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UJI TERATOGENIK CAMPURAN SERBUK BIJI JINTEN HITAM (Nigella sativa L.), BIJI KELABET (Trigonella foenum-graecum L.), DAN GINSENG (Panax ginseng C. A. Mey.) PADA TIKUS PUTIH GALUR WISTAR Christianty, Fransiska Maria; Winarti, Lina
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 9, No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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One of the empirical effects of black cumin seed or jinten hitam (Nigella sativa L.) is the agent of abortivum. Feenugreek seeds should not be prescribed medicinally for pregnant women since they can induce uterine contraction. The objectives of this study are to know whether the flavour mixture of black cumin seed, fenugreek, and ginseng can cause abnormalities or congenital malformation to the rat foetus and also whether the congenital malformation or birth defect have relationship significantly with the dosage given. The mixing was given orally to pregnant rats on the 7th day until 15th day of pregnancy to observe the sum of foetus, living foetus, fetal death, resorption (foetus biometric) and congenital malformation (gross morphology). The results indicated that there were many effects of the mixture toward rat foetus, such as the decrease of weight and length, increase of resorption and fetal death, but statistically not significant, except weight of foetus. The dosage of 520; 1697,8; 5543,3 mg/kg of body weight didnât show abnormalities or congenital malformation.

Evaluasi Pelayanan Kefarmasian di Puskesmas Kabupaten Ponorogo Norcahyanti, Ika; Hakimah, Farda; Christianty, Fransiska Maria
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.10525

Public health center is a primary health facility, and pharmacy services support its activities. Periodic monitoring and evaluation of activities are needed to assure the quality of pharmaceutical services. Pharmacy personnels can evaluate pharmaceutical services at the public health center using a guideline published in 2008 by the Directorate of Pharmacy and Community Clinics of the Indonesian Ministry of Health. The purpose of this study was to determine the characteristics, description, and quality of pharmaceutical services at the public health centers in Ponorogo after being evaluated using a list of pharmaceutical services in 2008. This research was an observational survey on all pharmacy personnels and other personnels responsible for the pharmacy room at the public health center in Ponorogo. The analysis of data was using descriptive techniques. The results show that the public health centers were mostly an inpatient center (n=19; 61.3%) and accredited â€˜madyaâ€™ (n=22; 71%). Morover, the head of a pharmacy room was dominantly a pharmacy technician (n=24; 77.4%). Pharmaceutical services generally fulfilled the supporting for and quality control indicators. However, several indicators did not fully meet the guideline, including clinical judgements, counseling, and home care. Overall, only three public health centers can be rated â€œgoodâ€ in delivering quality pharmaceutical services, whilst the other eight and twenty were rated â€œmoderateâ€ and â€œlessâ€, respectively.

Uji Aktivitas Antidiabetes Ekstrak Teh Hitam dan Teh Hijau secara In Vitro Menggunakan Metode Inhibisi Enzim α-Glukosidase Diana Holidah; Yasmin Yasmin; Fransiska Maria Christianty
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7573

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. Carbohydrates are metabolized into glucose, in gastrointestinal tract than absorbed into the bloodstream and increase blood glucose level. This absorption process is catalyzed by α-glucosidase enzyme. Previous studies showed that tea (Camellia sinensis) extract have antidiabetic activity in mice induced by streptozotocin. The aim of this study was to compared the in vitro activity of tea extract in inhibiting α-glucosidase. Black tea and green trea extracts were tested for α-glucosidase inhibitory activity. Acarbose was used as positive control. IC50 extract was 54.86 µg/mL for black tea and 44.79 µg/mL for green tea. This study showed that inhibitory effect of green tea was higher than black tea. Keywords: black tea, green tea, diabetes mellitus, α-glucosidase

Hubungan Efek Samping Suplemen Zat Besi (Fe) dengan Kepatuhan Ibu Hamil di Puskesmas Sumbersari Kabupaten Jember (The Association between Side Effects of Iron Supplementation and Medication Adherence among Pregnant Women in Sumbersari Health Center Jember Regency, East Java) Irvina Anggita Baharini; Antonius Nugraha Widhi Pratama; Fransiska Maria Christianty
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3946

