Garuda - Garba Rujukan Digital

AKTIVITAS ANTIINFLAMASI EKSTRAK METANOLIK BUAH MANGGA KASTURI (Mangifera casturi) MELALUI PENGHAMBATAN MIGRASI LEUKOSIT PADA MENCIT YANG DIINDUKSI THIOGLIKOLAT Fakhrudin, Nanang; Putri, Peni Susilowati; Sutomo, Sutomo; Wahyuono, Subagus
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Mangga kasturi (Mangifera casturi) adalah manggaÂ khas Kalimantan Selatan. Buah mangga Â Â kasturi dilaporkan memilikiÂ aktivitas antioksidan dan potensial untuk pengobatan berbagai penyakit termasuk penyakit yang berhubungan dengan inflamasi. Penelitian ini bertujuan untuk menguji aktivitas antiinflamasi dari ekstrak metanol buah mangga kasturi melalui uji migrasi leukosit pada mencit yang diinduksi thioglikolat. Secara singkat, mencit diinduksi dengan thioglikolat untuk menaikkan jumlah leukosit, dan dihitung penghambatan migrasi leukosit oleh ekstrak metanolik buah mangga kasturi. Thioglikolat diberikan selama 4,5 jam (i.p.) sedangkan ekstrak metanolik buah mangga kasturi (i.p.) diberikan 30 menit sebelum pemberian thioglikolat. Keduanya diberikanÂ secara injeksi intra peritoneal (i.p.). Penghitungan jumlah leukosit dilakukan menggunakan haemositometer dengan bantuan mikroskop. Jumlah leukosit pada kelompok normal, indometasin, ekstrak dosis 625; 125; dan 2,5 g/Kg BB berturut- Â turut adalah 38,24%; 11,28%; 65,24%; 19,72%; dan 7,18%. Analisis statistik dengan menggunakan uji post hoc multiple comparison Games Howell dengan tingkat kepercayaan 95% menunjukkan bahwa ekstrak metanolik buah mangga kasturi dosis 1250 dan 2500 mg/Kg BB mempunyai potensi antiinflamasi Â melalui penghambatan migrasi leukosit pada mencit yang diinduksi thioglikolat. Aktivitas ekstrak metanolik buah mangga kasturi tersebut lebih lemah dibandingkan indometasin yang menberikan respon antiinflamasi yang sama pada dosis yang lebih kecil. Uji Kromatrografi Lapis Tipis (KLT) menunjukkan ekstrak metanolik buah mangga kasturi mengandung senyawa triterpenoid dan fenolik.

PERBANDINGAN INHIBISI BERBAGAI EKSTRAK TUMBUHAN DAN VITAMIN C PADA FOTODEGRADASI TIROSIN YANG DIINDUKSI KETOPROFEN DAN KANDUNGAN FENOLIK TOTALNYA Tatang Irianti; Nanang Fakhrudin; Efendi Efendi; Sigit Hartomo; Siluh Putu Yuni Astuti; Ratih Anggar Kusumaningtyas; Argandita Meiftasari
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Antioxidant is known to inhibit free radical reaction. Tyrosine photodegradation can be caused by radical reaction. Nowadays, plant with antioxidants are widely used to inhibit free radical reaction. Study of inhibition of photodegradation used four groups. Those groups are: P1 consisted of 2mL tyrosine 0,05 %; P2 consisted of 2 mL tyrosine 0,05 %, and 600 μL Rhetoflam (topical ketoprofen) 1 %; P3 consisted of 2 mL tyrosine 0,05 %, 60μL Rhetoflam 1 %, and 100 μL tea leaf water ekstract 0,15 %; P4 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL mahkota dewa fruit water ekstract 0,15 %; P5 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL finger root etanolic ekstract 0,15 %; P6 consisted of 2 mL tyrosine 0,05 %, 600 μL Rhetoflam 1 %, and 100 μL vitamin C 0,15 %; each group is added with aquadest up to 5,0 mL and illuminated with mercuric lamp for four hours. Level of remaining tyrosine was measured with visible spectrophotometric method. We used ANOVA to analyse the data with convidence level of 0,95 and then continued by Tukey (HSD). Follin-Ciocalteu method with galic acid calibration curve was used to determine total phenolic level. The level of total phenolic of tea leaf aquoeus extract, mahkota dewa fruit aquoeus extract, fingerroot ethanolic extract were 29.64±0.86 %; 8.29 % 0.27 %; and 7.11 %, 0.15 %, respectively. Our investigation also found gallic acid equivalent (GAE) with the inhibition activity of 4.03; 1.58; and 2.09 and they were bigger than Vitamin C with the same concentration of 0.15 %.

