodium intake on callus formation in fracture healing. In this study, thirty-six rats (Rattus Norvegicus) with fractures were used and divided into two groups, namely 18 rats for the control and 18 rats for the treatment group. In the treatment group, each rat was given 1.8 mg sodium diclofenac/150 grams of body weight per day. In the control group, each rat was given CMC-Na 0.5% with equal volume as diclofenac sodium in the treatment group. After 28 days, all the rats were stunned until dead, and the diameter and strength of their calluses were measured. In the treatment group with diclofenac sodium1.8 mg/ 150 grams BW/ 28 days after the tibia bone callus was pressed using the Shimadzu tool, the lowest callus strength was found to be 56.500 N, and the highest callus strength was 59.000 N. The lowest callus diameter in the treatment group was 4 mm, the highest was 5 mm. In the control group, the lowest callus strength was 76 N, and the highest callus strength was 77 N. The lowest callus diameter in the control group was 6 mm, and the highest was 8 mm. The strongest callus in the treatment group was found in the sixth observation, with a value of 59 N and a diameter of 4 mm. In the control group, the highest callus strength was 77 N, with a diameter of 7-8 mm. These measurements were found on the 5th, 7th, 8th, 9th, 16th, and 17th observations. Diclofenac sodium with a dose of 1.8 mg/150 grams of body weight could decrease the callus quality parameters, such as callus strength and diameter on fracture healing.

Preparation of Hydroxyapatite Scaffold using Luffa Cylindrica Sponge as Template Ahmad Fadli; Prihartini Widiyanti; Deni Noviana; Agung Prabowo; Heni Ismawati
Jurnal Rekayasa Kimia & Lingkungan Vol 15, No 2 (2020): Jurnal Rekayasa Kimia & Lingkungan (December, 2020)
Publisher : Chemical Engineering Department, Syiah Kuala University, Banda Aceh, Indonesia

Hydroxyapatite (HA) scaffold has been widely applied in the biomedical field especially for bone implants. The purpose of this research is to determine the influence of dispersant addition and stirring time on HA scaffold which formed using gambas sponges as a template. HA slurry was made by mixing 10 grams of HA, 12 grams of aquadest, 0,2; 0,25; 0,3 grams of Darvan 821A and 1 gram of sago. The slurry was impregnated into Luffa cylindrica sponges. The sample then dried at 110oC for 3 hours. The green bodies were burned at 600oC for 1 hour and followed by sintering at 1250oC for 1 hour. The results showed that the addition of dispersant and increasing of stirring time lead to smaller porosity and shrinkage. In addition 0,2; 0,25; and 0,3 grams dispersant, the resulting porosity in the range of 63,85-70,78%; 58,74-70,35%; and 53,42-69,66%. Shrinkage 39,43-53,71%; 27,75-50,68%; and 13,61-41,25%. Compressive strength 0,61-1,05 MPa; 2,88-3,81MPa; and 0,52-2,96 MPa. The macroporous and microporous average pore sized was 50 µm dan 5 µm.

Peningkatan Daya Tarik Desa Kare Kecamatan Kare Kabupaten Madiun melalui Pengembangan Ekowisata Berbasis Pasrtisipatif – Kolaboratif Prihartini Widiyanti; Fitriyatul Qulub; Akhmad Jayadi; Gadis Meinar Sari
I-Com: Indonesian Community Journal Vol 3 No 1 (2023): I-Com: Indonesian Community Journal (Maret 2023)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Desa Kare adalah salah satu desa di wilayah Kabupaten Madiun yang potensial untuk pengembangan wisata dan produk alam. Pengabdian masyarakat bertema ekowisata bertujuan (1) mengembangkan kawasan wisata berbasis partisipatif-kolaboratif, (2) meningkatkan pola kesadaran masyarakat terhadap kesehatan, (3) memberikan fasilitas kesehatan sesuai protokol kesehatan, (4) menarik minat para wisatawan melalui promosi media sosial, (5) menambah wawasan tentang cara pengolahan limbah dan produk unggulan ciri khas Desa Kare. Pelaksanaan kegiatan berlangsung dalam tiga level tahapan yaitu perencanaan kegiatan, pelaksanaan kegiatan dan tindak lanjut acara. Ekowisata dijalankan menitikberatkan pada peran aktif masyarakat setempat dan dalam kegiatan Program Pengembangan Desa Binaan (PPDB) telah dilakukan pembinaan produk dan kemasan terstandar destinasi wisata pada Unit Mikro Kecil dan Menengah (UMKM). Melalui pengmas PPDB, masyarakat setempat diberikan edukasi untuk menyiapkan masyarakat supaya sadar akan potensi alam untuk ikut menjaga dan melestarikan. Kegiatan secara berkelanjutan diharapkan untuk meningkatkan kesejahteraan serta taraf hidup masyarakat Desa Kare.

Fast Microwave-Assisted Green Synthesis of Silver Nanoparticles Using Low Concentration of Seminyak (Champeria sp.) Leaf Extract Muhammad Bagas Ananda; Fathan Aditya Sanjaya; Tami Bachrurozy; Helmi Majid Ar Rasyid; Anggraini Barlian; Akfiny Hasdi Aimon; Fitriyatul Qulub; Prihartini Widiyanti; Arie Wibowo
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.78545

Silver nanoparticles (AgNPs) are fascinating materials for biomedical applications thanks to their strong antibacterial activity and biocompatibility. This study applied the green synthesis method using 0.5 wt.% Seminyak leaf extract and assisted with one min microwave irradiation to enhance AgNPs formation. Extremely small sizes AgNPs with an average particle size of 9.1 ± 4.1 nm and spherical shapes were obtained. The synthesized AgNPs displayed potent antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria with a zone of inhibition of 12.3 ± 0.1 and 13.7 ± 0.7 mm, respectively. The MTT assay results demonstrated that the cells’ viability of the obtained AgNPs was 88.5 ± 7.0 %, implying biocompatibility for biomedical applications.