Current knowledge shows that iron supplementation during pregnancy decreases risks of preterm birth and neonatal death. Adherence to iron supplements among pregnant women is very important as it has a large effect on mothers and fetuses. Side effects from iron tablets altogether with physical changes due to pregnancy may decrease patient adherence. Surveillance on medication adherence among pregnant women in Jember is limited. The purpose of this study was to determine the association between side effects and the adherence of pregnant mothers consuming iron tablets. This cross-sectional research used a questionnaire to assess mother's adherence in Puskesmas Sumbersari Jember Regency. A total of 90 pregnant women agreed to participate by giving their consent. The result showed that 58 respondents complained on nausea and vomiting (60.3 %), constipation (31.0 %), headache (17.2 %), diarrhea (10.3 %), and stomach pain (1.7 %). Side effects have negative association to the adherence in pregnant women (p=0.007). Keywords: side effects, iron supplementation, pregnancy

Pengaruh Konseling terhadap Kepatuhan Suplementasi Tablet Besi (Fe) pada Ibu Hamil di Kabupaten Lumajang Antonius Nugraha Widhi Pratama; Nanda Puspasari; Fransiska Maria Christianty
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9872

The prevalence of iron deficiency anemia in Indonesia is relatively high. However, adherence to iron supplementation among pregnant women is relatively low, even though the supplementation is provided free of charge by the government. Counseling is expected to increase patient adherence. Therefore, the present research was to study the effect of counseling on adherence to iron supplementation among pregnant women. A number of 62 respondents from a primary health center in Lumajang Regency were recruited after they gave informed consent and equally allocated to control and treatment groups based on their area residence. The control group received routine antenatal service, while the treatment group received the additional counseling using a brochure. The average of adherence score, based on Morisky Medication Adherence Scale-8 (MMAS-8), in the treatment group (5.9±1.9) was significantly different (p=0.027) from the control group (5.0±1.2). Counseling with brochure appeared to be effective to improve adherence to iron supplementation for pregnant women. Keywords: adherence, iron suplementation, pregnancy, pharmacy counseling

Aktivitas Minyak Jahe Merah (Zingiber Officinale var. rubrum) Terhadap Nyeri Inflamasi pada Mencit Balb-C dengan Induksi CFA (Completed Freund’s Adjuvant) (Activity of Red Ginger Oil (Zingiber officinale var. rubrum) on Inflammatory Pain in Mice Balb-C Wi Fransiska Maria Christianty; Gati Dwi Sulistyaningrum; Fifteen Aprilia Fajrin; Diana Holidah
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Pain is a multidimentional experiences. Chronic pain is caused by inflammation. Nowdays, the treatment of chronic pain is still a challenge. Plants that known to have analgetic activity is red ginger (Zingiber officinale var. rubrum). This research observed the effect of red ginger oil on inflammatory pain. Inflammatory condition was induced by intraplantar injection of CFA (Completed Freund's Adjuvant). Twenty mice were divided into 4 groups i.e sham, negative control, red ginger oil in two different doses (100 and 200 mg/kg BW). Red ginger oil was administrated per oral once a day for seven consecutive days, a week after CFA injection. Latency time toward thermal stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12, and 14 after CFA injection. Paw thickness at the ipsilateral site was also measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after CFA injection. The result showed that the administration of red ginger oil significantly increased latency time toward thermal stimulus compared to negative control. It also significantly reduced paw thickness especially at dose of 200 mg/kg BW. These findings suggested that administration of red ginger oil could treat the inflammatory pain, caused by CFA injection. Keywords: red ginger oil, inflammatory pain, CFA, hyperalgesia