Potensi Antioksidan Biji dan Daun Kacang Hijau (Vigna radiate L.) dan Studi Korelasinya Dengan Kadar Flavonoid Total Nanang Fakhrudin; Nimas Ayu Kurniailla; Kahfi Nur Fatimah
Jurnal Penelitian Pascapanen Pertanian Vol 17, No 1 (2020): Jurnal Penelitian Pascapanen Pertanian
Publisher : Balai Besar Penelitian dan Pengembangan Pascapanen Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/jpasca.v17n1.2020.48-58

Biji dan daun kacang hijau (KH) mengandung senyawa flavonoid sebagai antioksidan yang bermanfaat bagi kesehatan. KH dapat diekstrasi dengan air dan etanol menghasilkan ekstrak kaya flavonoid untuk bahan baku produk suplemen kesehatan dan obat tradisional. Penelitian bertujuan membandingkan potensi antioksidan dari biji dan daun KH, menganalisis kandungan flavonoid dan korelasinya dengan potensi antioksidan. Biji dan daun KH diekstraksi dengan air dan etanol masing-masing menggunakan metode dekokta dan maserasi. Potensi antioksidan ekstrak dievaluasi dengan metode FRAP menggunakan trolox sebagai pembanding, dan nilainya dinyatakan sebagai ekuivalensi terhadap trolox per gram ekstrak. Kadar flavonoid total ditetapkan secara spektrofotometri dengan rutin sebagai pembanding. Analisis kandungan flavonoid ekstrak dilakukan dengan kromatografi lapis tipis. Ekstraksi air biji KH memiliki potensi antioksidan 69,65±10,89 µmol TE/g, lebih tinggi dari daunnya 40,52±3,33µmol TE/g. Pada ekstraksi dengan etanol, potensi antioksidan biji KH lebih besar daripada daunnya (131,50±12,77µmol TE/g dibanding 9,37±0,42 µmol TE/g). Ekstrak air biji dan daun KH masing-masing memiliki kadar flavonoid total 2,98±0,03 dan 2,64±0,29 %, sedangkan ekstrak etanolnya masing- masing sebesar 4,71±0,72 dan 1,06±0,16 %. Kadar flavonoid ekstrak sebanding dengan potensi antioksidannya. Vitexin dan rutin merupakan senyawa flavonoid utama dalam biji dan daun KH. Daun KH juga memiliki potensi antioksidan yang cukup kuat dan kaya akan senyawa flavonoid. Antioxidant Potency of Mung Bean (Vigna radiate L) Seed and Leaf and Its Correlation with The Total Flavonoid Content.Mug Bean (MB) seeds dan leaves contain flavonoids with promising antioxidant activity. MB can be extracted with water and ethanol to yield flavonoid-enriched extract for health supplement and traditional medicine products raw material. This study aimed to compare the antioxidant potency of MB seed and leaf, and to analyze the flavonoid content and its correlation with antioxidant potency. MB seed and leaf were extracted with water and ethanol using decocta and maceration, respectively. The antioxidant potency of the extracts was evaluated by the FRAP method using Trolox as a reference control. The antioxidant potency was expressed as Trolox equivalent per gram of extract. The total flavonoid contents were determined spectrophotometrically with Rutin as a reference compound. Analysis of flavonoid component in the extracts was done by thin layer chromatography. The water extracts of MB seeds and leaves demonstrated antioxidant potency of 69.65±10.89 and 40.52±3.33 µm TE/g, whereas the ethanol extracts were 131.50±12.77 and 9.37±0.42 µmol TE/g, respectively. The water extracts of MB seeds and leaves have total flavonoid content of 2.98±0.03 and 2.64±0.29 %, whereas the ethanol extracts were 4.71±0.72 and 1.06±0.16 %, respectively. We found that the total flavonoid content is proportional with the antioxidant potency. Vitexin and Rutin are the main flavonoids in MB. MB leaves also showed a powerful antioxidant potency and are rich of flavonoids.

Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory. Lukitaningsih, Endang; Wirasti, Wirasti; Nurrochmad, Arief; Dirman, Arifin; Rahmawati, Adillah; Fakhrudin, Nanang
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Brown macroalgae (BM) which contain fucoxanthin exhibited high antioxidant activity. This study was performed to examine antioxidant, anti-collagenase, anti-elastase, anti-tyrosinase activities, and effect on cell viability of Human Dermal Fibroblast adult (HDFa) of BM, Turbinaria decurrens Bory. T. decurrens dried powder were macerated by ethanol to obtain extract (ETD) and was fractination by column chromatography to obtain fraction (FTD). Fucoxanthin content was determined using HPLC. The antioxidant activities, anti-collagenase, anti-elastase, and tyrosinase inhibitory assay were performed. The effect of ETD and fucoxanthin standard on cell viability were conducted on HDFa cell-induced by hydrogen peroxide (H2O2). The HPLC analysis showed that ETD and FTD contain fucoxanthin of 284.9±3.3µg/g and of 653.4±30.6µg/g dry-weight, respectively. The antioxidant assay showed that ETD and FTD produced high antioxidant activity by ferric reducing antioxidant power (FRAP) and b-carotene bleaching (BCB) methods that were comparable to fucoxanthin. ETD exhibited significantly higher tyrosinase inhibitory than kojic acid (p<0.01), while FTD had a comparable effect to kojic acid. The result also revealed that ETD and FTD produced anti-elastase and anti-collagenase (matrix metalloproteinase-1 (MMP-1). Fucoxanthin and ETD were able to maintain cell viability on HDFa cell-induced H2O2. This study suggests that T. decurrens may be effective to prevent skin aging and wrinkle formation, possibly through the antioxidant activity and maintain cell viability of fibroblast.

Comparison of the Subchronic Anti-Inflammatory Activity of the Ethanol and Ethyl Acetate Extracts of Breadfruit Leaves (Artocarpus altilis) on CFA-Induced Mice Widhihastuti, Endah; Ni'ma, Neli Syahida; Widyarini, Sitarina; Fakhrudin, Nanang
Indonesian Journal of Chemical Science Vol 10 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v10i1.46870

Chronic inflammation of the joints can cause rheumatoid arthritis (RA). Breadfruit (Artocarpus altilis) is known to have anti-inflammatory activity. Previous studies showed that ethanol and ethyl acetate extracts of breadfruit leaves have anti-inflammatory activity in an acute anti-inflammatory model. This study aimed to determine the sub chronic anti-inflammatory activity of the ethanol and ethyl acetate extracts in CFA-induced mice. Balp/c mice (15) were divided into 5 groups: normal group, solvent-treated group, diclofenac sodium-treated group (dose 3 mg/kgBW), ethyl acetate extract-treated group (500 mg/kgBW dose), and ethanol extract-treated group (500 mg/kgBW dose). The extracts were given orally every day for 28 days. The body weight and edema volume were measured on the day of 1, 7, 14, 21, and 28 after CFA induction. This study showed that the ethanol and ethyl acetate extracts were able to inhibit inflammatory process by reducing the edema in mice. Ethyl acetate extract exhibited a stronger anti-inflammatory activity compared to the ethanol extract. Although the body weight of the mice treated with the ethanol extract was higher than that of the ethyl acetate extract, both extracts did not cause a significant change in body weight compared to the normal group. The results of this study indicated that the ethanol and ethyl acetate extracts of breadfruit leaves both demonstrated a sub chronic anti-inflammatory activity in mice.

