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All Journal Jurnal Kedokteran Syiah Kuala Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Biomedika HIGEIA (Journal of Public Health Research and Development) Journals of Ners Community Medica Hospitalia Indian Journal of Forensic Medicine & Toxicology Jurnal SAGO Gizi dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Sains dan Kesehatan Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika Jurnal Keilmuan dan Keislaman International Conference on Education for All
Flora Ramona Sigit Prakoeswa
Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The protective effect of sunscreens against ultraviolet B-induced immunosuppression. A study on Langerhans cell depletion Yohanes Widodo Wirohadidjojo, Flora Ramona SP Fajar Waskito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 42, No 01 (2010)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3379.687 KB)

Abstract

Ultraviolet B (UVB) radiation can act as immunosuppressant by inducing an epidermal Langerhans cells (LC) depletionwhich could be inhibited by topical sunscreen. Several kinds of sunscreens with various SPF (Sunscreen ProtectionFactor) are now available. The minimal SPF which able to inhibit the immunosuppressive effect of UVB amongpeople with skin photo-type IV has not been established yet. The aim of this study is to determine the minimal SPFcapable to inhibit UVB-induced immunosuppression among people with skin photo-type IV. A simple experimental(post test only experimental) study was conducted among 5 people’s circumsized foreskins with Fitzpatrick’s skinphoto-type IV. Each of them was divided into equal 5 pieces of 0.5 cm2. Each of three pieces of skin was treated bysunscreen SPF 15, SPF 30, and SPF 50, a single piece of skin was treated with placebo, and all of them then weretreated by a single 100 mJ/cm2 of UVB 30 minutes later. A rest single piece of skin was used as control. After 24hours of incubation in incubator of 37O C and 5% CO2, all of them then was fixed by buffer formalin, blocked byparaffin, cut in 2mm of thickness, and then stained with anti CD 1a antibody with AEC as chromogen and Mayer’shematoxylin as counterstaining. The number of LC was counted by Image J Analysis programmed and the mean ofLCwere analyzed by Kruskal-Wallis test dan Mann-Whitney test. There were very significantly different of themean number of LC between UVB placebo group and control group (p < 0.01). Compared to the control group,mean number of LC among SPF 30 and SPF 50 treated groups were not significantly different (p>0.05). Sunscreenwith SPF 15 had LC number lower than control group significantly (p<0.05). The lowest SPF for preventing UVBinduced LC depletion among people with skin photo-type IV was 30.Key words : UVB - immunosupression – sunscreens – SPF -CD1aexpression
JUVENILE DERMATOMIYOSITIS: PENEGAKAN DIAGNOSIS Prakoeswa, Flora Ramona Sigit; Suswardana, .; Danarti, Retno
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

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Abstract

Juvenile dermatomiyositis (JDM) merupakan suatu penyakit autoimun infl amatif yang jarang dijumpai dan secara khas ditandai oleh adanya lesi-lesi kulit tipikal serta kelemahan otot proksimal yang simetris. Etiologi penyakit tersebut belum diketahui dengan pasti, namun demikian patogenesisnya diketahui bersifat multifaktorial meliputi faktor genetik, paparan sinar ultra violet (UV) serta infeksi oleh berbagai mikroba seperti virus Coxsackie atau Borrelia burgdorferi. Penegakan diagnosis JDM adalah berdasarkan kriteria Bohan-Peter meliputi: 1) kelemahan otot proksimal simetris, 2) peningkatan enzim otot, 3) infl amasi miopati pada hasil biopsi otot 4) gambaran miyopati pada hasil pemeriksaan EMG, dan 5) lesi kulit tipikal. Ditemukannya papul-papul Gottron dan heliotrope rash di kulit, serta adanya kelemahan otot proksimal yang simetris, merupakan manifestasi klinis yang khas untuk JDM. Terapi lini pertama penatalaksanaan JDM adalah kortikosteroid sistemik. Dilaporkan satu kasus JDM pada seorang anak perempuan berusia 6 tahun. Diagnosis ditegakkan berdasarkan adanya lesi kulit tipikal, kelemahan otot proksimal simetris dan peningkatan kadar enzim penanda infl amasi jaringan muskuloskeletal. Pasien berespon baik terhadap pemberian kortikosteroid adekuat serta tabir surya.Kata Kunci: Juvenile dermatomiyositis, systemic corticosteroid
HUBUNGAN ANTARA KELAINAN SIKLUS MENSTRUASI DENGAN KEJADIAN AKNE VULGARIS PADA SANTRIWATI SMA ISLAM TERPADU NUR HIDAYAH KARTASURA Siregar, Ersi Dwi Utami; Ramona, Flora; Dewi, Listiana Masyta
Biomedika Vol 8, No 2 (2016): Biomedika Agustus 2016
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v8i2.2912