IN VITRO ALFA-GLUCOSIDASE INHIBITORY ACTIVITY OF VARIOUS TEA (Camellia sinensis L.) EXTRACTS Fransiska Maria Christianty; Diana Holidah; Yasmin Yasmin
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diabetes mellitus is a group of metabolicdiseases characterized by hyperglycemia [1]. DM isclassified based on the pathogenic process that leadsto hyperglycemia as opposed to earlier criteria suchas age of onset or type of therapy. There are twobroad categories of DM, designated type 1 and type2 [2]. There were 10 million cases of diabetes inIndonesia in 2015. The number of these cases ispredicted to continue rising [3].Therapeutic approaches for the treatment oftype 2 diabetes, such as diet, sulphonylurea,metformin and insulin therapy, are all successful indecreasing fasting glucose levels. The importance ofpostprandial hyperglycaemia has led to thedevelopment of new agents to control this importantaspect of diabetes.Thus, α-glucosidase enzyme hasbecome one of important target in the treatment oftype-2 diabetes [4,5].α-glucosidase inhibition will slow thedigestion of carbohydrate and absorbtion ofmonosaccahrides in the proximal jejenum [6].Acarbose is an oligosaccharide which reversiblyinhibits intestinal α-glucosidase enzymes responsiblefor digestion of complex carbohydrates anddisaccharides to absorbable monosaccharides [7].The most common adverse effect of acarbose isabdominal discomfort associated with flatulence anddiarrhoea [8]. The undesirable side effects that existunderlie the emergence of research for alternativetherapy of type 2 diabetes, particularly through themechanism of inhibition enzyme α-glucosidase.Tea (Camellia sinensis L.) is annual plant thatwidely spread in Southest Asia, India, South China,Northwest Laos, Thailand and Burma. Tea is one ofthe most popular beverages consumed worldwide[9]. Various studies have reported beneficial effectof tea extract, including for diabetes mellitustherapy. Previous studies showed that tea extracthave antidiabetic activity in mice induced bystreptozotocin [10]. Antidiabetic activity of teaextract have been reported by Yang and Koh. Theresults showed that black tea extract had higheractivity to inhibit α-glucosidase than green teaextract. The present study was designed to comparein vitro α-glucosidase inhibitory activity of varioustea extracts, such as black tea, green tea, oolong tea,and white tea.

GREEN TEA EXTRACT EFFECT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY IN DIABETIC MICE Diana Holidah; Fransiska Maria Christianty; Wilda Zidni Ilma
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diabetes mellitus is a disorder of hyperglycemia andglucose intolerance due to insulin deficiency,impaired of insulin receptor or both (Unwin et al.,2009). There are generally two types of diabetes aretype 1 diabetes (pancreatic beta cell damage causedabsolute insulin deficiency) and type 2 (acombination of a lack of insulin production andsecretion and sensitivity to insulin receptor) (Dipiroet al, 2008).Diabetes mellitus disease is increasing rapidly inworlwide. The incidences in 2010 were about 285million people and It has been estimated that by theyear 2025, the global incidence of diabetes wouldincrease to 350 million (International diabetesfederation, 2006).In diabetes, activation of hepatic gluconeogenesisenzymes can increase glucose production and thuscontribute to increase blood glucose which coulddeteriorate diabetes (Sundaram et al., 2013). Thestate of diabetes characterized by decreased insulinsensitivity is the major cause of NAFLD (Non -Alcoholic Fatty Liver Disease), because in diabetesstate occurs disorders of glucose metabolism and fatso that could result in fibrosis, infiltration,necroinflamation, to acute liver disease (Marchesiniet al., 2001).Treatment of diabetes mellitus is chronic and longlife, causing undesirable side effects (Unwin et al.,2009). Metformin is an oral hypoglycemic agent,which belongs to the class known as the biguanides.Metformin is now widely used as one of themainstays in the management of type 2 diabetes.Metformin reduces fasting plasma glucoseconcentration by reducing rate of hepatic glucoseproduction via gluconeogenesis and glycogenolysis.Metformin improves glycemic control asmonotherapy and in combination with other oralantidiabetic agents, such as sulfonylureas andthiazolidinediones (Frendell et al. 2003).Several plant extracts are known to have antidiabeticproperties and a large number of compounds fromplant extracts have been reported to have beneficialeffects for treatment of diabetes mellitus (Anhauser,2003). Tea (Camellia sinensis L.) is one of plant thatcan decrease blood glucose. Green tea is producedby enzymatic inactivation of the leaves of Camelliasinensis followed by rolling or comminution anddrying. In the manufacturer of green tea, theenzymatic inactivation achieved by steam or panfiring treatment to preserve natural polyphenolswith respect to the health promoting properties.Green tea derived products are mainly extracts ofgreen tea in liquid or powder form varying in theproportion of polyphenols (45-90%) and caffeinecontent (0.4-10%). The polyphenolic fraction ofgreen tea, has been reported to have multiplepharmacological actions (Sano et al., 1995).Green tea is an excellent source of polyphenolantioxidants, known as green tea catechins. Theimportant catechins of green tea are epicatechin(EC), epicatechin-3-gallate (ECG), epigallocatechin(EGC) and epigallocatechin-3-gallate (EGCG). Thepolyphenolic fractions of green tea have beenreported to have multiple pharmacological actions.They exhibit potent antioxidant activity in vitro andin vivo. Epidemiologic observation and laboratorystudies have indicated that polyphenolic compoundspresent in the tea may reduce the risk of a variety ofillnesses, including cancer and coronary heartdisease (McKay and Blumberg 2002).Some studies suggest that green tea extract loweredcholesterol levels and blood glucose on mice and rat(Yang et al., 2001). Green tea extract at dose of300mg /kg /day can lower blood glucose in diabeticrats and was also able to reduce the lipids in heartdefects (Babu et al., 2006). Blood glucose loweringactivity of green tea was greater and totalpolyphenol content was higher when compared withblack tea and oolong tea (Holidah et al., 2015).

