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All Journal Journal of Agromedicine and Medical Sciences SRIWIJAYA JOURNAL OF MEDICINE SRIWIJAYA JOURNAL OF MEDICINE Jurnal Teknologi Sumberdaya Mineral
Zahrah Febianti, Zahrah
Fakultas Kedokteran, Universitas Jember
Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Antimicrobial in vitro Study of Cosmos caudatus H.B.K Leaves Extract Towards Methicillin-Resistant Staphylococcus aureus (MRSA) Febianti, Zahrah
Journal of Agromedicine and Medical Sciences Vol 1, No 2 (2015)
Publisher : Medical Faculty of Jember University (Fakultas Kedokteran Universitas Jember)

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Abstract

Cosmos caudatus H.B.K leaves is known to have many active substances with antimicrobial effect such as saponin, flavonoid, poliphenol, volatile oil, costunolide, and 4,4’-bipyridin. This research is conducted to prove the antimicrobial effect of Cosmos caudatus leaves extract on gram positive Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro. The sample of this research is served by Microbiology Laboratorium of Brawijaya University. An experimental study with tube dilution method was carried out. The treated groups are groups of bacteria treated with Cosmos caudatus leaves extract with a range concentrations of 14%; 12%; 10%; 8%; and 6%. The control group is groups treated with 0% extract. The result indicates that the MIC (Minimal Inhibitory Concentration) can not be observed due to the extract’s turbid green colour. The MBC (Minimal Bactericidal Concentration) is 14% for MRSA. Data analysis with CI=95% shows a significant difference of effects on the number of MRSA colonies growth (Anova, p = 0,000) with the change of extract concentrations. The correlation regression test shows a strong association between the extract concentration and the number of colonies growth (Correlation, r = -0,754, p=0,000). Cosmos caudatus leaves extract has antimicrobial effect on MRSA.Keywords : Cosmos caudatus leaves estract, Methicillin-Resistant Staphylococcus aureus (MRSA), antimicrobial.
Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4 Widiatmaja, Danang Tejamukti; Mufida, Diana Chusna; Febianti, Zahrah
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i1.155

Abstract

Streptococcus pneumoniae or pneumococcus is the main cause of community acquired pneumoniae (CAP). Infection of pneumococcal can be prevented by vaccines, like PPV and PCV. Those vaccines have several weaknesses, like, limited to several strain of bacteria and invasive. Nowadays, development of pneumococcal vaccines used the antigenic component of which occur on the bacteria, like epitope. One of the epitopes that can be used as vaccine candidate is epitope from RrgB protein of bacteria’s pili. One of the RrgB protein’s epitope that has been identified having antigenic property is epitope protein RrgB 255-270 of Streptococcus pneumoniae bacteria’s pili. That epitope will stimulate immune system to produce antibody against the antigen supported by cytokine, like IL-4. This research aim is to knowing the effect of intranasal immunization epitope protein RrgB 255-270 Streptococcus pneumoniae to IL-4 level. Wistar rat’s nasal rinse sample IL-4 levels measured by ELISA method. The mean of K1 is 28,852± 18 ng/L, K2 is 20.630 ± 9 ng/L and K3 is 18.519 ± 6 ng/L. Result of Welch ANOVA test shows that p-value of this research is 0.299. That can be concluded that the effect of intranasal immunization epitope protein RrgB 255-270 S. pneumoniae give non-significant difference (p-value > 0.05).
Pengaruh Pemberian Imunisasi Intranasal Epitope Protein RrgB 255-270 Streptococcus pneumoniae Terhadap Kadar IL-4 Widiatmaja, Danang Tejamukti; Mufida, Diana Chusna; Febianti, Zahrah
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i1.155

Abstract

Streptococcus pneumoniae or pneumococcus is the main cause of community acquired pneumoniae (CAP). Infection of pneumococcal can be prevented by vaccines, like PPV and PCV. Those vaccines have several weaknesses, like, limited to several strain of bacteria and invasive. Nowadays, development of pneumococcal vaccines used the antigenic component of which occur on the bacteria, like epitope. One of the epitopes that can be used as vaccine candidate is epitope from RrgB protein of bacteria’s pili. One of the RrgB protein’s epitope that has been identified having antigenic property is epitope protein RrgB 255-270 of Streptococcus pneumoniae bacteria’s pili. That epitope will stimulate immune system to produce antibody against the antigen supported by cytokine, like IL-4. This research aim is to knowing the effect of intranasal immunization epitope protein RrgB 255-270 Streptococcus pneumoniae to IL-4 level. Wistar rat’s nasal rinse sample IL-4 levels measured by ELISA method. The mean of K1 is 28,852± 18 ng/L, K2 is 20.630 ± 9 ng/L and K3 is 18.519 ± 6 ng/L. Result of Welch ANOVA test shows that p-value of this research is 0.299. That can be concluded that the effect of intranasal immunization epitope protein RrgB 255-270 S. pneumoniae give non-significant difference (p-value > 0.05).
Kajian Sistem Penyaliran Pada Tambang Terbuka Granit Pit Barat, PT. XYZ, Kabupaten Karimun, Kepulauan Riau Suparno, Fanteri Aji Dharma; Febianti, Zahrah
Jurnal Teknologi Sumberdaya Mineral (JENERAL) Vol 2 No 2 (2021)
Publisher : Program Studi Teknik Pertambangan Fakultas Teknik Universitas Jember

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Abstract

Salah satu kegiatan penting yang dilakukan pada usaha pertambangan adalah sistem penyaliran tambang. Tujuan penelitian adalah untuk mengendalikan air limpasan yang masuk kebukaan tambang agar proses penambangan tidak terganggu. Adapun metode yang digunakan untuk menghitung curah hujan rata-rata dan volume air limpasan yang masuk ke sumuran serta luas kolam pengendapan yang dibutuhkan, yaitu dengan menggunakan metode distribusi Gumbel, metode monobe, dan untuk perhitungan debit limpasan menggunakan metode empiris dan rasional. Dari hasil penelitian curah hujan rata-rata maksimum pada lokasi penelitian yaitu 142.27mm, curah hujan rencana diambil periode ulang 15 tahun sebesar 82.94 mm/jam serta debit limpasan maksimum yang masuk diestimasikan sebesar 6.92 m3/s yang akan masuk ke sump. Jumlah pompa yang digunakan dua unit (2) dengan kapasitas 1000 m3/hari. Jadi untuk mengendalikan air limpasan yang masuk kebukaan tambang dibutuhkan kapasitas kolam sebagai tempat pengendapan sebesar 120.52 m3.
Co-Authors Diana Chusna Mufida Suparno, Fanteri Aji Dharma Widiatmaja, Danang Tejamukti