Abstract

Akne vulgaris (AV) merupakan penyakit kulit yang meradang berasal dari folikel pilosebasea. Insidensi terbesar terjadi pada umur 14-17 tahun pada wanita, 16-19 tahun pada pria. Kejadian AV berkaitan dengan peningkatan produksi sebum oleh hormon androgen serta hormon estrogen dan progesteron yang merupakan pemacu terjadinya AV sebelum menstruasi. Penelitian ini bertujuan untuk mengetahui hubungan antara kelainan siklus menstruasi dengan kejadian akne vulgaris. Penelitian ini merupakan penelitian observasional analitik dengan rancangan cross sectional. Populasi penelitian adalah santriwati SMA-IT Nur Hidayah Kartasura yang berusia 15-18 tahun yang telah mengalami menstruasi.Pemilihan sampel dengan metode simple random sampling dan didapatkan 55 responden yang sesuai dengan kriteria inklusi.Data primer menggunakan kuesioner dan foto wajah responden.Uji analisis yang digunakan adalah uji chi square. Hasil uji statistik dengan menggunakan uji chi square didapatkan nilai p= 0,103 (p>0,05). Pada penelitian ini insidensi siklus menstruasi normal dengan AV sebesar 43,6% lebih tinggi dibandingkan dengan kelainan siklus menstruasi dengan AV sebesar 30,9%. Tidak terdapat hubungan yang signifikan antara kelainan siklus menstruasi dengan kejadian akne vulgaris pada santriwati SMA-IT Nur Hidayah Kartasura. Kata Kunci: akne vulgaris, menstruasi.
Faktor-Faktor yang Dapat Memengaruhi Keseimbangan Th17/Treg: Review Article Prakoeswa, Flora Ramona Sigit; Hidayat, Saiful; Satria, Yohanes Aditya Adhi; Awanis, Ghina Shabrina
HIGEIA (Journal of Public Health Research and Development) Vol 6 No 1 (2022): HIGEIA: January 2022
Publisher : Jurusan Ilmu Kesehatan Masyarakat, Fakultas Ilmu Keolahragaan, Universitas Negeri Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/higeia.v6i1.50196