UJI TERATOGENIK CAMPURAN SERBUK BIJI JINTEN HITAM (Nigella sativa L.), BIJI KELABET (Trigonella foenum-graecum L.), DAN GINSENG (Panax ginseng C. A. Mey.) PADA TIKUS PUTIH GALUR WISTAR Fransiska Maria Christianty; Lina Winarti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

One of the empirical effects of black cumin seed or jinten hitam (Nigella sativa L.) is the agent of abortivum. Feenugreek seeds should not be prescribed medicinally for pregnant women since they can induce uterine contraction. The objectives of this study are to know whether the flavour mixture of black cumin seed, fenugreek, and ginseng can cause abnormalities or congenital malformation to the rat foetus and also whether the congenital malformation or birth defect have relationship significantly with the dosage given. The mixing was given orally to pregnant rats on the 7th day until 15th day of pregnancy to observe the sum of foetus, living foetus, fetal death, resorption (foetus biometric) and congenital malformation (gross morphology). The results indicated that there were many effects of the mixture toward rat foetus, such as the decrease of weight and length, increase of resorption and fetal death, but statistically not significant, except weight of foetus. The dosage of 520; 1697,8; 5543,3 mg/kg of body weight didn’t show abnormalities or congenital malformation.

Profil Lipid dan Gambaran Histopatologi Aorta Tikus Hiperlipidemia dengan Pemberian EKSTRAK Kopi Hijau Fransiska Maria Christianty; Diana Holidah; Fifteen Aprila Fajrin; Monica Cinuradha Aura Salsabina; Andrean Roni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The high prevalence and risk of death from cardiovascular disease has led to the development of alternative treatments derived from nature. Green coffee has not undergone a roasting process. The product is claimed as a weight loser, even though the cardiovascular effects are still controversial. This study aim was to determine the impact of green coffee bean extract on rat lipid profiles and aortic histopathology. Green coffee bean extract made by a re-maceration method using 96% ethanol. Rats were induced with high-fat diet then treated with green coffee bean extract at a dose of 200; 400; and 800 mg/kg BB. Rats were sacrificed, blood was taken for lipid profile measurements and observations were made on histopathological preparations of rat aorta. The results showed that administration of green coffee bean extract (especially doses of 200 mg/kg BW) for 14 days in hyperlipidemic mice could significantly improve lipid profiles, except HDL levels. Microscopic observations showed that green coffee bean extract could enhance the rat aorta histopathology even though it did not match normal conditions. We can conclude that green coffee bean extract has potential effects to be developed as an alternative to traditional medicine that has antihyperlipidemic effects and cardiovascular protective effects.

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