AKTIVITAS ANTIINFLAMASI EKSTRAK METANOLIK BUAH MANGGA KASTURI (Mangifera casturi) MELALUI PENGHAMBATAN MIGRASI LEUKOSIT PADA MENCIT YANG DIINDUKSI THIOGLIKOLAT Nanang Fakhrudin; Peni Susilowati Putri; Sutomo Sutomo; Subagus Wahyuono
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kasturi (Mangifera casturi) is a plant originally from Kalimantan, mainly in South Kalimantan. Although there is no report regarding the usage of the fruit in traditional healings, current research demonstrate that methanolic extract of Mangifera casturi fruit demonstrated high antioxidant activity. As oxidant plays crucial role in inflammatory related diseases, we investigate the antiinflammatory effect of Mangifera casturi fruit methanolic extract. To assess the antiinflammatory activity, we used thioglycollate-induced leukocyte migration in mice. Male balb/c mice were pretreated (i.p) with Mangifera casturi fruit methanolic extract followed by thioglikolat (i.p) to induce leukocyte migration. After 4,5 hours, the mice were sacrificed and the number of leukocytes were counted using hemocytometer under light microscope. Our experiment indicates that Mangifera casturi fruit methanolic extract significantly exhibited antiinflammatory activity by inhibiting the migration of leukocytes induced by thioglycollate. However, the activity of the extracts was lower than the positive control, indomethacin. Further purification was required to obtain the active compound with the activity comparable to indomethacin. Thin layer chromatography (TLC) analysis demonstrates that the methanolic extract of Mangifera casturi fruit contains terpenoid and phenolic compounds.

KAJIAN ETNOBOTANI, FITOKIMIA, FARMAKOLOGI DAN TOKSIKOLOGI SUKUN (Artocarpus altilis (Park.) Fosberg) Gharsina Ghaisani Yumni; Sitarina Widyarini; Nanang Fakhrudin
Jurnal Tumbuhan Obat Indonesia Vol 14 No 1 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i1.3944

ABSTRACT Indonesia is a country with large plant biodiversity with medicinal properties, such as “sukun” (Artocarpus altilis) or known as “breadfruit”. Breadfruit is a woody evergreen plant that has been used traditionally for various purposes, including medication. The fruit is rich in carbohydrates and fibers as a food source. The leaf and cortex are the most widely used for treating various diseases and other health benefits. This article aimed to present a comprehensive review on the potency of breadfruit from the perspective of ethnobotany, phytochemistry, pharmacology, and toxicology. The data in this narrative review was obtained from the scientific journals in the databases of Google Scholar, PubMed, Scopus, and ScienceDirect. Other credible sources, such as textbooks, student thesis, and patents were also used to support the main data. Based on the literature study, breadfruit has been used empirically in Indonesia as a medicinal herb. The scientific data of breadfruit showed antiinflammatory, antiplatelet, antioxidant, antiatherosclerosis, antihyperlipidemic, antimalaria, antidiabetic, cardioprotective, and anticancer activities. Breadfruit contains terpenoids, flavonoids, alkaloids, and phenolics as bioactive compounds. However, the unique compounds are geranylated and prenylated flavonoids such as cycloartenol, artonin V, and cyclomulberin. These compounds are distributed in the leaf, cortex, wood, and fruit. Limited data is available regarding the toxicology profile of breadfruit. Breadfruit leaves ethanol extract did not show any significant toxic effects in the animal experiments. However, the toxicity of the water extract is unclear, and thus, needs to be investigated to ensure its safety. Keywords: Artocarpus communis, bioactivity, chemical constituents, ethnopharmacology ABSTRAK Indonesia dikenal sebagai negara yang kaya akan keragaman tumbuhan berpotensi obat, diantaranya sukun (Artocarpus altilis). Sukun merupakan tanaman berkayu yang secara tradisional dimanfaatkan untuk berbagai keperluan termasuk pengobatan. Buah sukun mengandung karbohidrat dan serat sebagai sumber pangan. Daun dan batang sukun merupakan bagian yang paling banyak dimanfaatkan dalam pengobatan dan kesehatan. Reviu artikel ini bertujuan untuk mengkaji secara komprehensif potensi sukun dari sudut pandang etnobotani, fitokimia, farmakologi, dan toksikologi. Artikel narrative review ini ditulis berdasarkan data yang diperoleh dari kajian literatur hasil penelitian yang ada di basis data Google Scholar, PubMed, Scopus, dan ScienceDirect. Beberapa sumber pustaka lain seperti buku, naskah tugas akhir dan paten juga digunakan untuk memperkaya penulisan. Hasil kajian literatur sukun menunjukkan bahwa tanaman ini memiliki riwayat empiris digunakan sebagai obat tradisional di Indonesia. Hasil penelitian ilmiah menunjukkan sukun memiliki aktivitas antiinflamasi, antiplatelet, antioksidan, antiatherosklerosis, antihiperlipi-demia, antimalaria, antidiabetes, kardioprotektif, dan antikanker. Sukun mengandung senyawa terpenoid, flavonoid, alkaloid, dan senyawa fenolik. Senyawa khas dari tumbuhan genus Artocarpus ini adalah flavonoid dengan gugus geranil atau prenil, misalnya sikloartenol, artonin V, dan siklomulberin. Senyawa tersebut tersebar dalam daun, kulit kayu, batang, dan buah. Data terkait profil toksikologi sukun masih terbatas. Ekstrak etanol daun sukun tidak menunjukkan efek toksik pada hewan uji. Namun, ekstrak airnya belum memiliki profil toksikologi yang jelas sehingga perlu dilakukan pengujian untuk memastikan keamanannya. Kata kunci: Artocarpus communis, bioaktivitas, kandungan kimia, etnofarmakologi

