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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Farmasi Klinik Indonesia Indonesian Journal of Biotechnology WARTA Tajdida Biomedika Pharmacon INDONESIAN JOURNAL OF PHARMACY Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Journal of Nutraceuticals and Herbal Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sasambo Journal of Pharmacy Abdi Geomedisains Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika Warta LPM Medical Sains : Jurnal Ilmiah Kefarmasian
Em Sutrisna
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI PENURUNAN KADAR GLUKOSA DARAH OLEH EKSTRAK ETANOL 70% DAUN BUNCIS (Phaseolus vulgaris L) PADA KELINCI JANTAN YANG DIBEBANI GLUKOSA Kurniawati, Desy; Sutrisna, EM; Wahyuni, Arifah Sri
Biomedika Vol 4, No 1 (2012): Biomedika Februari 2012
Publisher : Universitas Muhamadiyah Surakarta

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This research aim to know the descent of blood glucose rate by extract etanol 70% of bean leaf at male rabbit which induced glucose. Research using the method test glucose tolerance of oral was including category research of sham eksperimental with complete random attempt device of unidirectional pattern. This research use 20 male rabbits which divided in 5 treatment group. Group I given by CMC Na 1% as negative control, group II given by acarbose suspensi 2,33 mg/kgBB as positive control, group III, IV and V given by extract etanol 70% bean leaf with each dose 200, 300 and 450 mg/kgBB. Treatment given at once after test animal induced glucose 50% ( 5 ml/1,5 kgBB). Glucose blood rate to define every 30 minute, 0 minute until 300 minutes by using method of enzimatik GOD PAP (Glucose Oxidase Phenol Aminoantipyrina Peroxidase), what was later then analysed with one track Anava and continued by test of LSD (Least Significant Diffeerence) with trust level 95%. Extract etanol 70% bean leaf with dose 200, 300 and 450 mg/kgBB have effect descent of blood glucose rate to negative control of CMC Na 1% (p = 0,000) with each percentage descent of blood glucose rate (% PKGD) 80,88 ± 0,93 ; 82,73 ± 0,67 and 85,32 ± 0,21.Keyword : Extract etanol 70%, bean leaf (Phaseolus vulgaris L), degradation of glucose rate
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

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Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
EFEK INFUSA AKAR TEMPUYUNG (SONCHUS ARVENSIS) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS PUTIH (RATTUS NORVEGICUS) Retnowati, Kurnia; Sutrisna, EM; Nurmahmudah, Iin Novita
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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Tempuyung (Sonchus arvensis) consisted of fiavonoid were effect as obstruct xantine oksidase enzyme, antioxidant captur superoxsidase radical. The fiavonoid total in leave of tempuyung is 0,1044%, in its root have 0,5% fiavonoid and the more is apigenin-7-O-glikosida (3,4,5). This research aim to know effect of infusa root of tempuyung (Sonchus arvensis) to lower the uric acid level at blood serum and infusa root of Tempuyung (Sonchus arvensis) to lower the uric acid level at mouse blood serum compared to allopurinol.This research is laboratory experimental method. The object were 25 Wistar male mice 2-3 months old, 150-200 gr divided into 5 groups. Negative Control group given potassium oxonate by intraperitoneal, Positive Control group given potassium oxonate by intraperitoneal, added by allopurinol 18mg/kgBB, Infusa Concentrated Group 1 given potassium oxonate by intraperitoneal added by infusa root of tempuyung 1,25g/kgBB, Infusa Concentrated Group 2 given potassium oxonate by intraperitoneal added by infusa root of tempuyung 2,5g/kgBB, Infusa Concentrated Group 3 given potassium oxonate by intraperitoneal added by infuse root of tempuyung 5g/kgBB. Executed until one day, where measurement of uric acid of mouse blood serum done before and after treatment. Measurement of uric acid level is done by using spectrophotometer. Obtained to be data to be analysed with Kolgomorov-Smirnov test, One-Way ANOVA and continued with LSD (Least Significant Difference) test with 95% confidence interval (CI). Result of statistical test of research shoe that infusa root of Tempuyung (Sonchus arvensis) dose 1,25g/kgBB, 2,5g/ kgBB, 5g/kgBB have effect to lower the uric acid level at mouse blood serum. Infusa root of Tempuyung (Sonchus arvensis) concentrated 5g/kgBB proportional wih dose allopurinol 18mg/kgBB to lower the uric acid level at mouse blood serum.Keyword: Infusa, root of Tempuyung (Sonchus arvensis), uric acid
UJI EFEK ANTIBAKTERI EKSTRAK ETIL ASETAT DAN KLOROFORM MENIRAN (Phyllanthus niruri Linn) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus ATCC 6538 DAN Escherichia coli ATCC 11229 SECARA in vitro Rahman, Dwiariawan Tauchid; Sutrisna, EM; Candrasari, Anika
Biomedika Vol 4, No 2 (2012): Biomedika Agustus 2012
Publisher : Universitas Muhamadiyah Surakarta