Polyvinyl Chloride (PVC)-Glycerol with Chitosan Addition for Antibacterial Blood Bag Application Prihartini Widiyanti; Tarissa Diandra Putri Wibowo; Andhi Baskoro; Siswanto
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.43104

Blood bag is a medical device that stokes and transports whole blood or blood components. The material that is often used for blood bag membranes is Polyvinyl Chloride (PVC), however the common problem that is bacterial contamination and that material have not antibacterial characteristic.Â Because of this matter, the aim of this reseach are a blood bag that has antibacterial function is needed and meet the ideal standard as bloodbag. Chitosan as a blood bag membrane material fabrication to get the antibacterial effect. Chitosan is chosen as a blood bag material fabrication to get the antibacterial effect. Chitosan has several specific biocompatibility properties, antibacterial, chelation, and biodegradability. This study used various Chitosan concentrations of 1.5%, 2%, 2.5%, and 3%, and Glycerol was added as a plasticizer. The composition of Chitosan: Glycerol is 1:1. Then, the mixture is added to the PVC solution in a ratio of 1:5 then poured into a petri dish. The results showed characterization that the biocomposite PVC-Glycerol with the addition of 3% concentration of chitosan was the best composition, the tensile strength test result of biocomposite is 21.20 MPa, the absence of membrane pores in the morphology of the blood bag, the hemolytic activity is 0.24%, and the inhibition zones of E. coli and S. aureus, respectively 11.66 mm and 12.66 mm in diameter. Based on the characterization results, the biocomposite PVC-Glycerol membrane with the addition of Chitosan has a very high potential as a candidate for blood bag membranes

Co-Authors - Aminatun - Siswanto Achmad Ardianto Achmad Ardianto, Achmad Adanti Wido Paramadini Adiana Mutamsari Witaningrum Adri Supardi Agung Prabowo Ahmad Fadli Akfiny Hasdi Aimon Akhmad Jayadi Akhmad Jayadi Alfian Pramudita Putra Andhi Baskoro Andini Isfandiary Anggraini Barlian Arie Wibowo Bambang Prajogo Bambang Prajogo Eko Wardoyo Bella Wahyu Sukma Wati Bimo Aksono Bimo Aksono Bimo Dwi Lukito Bimo Dwi Lukito, Bimo Dwi Bramantono - Budi Utomo Budi Utomo Cindy Narita Kusuma Astuti DENI NOVIANA Dina Kartika Putri Dio Nurdin Setiawan Dio Nurdin Setiawan, Dio Nurdin Dita Ayu Mayasari, Dita Ayu Djony Izak Rudyardjo Dyar Sasmito Dyar Sasmito, Dyar Eko Budi Kuntjoro Eko Budi Kuntjoro, Eko Budi Endah Purwanti Fathan Aditya Sanjaya Fatkhunisa Rahmawati Fatkhunisa Rahmawati Fatkhunisa Rahmawati, Fatkhunisa Fa’ilal Chusna Fendy Purwanda Fendy Purwanda, Fendy Ferdiansyah Ferdiansyah Ferdiansyah Ferdiansyah Fitriyatul Qulub Fitriyatul Qulub Fitriyatul Qulub Fitriyatul Qulub Fitriyatul Qulub Franky Arisgraha Franky Arisgraha, Franky Gadis Meinar Sari Gadis Meinar Sari Ganis Tjahjono Hafrizal Riza Hafrizal Riza, Hafrizal Hajria Jabbar Helmi Majid Ar Rasyid Hendita Nur Maulida Heni Ismawati Heri Purnobasuki Heri Purnobasuki, Heri Herry Wibowo Jan Ady Jan Ady Julieta Kartikasari Juniastuti Juniastuti Juniastuti Juniastuti Kholifatul Wanda Putri Kholifatul Wanda Putri, Kholifatul Wanda Kirana Anugerah Putri Ludita Woro Indrio M. Qushay M. Qushay, M. Maria Inge Lusida Maria Inge Lusida Mirzaq Hussein Anwar Mirzaq Hussein Anwar, Mirzaq Hussein Muhammad Bagas Ananda Muhammad Vitanata Arfijanto Nabila Safira Khairina Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Ni Putu Ermi Hikmawati Ni Putu Ermi Hikmawati, Ni Putu Ermi Nilna Faizah Fiddarain Nilna Faizah Fiddarain, Nilna Faizah Radicha Arnanda Putri Indrawati Retna Apsari Retno Indrawati Roestamadji Retno Pudji Rahayu Satrio Adhitioso Satrio Adhitioso Sherina Pradita Eka Wahyudi Siswanto Siswanto Siswanto Siti Irma Mashitah Siti Qamariyah Khairunisa Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa Siti Qomariyah Khairunisa, Siti Qomariyah Tami Bachrurozy Tarissa Diandra Putri Wibowo Tia Rahayu Wijayanti Tomohiro Kotaki Tomohiro Kotaki Tomohiro Kotaki, Tomohiro Tri Arif Sardjono Tri Arif Sardjono, Tri Arif Tria Refi Indriani Veren Audia Nurmansya Wulandari Prima Devi Yufan Fibriawan Yufan Fibriawan, Yufan

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