Comparison of the Subchronic Anti-Inflammatory Activity of the Ethanol and Ethyl Acetate Extracts of Breadfruit Leaves (Artocarpus altilis) on CFA-Induced Mice Widhihastuti, Endah; Ni'ma, Neli Syahida; Widyarini, Sitarina; Fakhrudin, Nanang
Indonesian Journal of Chemical Science Vol 10 No 1 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v10i1.46870

Chronic inflammation of the joints can cause rheumatoid arthritis (RA). Breadfruit (Artocarpus altilis) is known to have anti-inflammatory activity. Previous studies showed that ethanol and ethyl acetate extracts of breadfruit leaves have anti-inflammatory activity in an acute anti-inflammatory model. This study aimed to determine the sub chronic anti-inflammatory activity of the ethanol and ethyl acetate extracts in CFA-induced mice. Balp/c mice (15) were divided into 5 groups: normal group, solvent-treated group, diclofenac sodium-treated group (dose 3 mg/kgBW), ethyl acetate extract-treated group (500 mg/kgBW dose), and ethanol extract-treated group (500 mg/kgBW dose). The extracts were given orally every day for 28 days. The body weight and edema volume were measured on the day of 1, 7, 14, 21, and 28 after CFA induction. This study showed that the ethanol and ethyl acetate extracts were able to inhibit inflammatory process by reducing the edema in mice. Ethyl acetate extract exhibited a stronger anti-inflammatory activity compared to the ethanol extract. Although the body weight of the mice treated with the ethanol extract was higher than that of the ethyl acetate extract, both extracts did not cause a significant change in body weight compared to the normal group. The results of this study indicated that the ethanol and ethyl acetate extracts of breadfruit leaves both demonstrated a sub chronic anti-inflammatory activity in mice.