Abstract

Abstrak Sistem imun manusia terdiri dari sistem imun alami dan adaptif. Sistem imun alami berperan sebagai pertahanan pertama tubuh terhadap pathogen, sedangkan sistem imun adaptif berperan dalam menjalankan respon imun spesifik. Di antara berbagai efektor sistem imun adaptif, Th17 yang bertugas melawan pathogen dapat menimbulkan terjadinya autoimun dan inflamasi ketika jumlahnya berlebih. Sebaliknya, Treg yang bertugas menjaga homeostasis imun dapat menyebabkan terjadinya autoimun ketika jumahnya menurun. Ketidakseimbangan antara Th17 dan Treg berperan penting dalam patogenesis berbagai penyakit autoimun, seperti systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), dan psoriasis. Artikel ini dibuat untuk mengevaluasi faktor-faktor yang dapat memengaruhi keseimbangan Th17 dan Treg sehingga dapat digunakan sebagai pendekatan terapeutik tambahan dalam merawat pasien-pasien autoimun. Beberapa hal yang dapat dilakukan untuk mengembalikan keseimbangan Th17 dan Treg di antaranya adalah pemberian suplemen vitamin D, paparan terhadap sinar matahari, paparan terhadap mikrobiota, dan pengaturan diet. Abstract The human immune system consists of the innate and adaptive immune systems. The innate immune system acts as the body's first defense against pathogens, while the adaptive immune system plays a role in carrying out specific immune responses. Among the various effects of the adaptive immune system, Th17 which is in charge of fighting pathogens can induce inflammation and autoimmune when there is an excessive amount of them. On the other hand, Tregs that maintain immune homeostasis can lead to autoimmunity when their amount is low. The imbalance between Th17 and Tregs plays an important role in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), and psoriasis. This article is aimed to evaluate factors that can affect Th17 and Treg balance so that they can be used as an adjuvant treatment for autoimmune patients. Some things that can be done to restore the balance of Th17 and Tregs include supplementation of vitamin D, exposure to sunlight, exposure to microbiota, and dietary regulation. Keywords: autoimmune, Th17/Treg balance, therapy
Immune Dysregulation in Childhood Leprosy Flora Ramona Sigit Prakoeswa; Budi Prasetyo; Santi Martini; Hardyanto Soebono; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14725

Abstract

Leprosy is a chronic infection which is caused by Mycobacterium leprae. Leprosy has long been considereda complex disease, in which host and environmental characteristics are as important as the pathogen todetermine disease outcome. Leprosy is an excellent model for examining the immunoregulatory functions.Children are believed to be the most vulnerable group to leprosy infection due to their immature immunity.This review is aimed to summarize the findings of previous studies about immune dysregulation in childhoodleprosy. This study highlighted the plausible maternal-fetal connection which are related in immunedysregulation in childhood leprosy.
Environmental Factors and Leprosy in Mother and Child: A Study in Endemic Areas in East Java, Indonesia Flora Ramona Sigit Prakoeswa; Hardyanto Soebono; Dominicus Husada; Hari Basuki Notobroto; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14726

Abstract

Background: Leprosy is a chronic infection caused by Mycobacterium leprae. In endemic locations,children become vulnerable as a result of being continuously exposed to foci of active transmission from avery young age, especially from their mothers. This study aims to find association between environmentalrisk factors and leprosy in mothers and children in endemic areas.Methods: This study is a case-control study in endemic areas in Tuban Regency, East Java Province,Indonesia. Retrieval of data was done using structured questionnaire and direct measurement. Chi-squarewas used to assess the association between environmental factors and leprosy in mothers and children groups.Results: 22 pairs of cases and 57 pairs of controls were examined. It is found that access to clean wateris associated with leprosy in mothers in endemic areas (p value = 0.047, OR 3.080, CI 95% 2.232-4.251).Environmental factors are not associated with pediatric leprosy in endemic areas.Conclusion: The results of our study show that environmental factors are not associated with pediatricleprosy in endemic areas. Access to clean water is associated with leprosy in mothers in endemic areas.
Nutritional Status and Blood Profile amongst Patient withChildand Maternal Leprosy in Endemic and Non-Endemic Area of Indonesia Flora Ramona Sigit Prakoeswa; Yohanes Aditya Adhi Satria; Budi Prasetyo; Santi Martini; Muhammad Yulianto Listiawan; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15761

Abstract

Leprosy remains endemic in several country, where the disease is still considered as a health burden. The development of the disease is determined by several factors, amongst which that play significant role are close household contact and impaired immunity. Maternal index case significantly associated with leprosy case in children and nutritional status plays a pivotal role in shaping the immune response against the bacteria Mycobacterium leprae. Thus, this paper aims to evaluatethe association between nutritional status and leprosy, especially in maternal and child leprosy. The study was conducted in Tuban, Indonesia. We foundsignificant difference in haemoglobin, red blood cells, and haematocrit levels in subject with maternal leprosy in the group of child without leprosy and leprous mother compared to the control group. The difference in haemoglobin and haematocrit level are also associated with child leprosy in the group of child with leprosy and mother with leprosy.In addition, although no significant association on BMI were observed, we found that the child whose mother contracted leprosy has a lower BMI compared to the other groups
Socioeconomic Factors and The Incidence of Maternal and Child Leprosy: A Study in Endemic Areas in East Java, Indonesia Hari Basuki Notobroto; Flora Ramona Sigit Prakoeswa; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15775