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Meniran is one of traditional plants that contains several compounds such as terpenoid, flavonoid, and alkaloid that role as antibactrial agent. The aims of the research are to determine the antibacteria effect of extract aethyl acetat and chloroform of meniran. This research was conducted as a laboratory experimental by using post test control group design only. The concentration of extract aethyl acetat and chloroform meniran are 5%, 10%, 20%, 40%, and 80%. The result indicate that extract aethyl acetat of meniran have not effect to Escherichia coli. Meanwhile, to Staphyloccus aureus have an effect (p=0,003). The concentration of the extract chloroform meniran are effective to inhibite the growth of Escherichia coli (p=0,029) and Staphylococcus aureus (p=0,004). The extract aethyl acetat of meniran have an antibacteria effect to Staphylococcus aureus but not to Escherichia coli. Whereas, the extract chloroform of meniran have an antibacteria effect to Staphylococcus aureus and Escherichia coli.Keyword : The aethyl acetat and chloroform extract of Meniran (Phyllanthus niruri L.), antibacteria effect, Staphylococcus aureus and Escherichia coli
FARMAKOGENETIK PENGOBATAN BETA 2 AGONIST DAN STEROID PADA PENDERITA ASMA Sutrisna, EM
Biomedika Vol 6, No 2 (2014): Biomedika Agustus 2014
Publisher : Universitas Muhamadiyah Surakarta

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In the worldwide about 300 million people have asthma. β-2 agonists and steroids are widely prescribed drugs in the treatment of asthma. Different responses raises the suspicion of a genetic infiuence on the host’s response to the treatment of this disease. The purpose of this review is to provide a comprehensive understanding of the infiuence of genetic factors on the treatment of asthma. This review is done by the method in Pubmed search using keywords Pharmacogenetic asthma; polymorphism beta agonist AND asthma. The analysis shows that there are several genes that affect treatment response. ADRB2 gene affects the bronchodilatation response for asthmatics treated with β-2 agonist. CRHR1 gene polymorphism, Glucocorticoid-complex genes, and CER2 genes and TBX21 genes affect the response to corticosteroids inhalers.Keywords: Asthma, Pharmacogenetics, Treatment response
UJI EFEK PEMBERIAN EKSTRAK ETANOL 70% BIJI BUAH TERUNG UNGU (SOLANUM MELONGENA L.) TERHADAP KADAR KOLESTEROL HDL SERUM DARAH TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) GALUR WISTAR Fajriyatun, Baiq Nova; Sutrisna, EM; Nirlawati, Dona Dewi
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