Application of Ultrasonic-Assisted Fractionation with Full-Factorial Design for the Production of Alkaloid-Rich Fraction from Ficus septica Leaves Muhammad Hafizh Ridho; Andayana Puspitasari Gani; Subagus Wahyuono; Nanang Fakhrudin
Journal of Food and Pharmaceutical Sciences Vol 8, No 3 (2020): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.852

Ficus septica Burm. F (Awar-awar) in Indonesian herbal medicine traditionally used for the treatment of various disease. Previous studies indicated that the F. septica leaves contained phenantroindolizidine alkaloids with anticancer activity. Fractionation of the ethanol extract of F. septica leaves using n-hexane was able to separate chlorophylls and other inert non–polar constituents from the extract. This fractionation process can be optimized using ultrasonic-assisted fractionation to yield n-hexane insoluble fraction (HIF) that is rich in alkaloids. This study aimed to produce HIF from the ethanol extract of F. septica leaves by using optimized ultrasonic-assisted fractionation with n-hexane as a solvent and full factorial as experimental design. Ficus septica leaves were macerated in ethanol (60%) and the extract was used for the ultrasonic-assisted fractionation process. The duration of fractionation (5-30 minutes), the extract : n-hexane ratios (1:0.1 - 1:1.66 ml/ml), and the ultrasonic power (21-106 Wrms) were optimized to determine the optimal condition for each variable. These optimal variables were used for the production of HIF from the extract by using full factorial design in the ultrasonic-assisted fractionation process. The total alkaloid content was measured using spectrophotometry and was used as parameter for the optimization process. We found that the optimal condition for the fractionation process based on each single variable optimization were 5 minutes of the fractionation duration, 66-70Wrms of the ultrasonic power, and 1:0.7 - 1:0.8 of the extract : n-hexane ratio. By using these optimized variables, the ultrasonic-assisted fractionation using full factorial design yielded up to 0.035% total alkaloid content which is almost double from those in the extract (0.019%). This study provided a basic experimental model for the production of alkaloid-enriched HIF from F. septica leaves in the industrial or pilot scale, and might contribute to the development of Indonesian herbal medicine products from natural resources.

Profil Fitokimia dan Aktivitas Antioksidan Beberapa Tumbuhan Genus Artocarpus di Indonesia Ayu Ina Solichah; Khoerul Anwar; Abdul Rohman; Nanang Fakhrudin
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2026

Artocarpus merupakan tumbuhan genus utama keluarga Moraceae dengan jumlah spesies hampir 1.400. Beberapa spesies dari genus tersebut dapat dimanfaatkan sebagai makanan dan obat tradisional di Asia Tenggara, termasuk Indonesia. Jenis yang banyak tumbuh di Indonesia yaitu Artocarpus altilis (sukun), Artocarpus camansi (kluwih), Artocarpus heterophyllus (nangka), Artocarpus integer (cempedak), dan Artocarpus odoratissimus (tarap). Tumbuhan tersebut memiliki potensi sebagai bahan obat dan punya nilai gizi yang tinggi. Review ini bertujuan untuk mengkaji perbedaan antar spesies, profil fitokimia, dan aktivitasnya sebagai antioksidan dari kelima tumbuhan tersebut. Narrative review ini ditulis berdasarkan penelusuran literatur yang berupa publikasi artikel penelitian yang ada di basis data Google Scholar, PubMed, dan Science Direct. Selain itu digunakan sumber pustaka lain berupa buku dan naskah tugas akhir untuk memperkaya isi artikel. Hasil kajian literatur terhadap 5 tumbuhan tersebut menunjukkan bahwa beberapa tumbuhan memiliki kemiripan morfologi daun walaupun secara fisik masih bisa dibedakan. Profil fitokimianya memiliki keunikan dengan kandungan utama berupa senyawa fenolik termasuk flavonoid, stilbenoid, arilbenzofuron, dan neolignan yang tersebar pada bagian daun, buah, bunga, dan kulit. Keunikan tersebut ditemui dengan adanya senyawa golongan flavonoid terprenilasi dan tergeranilasi. Senyawa fenolik tersebut mempunyai kemampuan sebagai antioksidan pada beberapa model uji dan potensial untuk dikembangakan sebagai antioksidan atau kandidat obat terutama untuk penyakit yang melibatkan mekanisme radikal bebas dalam mekanisme patofisiologinya.

Title

Found 18 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 18 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 18 Documents
Search