Abstract

Background: Leprosy is one of the neglected tropical disease caused by Mycobacterium leprae. Endemicareas are still found due to incapability of MDT regimen alone to eradicate leprosy. The good understandingof high-risk population characteristic to plan elimination strategy of leprosy is needed, especially invulnerable populations such as mothers and children population. This study aims to find association betweensocioeconomic factors and the incidence of leprosy in maternal and children leprosy in endemic areas.Methods: This is a case-control study in endemic areas in Tuban Regency, East Java Province, Indonesia.The obtained data was done using structured questionnaire and direct measurement. Chi-square, t-test/Mann-Whitney test was used to assess the association between socioeconomic factors and the incidence ofleprosy in maternal and children leprosy in endemic areas.Results: 22 pairs of cases and 57 pairs of controls were analyzed. This study found that education isassociated with the incidence of leprosy. Significant results were observed in father’s education (p value=0.023) with the incidence of maternal leprosy and mother’s education (p value= 0.003) education) andfather’s education (p value= 0.013) with the incidence of children leprosy. Family income also associatedwith the incidence of maternal (p value= 0.040) and children leprosy (p value= 0.036). Occupation is notassociated with the incidence of leprosy.Conclusion : The result of this study shows that education and family income are related with the incidenceof leprosy in both, mothers and children population.
Correlation of Hematological Parameters on Maternal and Pediatric Leprosy ImmunityRatio: A Study in Endemic Areas in East Java, Indonesia Muhammad Yulianto Listiawan; Flora Ramona Sigit Prakoeswa; Anang Endaryanto; Cita Rosita Sigit Prakoeswa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15882

Abstract

Background: Leprosy is chronic infectious disease caused by Mycobacterium leprae. Endemic areas stillexisted with stable number of new cases including new cases of pediatric leprosy and female leprosy cases.Close contact and women’s role in household increase the risk of transmission of leprosy to their children.Population lived in endemic areas are prone to contract leprosy due to dysregulation of immune system. Thisstudy aims to analyze correlation of hematological parameters and immunity ration in maternal and pediatricleprosy in endemic areas.Methods: This is a cross-sectional study in endemic areas in Tuban Regency, East Java Province,Indonesia. The blood sample was taken from the subjects and underwent complete hematological parametertest (hemoglobin, red blood cells, white blood cells, platelets, hematocrit) and measurement of T cellsactivityratio(Th1/Th2 ratio and Th17/Treg ratio) by ELISA. Correlation test was done between blood testresultsand the immunity ratio of maternal and pediatric leprosy in endemic areas.Results: 33 pairs of maternal and pediatric leprosy cases were analyzed. This study found correlationbetween RBC (p value= 0.029) and HCT (p value= 0.038) with Th17/Treg ratio in children population. Nosignificant results observed in mothers population.Conclusion: The result of this study shows that hematological paramaters (HB and HCT) related to theTh17/Treg ratio and could play roles in the incidence of dysregulation of immune system in children leprosy.
The protective effect of sunscreens against ultraviolet B-induced immunosuppression. A study on Langerhans cell depletion Flora Ramona SP Fajar Waskito Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 42, No 01 (2010)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3379.687 KB)