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Extract of eggplant fruit (Solanum melongena L.) seed is a plant that has anti-hypercholesterolemia effect on the state of dyslipidemia. One of the compounds contained in them are fl avonoids nasunin which can increase levels of HDL cholesterol (high density lipoprotein). HDL cholesterol is considered as a compound have the ability to remove excess cholesterol from the arteries, and therefore called good cholesterol. This study is a laboratory experimental research using pretest and posttest control group. The sample consisted of 25 rats were divided into 5 groups. Group I is a negative control (-), Group II is a positive control (+), group III was treated 1 (dose 1), group IV was treated 2 (dose 2), and V is the treatment group 3 (dose 3). Each group was given a high-cholesterol diet. Negative and positive control group were not given the extract of fruit seed of eggplant, the treatment groups III, IV, and V were given the extract of fruit seed of eggplant with each dose of 20 mg/kg, 40 mg/kg, 80 mg/kg were given for 4 weeks. HDL cholesterol levels will be measured before and after cholesterol diet and calculated each week after giving of the extract. The data obtained tested with statistical tests One-Way Anova. HDL cholesterol positive control group and the treatment group showed signifi cant differences between groups. Treatment groups 1 and 2 levels of HDL cholesterol lower than the positive control group and the treatment group 3. Extract of eggplant fruit seed dose of 80 mg/kg show an increase in HDL cholesterol levels were signifi cantly (p <0.05). The 70% ethanol extract of eggplant fruit seed at a dose of 80 mg/kg can increase HDL cholesterol levels signifi cantly.Keywords : extract of eggplant fruit seed, hypercholesterol, HDL cholesterol
EFEK INFUSA DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Sceff.) Boerl.) TERHADAP PENURUNAN KADAR ASAM URAT DARAH MENCIT PUTIH JANTAN YANG DIINDUKSI DENGAN POTASSIUM OXONATE Sutrisna, EM
Pharmacon Vol 11, No 1 (2010)
Publisher : Pharmacon

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Mahkota dewa (Phaleria macrocarpa (Sceff.) Boerl.)  merupakan tanaman yang secara empiris telah dimanfaatkan untuk mengobati penyakit salah asam urat. Perasan daging buah mahkota dewa  dosis 13,16 g/kgBB tealah terbukti dapat menurunkan kadar asam urat darah pada ayam jantan jenis Lohman Brown. Penelitian ini bertujuan untuk mengetahui efek infusa daging buah mahkota dewa dalam menurunkan kadar asam urat mencit putih jantan yang diinduksi potassium oxonate. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian acak lengkap pola searah. Mencit jantan sebanyak 25 ekor diberi jus hati ayam konsentrasi 10% sebanyak 3 kali sehari selama 2 hari. Kemudian dibagi menjadi 5 kelompok. Kelompok I (kontrol negatif) diberi aqua p.o 0,5 ml/20 gBB. Kelompok II (kontrol positif) diberi allopurinol p.o 10 mg/kgBB. Kelompok III, IV dan V diberi infusa daging buah mahkota dewa dengan dosis berturut-turut 1,25; 2,5 dan 5 g/kgBB. Hewan uji diinduksi dengan potassium oxonate 250 mg/kgBB secara intraperitoneal 1 jam setelah pemberian sediaan uji untuk menaikkan kadar asam urat. Serum darah diambil dari vena opthalmicus pada jam ke 2 setelah induksi. Kadar asam urat ditetapkan dengan spektrofotometer visibel pada panjang gelombang 546 nm. Hasil menunjukkan infusa daging buah mahkota dewa dosis 1,25; 2,5 dan 5 g/kgBB mampu menurunkan kadar asam urat darah dalam serum mencit putih jantan yang diinduksi potassium oxonate dosis 250 mg/kgBB dan setara dengan kontrol positif (allopurinol 10 mg/kgBB).  Kata kunci : Phaleria macrocarpa (Sceff.) Boerl., asam uratmunohistokimia, ekspresi p53
UJI PRAKLINIS EFEK HIPOGLIKEMIK BLIMBING WULUH (AVERRHOA BILIMBI L.) DAN DAUN TAPAK DARA(CATHARANTHUS ROSEUS G) Sutrisna, EM
Pharmacon Vol 13, No 1 (2012)
Publisher : Pharmacon