Abstract

Ultraviolet B (UVB) radiation can act as immunosuppressant by inducing an epidermal Langerhans cells (LC) depletionwhich could be inhibited by topical sunscreen. Several kinds of sunscreens with various SPF (Sunscreen ProtectionFactor) are now available. The minimal SPF which able to inhibit the immunosuppressive effect of UVB amongpeople with skin photo-type IV has not been established yet. The aim of this study is to determine the minimal SPFcapable to inhibit UVB-induced immunosuppression among people with skin photo-type IV. A simple experimental(post test only experimental) study was conducted among 5 people’s circumsized foreskins with Fitzpatrick’s skinphoto-type IV. Each of them was divided into equal 5 pieces of 0.5 cm2. Each of three pieces of skin was treated bysunscreen SPF 15, SPF 30, and SPF 50, a single piece of skin was treated with placebo, and all of them then weretreated by a single 100 mJ/cm2 of UVB 30 minutes later. A rest single piece of skin was used as control. After 24hours of incubation in incubator of 37O C and 5% CO2, all of them then was fixed by buffer formalin, blocked byparaffin, cut in 2mm of thickness, and then stained with anti CD 1a antibody with AEC as chromogen and Mayer’shematoxylin as counterstaining. The number of LC was counted by Image J Analysis programmed and the mean ofLCwere analyzed by Kruskal-Wallis test dan Mann-Whitney test. There were very significantly different of themean number of LC between UVB placebo group and control group (p < 0.01). Compared to the control group,mean number of LC among SPF 30 and SPF 50 treated groups were not significantly different (p>0.05). Sunscreenwith SPF 15 had LC number lower than control group significantly (p<0.05). The lowest SPF for preventing UVBinduced LC depletion among people with skin photo-type IV was 30.Key words : UVB - immunosupression – sunscreens – SPF -CD1aexpression
Co-Authors . Suswardana . Suswardana, . Agus Sri Wardoyo Anang Endaryanto Anggelina Aiyoslla Nabilla Putu Pratomo Anik Enikmawati Annisa Nur Kharisma Annisa Rizki Maharani Ardhana Januar Mahardhani Arief Hidayat Awanis, Ghina Shabrina Az zahra Miftahul Husna Bayu Hendro Wicaksono Budi Prasetyo Budi Utomo Burhannudin Ichsan Cita Rosita Sigit Prakoeswa Dadi Rosadi Dewi, Listiana Masyita Dewi, Listiana Masyta Dian Ardifah Iswari Dita Rahmawati Dominicus Husada Dyah Puji Astuti Erika Diana Risanti Erlita Puspitasari Erma Widyastuti Ersi Dwi Utami Siregar Fanani Firdaus Faradiba Maharani Febriani Aldila Safitri Hardyanto Soebono Hari Basuki Notobroto Ida Betanursanti Inggrit Thalasavia Utami Isnaeni Nur Fauziah Isnaniyanti Fajrin Arifin Jihan Naufa Hazimah Kohar Hari Santoso Listiana Masyita Dewi Listiana Masyta Dewi M. Yulianto Listiawan Martdwitanti Ajeng Kumalaningtyas Mitha Amelia Rahmawati N. Juni Triastuti Nada Ayu Saputri Nining Lestari Oki Wihardiyanto Pipit Melyana Kurniawati Raafika Studiviani Dwi Binuko Raden Roro Nadya Maureen Rahmi Kurniasih Ratih Pramuningtyas Ratih Pramuningtyas Ratih Pramuningtyas Rima Munawaroh Rima Munawaroh Rochmadina Suci Bestari Rully Setia Agus Dimawan Rully Setia Agus Dimawan Rully Setia Agus Dimawan Saiful Hidayat Salma Febrina Putri Santi Martini Satria, Yohanes Aditya Adhi Septi Rismala Ekayanti Shafira Nurul Amalia Sidiq Diwa Montella Siregar, Ersi Dwi Utami Siti An Nisa Sitta Rahma Tika Melandya Santi Trias Mahmudiono Vina Khoirunisya Winda Atika Sari Yohanes Aditya Adhi Satria Yohanes Aditya Adhi Satria Yundari, Yundari Yusuf Alam Romadhon Zamawi Zamawi