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Abstract

Beberapa penelitian sebelumnya menyatakan bahwa perasan air blimbing wuluh (Averrhoa bilimbi L.)dan dekokta daun tapak dara (Catharanthus roseus G) mampu menurunkan kadar glukosa darah pada hewan uji. Penelitian ini bertujuan menguji efek hipoglikemik dari buah blimbing wuluh (Averrhoa bilimbi L.) dan daun tapak dara (Catharanthus roseus G) dengan larutan penyari etanol 70%. Sebanyak 40 ekor tikus putih jantan (Rattus norvegicus) galus Wistar dibagi dalam 8 kelompok dan diukur  kadar glukosa darah puasanya (GD1). Semua tikus kemudian diinjeksi alloksan monohydrate dosis 30mg/200g bb tikus secara intraperitoneal dan diukur kadar glukosa darah puasanya (GD2). Setelah itu, tikus pada Kelompok I diberi aquadest ad libitum selama 7 hari, kelompok II diberi glibenklamid 0,126 mg/200g BB 1x pemberian. Kelompok III sampai V diberi ekstrak etanol 70% blimbing wuluh berturut-turut dosis 20mg/200g tikus, 40mg/200g tikus, 80mg/200g tikus. Kelompok VI-VIII diberi ekstrak  etanol 70% daun tapak dara berturut-turut dosis 20mg/200g tikus, 40mg/200g tikus, 80mg/200g tikus. Semua ekstrak diberikan per oral selama 7 hari. Semua tikus kemudian diukur kadar glukosa darah puasanya (GD3). Hasil penelitian menunjukkan bahwa ekstrak etanol 70% blimbing wuluh dosis 20g/200g; 40g/200g dan 80g/200g mampu menurunkan kadar glukosa darah dengan persen penurunan berturut-turut sebesar 42,51%; 43,40% dan 58,95%. Ekstrak etanol 70% daun tapak dara(Catharanthus roseus G) dosis 20g/200g; 40g/200g dan 80g/200g mampu menurunkan kadar glukosa darah dengan persen penurunan berturut-turut sebesar 43,46%; 53,70% dan 58,85% Kata kunci: Hipoglikemik, Averrhoa bilimbi L. dan Catharanthus roseus G
EFEK EKSTRAK ETANOL DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR ASAM URAT PADA MENCIT PUTIH JANTAN YANG DIINDUKSI POTASSIUM OXONATE Sutrisna, EM
Pharmacon Vol 11, No 2 (2010)
Publisher : Pharmacon

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Abstract

Mahkota dewa (Phaleria macrocarpa (Sceff.) Boerl.) merupakan tanaman obat yang digunakan secara empiris sebagai obat berbagai penyakit salah satunya asam urat. Asam urat adalah produk akhir metabolisme purin pada manusia. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daging buah mahkota dewa dalam menurunkan kadar asam urat mencit putih jantan yang diinduksi potassium oxonate 250mg/kgBB. Dua puluh lima ekor mencit jantan diberi jus hati ayam konsentrasi 10% 3 kali sehari selama 2 hari, lalu dibagi menjadi 5 kelompok. Kelompok I kontrol negatif (CMC Na 0,5% p.o 0,5ml/20gBB). Kelompok II kontrol positif (allopurinol p.o 10mg/kgBB). Kelompok III, IV dan V diberi sediaan ekstrak etanol daging buah mahkota dewa dosis berturut-turut 1,25; 2,5 dan 5g/kgBB. Kelompok I-V dibuat hiperurisemia dengan induksi potassium oxonate 250mg/kgBB secara intraperitoneal 1 jam setelah pemberian sediaan uji. Darah diambil dari vena opthalmicus 2 jam setelah pemberian potassium oxonate, serum ditambah reagen uric acid*FS TBHBA (2,4,6,tribromo 3-hydroxy benzoid acid) dan dibaca kadar asam uratnya pada panjang gelombang 546 nm. Data persentase penurunan kadar asam urat diuji dengan ANAVA satu jalan (taraf kepercayaan 95%) dilanjutkan uji Bonferroni. Hasil penelitian menunjukkan sediaan ekstrak etanol daging buah mahkota dewa dosis 1,25; 2,5 dan 5g/kgBB mampu menurunkan kadar asam urat pada serum darah mencit putih jantan yang diinduksi potassium oxonate. Ekstrak etanol daging buah mahkota dewa dosis 1,25; 2,5 dan 5g/kgBB mempunyai potensi yang sama dengan allopurinol dosis 10mg/kgBB dalam menurunkan kadar asam urat tetapi kemampuan penurunannya lebih allopurinol.  Kata kunci : Phaleria macrocarpa (Sceff.) Boerl., potassium oxonate, asam uratt-family:Calibri>  tingkat kepatuhan mempengaruhi keberhasilan terapi sebesar 18,03%.  Kata kunci: Hipertensi,  kepatuhan, keberhasilan terapi
CYP3A4*1G gene Polymorphism on Javanese People Sutrisna, Em; Dwiprahasto, Iwan; Astuti, Indwiani; Kristin, Erna
Indonesian Journal of Biotechnology Vol 16, No 2 (2011)
Publisher : Universitas Gadjah Mada

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AbtractMost of drugs are metabolized by cytochrome P 450 (CYP) enzyme. Cytochrome P450 3A4 is the cytochrome that is involved in metabolizing more than 60% of all medicine used in human. The variation of this CYP3A4 gene will affect the catalytic activity of this enzyme. Recently, CYP3A4*1G in intron 10 was found in Chinese and Japanese population. There is a substitution of G to A at position 82266 in intron 10. The purpose of this research was to investigate the frequency of allele and genotype CYP3A4*1G. Samples were taken from bloods of the subjects of the research. The examination of CYP3A4*1G was conducted by RTLP-PCR method.As the results of this research, the frequency of CYP3A4*1G in Javanese people is CYP3A4*1/*1 0.25, CYP3A4*1/*1G 0.55 and CYP3A4*1G/*1G 0.20. Frequency of allele G: 0.53, allele A: 0.47. The Fisher’s exact- test shows that the allele and genotype frequencyis p. 1.000. The allele and genotype frequency of Javanese people isstill in Hardy-Weinberg equilibrium.Keywords : CYP3A4*1G gene, polymorphism, Javanese people
Co-Authors . Muhtadi . MUHTADI Amalinda Ayu Faroska Andi Suhendi Andi Suhendi Andi, Andi Suhendi Anika Candrasari Annissa, Yanis Nur Arifah Sri Wahyuni Baiq Nova Fajriyatun Baiq Nova Fajriyatun, Baiq Nova Dedi Hanwar DESY KURNIAWATI Desy Kurniawati Devi Usdiana Rosyidah Dewi, Listiana Masyita Dodik Nursanto Dona Dewi Nirlawati Dwiariawan Tauchid Rahman Dwiariawan Tauchid Rahman, Dwiariawan Tauchid Erna Kristin Faradisa, Nida Faroska, Amalinda Ayu Fauziana, Eni Flora Ramona Sigit Prakoeswa Frans Saputra Gunawan, Ryan Budi Hasna Zahro Iftikhonsa Ihwan Susila Iin Novita Nurmahmudah, Iin Novita Ika Trisharyanti Ika Trisharyanti, Ika Imronudin Imronudin, Imronudin Indra Nuroso Indwiani Astuti Iwan Dwiprahasto Iwan Dwiprahasto Kelik Wardiono Khaeditama Purnama Anwar Khusnul Khotimah Kurnia Retnowati Kurnia Retnowati, Kurnia Mada Sukma Dytho Maimun, Muhammad Halim Maryati Maryati Maryati Maryati Maryati Maryati Mida Pratiwi Muchlison Anis Muhammad Ibrahim Muhtadi Muhtadi Muhtadi N Nurhayani Noer Safita Noer Safita Nur Mahmudah Nurcahyanti . Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurfauzia, Elita Nadia Nurhaliza, Alfida Aulia Rahma Firdauzy Nurhayani nurhayani Nurhayani Nurhayani Peni Indrayudha Pranesti, Rahma Pratiwi, Betty Intan Rahmi, Anggraita Nur Ratih Pramuningtyas Ratnaningrum, Anna Retno Sintowati - Riandini Aisyah Rima Munawaroh Rima Munawaroh Rochmadina Suci Bestari Ryan Budi Gunawan Safari Wahyu Jatmiko Saputra, Frans Selly Ayustine Winarta Siti Zulaekah Sri Darnoto Sri Wahyuni Suprapto . Suprapto . Tanti Azizah Sujono Vianti, Melita Febry Werdany, Kusuma Estu Widananda, Clarisa Yanis Nur Annissa Yuli Kusumawati Yuniar, Siska Zaid Ziyaadatulhuda Ashshiddiiq